Application of copperleaf herb aqueous extract in preparation of weight-losing and lipid-lowering medicines or weight-losing and lipid-lowering health-care products

A technology of iron amaranth and water extract, which is applied in the application field of iron amaranth water extract in the preparation of weight-loss and lipid-lowering drugs or weight-loss and lipid-lowering health products, which can solve the problems of unable to reduce blood lipids and difficulty in curing diseases, and achieve relief from liver disease. damage, increased SOD enzyme activity, and high antioxidant activity

Inactive Publication Date: 2020-12-11
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used lipid-lowering drugs can not reduce blood lipids to normal levels due to side effects and other side effects, which brings great difficulties to cure the disease

Method used

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  • Application of copperleaf herb aqueous extract in preparation of weight-losing and lipid-lowering medicines or weight-losing and lipid-lowering health-care products
  • Application of copperleaf herb aqueous extract in preparation of weight-losing and lipid-lowering medicines or weight-losing and lipid-lowering health-care products
  • Application of copperleaf herb aqueous extract in preparation of weight-losing and lipid-lowering medicines or weight-losing and lipid-lowering health-care products

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An application of an aqueous extract of amaranth in the preparation of a weight-loss and lipid-lowering drug, wherein the preparation method of the aqueous extract of amaranth is as follows: collecting the whole herb of amaranth, washing it three times with clean water, and then cleaning it with deionized water, Place in an oven at 60°C and dry until constant weight; crush and grind through a 0.5mm sieve to obtain the whole herb dry powder of amaranth; add the dry powder of whole amaranth to the extraction tank, then add 10 times pure water to soak for 90 minutes, and decoct for 2 hours , filter, collect the filtrate, decoct the filtered solid with 8 times pure water for 2 hours again, filter, collect the filtrate, add 6 times pure water to the filtered solid and decoct for 1 hour, filter, collect the filtrate, combine the filtrate three times, and Rotary evaporator at 80°C was concentrated to 1 g / mL paste to obtain the original drug solution of the water extract of amar...

Embodiment 2

[0034] An application of the water extract of Amaranthus in the preparation of health products for weight loss and fat reduction, wherein the preparation method of the water extract of Amaranth is as follows: collect the whole herb of Amaranth, wash it three times with clean water, and then clean it with deionized water , placed in a 60°C oven and dried to constant weight; crushed and ground through a 0.5mm sieve to obtain the dry powder of the whole plant of Amaranth; add the dry powder of the whole plant of Amaranth into the extraction tank, then add 10 times of pure water to soak for 90 minutes, and decoct for 2 hours Finally, filter, collect the filtrate, decoct the filtered solid with 8 times pure water for 2 hours again, filter, collect the filtrate, add 6 times pure water to the filtered solid and decoct for 1 hour, filter, collect the filtrate, and combine the filtrate three times, Concentrate in a rotary evaporator at 80°C to a paste of 1 g / mL to obtain the original dr...

Embodiment 3

[0038] Study on the weight-loss and lipid-lowering effect of water extract of amaranth on hyperlipidemia mice

[0039] Test animals:

[0040] 84 SPF grade Kunming mice, weighing 18-20 g, half male and half male, were purchased from Chengdu Dashuo Experimental Animal Co., Ltd., Sichuan Province, license number: SYXK (Sichuan) 2014-189, in line with the national standard GB14925-2010. All animal manipulations were approved by the Animal Care and Use Committee of the School of Life Science and Engineering, Southwest University of Science and Technology.

[0041] Raising conditions for mice:

[0042] There are 4 to 5 mice per cage, and male and female are separated into cages; temperature is 20-26°C; relative humidity is 40-70%; the cycle of light and dark in the animal room is 12 / 12h, and the animals are given free access to water and food.

[0043] Animal food:

[0044] Ordinary feed, the main raw materials include high-quality corn, high-quality wheat, puffed soybean meal, h...

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Abstract

The invention discloses application of a copperleaf herb aqueous extract in preparation of weight-losing and lipid-lowering medicines or weight-losing and lipid-lowering health-care products. A preparation method of the copperleaf herb aqueous extract includes the steps that whole copperleaf herb is collected, cleaned, and dried; the copperleaf herb is crushed to obtain copperleaf herb dry powder;the copperleaf herb dry powder is added into an extraction tank, then pure water is added, and then soaking, decocting, and filtering are conducted; filtrate is collected, filtered solids is decoctedwith the pure water again, filtering is conducted, and the filtrate is collected; the pure water is finally added into the filtered solids, decocting and filtering are conducted, and the filtrate iscollected; and the filtrate from the filtration for three times is combined and concentrated in a rotary evaporator, and a copperleaf herb aqueous extract original liquid medicine is obtained. In-vivoanimal tests show that the copperleaf herb aqueous extract has obvious weight-losing and lipid-lowering effects; the copperleaf herb aqueous extract can also inhibit the contents of TC, TG and LDL-Cin serum of mice, increase the activity of SOD enzymes in livers of the mice, and reduce the content of MDA, so that the antioxidant activity of organisms is high, lipid oxidation is reduced, liver injury is relieved, and the effect of protecting the organisms is achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of an aqueous extract of amaranth in preparing weight-loss and lipid-lowering medicines or weight-loss and lipid-lowering health care products. Background technique [0002] With the rapid development of social economy and the continuous improvement of people's living standards and quality, the number of obese patients due to excessive calorie and nutrient intake is increasing year by year. Obesity has become a hot spot of global medical attention. At the same time, complications such as cardiovascular diseases caused by obesity have become one of the global problems that threaten the health of all human beings. Currently commonly used lipid-lowering drugs can not reduce blood lipids to normal levels due to side effects and other side effects, which brings great difficulties to cure diseases. Therefore, the study of safe and stable biological lipid-lowering...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P3/04A61P3/06A61P1/16A61P1/00A23L33/105
CPCA23V2002/00A61K36/47A23L33/105A61P1/00A61P1/16A61P3/04A61P3/06A23V2250/21A23V2200/32A23V2200/3324
Inventor 徐健蓉张清东李宁宁陈红英帕拉沙提·斯然李凤霞王迪龙向发椿孙琰游朗
Owner SOUTHWEAT UNIV OF SCI & TECH
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