Composition for preventing or/and treating insulin resistance and related diseases
A technology for insulin resistance and related diseases, applied to the composition for preventing or/and treating insulin resistance and related diseases, and in the field of phenylalanine or/and phenylpyruvate metabolizing bacteria, which can solve the problems without insulin resistance and related diseases Questions like medication or food
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Embodiment 1
[0074] Embodiment 1.Ins3Pa is to the effect of high-fat diet-STZ joint induction hyperglycemia rat
[0075] Objective: To study the effect of Ins3Pa on the diabetic rat model induced by high-fat diet combined with streptozotocin (STZ).
[0076] Methods: 8-week-old male Wistar rats of SPF grade, body mass (150-170) g, were fed high-fat diet for 4 weeks, fasted for 12 hours, and intraperitoneally injected with STZ 30 mg / kg, and the blank group was injected with an equal volume of citrate buffer.
[0077] One week later, the rats with successful modeling were randomly divided into model group, Ins3Pa group and metformin group (Metformin, DMBG).
[0078] The treatment group was given Ins3Pa 20ml / kg.bw and metformin 500mg / kg.bw respectively, and the model group was given equal volume of distilled water once a day.
[0079] After administration for 14 days, plasma insulin and glycosylated hemoglobin were detected, and the insulin sensitivity index ln[1 / (FPG×FINS)] was calculated. T...
Embodiment 2
[0084] The influence of embodiment 2.Ins3Pa on normal mouse glucose tolerance
[0085] 40 normal mice were randomly divided into 4 groups, 10 in each group: after fasting for 12 hours, the blank control group and glucose control group were given distilled water, and the positive control group and Ins3Pa group were given phenformin (Phenformin, DBI) aqueous solution respectively. 500mg / kg.bw and 20ml / kg.bw of Ins3Pa, after administration, except the blank control group, each group was given glucose solution at 2.5g / kg.bw immediately, and immediately after 0min, 15min, 45min, and 75min, respectively Take blood, measure blood sugar. Ins3Pa improves glucose tolerance in normal mice. The results are shown in Table 2..
[0086] Table 2. Effect of Ins3Pa on glucose tolerance in normal mice (mmol / L)
[0087]
[0088] Compared with the model control group, *P<0.01; #P<0.05
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