The invention discloses a high-weather-resistance anti-sticking coating and a preparation method thereof. The high-weather-resistance anti-sticking coating is prepared from a main agent and a curing agent, wherein the ratio of the main agent to the curing agent is (95-105): 1. (35-45), the main agent is from following components in parts by weight: 40-60 parts of resin; 2-6 parts of a solvent I; 0.5-2.5 parts of a solvent II, 1-3 parts of a nano auxiliary agent, 0.1-0.3 part of an antifoaming agent, 4-8 parts of silicone oil, 0.1-2 parts of an anti-settling agent, 10-30 parts of a pigment I, 5-35 parts of a filling material, and 0.1-1 part of a pigment II, and the curing agent is an aliphatic isocyanate curing agent. Organic silicon modified hydroxyl acrylic resin is selected as matrix resin, so that the performance complementation of two resins can be realized, the hydrophobicity and oleophobicity are improved, and the wiping performance and anti-sticking performance of an anti-marking pen are improved.