34results about How to "Lower LDL-C levels" patented technology

A tea bag with a blood fat reducing action is formed by mixing, smashing and packaging green tea, ampelopsis grossedentata leaves, golden camellia and three-nerved spicebush leaves. The ampelopsis grossedentata leaves, golden camellia and three-nerved spicebush leaves can reduce TC, TG, and LDL-C levels of serum and increase HDL-C level of the serum, the ampelopsis grossedentata leaves can also improve serum SOD activity, reduce a liver coefficient and relieve a damage action of high fat to liver cells. The three-nerved spicebush leaves can reduce an arteriosclerosis index AI, a fat coefficient and body weight and relieve fatty degeneration degree of the liver, and lipid droplet formation in the HpeG2 cells is obviously reduced. The ampelopsis grossedentata leaves, golden camellia and three-nerved spicebush leaves coordinately act and are superior to single ampelopsis grossedentata leaf general flavone, single golden camellia total polysaccharide extract and single three-nerved spicebush leaf general flavone in the blood fat reducing effect and has more comprehensive preventing action agaisnt blood fat and blood fat-reducing effect.

The invention discloses a phytosterol compound lipid-decreasing formula and a preparation method for a tablet thereof. The formula comprises the following components in parts by weight: 15-70 parts of phytosterol, 5-50 parts of soybean peptide, 5-30 parts of beta-glucosan, 1-20 parts of lecithin, 10-70 parts of mannite, 1-30 parts of maltodextrin, 0.01-1 part of sucralose and 5-30 parts of microcrystalline cellulose. The preparation method for the tablet thereof comprises the following steps: mixing and stirring; performing wet granulation; drying; stabilizing grain size; and pressing into the tablet, thereby acquiring the tablet of the formula. The invention has the beneficial effects that the formula has an excellent lipid-decreasing effect, is capable of effectively reducing the blood lipid level of hyperlipidemia patient and has a lipid-decreasing healthcare function; the tablet prepared according to the preparation method for the tablet tastes nice; the tablet is high in stability.

The invention discloses an application of naringin in preparing medicaments for curing atherosclerosis. Tests prove that the naringin can decrease level of serum cholesterol, inhibit cholesterin on arterial vascular walls from depositing, obviously decrease level of serum TC, TG, LDL-C, remarkably raise level of serum HDL-C, improve activity of serum SOD and increase level of NO, obviously decrease level of MDA, effectively prevent atheromatous plaques from being formed or damaged, and have the obvious function of curing atherosclerosis.

The present invention relates to a medicine for treating fat live of obesity. It is prepared with seven kinds of Chinese medicinal materials including giant knotwood, pinellia tuber, oriental water plantain, zedoary, peach kernel, prince's-feather fruit and licorice. The preparation process is also disclosed. The medicine has the functions of promoting diuresis, eliminating phlegm, promoting blood circulation and elimianting abdominal mass. It is used to treat fat liver of obesity caused by wetness phlegm stasis mainly. Clinical application shows that it has fast and obviously treating effect and no bad reaction.

The invention discloses functional food containing lithocarpus litseifolius leaves and fructus momordicae and a preparation method of the functional food. The functional food is prepared from raw materials in percentage by mass as follows: 20%-80% of lithocarpus litseifolius leaves and 20%-80% of fructus momordicae. The preparation method of the functional food comprises the steps as follows: after the lithocarpus litseifolius leaves and the fructus momordicae are pretreated, ethanol is added for reflux extraction, obtained filtrates are mixed, ethanol is recovered, extract is dispersed in hotwater, standing, centrifugation, precipitation and vacuum drying are performed, maltodextrin is added, a soft material is prepared, granulation, drying and shaping are performed, total granules are obtained, and the functional food is obtained. Research finds that after all raw materials are matched for use, the synergistic effect is played, and the functional food has significant functions of reducing blood sugar and blood lipid.

