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Hypoglycemic active part of osmanthus fragrans, preparation method and application thereof

An effective part, a technology for lowering blood lipid, applied in the preparation of the effective part, the application field of osmanthus in the field of lowering blood lipid, can solve the problems of single target, muscle toxicity, side effects, etc., achieve low cost, significant anti-oxidation and reduce The effect of blood lipids

Inactive Publication Date: 2010-03-10
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although Western medicine has a certain effect on regulating blood lipids, it has side effects of varying degrees, and the target is single.
Western medicine statins are currently recognized as the most effective and widely used drugs for lipid-lowering, but they have side effects such as liver and muscle toxicity

Method used

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  • Hypoglycemic active part of osmanthus fragrans, preparation method and application thereof
  • Hypoglycemic active part of osmanthus fragrans, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] This embodiment is the preparation method of the effective parts and active ingredients of osmanthus fragrans.

[0019] Take dried golden osmanthus (1.9kg), pulverize, cold soak with acetone and water (7:3 by volume) / ethanol for 3 times, each time for 7 days, filter, combine the filtrates, recover the solvent under reduced pressure to obtain a concentrate; The extract was dispersed in water and extracted 3 times with petroleum ether, ethyl acetate and n-butanol successively to obtain 10 g of petroleum ether extract, 33.4 g of ethyl acetate extract and 400 g of n-butanol extract.

[0020] 33.4 g of the obtained ethyl acetate extract was subjected to 200-300 mesh silica gel column chromatography, and gradient elution was carried out with chloroform:methanol (100:1→8:2), and the obtained petroleum ether-acetone (20:1) was partially purified by Silica gel H column chromatography, eluting with petroleum ether-acetone (20:1), combined with TLC detection, and Sephadex LH-20 co...

Embodiment 2

[0022] This embodiment is the application example of osmanthus fragrans triterpenoids, the effective part of osmanthus fragrans for lowering blood fat. Its in vivo blood fat lowering and antioxidant tests are as follows:

[0023] Animals: Kunming mice, all males with a fasting body weight of 23±2 g. Provided by Henan Medical Animal Experiment Center.

[0024] Materials and reagents: Osmanthus fragrans triterpenoids were provided by the Institute of Natural Medicine, Henan University. Semen Cassiae Jiangzhi Tablets, Jilin Jichun Pharmaceutical Co., Ltd. Batch number: 070501. Superoxide dismutase (SOD) and malondialdehyde (MDA) assay kits were provided by Nanjing Jiancheng Bioengineering Institute. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) assay kits were provided by Beijing Zhongsheng Bioengineering High-Tech Co., Ltd.

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Abstract

The invention relates to a hypoglycemic active part of osmanthus fragrans, a preparation method and application thereof, and application of the osmanthus fragrans in reducing blood fat, wherein the hypoglycemic active part of the omanthus fragrans is that the osmanthus osmanthus is extracted by petroleum ether, ethyl acetate and normal butanol to prepare petroleum ether, ethyl acetate and normal butanol extracts respectively, wherein the ethyl acetate extract is further separated to prepare triterpene from osmanthus fragrans. An effective component, namely the triterpene from osmanthus fragrans, can be used for preparing natural hypolipidemic and anti-oxidant medicaments; and the osmanthus fragrans of the invention and the effective component thereof, namely the triterpene from osmanthus fragrans, are used for preparing health products for the application of the prevention and adjuvant therapy of hyperlipemia. In vivo animal experiments prove that the triterpene from osmanthus fragranshas the remarkable effect of reducing the level of TC, TG and LDL-C in serum of mice with the hyperlipemia, and also has the effect of reducing MDA and increasing the activity of SOD at the same time. Therefore, the osmanthus fragrans not only can reduce the blood lipid level in the serum by improving the autoimmunity, but also can reduce the blood fat by improving the in vivo antioxidant mechanism.

Description

technical field [0001] The present invention relates to an effective part of sweet-scented osmanthus fragrans for lowering blood fat, a preparation method and application of the effective part, and an application of sweet-scented osmanthus in lowering blood fat. Background technique [0002] Hyperlipaemia (HLP) mainly refers to high serum total cholesterol (TC) or triglyceride (TG) levels and / or low serum high-density lipoprotein-cholesterol (HDL-C) levels. Hyperlipidemia is a common and frequently-occurring disease in middle-aged and elderly people. With the improvement of people's living standards and changes in living habits, the incidence of this disease has increased significantly, and the age of onset has also advanced. Atherosclerosis (AS) caused by hyperlipidemia is the main cause of coronary heart disease, hypertension and cerebrovascular disease, which seriously endangers human life and health. At present, although Western medicines have certain curative effects o...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/06A61K133/00
Inventor 康文艺宋艳丽姬志强贺光东
Owner HENAN UNIVERSITY
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