265 results about "Decreased serum cholesterol" patented technology

Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.

The present invention describes compositions and methods containing water-dispersible phytosterol esters useful in the reduction of serum cholesterol when consumed as part of a heart healthy diet. The compositions and methods can be used to incorporate phytosterol esters into aqueous based dry foods and beverages that are extracted or reconstituted with hot water. The composition comprises a mixture of phytosterol esters, a surfactant and optionally an oil soluble antioxidant and needs no prior emulsification, homogenization or drying to render the phytosterol esters water dispersible in the recommended food applications.

The invention relates to a method for preparing wheat bran dietary fiber by utilizing ultrasound-assisted enzymatic hydrolysis, and in particularly belongs to the technical field of the agricultural and sideline product development, the functional food additive and the nutritional heath caring. The invention is characterized in that the invention adopts wheat bran as the raw material, and the wheat bran dietary fiber preparation is realized through utilizing the ultrasound treatment, and removing starch and protein by enzymatic method, and then the preparation of fine dietary fiber with different grain size is realized by crumbling with a grinder. The invention realizes the effective value increment and the utilization of the wheat bran, the prepared functional dietary fiber has important physiological function, and thereby can realize the functions of preventing constipation, colon cancer, intestina diverticulum, hemorrhoid and varicose veins of the lower extremities; the serum cholesterol is lowered, and the heart disease caused by coronary sclerosis can be prevented; the sensitivity of the peripheral nerve tissue to the insulin is improved, and the blood sugar level of the diabetes patient can be regulated, the invention is very useful for human health, and the economic benefit as well as the social benefit are greatly increased.

The subject disclosure provides compositions for reducing serum cholesterol and / or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and / or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease.

This invention is related to the obtention of a new natural mixture composed of long chain fatty alcohols and long chain fatty acids. This mixture has a relative composition of long chain fatty alcohols and long chain fatty acids that is highly reproducible batch to batch and it is extracted from animal or vegetable wax. This mixture has specific therapeutic properties that support its use as an active component of dietary supplement formulations for reducing serum cholesterol levels (while not decreasing HDL-cholesterol levels) and therefore is effective treating Hypercholesterolemia and reducing the risk of coronary heart disease. This mixture also has been shown to improve male sexual activity. When used in conjunction with salicylic acid the mixture has other therapeutic effects such as inhibiting the atherosclerotic process, platelet hyperaggregability, inhibiting thrombosis and inhibiting inflammation.

A composition is provided which contains policosanol and HMG-Co-A reductase inhibitor and which may be used for treating and or reducing hypercholesterolemic diseases, total cholesterol, LDL-cholesterol, coronary heart disease (heart attacks and strokes), inflammation, deep-vein thrombosis immunoregulatory diseases, cardiovascular diseases, and / or neurodegenerative disorders in humans and animals. The method comprises administering policosanol and HMG-Co-A reductase inhibitor which together effectively lower serum cholesterol levels. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to HMG-Co-A reductase inhibitor.

The invention discloses lactobacillus plantarum L01 which is assigned the accession number CCTCC No.M2014568, and also provides an application of the lactobacillus plantarum L01 in degradation of cholesterol and preparation of a fermented dairy product capable of degrading the cholesterol. The invention has following advantageous effects: the lactobacillus plantarum L01, which is obtained through separation and screening from traditional pickled vegetables, is sourced from traditional foods so that the lactobacillus plantarum L01 is excellent in safety and meanwhile is excellent in acid resistance, cholate resistance and cell adhesion and has a certain effect of maintaining enteric microorganism colony balance. The lactobacillus plantarum L01 can be used for preparing the fermented dairy product, is strong in cholesterol degrading function, can effectively reduce serum cholesterol and can enhance body immunity.

