Pharmaceutical application and composition of Huashan alum polysaccharide

A technology of polysaccharides and medicines, which is applied in the field of pharmaceutical application of Huashan alum polysaccharide and its composition, can solve the problems of Huashan alum polysaccharide research, the effect of lowering blood fat and antioxidant activity of Huashan alum polysaccharide, and the study of medicinal value, etc. Achieve the effects of reducing the risk of coronary heart disease and atherosclerosis, improving free radical metabolism, and preventing hyperlipidemia complications

Inactive Publication Date: 2020-06-12
HECHI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no one has conducted research on Huashan alum polysaccharide, nor has it studied the related medicinal value, and there is no report that Huashan alum polysaccharide has the effect of lowering blood fat and antioxidant activity

Method used

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  • Pharmaceutical application and composition of Huashan alum polysaccharide
  • Pharmaceutical application and composition of Huashan alum polysaccharide
  • Pharmaceutical application and composition of Huashan alum polysaccharide

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Effect test

Embodiment 1

[0030] The application of the Huashan alum polysaccharide pharmaceutical composition of the present invention in the preparation of drugs for preventing and treating blood fat and blood pressure lowering, the composition is calculated as 3 parts of Huashan alum polysaccharide, 3 parts of Polygonum multiflorum, 3 parts of Salvia miltiorrhiza, and 5 parts of hawthorn according to the ratio of parts by weight. 5 parts of Gynostemma, 8 parts of Cassia, 8 parts of chrysanthemum and 8 parts of medlar. The above composition is made into tablets or granules according to conventional techniques.

[0031] The preparation method of Huashan alum polysaccharide of the present invention is:

[0032] Step 1: Take the dry product of Huashan alum with a moisture content of 5%, crush it and sieve it, take the Huashan alum powder with a particle size of 100 microns after sieving, and extract it twice with hot water at 75°C for 1 hour each time, and then pass through Centrifuge, filter with suct...

Embodiment 2

[0036] The Huashan alum polysaccharide pharmaceutical composition of the present invention comprises 5 parts of Huashan alum polysaccharide, 5 parts of Polygonum multiflorum, 5 parts of Salvia miltiorrhiza, 3 parts of hawthorn, 3 parts of Gynostemma pentaphyllum, 5 parts of Cassia herba, 15 parts of chrysanthemum and Lycium barbarum 8 servings. The above composition is made into capsules or pills according to conventional techniques.

[0037] Wherein, the preparation method of Huashan alum polysaccharide is:

[0038] Step 1: Take the dry product of Huashan alum with a water content of 4%, crush it and sieve it, take the Huashan alum powder with a particle size of 200 microns after sieving, and extract it with hot water at 90°C for 5 times, each time for 3 hours, and then successively pass through Centrifuge, filter, and combine the filtrates, then vacuum concentrate the filtrate to 1 / 5 of the original volume, adjust the alcohol content of the filtrate to 80%, collect the prec...

Embodiment 3

[0042] A pharmaceutical composition of Huashan alum polysaccharide, the composition is calculated according to the ratio of parts by weight: 4 parts of Huashan alum polysaccharide, 4 parts of Polygonum multiflorum, 4 parts of Salvia miltiorrhiza, 4 parts of hawthorn, 4 parts of Gynostemma pentaphyllum, 6 parts of Cassia, and 12 parts of chrysanthemum and 13 parts of medlar. The above composition is made into injection according to conventional techniques.

[0043] Wherein, the preparation method of Huashan alum polysaccharide is:

[0044] Step 1: Take the dry product of Huashan alum with a water content of 3%, crush it and sieve it, take the Huashan alum powder with a particle size of 100-200 microns after sieving, and extract it with hot water at 80°C for 3 times, each time for 2 hours, and then After centrifugation, suction filtration, and merging of the filtrates, the filtrate was vacuum concentrated to 1 / 6 of the original volume, the alcohol content of the filtrate was ad...

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Abstract

The invention discloses an application of Symplocos chinensis polysaccharides in the preparation of medicines for preventing and treating hyperlipidemia and hypertension. The Symplocos chinensis polysaccharides can be used in the preparation of medicinal preparations for preventing and treating hyperlipidemia and hypertension as one of active components or as the only one active component. The Symplocos chinensis polysaccharides can effectively reduce the content of total cholesterol (TC), triglycerides (TG) and LDL-C in hyperlipidemia mouse serums, and have active effects on fat metabolism adjustment and AS prevention. The HDL-C transports cholesterols in blood to the liver, and converts the cholesterols into bile acid or makes the cholesterols be directly excreted through bile. Obvious increase of the HDL-C in Symplocos chinensis polysaccharide group mice shows that the Symplocos chinensis polysaccharides can promote transportation of the cholesterols in the blood to the liver and promote conversion and drainage in order to reduce the cholesterols in the blood and reduce rises of the coronary heart disease and atherosclerosis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicinal application of Huashan alum polysaccharide and a composition thereof. Background technique [0002] Huashan alum Symplocoschinensis (Lour.) Druce is a plant of the genus SymplocosJacq. of the genus Symplocaceae (Symplocaceae). For medicinal purposes, the main functions are to clear away heat and dampness, reduce phlegm and stop malaria, and detoxify. Moreover, the plant is a poisonous Chinese herbal medicine, and symptoms such as nausea, vomiting, dizziness, and chest tightness may occur if overdose is taken. [0003] At present, there are few studies on the chemical components of Huashan alum at home and abroad, and the relevant research mainly focuses on the chemical components of triterpenoids and their antitumor activities. So far, no one has conducted research on Huashan alum polysaccharide, nor has it conducted research on rel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K31/715A61K36/815A61P3/06A61P9/12A61P39/06
CPCA61K9/0019A61K31/715A61K36/185A61K36/21A61K36/287A61K36/424A61K36/482A61K36/537A61K36/704A61K36/734A61K36/815A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 罗泽萍潘立卫覃拥灵安慧
Owner HECHI UNIV
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