Use of russule extract in preparing preparation for treating and/or preventing intestinal flora disorder and related diseases

A technology of intestinal flora imbalance and extracts, which is applied in metabolic diseases, allergic diseases, anti-inflammatory agents, etc., can solve the problems of functional scope and marketing confusion, unclear quality control indicators of functional factors, and insufficient functions , to achieve the effect of improving various physiological and pathological indicators related to immunity, contributing to the diversification of flora, and obvious therapeutic and/or preventive effects

Inactive Publication Date: 2019-05-17
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the improvement of the health quality of consumers, there is an even greater demand for refined health products. However, most of the existing edible and medicinal fungus health products have a confusing range of functions and market promotion. Functional ...

Method used

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  • Use of russule extract in preparing preparation for treating and/or preventing intestinal flora disorder and related diseases
  • Use of russule extract in preparing preparation for treating and/or preventing intestinal flora disorder and related diseases
  • Use of russule extract in preparing preparation for treating and/or preventing intestinal flora disorder and related diseases

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preparation example Construction

[0050] In the fifth aspect of the present invention, a preparation method of russula extract is provided, comprising: after crushing the fruiting body of russula, sequentially extracting with alcohol, water, and sodium hydroxide (NaOH aqueous solution) to obtain The solution is extracted, concentrated and freeze-dried respectively to obtain the alcohol extract of the russula, the water extract of the russula and the alkali extract of the russula.

[0051] Preferably, a preparation method of Russula russula extract comprises: after crushing the fruiting body of Russula russula, extracting with 95% ethanol, water, and 1%-2% NaOH alkaline water successively to obtain extraction solutions respectively, and then separately After concentrating and freeze-drying, the alcohol extract of russula, water extract of russula and alkali extract of russula are obtained.

[0052] Preferably, a method for preparing a russula extract, comprising: crushing the fruit body of russula, extracting w...

Embodiment 1

[0066] Embodiment 1: the preparation of russula extract, the steps are as follows:

[0067] (1) Pulverize the fruiting bodies of Russula russula, use ethanol with a solid-to-liquid ratio of 1:8-1:15, extract by reflux for 2-4 hours, filter with suction, obtain the filtrate, concentrate under reduced pressure to obtain a thick paste of appropriate concentration, thick paste Freeze overnight at -80°C and dry in a freeze dryer to obtain the alcohol extract of Russatus.

[0068] (2) Take the above-mentioned filter residue after alcohol extraction, use water with a material-to-liquid ratio of 1:8-1:15, reflux extraction for 1-3 hours, and suction filter to obtain the filtrate, concentrate under reduced pressure to obtain a thick paste of appropriate concentration, The thick paste was frozen overnight at -80°C, and dried in a freeze dryer to obtain the water extract of Russula edodes.

[0069] (3) Take the above-mentioned filter residue extracted by alcohol and water, use 2% NaOH a...

Embodiment 2

[0074] Example 2: Improvement effect of Russula extract on indicators related to intestinal flora imbalance in mice induced by high-fat diet

[0075] 1. Reagents:

[0076] Total cholesterol (T-CHO) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0077] Triglyceride (TG) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0078] Low-density lipoprotein cholesterol (LDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0079] High-density lipoprotein cholesterol (HDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0080] Thirty female C57 mice, SPF grade, weighing 12-14 g, and 28-30 days old, were purchased from Guangdong Medical Experimental Animal Center with license number SCXK (Guangdong) 2013-0002.

[0081] Rats and mice maintained feed: Guangdong Medical Experimental Animal Center, license number SCXK (Guangdong) 2013-0002.

[0082] The high-fat and high-cholesterol feed formula is shown in Table 2.

[0083] Table 2 Main component...

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Abstract

The invention relates to a use of an edible fungus extract in preparing a preparation for treating and/or preventing intestinal flora disorder and related diseases, in particular to a use of a russuleextract in preparing a preparation for treating and/or preventing the intestinal flora disorder and related diseases. The preparation method is simple and easy to implement and low in operation cost;and an extraction solvent in the preparation method can be recycled, so that the residual risk of an organic reagent is avoided, the natural quality of the ressule extract is ensured, the preparationmethod is environment-friendly, and the preparation method belongs to a green manufacturing technology. According to the invention, the raw materials are completely extracted, the raw materials are fully utilized, and the utilization rate of the raw materials is high. The russule extract not only can obviously contribute to the recovery of the dominant flora structure in a intestinal tract and the diversity of the flora, but also has obvious treatment and/or prevention effects on diseases related to the flora structure of the intestinal tract, can be used in various fields such as medicines,health care products and the like, and has great economic and social values.

Description

technical field [0001] The present invention relates to the use of an edible fungus extract in the preparation of preparations for treating and / or preventing intestinal flora disorders and related diseases, in particular to the use of red mushroom extracts in the preparation of treating and / or preventing intestinal flora disorders and related diseases. Background technique [0002] In recent years, studies on gut microbiota have been emerging, and the role of gut microbiota in human health has attracted more and more attention. Gut flora is the sum of all microorganisms in the human intestinal tract. There are many types (including bacteria, fungi and viruses), and the number is even more amazing. It is estimated that in a normal adult, the total weight of intestinal bacteria can reach 1-1.5kg. They can affect body weight, digestion and absorption capacity, and resist the risk of infection and autoimmune diseases; in addition, they are also associated with some endocrine a...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P1/00A61P37/04A61P3/06A61P3/04A61P29/00A61P37/08A61P31/04A23L33/00A23L31/00
Inventor 陈地灵唐晓萃郭殷锐吴清平谢意珍帅欧杨柏华
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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