The invention relates to an application of lactobacillus plantarum in preparation of food, health food, a health product or a medicine with a function of reducing blood fat or assisting fat-reducing. The collection number of the lactobacillus plantarum is CGMCC No.8198. the lactobacillus plantarum was collected in China General Microbiological Culture Collection Center (CGMCC) on Sep. 17, 2013. The address is 1 Beichen West Road, Chaoyang District, Beijing. The strain achieves the effect of reducing blood fat by reducing the level of serum cholesterol, triglyceride and low-density lipoprotein cholesterin. L.plantarum CGMCC No.8198 and its fermented products also play a role in controlling and reducing weight, and have an effect of assisting fat-reducing. The invention provides a biological therapy for effectively reducing serum cholesterol and assisting fat-reducing. The biological therapy has long-term eating safety and has a considerable application prospect.

The invention provides five-alga probiotic enzyme tablets and a preparation method thereof. The five-alga probiotic enzyme tablets are prepared from the following raw materials in parts by mass: 10-20 parts of chlorella vulgaris, 1-10 parts of dunaliella salina, 1-10 parts of euglena, 1-10 parts of red algae, 10-20 parts of spirulina and 10-20 parts of probiotic powder. The five-alga probiotic enzyme tablets provided by the invention adopt the chlorella, dunaliella salina, red algae, spirulina and euglena for complementation in nutrition, and obtain trace elements easier to absorb by a human body through probiotic fermentation, thereby helping to reinforce the immunologic function of the human body, resist virus infection and proliferation, inhibit cancer cell proliferation, repair the damage of an organism quickly, remove vivotoxin, suppress blood pressure and blood sugar rise, reduce the serum cholesterol content, and thus improve the comprehensive conditioning of the human body.

The invention relates to probiotic solid beverage and a preparation method thereof. The probiotic solid beverage comprises the following raw materials in parts by weight: 24 to 70 parts of maltodextrin, 20 to 60 parts of inulin and 1 to 5 parts of probiotics, wherein the probiotics comprises lactobacillus salivarius, lactobacillus acidophilus, bacillus coagulans, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus plantarum and bifidobacterium longum. The probiotic solid beverage provided by the invention has high living bacterium quantity and can reduce loss of the probiotics whenthe probiotics pass through the gastrointestinal tract and increase the survival rate; in addition, the probiotic solid beverage can promote intestinal colonization of the probiotics; moreover, through mutual promotion of the actions of various bacteria, the probiotic solid beverage can adjust intestines and stomach well, promote intestinal tract movement, relieve constipation and diarrhea, reduce serum cholesterol, reduce lactose intolerance, accumulate proteolytic enzyme, adjust nutrient absorption and adjust the immunologic function.

The invention provides a method for lowering circulating LDL-cholesterol or total cholesterol in a human in need thereof, comprising: orally administering to the human a therapeutically effective amount of a statin and vitamin D daily for at least about 6 weeks, wherein the vitamin D is administered by one or more pharmaceutical compositions.

The invention relates to a Chinese medicine composition for regulating blood fat and decreasing blood sugar, and a preparation method of an oral solid preparation ora health beverage by the Chinese pharmaceutical composition. The preparation raw materials contain the following active ingredients in parts by weight: 20 to 40 parts of radix puerariae, 20 to 40 parts of corn silk, 4 to 8 parts of mulberry leaf, 20 to 40 parts of cassia seed, 10 to 20 parts of hawthorn, 4 to 8 parts of ginger, and 5 to 15 parts of lotus leaf. The preparation raw materials are weighed in proportion; each raw material is decocted with water many times to obtain decoction solution; all decoction solutions are mixed and concentrated to obtain clear paste, and the relative density of the clear paste at the temperature of 80 DEG C is 1.26 to 1.38; accessories are added in the clear paste to prepare the oral solid preparation according to a conventional method, or all decoction solutions are mixed and filtered to obtain filtrate; the filtrate is decompressed and concentrated and placed still to obtain supernatant fluid; accessories are added in the supernatant fluid to prepare the health beverage according to a conventional method. The invention has simple, convenient and easy preparation method; and the obtained preparation has convenient use and obviously has the efficacy of regulating blood fat, decreasing blood sugar and decreasing serum cholesterase.