The invention belongs to the field of biochemistry, and particularly relates to an RNA inhibitor for inhibiting proprotein convertase subtilisin Kexin9 (PCSK9) gene expression in hepatocytes and application thereof. The RNA inhibitor is formed by a positive-sense strand and an antisense strand through base pairing, at least 85% of bases between the positive-sense strand and the antisense strand are complementary, -OH at the 2' site of partial or all nucleotide glycosyls is substituted by fluorine or methoxyl, and phosphate among at least three continuous nucleotides at the tail end is sulfated. The structure of the RNA inhibitor provided by the invention also contains 5' MVIP and 3' MVIP, so that the RNA inhibitor has specific liver targeting. In-vivo and in-vitro pharmacological experiments prove that: the RNA inhibitor directly acts on PCSK9 mRNA, continuously and efficiently inhibits PCSK9 gene expression and reduces the level of LDL-C in plasma, and is used for treating or/and preventing PCSK9 gene mediated diseases including but not limited to hyperlipidemia, atherosclerosis or PCSK9 gene mediated other diseases.

The invention discloses a malus toringoides leave and sea buckthorn functional food and a preparation method thereof. The malus toringoides leave and sea buckthorn functional food is prepared from thefollowing raw materials in percentage by mass: 20 to 80 percent of malus toringoides leave and 20 to 80 percent of sea buckthorn. The preparation method of the malus toringoides leave and sea buckthorn functional food comprises the following steps: pretreating the malus toringoides leave and the sea buckthorn and then adding ethanol for reflux extraction; combining the obtained filtrate, recovering ethanol, dispersing extract by using hot water, standing, centrifuging, precipitating and carrying out vacuum drying; adding maltodextrin, preparing a soft material, granulating, drying and granulating to obtain total particles, thus obtaining the malus toringoides leave and sea buckthorn functional food. The research on the malus toringoides leave and sea buckthorn functional food disclosed bythe invention shows that after the combination of various raw materials, a synergistic effect is played; the malus toringoides leave and sea buckthorn functional food has obvious effects of loweringblood sugar and lowering blood lipid.

The invention relates to a hypoglycemic active part of osmanthus fragrans, a preparation method and application thereof, and application of the osmanthus fragrans in reducing blood fat, wherein the hypoglycemic active part of the omanthus fragrans is that the osmanthus osmanthus is extracted by petroleum ether, ethyl acetate and normal butanol to prepare petroleum ether, ethyl acetate and normal butanol extracts respectively, wherein the ethyl acetate extract is further separated to prepare triterpene from osmanthus fragrans. An effective component, namely the triterpene from osmanthus fragrans, can be used for preparing natural hypolipidemic and anti-oxidant medicaments; and the osmanthus fragrans of the invention and the effective component thereof, namely the triterpene from osmanthus fragrans, are used for preparing health products for the application of the prevention and adjuvant therapy of hyperlipemia. In vivo animal experiments prove that the triterpene from osmanthus fragranshas the remarkable effect of reducing the level of TC, TG and LDL-C in serum of mice with the hyperlipemia, and also has the effect of reducing MDA and increasing the activity of SOD at the same time. Therefore, the osmanthus fragrans not only can reduce the blood lipid level in the serum by improving the autoimmunity, but also can reduce the blood fat by improving the in vivo antioxidant mechanism.

The invention relates to a culture medium for culturing a living biological medicine and application of the culture medium. The culture medium for culturing the living biological medicine is prepared from peptone, beef extract, lactulose, mannose oligomer, raffinose, yeast extract, diammonium hydrogen citrate, K2HPO4, MgSO4, MnSO4, Tween-80 and L-cysteine. The living biological medicine comprises any one or a combination of at least two of lactobacillus reuteri, lactobacillus paracasei, lactobacillus acidophilus, lactobacillus rhamnosus, bifidobacterium longum, pediococcus pentosaceus, lactobacillus crispatus, lactobacillus jensenii or lactobacillus gasseri. The culture medium has an unexpected promoting effect on growth, proliferation, metabolism and efficacy exertion of living biological medicines. The efficacy is such as prevention or treatment of gastrointestinal diseases, immune diseases, cancers, vaginitis and other diseases.

