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Application of radix puerariae extract in preparation of medicine or health care product for regulating intestinal flora and reducing blood fat

A technology for regulating intestinal flora and kudzu root extract, which is applied in the application field of medicine or health care products, can solve problems such as rhabdomyolysis and liver damage, and achieve the effect of low price and easy promotion

Pending Publication Date: 2021-12-21
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other therapies such as diet adjustment, smoking cessation, and exercise can also reduce blood lipid levels, but it takes a long time to persist, and it is difficult for most people to achieve
Statins, niacin, and fibrates are currently commonly used lipid-lowering drugs in clinical practice, with obvious curative effects, but may cause liver damage, rhabdomyolysis, etc.

Method used

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  • Application of radix puerariae extract in preparation of medicine or health care product for regulating intestinal flora and reducing blood fat
  • Application of radix puerariae extract in preparation of medicine or health care product for regulating intestinal flora and reducing blood fat
  • Application of radix puerariae extract in preparation of medicine or health care product for regulating intestinal flora and reducing blood fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: (1) modeling and administration method

[0043] 75 male C57BL / 6J mice, weighing 18-22 g, were purchased from Chengdu Dashuo Experimental Animal Co., Ltd. (experimental animal license number: SYXK (Dian) K2013-0007), and were kept in the SPF animal room of Yunnan University of Traditional Chinese Medicine. , free to eat and drink for 1 week. According to the random number table method, the animals were divided into blank control group and model group. The blank control group was given control feed (10% fat, 20% protein, 70% carbohydrate); the model group was given high-fat feed (38.25% fat, 20% protein, 40% carbohydrate, 1.25% cholesterol, 0.5% cholic acid Na) to replicate the HLP mouse model at 10 weeks.

[0044] After successful modeling, the model mice were divided into model group and kudzu root extract group according to the random number table method. The pueraria root extract group was given pueraria root extract (50, 100, 200 mg / kg / day) by intrag...

Embodiment 2

[0046] Embodiment 2: (2) Bacteria removal experiment

[0047] 90 male C57BL / 6J mice, weighing 18-22 g, were purchased from Chengdu Dashuo Experimental Animal Co., Ltd. (experimental animal license number: SYXK (Dian) K2013-0007), raised in SPF grade animal room, free to eat and drink 1 week. According to the random number table method, the animals were divided into control group and bacteria cleaning group. The control group was given normal saline every day, and the antibacterial group was given quadruple antibiotics every day for 21 consecutive days. Then the control group was divided into blank control group, model group, and Pueraria root extract group. group and Qingjun Pueraria root extract group were intervened with high-fat diet for 10 weeks.

[0048] After successful modeling, the pueraria root extract group and the Qingjun pueraria root extract group were given pueraria root extract (200 mg / kg / day), and the other groups were given the same amount of normal saline,...

Embodiment 3

[0050] Embodiment 3: (3) HE staining

[0051] Firstly, the paraffin sections were dewaxed to water in xylene, absolute ethanol and alcohol successively, and then stained with hematoxylin. Dehydrate in toluene, air dry and mount the slides for image collection and analysis under a microscope.

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PUM

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Abstract

The invention provides application of a radix puerariae extract in preparation of a medicine or health care product for regulating intestinal flora and reducing blood fat, and relates to the technical field of traditional Chinese medicine. Experiments prove that the radix puerariae extract can regulate the intestinal flora structure of a high-fat rat, further regulate the content of short-chain fatty acid, improve the disorder of the intestinal flora, promote the metabolism of fat and inhibit the accumulation of the fat, thereby playing roles in reducing the blood fat and protecting the liver.

Description

technical field [0001] The invention belongs to the technical field of medicines for treating diseases, and particularly relates to the application of kudzu root extract in the preparation of medicines or health care products for regulating intestinal flora, especially in medicines for regulating the proportion of intestinal bacteria, increasing the production of intestinal short-chain fatty acids, and lowering blood lipids Or application in health food. Background technique [0002] Hyperlipidemia (HLP) is a disorder of lipid metabolism, mainly characterized by changes in blood lipids, including total cholesterol (TC), triglyceride (Tglyceride, TG) and low-density lipoprotein Cholesterol (Low-density lipoprotein cholesterol, LDL-C) abnormal increase, high-density lipoprotein cholesterol (High-density lipoprotein cholesterol, HDL-C) deficiency. HLP can be caused by eating disorders, excessive comfort, smoking, drugs, genetic diseases (such as familial hypercholesterolemia) ...

Claims

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Application Information

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IPC IPC(8): A61K36/488A61P1/00A61P3/06A23L33/105
CPCA61K36/488A61P1/00A61P3/06A23L33/105A23V2002/00A23V2200/3262A23V2200/32A23V2250/21
Inventor 袁嘉丽孙春斌羊忠山吴月滢侯迥
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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