The invention relates to the technical field of biological engineering and the fields of food and medicaments, particularly provides a method for extracting refined yeast grease from yeast, particularly waste saccharomyces cerevisiae and oil production yeast, and further provides soft capsules prepared by compounding the yeast grease, vegetable grease rich in necessary fatty acid for a human bodyand anti-oxidation grease and a preparation method thereof. The obtained yeast grease composite soft capsules have the effects of reducing serum cholesterol and reducing blood fat; the method for producing the yeast grease by using the waste yeast has powerful results of improving the additional value of the waste yeast and generating higher economic benefit; and meanwhile, by comprehensive utilization of the waste yeast, the problem that wastes pollutes environment is solved, and the requirement of circular economy development is met.

The invention provides a lactobacillus paraplantarum capable of reducing cholesterol and nitrite. The lactobacillus paraplantarum is separated from traditional fermented preserved vegetables of minority nationalities in Guizhou, and is named as Lactobacillus paraplantarum GUFHSL-70, and lactobacillus paraplantarum pure culture is collected by CCTCC (China Center For Type Culture Collection) with the collection number of CCTCC M 2016002 in Wuhan University, Wuhan, China on Jan. 1 2016. The lactobacillus paraplantarum GUFHSL-70 is functional lactobacillus which has favorable characteristic in the aspect of reducing cholesterol and nitrite; through developing the lactobacillus paraplantarum GUFHSL-70 into health foods or medicine and taking the health foods or medicine for a long term, intestinal flora can be improved, serum cholesterol is reduced, and the immunity of the organism is improved; or by virtue of adding the lactobacillus paraplantarum GUFHSL-70 into the fermented preserved vegetables, the amount of nitrate residues in the preserved vegetables is reduced, the fermentation period is shortened, and the product flavor is improved.

To provide a cholesterolemia treatment agent comprising, as an active ingredient, a bacterial mixture of three bacterial types consisting of lactic acid bacteria, butyric acid bacteria, and glycation bacteria which are effective in lowering serum cholesterol. And to provide a triglyceridemia treatment agent comprising, as an active ingredient, a bacterial mixture of three bacterial types consisting of lactic acid bacteria, butyric acid bacteria, and glycation bacteria which are effective in lowering triglycerides.

The present invention relates to a diet composition comprising brown rice, job's tear, red beans, buckwheat, Italian millet, Indian millet, white beans, black beans, black rice, barley, brown rice sprouts, kale, matured pumpkin (Curcurbia moschata), carrot, Angelica, cabbage, wild Lanceolate root, Lotus root, radish, green radish, mugwort, pine needles, laver, sea mustard, sea tagle, Shiitake mushroom, Reishi mushroom, soy peptide, isolated soy protein, L-carnitine, Hibiscus extract, green tea extract and solomon's seal extract. The composition is useful in reducing body weight and body fat; controlling body shape; and lowering serum cholesterol and neutral fat.

The invention discloses pueraria root powder and a preparation method thereof. The pueraria root powder is characterized by comprising the following raw materials in percentage by weight: 40-60 percent of pueraria root powder, 10-30 percent of red Chinese date powder and 10-30 percent of carrot powder. The preparation method comprises the following steps: cleaning, peeling and slicing a pueraria root, superfine pulverizing and breaking wall of the pueraria root and drying the pueraria root by using hot air; carrying out cleaning, denucleating, slicing, color protection, vacuum freezing and drying and then superfine pulverizing on the red Chinese date; cleaning, slicing, preliminarily drying and then superfine pulverizing carrots and finally drying by hot air; and uniformly mixing the dried pueraria root powder, the red Chinese date powder and the carrot powder according to proper proportion and packaging to obtain the pueraria root powder. The invention has the functions of reducing pathogenic fire, neutralizing the effect of alcoholic drinks, enhancing the immunity, effectively reducing the serum cholesterol and enhancing the serum total protein and blood protein, traditional Chinese medicine values and health care efficacies of tonifying kidney and strengthening stomach, nourishing the blood and tranquilization and the like as well as the relieving function on nyctalopia.

