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Application of Ovularia raphanipes extract in preparation of preparations used for treating and/or preventing diseases related to alteration of intestinal florae

A technology of intestinal flora imbalance and Oder mushroom, applied in the fields of plant/algae/fungus/moss composition, application, food science, etc., can solve the problem of less research, achieve inhibition of expression, alleviate the deterioration of inflammation, and help effect on bacterial flora diversification

Inactive Publication Date: 2017-12-22
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Ouderia oospora is an edible fungus with great nutritional, health and medicinal value, but there are few studies on it at present

Method used

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  • Application of Ovularia raphanipes extract in preparation of preparations used for treating and/or preventing diseases related to alteration of intestinal florae
  • Application of Ovularia raphanipes extract in preparation of preparations used for treating and/or preventing diseases related to alteration of intestinal florae
  • Application of Ovularia raphanipes extract in preparation of preparations used for treating and/or preventing diseases related to alteration of intestinal florae

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preparation example Construction

[0038] In a preferred embodiment, the preparation method of the extract of Oudia oodbeckia may include the following steps: using Oudia oodhime ovale as a raw material, crushing, and extracting with water such as distilled water as a solvent to obtain a polysaccharide-containing extract ; recovery of the extract, for example, recovery under reduced pressure to an appropriate volume, adding ethanol precipitation to obtain the precipitation of Oudia oodhimonas polysaccharide; redissolving the precipitate in water, adding alcohol precipitation to remove alcohol-soluble impurities, and repeating the operation 1-4 times; The product is redissolved in water, decolorized by D-900 anion exchange resin, and the eluent is recovered, for example, under reduced pressure, to a certain volume, added with alcohol to precipitate, and dried to obtain an extract of Ouderia oodota with a purity of more than 90%.

[0039] Preferably, the alcohol described in the extraction method can be a monohydr...

Embodiment 1

[0062] Embodiment 1: the preparation of Oudia oordiae extract (PACOR)

[0063] The fresh product of Oudia oodota is used as raw material, crushed appropriately, and directly extracted with distilled water as a solvent to obtain an extract containing polysaccharides; the extract is recovered to an appropriate volume under reduced pressure, and ethanol is added to precipitate to obtain the polysaccharide of Oudia oodota; the precipitation Redissolve in water and add alcohol to precipitate for many times to remove alcohol-soluble impurities; the crude polysaccharide is redissolved in water, decolorized by D-900 anion exchange resin, and the eluate is recovered to a small volume, added to ethanol for precipitation, standing still, pumping Filter and dry to obtain the extract of Ouderda oospore with a purity of more than 90%.

[0064] Infrared spectroscopic analysis was carried out on the obtained Ouderia oosperum extract, such as figure 1 mentioned.

[0065] The above-mentioned ...

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Abstract

The invention relates to application of an Ovularia raphanipes extract in pharmaceutical field, in particular to application of the Ovularia raphanipes extract in preparation of preparations used for treating and / or preventing diseases related to alteration of an intestinal florae. The Ovularia raphanipes extract not only can be obviously beneficial to structure recovery of dominant florae in intestinal tracts and beneficial to flora diversification but also shows obvious treatment and / or prevention effect on diseases related to structure of the intestinal flora, for example, expression of an inflammatory factor can be effectively inhibited, deterioration of inflammation is effectively alleviated, and various immunity-associated physiological and pathological indexes are improved. Meanwhile, in a main body with the structure of the intestinal florae destroyed due to factors such as containing of excessive antibiotics, symptoms such as ulceration and inflammation exacerbation of the intestines are observed, and the Ovularia raphanipes extract can effectively alleviate symptoms such as ulcerative colitis of the main body, maintain integrity of the intestinal florae of the main body, has obvious repairing effect, can be used in various fields such as medicines, health products and the like and has economic and social values.

Description

technical field [0001] The present invention relates to the pharmaceutical use of the extract of Ouderia oodendii, in particular to the use of the extract of Ouderia oodendida in the preparation of preparations for treating and / or preventing diseases related to intestinal flora imbalance. Background technique [0002] In recent years, studies on gut microbiota have been emerging, and the role of gut microbiota in human health has attracted more and more attention. Gut flora is the normal microorganisms in the human intestinal tract. It is estimated that in a normal adult, the total weight of intestinal bacteria can reach 1-1.5kg. They can affect body weight and digestion, resist the risk of infection and autoimmune diseases, in addition, they are also associated with the occurrence of some endocrine and metabolic diseases, kidney diseases, neurological diseases, cardiovascular diseases, respiratory diseases and cancer are closely related. [0003] The intestinal flora is ...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P1/00A61P1/04A23L33/105A23L31/00
CPCA23L31/00A23L33/105A23V2002/00A61K36/07A61K2236/331A61K2236/53A61K2236/55A23V2200/32A23V2200/324A23V2250/208
Inventor 陈地灵杨俭唐晓萃帅欧谢意珍吴清平
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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