Chitosan-based composition with weight-losing and lipid-lowering functions as well as preparation method and application of chitosan-based composition

A chitosan and composition technology, applied in the field of chitosan-based composition and preparation, can solve the problems of singleness and limited application effect, and achieve the effects of weight loss and lipid reduction, good weight loss and lipid reduction effect, and good hydrophobic performance.

Pending Publication Date: 2021-06-18
JIHUA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned patents all use a single chitosan, chitosan oligosaccharide or their derivatives as effective active ingredients, and the actual application effect is limited.

Method used

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  • Chitosan-based composition with weight-losing and lipid-lowering functions as well as preparation method and application of chitosan-based composition
  • Chitosan-based composition with weight-losing and lipid-lowering functions as well as preparation method and application of chitosan-based composition
  • Chitosan-based composition with weight-losing and lipid-lowering functions as well as preparation method and application of chitosan-based composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example provides a chitosan-based composition with weight-loss and lipid-lowering functions, including 30 g of chitosan with high deacetylation degree and large molecular weight (the degree of deacetylation is 88%, and the weight average molecular weight is 1.2 million Da), high deacetylation degree Chitosan with medium molecular weight (90% deacetylation degree, 15,000 Da weight average molecular weight) 20 g, 5 g high deacetylation degree chitosan (90% deacetylation degree, 1500 Da weight average molecular weight), Low deacetylation degree and high molecular weight chitosan (deacetylation degree is 48%, weight average molecular weight is 1.2 million) 40 g.

[0035] The preparation method of described high degree of deacetylation large molecular weight chitosan is:

[0036] After α-chitin is crushed, add it to 45% sodium hydroxide aqueous solution, the ratio of chitin to NaOH solution is 1:10, heat it to 110°C and keep it warm, condense and reflux, react under sti...

Embodiment 2

[0045] This example provides a chitosan-based composition with weight-loss and lipid-lowering functions, including 30 g of chitosan with a high degree of deacetylation and a large molecular weight (the degree of deacetylation is 92%, and the weight-average molecular weight is 1.1 million Da), high deacetylation 20 g of medium molecular weight chitosan (95% deacetylation degree, 30,000 Da weight average molecular weight), 5 g high deacetylation degree chitosan oligosaccharide (96% deacetylation degree, 2000 Da weight average molecular weight), Low deacetylation degree and high molecular weight chitosan (deacetylation degree is 56%, weight average molecular weight is 1.1 million) 40 g.

[0046] The preparation method of described high degree of deacetylation large molecular weight chitosan is:

[0047] The chitin raw material was pulverized by an ultrafine pulverizer, put into a reaction kettle, added 50wt% NaOH solution (the ratio of chitin to NaOH solution was 1:10), and hea...

Embodiment 3

[0056] This example provides a chitosan-based composition with weight-loss and lipid-lowering functions, including 30 g of chitosan with a high degree of deacetylation and a large molecular weight (the degree of deacetylation is 96%, and the weight-average molecular weight is 800,000 Da), high deacetylation 20 g of medium molecular weight chitosan (98% deacetylation degree, 150,000 Da weight average molecular weight), 5 g high deacetylation degree chitosan (98% deacetylation degree, 3000 Da weight average molecular weight), Low deacetylation degree and high molecular weight chitosan (deacetylation degree is 23%, weight average molecular weight is 1.3 million) 30 g.

[0057] The preparation method of described high degree of deacetylation large molecular weight chitosan is:

[0058] The chitin raw material was pulverized by an ultrafine pulverizer, put into a reaction kettle, added 50wt% NaOH solution (the ratio of chitin to NaOH solution was 1:10), and heated to 120°C. Afte...

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Abstract

The invention belongs to the technical field of medicines and health-care foods, and particularly relates to a chitosan-based composition with weight-losing and lipid-lowering functions as well as a preparation method and application of the chitosan-based composition. The chitosan-based composition is prepared from 10 to 50 parts of high-deacetylation-degree large-molecular-weight chitosan, 10 to 50 parts of high-deacetylation-degree medium-molecular-weight chitosan, 2 to 20 parts of high-deacetylation-degree chitosan oligosaccharide and 10 to 50 parts of low-deacetylation-degree large-molecular-weight chitosan. According to the composition, the large-molecular-weight chitosan, the medium-molecular-weight chitosan and the small-molecular-weight chitosan are mixed together to perform respective functions and complement each other, so that better weight-losing and lipid-lowering effects can be achieved under the condition of small-dose administration; and meanwhile, the chitosan with the high deacetylation degree and the chitosan with the low deacetylation degree are mixed, and due to the fact that the chitosan with the low deacetylation degree has better hydrophobic performance, the composition shows more excellent fat adsorption performance.

Description

technical field [0001] The invention belongs to the technical field of medicine and health food, and in particular relates to a chitosan-based composition with functions of reducing weight and fat, a preparation method and application thereof. Background technique [0002] Obesity is a chronic metabolic disease caused by excessive accumulation of body fat caused by multiple factors. It can cause hyperlipidemia, diabetes, atherosclerosis, hypertension and other diseases, which can pose a huge threat to human health. With the development of social economy and excessive intake of nutrition and high-fat food, the large number of obese people has become one of the most serious public health problems in the world. Statistics show that the obesity rate in developed countries such as Europe and the United States is above 10%, while the number of obese people in China has exceeded 250 million. [0003] The weight-loss drugs developed for the pathogenesis of obesity mainly include am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P3/04A61P3/06C08B37/00C08B37/08
CPCA61K31/722A61P3/04A61P3/06C08B37/0003C08B37/003A61K2300/00
Inventor 赵岩柳云恩韩涛邹如飞
Owner JIHUA LAB
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