The invention provides methods and compositions for treating hyperlipidemia and disorders associated with hyperlipidemia in a mammal. Compositions useful in the practice of the invention include a microsomal triglyceride transport protein inhibitor (“MTPI”) and at least two other cholesterol lowering drugs selected from the group consisting of a cholesterol absorption inhibitor (“CAI”), a HMG-CoA reductase inhibitor, a bile acid sequestrant, a fibric acid derivative, niacin, and squalene synthetase inhibitor.

The invention discloses health drink taking yellow serofluid as the main raw material and a preparation method thereof. The health drink comprises the following components in percentage by weight: 70-85% of yellow serofluid, 5-10% of sucrose, 3-20% of juice, 0.12-0.25% of acidulant, 0-0.08% of edible essence and 3-20% of bean dregs fermentation broth. The health drink disclosed by the invention is rich in the natural soybean oligosaccharide and dietary fiber necessary to human body; by long-term drinking of the health drink, the following functions of human body can be improved: 1, purgation and intestines are cleaned, experiments prove that taking 3g of soybean oligosaccharide and a proper amount of dietary fiber by healthy people can effectively promote the growth of bifidobacterium and realize a purgation effect, and the soybean oligosaccharide and dietary fiber also can promote intestine peristalsis to accelerate excretion; 2, serum cholesterol is reduced, the bifidobacterium directly influences and interferes with the activity of p-radial basis-p-methylglutaryl enzyme A reducing enzyme and can suppress the synthesis of cholesterol so as to reduce the serum cholesterol; 3, liver is protected, long-term intake of soybean oligosaccharide can reduce the generation of in vivo toxic metabolic substances and reduce the burden on liver detoxification, and thus a certain effect on preventing hepatitis and cirrhosis is realized; and 4, the generation of intra-intestinal putrefaction is suppressed.

The invention discloses a lactic acid bacterium feed used for layers, which comprises chicken feed, and 0.1%-1% (by weight) of the lactic acid bacterium, shrubby sophora extract, allium sacculiferum maxim extract and gold theragran P.E. extract are added into the chicken feed. The feed of the invention specially used by the layers can adjust normal gastrointestinal flora, keep microcosmic ecological balance so as to improve the function of intestine, can improve the digestibility and biological valence of the food, reduce the serum cholesterol, control the endotoxin, restrain the growth of spoilage organisms inside the intestine and improve the body immunity. The lactic acid bacterium generates the matters such as organic acid special enzyme system, surface composition, and the like, by the zymolysis; the matters have physiological functions and can stimulate the tissue development. The feed of the invention has the advantages of no toxicity, no drug resistance, no residue, no side effects, etc.

The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as a suitable composition comprising (a) one or more phytosterols and / or phytostanols capable of reducing cholesterol absorption in the intestine and / or one or more soluble fibres capable of inhibiting ileal bile acid absorption, (b) a composition capable of inhibiting cholesterol biosynthesis, and (c) a composition capable of increasing cholesterol metabolism, wherein at least one of compositions (b) and (c) is preferably derived from plants.

The invention discloses a preparation method of extract of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and an application thereof. The extract of the effective part is prepared from Clinopodium chinense (Benth.) O. Kuntze as a raw material, a concentrate is obtained by pulverizing, ethanol extraction and reduced pressure recovery, the concentrate is extracted by petroleum ether and ethyl acetate, and the obtained ethyl acetate extract is purified by macroporous resin. The extract of the effective part mainly comprises total flavone and terpenoids, and has obvious effects of reducing blood sugar of rats with streptozotocin diabetes, reducing the content of serum cholesterol, protecting the islet cells, inhibiting the activity of alpha-glucosidase, and protecting the vascular endothelial cells. Thus, the extract of the effective part of Clinopodium chinense (Benth.) O. Kuntze has favorable functions for reducing blood sugar, reducing blood fat, and protecting the islet cells and the vascular endothelial cells, and can be used for preventing and treating diabetes, dyslipidemia induced by diabetes and diabetic cardiovascular and cerebrovascular complications.