A rosemary-containing composition, a preparing method thereof and applications of the composition are disclosed. The composition includes, by weight, 20-100 parts of rosemary, 10-20 parts of phytosterol, 10-30 parts of tomato seed oil and 10-30 parts of diacylglycerol. The composition is used for adjusting human body blood fat metabolism. The rosemary, the phytosterol, the tomato seed oil and the diacylglycerol which are raw materials are free of incompatibility so that safety can be fully ensured. The composition is adopted as a diet control means, and after the composition is eaten, through adjusting human body blood fat metabolism, occurrence and development of dyslipidemia can be prevented and treated, the risk of atherosclerotic cardiovascular and cerebrovascular diseases is reduced, and quality of life of people with some diseases is improved.

The invention discloses folium mali hupehensis and fructus Lycii ruthenici functional food and a preparation method thereof. The functional food contains, by mass, 20%-80% of folium mali hupehensis and 20%-80% of fructus Lycii ruthenici. The preparation method includes: after pretreatment of folium mali hupehensis and fructus Lycii ruthenici, adding ethanol for reflux extraction, combining filtrates, recovering ethanol, dispersing extract in hot water, standing, centrifuging, precipitating, performing vacuum drying, adding maltodextrin, preparing a soft material, granulating, drying and finishing to obtain total particles, so that the functional food is obtained. According to researches, by compatible utilization of the raw materials, synergistic effects are achieved, and blood sugar and blood fat reduction effects are remarkable.

The invention discloses functional food containing dry Malus toringoides and Malus transitoria leaves and Zea mays styles and stigma and a preparation method of the functional food. The functional food comprises raw materials in percentage by mass as follows: 20%-80% of the dry Malus toringoides and Malus transitoria leaves and 20%-80% of the Zea mays styles and stigma. According to the preparation method of the functional food, the dry Malus toringoides and Malus transitoria leaves and the Zea mays styles and stigma are pretreated, ethanol is added for reflux extraction, obtained filtrates are mixed, ethanol is recovered, extract is dispersed in hot water, left to stand and centrifuged, then precipitates are dried in vacuum, maltodextrin is added, a soft material is prepared, granulation,drying and pelletizing are performed, and total pellets are obtained. Study finds that the raw materials have synergy after being used concomitantly, and the functional food has remarkable effects ofreducing blood sugar and reducing blood lipid.

The invention discloses malus toringoides leaf momordica grosvenori functional food and a preparation method thereof. The malus toringoides leaf momordica grosvenori functional food is prepared from the following raw materials in percentage by mass: 20 to 80 percent of malus toringoides leaves and 20 to 80 percent of momordica grosvenori. The preparation method comprises the following steps of pretreating malus toringoides leaves and momordica grosvenori; adding ethanol; performing backflow extraction; merging the obtained filter liquid; recovering ethanol; performing hot water dispersion on extracts; performing standing, centrifugation and precipitation vacuum drying; adding maltodextrin; making soft materials; performing granulation, drying and particle sorting to obtain total particles;obtaining a final product. Through study, the conditions that after the matched use of all raw materials, the synergistic interaction effect is achieved, and the blood sugar and blood fat reducing effects are obvious are discovered.

The invention belongs to the technical field of traditional Chinese medicine and especially relates to a compound with blood lipid-reducing and oxidation-resisting effects. The compound with blood lipid-reducing and oxidation-resisting effects is characterized in that the compound is prepared from the following raw materials in parts by weight: 3-20 parts of Huashan alum polysaccharide, 3-25 parts of fleece-flower roots, 3-25 parts of red sage roots, 3-25 parts of hawthorn fruits, 3-25 parts of Gynostemma pentaphylla, 5-30 parts of semen cassiae torae, 8-35 parts of chrysanthemum flowers and 8-35 parts of Chinese wolfberry fruits. The compound is prepared into tablets, capsules, pills, granules and injections by conventional processes. The Huashan alum polysaccharide resources are fully utilized in the compound, and the medicinal uses of the Huashan alum are developed; moreover, the developed Huashan alum polysaccharide has good effects of reducing blood lipid as well as good antioxidant activity and low adverse reaction rate. Curative effects of the medicament prepared from the compound for treating hyperlipidemia are better than the curative effects of the single use of the Huashan alum polysaccharide for treating hyperlipidemia in rats.