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Application of bacillus coagulans in preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia

A technology of Bacillus coagulans and high blood sugar, applied in the field of microbial strains, can solve the problems of regulatory dysfunction, high blood sugar, high blood lipids, etc., and achieve the effect of prevention group with excellent effect and the effect of reducing intestinal short-chain fatty acids

Active Publication Date: 2022-05-13
THANKCOME BIOLOGICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Hyperglycemia and hyperlipidemia are two of the so-called "three highs". Under normal circumstances, blood sugar and blood lipids can be regulated by hormones and nerves Keep blood sugar and blood lipids in a balanced state, but due to the joint action of genetic factors and environmental factors, the regulatory functions of the two regulatory systems are disordered, and high blood lipids and blood sugar will occur

Method used

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  • Application of bacillus coagulans in preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia
  • Application of bacillus coagulans in preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia
  • Application of bacillus coagulans in preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Example 1 Isolation and identification of bacillus coagulans

[0054] Medium: MRS liquid and solid medium (Qingdao Haibo), MC liquid and solid medium (Best), BHI liquid and solid medium (Qingdao Haibo)

[0055] Take 10g of salted beans and add them to the conical flask, shake the table for 30min, draw 1ml, and add 10ml of diluent to 9mL of diluent -1 The dilution solution was serially diluted 6 times, and then spread and inoculated on the MRS / MC / BHI agar medium in turn, and then placed in an anaerobic inverted culture at 37°C for 72h. Take out the plate after culture, observe the colony morphology on the solid medium, including shape, color, size, surface, edge, uplift, transparency, etc., select single bacteria with different colony morphology to divide and draw lines, and culture at 37°C for 48h. Bacterial colonies were microscopically examined and photographed for record. The purified colony was picked with a sterile toothpick and placed in a liquid test tube, and ...

Embodiment 2

[0058] The application of embodiment 2 bacillus coagulans BC69

[0059] 1. Materials and methods

[0060] 1.1 Materials and diet

[0061] Bacillus coagulans BC69, from Shanenkang Biotechnology (Suzhou) Co., Ltd. (6 × 10 8 CFU / g). Normal diet (ND, 3.8kcal / g) and high-sugar high-fat diet (HSD, 4.7kcal / g) were purchased from Beijing Botai Hongda Biotechnology Co., Ltd.

[0062] 1.2 Experimental animals

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Abstract

The invention discloses application of bacillus coagulans in preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia, and belongs to the field of microbial strains. The invention discloses bacillus coagulans which is preserved in China General Microbiological Culture Collection Center (CGMCC) on November 10, 2021, the preservation number is CGMCC No.23766, and the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain has a certain effect on relieving weight rise, inflammatory response, tissue fat accumulation, memory ability decline, intestinal short-chain fatty acid reduction and intestinal flora imbalance caused by high-glucose and high-fat diet, and provides a new raw material and direction for screening food, health care products or medicines for regulating and controlling body function decline caused by hyperlipidemia and hyperglycemia.

Description

technical field [0001] The invention relates to the field of microbial strains, in particular to the application of bacillus coagulans in the preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia. Background technique [0002] Hyperglycemia and hyperlipidemia are two of the so-called "three highs". Under normal circumstances, blood sugar and blood lipids can be kept in balance through hormone regulation and nerve regulation, but due to genetic factors and environmental factors The combined action of the two regulatory systems, the regulatory function of the two regulatory systems will be disordered, and hyperlipidemia and hyperglycemia will occur. Excessive blood sugar and blood lipids can cause various diseases, such as hyperlipidemia, hyperglycemia, obesity, coronary heart disease, etc., and lead to a decline in various functions of the body. More importantly, diseases caused by hyperglycemia and hyperlipidemia are ...

Claims

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Application Information

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IPC IPC(8): C12N1/20A23L33/135A61K35/742A61P3/06A61P3/10C12R1/07
CPCA23L33/135A61K35/742A61P3/06A61P3/10A23V2002/00A23V2200/328A23V2200/3262
Inventor 喻扬马新郁雪平
Owner THANKCOME BIOLOGICAL SCI & TECH CO LTD
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