Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Statin and vitamin d composition and preparation method and use thereof

A vitamin and composition technology, applied in the field of statin and vitamin D composition and its preparation, can solve problems such as rhabdomyolysis, and achieve the effects of improving solubility, preventing LDL-C level, increasing absorption and bioavailability in the body

Active Publication Date: 2022-07-15
BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Muscle toxicity with statins, particularly possible rhabdomyolysis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Statin and vitamin d composition and preparation method and use thereof
  • Statin and vitamin d composition and preparation method and use thereof
  • Statin and vitamin d composition and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0027] One implementation is:

[0028] The composition includes: using a statin composition and vitamin D as active ingredients, wherein the material ratio of the two is 1-80 mg of the statin composition and 1000-50000 units of vitamin D.

[0029] Wherein, the statin composition includes lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, rosuvastatin or pitavastatin; vitamin D includes vitamin D2 and / or vitamin D3.

[0030] Another embodiment is: a composition, comprising: a statin composition and vitamin D as active ingredients, and also comprising: an oil phase, a surfactant, a co-surfactant, and a solid adsorbent, wherein the material ratio of the two is 1-80 mg of statin composition, 1000-50000 units of vitamin D, and the weight ratio of oil phase, surfactant, co-surfactant, and solid adsorbent is 1:1-2:1-3:2-3.

[0031] The statin drug and vitamin D are mixed and then added to the oil phase and stirred to dissolve to form an oil phase system. The surfactant...

example

[0040] compositions, prepared into capsules;

[0041] Weigh the composition of statin and vitamin D2, microcrystalline cellulose and cross-linked carboxymethyl cellulose, mix them uniformly for 30 minutes, add an appropriate amount of 2% hypromellose aqueous solution to make a soft material, pass through a 24-mesh sieve for granulation , dried at 60°C, sieved through a 24-mesh sieve to granulate the dry particles, add the prescribed amount of talcum powder and mix evenly, measure the content of the intermediate, calculate the filling amount, and fill it with 2# capsules.

[0042] Appropriate amount of statin × 1000, vitamin D2 5000 units × 1000, microcrystalline cellulose 14g, croscarmellose 5g, talc 1g, hypromellose solution (2%) appropriate amount to make 1000 capsules.

[0043] Each capsule contains statin and vitamin D2 dosage ratio:

[0044] Simvastatin (SIM, Simvastatin) 10 mg; vitamin D2 5000 units.

[0045]

[0046] composition, prepared into soft capsules;

[0047]...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a composition, comprising: statin medicine and vitamin D as active ingredients, wherein the material ratio of the two is 1-80 mg of the statin composition and 1000-50000 units of vitamin D. The invention also discloses the preparation method and application of the solid self-microemulsion. The present invention can supplement the use of vitamin D in conjunction with statins, reduce and alleviate the related toxic and side effects of statins, and has important practical significance for promoting statins to reduce the level of low-density lipoprotein to the greatest extent and prevent the reconstruction of cardiovascular diseases.

Description

technical field [0001] The present invention relates to medicines. More specifically, the present invention relates to a statin and vitamin D composition and its preparation method and use. Background technique [0002] Hyperlipidemia refers to high blood lipid levels, which can directly cause some diseases that seriously endanger human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc. The clinical manifestations of hyperlipidemia are mainly xanthoma caused by lipid deposition in the dermis and arteriosclerosis caused by lipid deposition in the vascular endothelium. Dyslipidemia is often associated with multiple cardiovascular risk factors. A decrease in blood lipid levels and a reduction in cardiovascular disease morbidity and mortality is associated with a decrease in serum total cholesterol and LDL cholesterol levels. [0003] Statins are first-line lipid-lowering drugs and are widely used in clinical practice. Statins are selective inhibitor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/592A61K31/593A61K31/366A61K31/22A61K31/405A61K31/40A61K31/505A61K31/47A61K31/4709A61K9/107A61K47/44A61K47/14A61K47/04A61K47/02A61P3/06A61P9/00A61P1/16A61P13/12A61P29/00
CPCA61K45/06A61K31/592A61K31/593A61K31/366A61K31/22A61K31/405A61K31/40A61K31/505A61K31/47A61K31/4709A61K9/1075A61K47/44A61K47/14A61K47/02A61P3/06A61P9/00A61P1/16A61P13/12A61P29/00A61K2300/00
Inventor 刘丽宏宫丽丽刘河任路路万子睿于晓佳王华光
Owner BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com