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Use of naringin in preparing antiatherosclerotic medicine

A kind of atherosclerosis, naringin technology, applied in the field of new medicinal use of naringin

Inactive Publication Date: 2009-02-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Naringin, naringin, is derived from the fruits of pomelo, grapefruit, chrysanthemum or citrus, leaves of sycamore plants, etc., and there is no report that naringin is used to resist atherosclerosis

Method used

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  • Use of naringin in preparing antiatherosclerotic medicine
  • Use of naringin in preparing antiatherosclerotic medicine
  • Use of naringin in preparing antiatherosclerotic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Effects of naringin on serum and arterial wall cholesterol in rabbits with experimental atherosclerosis

[0012] Take 48 healthy New Zealand white rabbits, half male and half female, body weight (2.0±0.2) kg, randomly divided into normal control group, atherosclerosis model group, positive drug (cholestyramine) control group, and low-dose naringin group , middle dose group of naringin, high dose group of naringin. Except the normal diet of normal control group, the other groups were fed with high-fat diet (3% cholesterol, 5% lard, 5% egg yolk powder, 0.2% methylthiouracil, 87% basic feed). After continuous feeding and drug infusion for 60 days, the aorta and serum of the animal were taken to measure the arterial wall and serum cholesterol content. The experimental results are shown in Table 1.

[0013] Table 1 Effects of naringin on cholesterol content in arterial serum and arterial wall of rabbits with experimental atherosclerosis

[0014]

[0015] Not...

Embodiment 2

[0017] Example 2: Effect of naringin on experimental atherosclerosis in rabbits

[0018] Take 48 healthy New Zealand white rabbits, half male and half male, body weight (2.0±0.2) kg, randomly divided into normal control group, atherosclerosis model group, positive drug (simvastatin) control group, and low-dose naringin group , middle dose group of naringin, high dose group of naringin. Except the normal diet of normal control group, the other groups were fed with high-fat diet (3% cholesterol, 5% lard, 5% egg yolk powder, 0.2% methylthiouracil, 87% basic feed). After continuous feeding and drug administration for 60 days, fasting blood was taken to measure serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) on an automatic biochemical analyzer. The content of protein cholesterol (LDL-C), the activity of serum superoxide dismutase (SOD) and the content of malondialdehyde (MDA) and nitric...

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Abstract

The invention discloses an application of naringin in preparing medicaments for curing atherosclerosis. Tests prove that the naringin can decrease level of serum cholesterol, inhibit cholesterin on arterial vascular walls from depositing, obviously decrease level of serum TC, TG, LDL-C, remarkably raise level of serum HDL-C, improve activity of serum SOD and increase level of NO, obviously decrease level of MDA, effectively prevent atheromatous plaques from being formed or damaged, and have the obvious function of curing atherosclerosis.

Description

technical field [0001] The invention relates to naringin, in particular to a new medicinal application of naringin. Background technique [0002] Coronary heart disease, cerebrovascular disease, and peripheral vascular disease caused by atherosclerosis seriously endanger human health, and its morbidity and mortality rank among the forefront of various diseases. According to epidemiological surveys, the incidence rate of cardiovascular and cerebrovascular diseases in the world is about 5-6%, and the incidence rate in some developed countries is close to 10%, killing 12 million people every year, which is close to the total death rate of the world population. 1 / 4 of the number. The medical expenses for the prevention and treatment of atherosclerosis and the resulting cardiovascular and cerebrovascular diseases are 40 billion US dollars per year. There are 70 million patients with cardiovascular and cerebrovascular diseases in my country, and more people have atherosclerotic ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
Inventor 苏薇薇李沛波彭维王永刚吴忠
Owner SUN YAT SEN UNIV
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