Composition for preventing or/and treating insulin resistance and related diseases

A technology for insulin resistance and related diseases, applied to the composition for preventing or/and treating insulin resistance and related diseases, and in the field of phenylalanine or/and phenylpyruvate metabolizing bacteria, which can solve the problems without insulin resistance and related diseases Questions like medication or food

Inactive Publication Date: 2015-03-18
萧湘
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0051] After searching, there are currently no patents or reports on the use of compositions containing phenyllactic acid or its salts and phenylpyruvic acid or its salts in the preparation of medicines or foods for improving, preventing or treating insulin resistance and its related diseases

Method used

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  • Composition for preventing or/and treating insulin resistance and related diseases
  • Composition for preventing or/and treating insulin resistance and related diseases
  • Composition for preventing or/and treating insulin resistance and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1.Ins3Pa is to the effect of high-fat diet-STZ joint induction hyperglycemia rat

[0075] Objective: To study the effect of Ins3Pa on the diabetic rat model induced by high-fat diet combined with streptozotocin (STZ).

[0076] Methods: 8-week-old male Wistar rats of SPF grade, body mass (150-170) g, were fed high-fat diet for 4 weeks, fasted for 12 hours, and intraperitoneally injected with STZ 30 mg / kg, and the blank group was injected with an equal volume of citrate buffer.

[0077] One week later, the rats with successful modeling were randomly divided into model group, Ins3Pa group and metformin group (Metformin, DMBG).

[0078] The treatment group was given Ins3Pa 20ml / kg.bw and metformin 500mg / kg.bw respectively, and the model group was given equal volume of distilled water once a day.

[0079] After administration for 14 days, plasma insulin and glycosylated hemoglobin were detected, and the insulin sensitivity index ln[1 / (FPG×FINS)] was calculated. T...

Embodiment 2

[0084] The influence of embodiment 2.Ins3Pa on normal mouse glucose tolerance

[0085] 40 normal mice were randomly divided into 4 groups, 10 in each group: after fasting for 12 hours, the blank control group and glucose control group were given distilled water, and the positive control group and Ins3Pa group were given phenformin (Phenformin, DBI) aqueous solution respectively. 500mg / kg.bw and 20ml / kg.bw of Ins3Pa, after administration, except the blank control group, each group was given glucose solution at 2.5g / kg.bw immediately, and immediately after 0min, 15min, 45min, and 75min, respectively Take blood, measure blood sugar. Ins3Pa improves glucose tolerance in normal mice. The results are shown in Table 2..

[0086] Table 2. Effect of Ins3Pa on glucose tolerance in normal mice (mmol / L)

[0087]

[0088] Compared with the model control group, *P<0.01; #P<0.05

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PUM

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Abstract

The invention relates to metabolism of enteric microorganisms and phenylalanine and phenylpyruvic acid of the enteric microorganisms, and provides a composition containing phenyllactic acid or salts of phenyllactic acid and phenylpyruvic acid or salts of phenylpyruvic acid and used for preventing or / and treating insulin resistance and related diseases, use of the composition in preparation of a medicine or food for improving, preventing or treating insulin resistance and related diseases, and a method for preventing or treating insulin resistance and related diseases. The related diseases include intestinal dysbacteriosis, metabolic syndrome, obesity, diabetes, podagra and tumors.

Description

technical field [0001] The present invention relates to intestinal microorganisms, especially phenylalanine or / and phenylpyruvate metabolizing bacteria. It further relates to a composition for preventing and / or treating insulin resistance and related diseases, the composition contains phenyllactic acid or a salt thereof and phenylpyruvic acid or a salt thereof. And the use in the preparation of medicine or food for improving, preventing or treating insulin resistance and related diseases. And a method of preventing and / or treating insulin resistance and related disorders. Associated conditions include gut dysbiosis, metabolic syndrome, obesity, diabetes, gout and cancer. Background of the invention [0002] Phenylalanine, the biologically active optical isomer of 2-amino-3-phenylalanine Phe is L-phenylalanine, which is an essential amino acid that the body must ingest from the outside world. What's special about phenylalanine: All natural proteins contain some proportion ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K35/744A61P5/50A61P1/00A61P3/00A61P3/10A61P3/04A61P19/06A61P35/00A23L1/30A23L33/10
CPCA61K31/192A23L33/10A23L33/135A23V2002/00A61K35/744
Inventor 萧湘
Owner 萧湘
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