Method for reducing blood sugar and blood fat of hyperlipemia rats
A technology for hyperlipidemia and blood lipids, applied in the field of hyperlipidemia, can solve the problems of liver and kidney damage, elevated blood lipids, high morbidity, improve the degree of degeneration, control blood sugar well, reduce liver weight and epididymal circumference The effect of fat weight
Pending Publication Date: 2022-05-17
内蒙古自治区综合疾病预防控制中心
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[0002] A high-fat diet can lead to elevated blood lipids. In severe cases, it can cause a series of glucose and lipid metabolism diseases, such as hyperlipidemia. Long-term consumption of a high-fat diet can cause abnormal accumulation of body fat and imbalance of intestinal microbiota. Hyperlipidemia is Metabolic diseases caused by lipid deposition, characterized by elevated blood cholesterol (TC), triglycerides (TG), low-density lipoprotein choleste
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[0024] Example 1
[0025] A method of lowering blood glucose and lipids in hyperlipidemia rats, including the following steps:
[0026] S1, prepare experimental animals, experimental materials and experimental instruments backup;
[0027]S2, take 5g potato resistant starch, add hydrochloric acid - potassium chloride buffer, add pepsin solution 1mL, shake at 40 °C for 1h, adjust pH = 6.0, add 1 mL high temperature resistant α- amylase solution, and then add glucose amylase solution 1 mL, 70 °C shaking for 1 h, hydrolyzed digestible starch for glucose, cooling, centrifugation, discard supernatant at room temperature, 3 times, add 5mol / L potassium hydroxide solution 5 mL, then add glucose amylase solution 1 mL, 60 °C oscillation for 1 h, Cooling at room temperature, centrifugation, supernatant combined, 100 mL volume fixation;
[0028] S3. The content of reducing sugar in potato resistant starch was determined by sulfuric acid-phenol method, and the calculation formula for the yield...
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The invention relates to the technical field of hyperlipemia, and discloses a method for reducing blood sugar and blood fat of a hyperlipemia rat, at present, medicines commonly used clinically are chemical medicines and have obvious curative effects but have certain damage to the liver and kidney, S1, experimental animals, experimental materials and experimental instruments are prepared for standby application, S2, 5g of potato resistant starch is taken, and S3, the potato resistant starch is added into the experimental animals, the experimental materials and the experimental instruments are added into the experimental animals, the experimental materials and the experimental instruments for standby application. Adding a hydrochloric acid-potassium chloride buffer solution, then adding 1mL of a pepsin solution, oscillating at 40 DEG C for 1 hour, adjusting the pH value to 6.0, adding 1mL of a high-temperature-resistant alpha-amylase solution, then adding 1mL of a glucamylase solution, oscillating at 70 DEG C for 1 hour, hydrolyzing digestible starch into glucose, cooling at room temperature, centrifuging, and discarding supernate. The potato resistant starch has good effects of controlling blood sugar, reducing serum TC, TG, LDL-C and AI levels of hyperlipemia rats, and reducing liver weight and epididymal fat weight, not only can effectively improve the degree of fat degeneration, but also can effectively prevent and treat hyperlipemia.
Description
technical field [0001] The invention relates to the technical field of hyperlipidemia, in particular to a method for reducing blood sugar and blood fat in rats with hyperlipidemia. Background technique [0002] A high-fat diet can lead to elevated blood lipids. In severe cases, it can cause a series of glucose and lipid metabolism diseases, such as hyperlipidemia. Long-term consumption of a high-fat diet can cause abnormal accumulation of body fat and imbalance of intestinal microbiota. Hyperlipidemia is Metabolic diseases caused by lipid deposition, characterized by elevated blood cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) Its main feature is the reduction of blood pressure, high incidence and many complications. In recent years, the number of patients with hyperlipidemia has gradually increased. Hyperlipidemia has become an important risk factor for cardiovascular and cerebrovascular di...
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Login to view more IPC IPC(8): A61K31/718A61K36/81A61P3/10A61P3/06A61K49/00A01K67/02
CPCA61K31/718A61K36/81A61P3/10A61P3/06A61K49/0008A01K67/02
Inventor 吴建美丁玉林曲琳尹幸念樊树理尉迟邈
Owner 内蒙古自治区综合疾病预防控制中心
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