Lactobacillus pentosus for reducing cholesterol and nitrite is disclosed. The lactobacillus pentosus is separated from Guizhou traditional food fermented rice noodle. The strain is called lactobacillus pentosus GUFHSL-69 and was collected in the China Center for Type Culture Collection on January 4, 2016. The collection unit address is Wuhan University, Wuhan, China. The collection number is CCTCC M 2016001. Lactobacillus pentosus GUFHSL-69 is functional lactic acid bacteria, has good characteristics of reducing cholesterol and nitrite. The cholesterol removal rate is 25.66%, and nitrite degradation rate is 94.45% after 24h of culture. The strain is developed into a health-care food or drug which can improve intestinal flora, reducing serum cholesterol and boosting body immunity after long-term use. By the use of the strain, residual quantity of nitrite in a fermented product can be reduced, fermentation period is shortened, and flavor of a product is improved.

A tea is prepared from 7 Chinese-medicinal materials including Momordica grosvenori flower, cassia seed, wolfberry fruit, liquorice root, etc. It can prevent and treat angiosclerosis and hypertesion with a certain curative effect.

The invention discloses a method for preparing gamma-aminobutyric acid rich vinegar, belongs to the technical field of seasoning brewing engineering, and particularly relates to the technical field of edible vinegar production. The method for preparing health-care vinegar comprises processes of liquefaction, saccharification, yeast addition, yeast fermentation and acetic fermentation; and lactobacillus brevis and acetic acid bacteria are added in the acetic fermentation process, the lactobacillus brevis is added before the acetic acid bacteria is added or synchronously added with the acetic acid bacteria, and sodium glutamate is added when the lactobacillus brevis is added. The product of the invention is soft when entering the mouth and acid after tasting, has no peculiar smell, has clear vinegar liquid and gloss, and is amber edible vinegar, or the edible vinegar with health-care functions of reducing blood pressure, promoting sleep, reducing serum cholesterol, delaying senility, and the like.

The invention relates to a preparation method of serum cholesterol reduction Kluyveromyces marxianus freeze-dried powder. The preparation method is applicable to the production of serum cholesterol reduction functional probiotic preparations and fermentation dairy products. The two serum cholesterol reduction strains of Kluyveromyces marxianus K1 and M3 screened from Tibetan kefir are utilized, and the freeze-dried powder is prepared through activation and amplification culture, fermentation, centrifugal concentration, freeze-dried protection agent addition, pre-freezing and freeze drying. A free-dried protection agent composition recipe is optimized, so the strain survival rate is higher than 65 percent, and in addition, the viable count of the free-dried powder is higher than 109cfu / g. The serum cholesterol reduction Kluyveromyces marxianus freeze-dried powder prepared by the method has various probiotic effects of reducing the serum cholesterol, improving the organism antioxidation, promoting the intestinal tract flora balance and the like.

The present invention relates to compositions for lowering the serum cholesterol level, which contain (Yucca) extract and / or (Quillaja) extract. The compositions according to the invention, as the human-safe and medically functional compositions, can be used for various purposes comprising the prevention and treatment of cardiovascular disorders such as a hyperlipidemia, and intestinal disorders.

The invention discloses a making method of health vinegar, which is characterized by the following: adopting Chinese sorghum (rice) as raw material and bran, Chinese sorghum, rice shell (jujube,longan, safflower, liquorice, tremella, honey and so on) as auxiliary material; obtaining the health vinegar with total acid not less than 2. 5% and not less than 1. 0% non-volatile acid and reducing sugar not less than 2. 0g / 100ml; displaying gloss, amber colour to reduce serum cholesterol.