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Preparation method of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and medicine application thereof

A technology of the effective part and the spinach, which is applied in the field of preparation and medicinal application of the effective part of the spinach for preventing and treating diabetes

Inactive Publication Date: 2011-01-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preliminary studies in our laboratory have found that Pinnata pachyrhiza has a hypoglycemic effect, but there is no preparation process for the extract of the effective part of Pinnata pachyrhiza, and the functions of the extract of the effective part in lowering blood sugar, blood fat, protecting islet cells and vascular endothelial cells , and its reports on the prevention and treatment of diabetes and diabetic cardiovascular and cerebrovascular complications

Method used

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  • Preparation method of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and medicine application thereof
  • Preparation method of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and medicine application thereof
  • Preparation method of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and medicine application thereof

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Experimental program
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Effect test

Embodiment 1

[0045] Embodiment 1: Preparation of the extract of the effective part of Campanula chinensis :

[0046] Take 10kg of dried Pinnaea chinensis whole herb, crush it into a coarse powder, add 6 times the volume of 80% ethanol to reflux and extract 3 times, combine the extracts, concentrate under reduced pressure, and use 3 times the amount of petroleum ether and ethyl acetate in turn to concentrate the concentrated solution. The ester was extracted 4 times, and the ethyl acetate extract was subjected to column chromatography with a macroporous resin column. After the impurities were eluted with water, the ethanol gradient elution (the elution range was 20-80%) was collected, and the ethanol eluate was collected and depressurized. After concentrating and drying, the extract of the effective part of Pinnata chinensis is obtained, and the yield is 1.5%.

Embodiment 2

[0047] Embodiment 2: the preparation of capsule

[0048] In Example 1, 65 g of the extract of the effective part of Campanula chinensis and 135 g of microcrystalline cellulose were ground and mixed for 10-30 minutes until uniform. The mixed medicinal powder is filled in No. 1 capsules, and the amount of each capsule is controlled at 0.2 g by random sampling, and the extract containing the effective part of Pinnata chinensis is 65 mg.

Embodiment 3

[0049] Embodiment 3: the preparation of tablet

[0050] In Example 1, 25g of the effective part extract of Pinnata chinensis and 49g of microcrystalline cellulose were ground and mixed for 10-30 minutes until uniform; 1g of magnesium stearate was added and fully mixed; the mixture was pressed into a diameter 6mm, 300mg tablet, each containing 100mg of the active part extract of Campanula chinensis.

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Abstract

The invention discloses a preparation method of extract of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and an application thereof. The extract of the effective part is prepared from Clinopodium chinense (Benth.) O. Kuntze as a raw material, a concentrate is obtained by pulverizing, ethanol extraction and reduced pressure recovery, the concentrate is extracted by petroleum ether and ethyl acetate, and the obtained ethyl acetate extract is purified by macroporous resin. The extract of the effective part mainly comprises total flavone and terpenoids, and has obvious effects of reducing blood sugar of rats with streptozotocin diabetes, reducing the content of serum cholesterol, protecting the islet cells, inhibiting the activity of alpha-glucosidase, and protecting the vascular endothelial cells. Thus, the extract of the effective part of Clinopodium chinense (Benth.) O. Kuntze has favorable functions for reducing blood sugar, reducing blood fat, and protecting the islet cells and the vascular endothelial cells, and can be used for preventing and treating diabetes, dyslipidemia induced by diabetes and diabetic cardiovascular and cerebrovascular complications.

Description

1. Technical field [0001] The present invention relates to a preparation method of an extract from the effective part of the traditional Chinese medicine Pinnata chinensis, and the functions of the extract of the effective part in lowering blood sugar, lowering blood fat, protecting pancreatic islet cells and vascular endothelial cells, and preventing and treating diabetes, lipid metabolism disorders and diseases caused by diabetes. Application in diabetic cardiovascular and cerebrovascular complications. 2. Background technology [0002] Diabetes is a group of metabolic abnormal syndromes caused by the interaction of genetic and environmental factors. According to WHO estimates, from 1995 to 2025, the global incidence of diabetes will increase to 3% to 5%, estimated to reach 300 million patients, and the age of patients tends to be from 65 years old to 45 to 54 years old. Diabetes can be divided into insulin-dependent diabetes mellitus (Insulin Dependent Diabetes Mellitus,...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P3/06A61P3/10A61P9/00
Inventor 吴斐华梁敬钰刘洋任燕利
Owner CHINA PHARM UNIV
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