Application of prevotella in preparation of medicine for treating cholestatic diseases
A technology of cholestasis and Prevotella, applied in the field of biomedicine, can solve the problems of Prevotella improving liver fibrosis in cholestasis, limited effect on patients, and high price, so as to prevent or treat cholestatic diseases and reduce cholestasis , improve the effect of liver fibrosis
Pending Publication Date: 2021-10-19
NANJING MEDICAL UNIV
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Problems solved by technology
[0003] At present, ursodeoxycholic acid (ursodesoxycholic aci, UDCA) is the drug of choice in the clinical treatment of this disease, but it can only improve cholestasis for some patients in the early stage, but the effect on patients in the middle and late stage is limited
In addition, some traditional Chinese medicines, such as astr
Method used
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Embodiment 1
[0026] 1. Cultivation of P.copri
[0027] P.copri (DSM 18205) was purchased from Ningbo Mingzhou Biotechnology Co., Ltd., resuscitated, activated and passaged on blood agar plates (Ningbo Mingzhou Biotechnology Co., Ltd.), and placed in a 2.5L anaerobic culture tank immediately after inoculation ( The anaerobic gas-generating bag and anaerobic indicator have been placed), cultured in blood agar medium at 37°C for 18-36h, and obtained bacterial liquid.
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Abstract
The invention discloses application of prevotella in preparation of a medicine for treating cholestatic diseases. The cholestatic diseases include, but is not limited to, primary sclerosing cholangitis. After the inventor constructs a PSC animal model, it is determined that the abundance of P.copri in mice is consistently reduced in the same population, then intervention effects of P.copri on inflammation, fibrosis, cholestasis and the like of the PSC model are observed and evaluated through intragastric administration for one week and daily supplementation of 1*10<8> CFU of P.copri bacterial liquid, bile acid metabolism changes are determined through total bile acid determination and targeted bile acid detection analysis, and the action mechanism is analyzed. Experiments prove that the P.copri can obviously relieve cholestasis in hepatointestinal circulation of PSC mice and obviously improve liver fibrosis, which is of great significance to prevention or treatment of cholestatic diseases.
Description
technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of Prevotella in the preparation of medicines for treating cholestasis diseases. Background technique [0002] Cholestasis disease is a kind of disease of bile synthesis, metabolism and excretion disorder, which will cause a large amount of bile components such as bile acid to accumulate in the liver and flow back into the blood, thus causing organic damage, metabolic disorder and dysfunction in the hepatobiliary system Clinically, patients will be accompanied by jaundice, pruritus, and elevated serum alkaline phosphatase. Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease characterized by progressive inflammation and fibrosis of intrahepatic and extrahepatic bile ducts and multifocal biliary strictures. Clinically, PSC remains a rare disease of unknown etiology with a poor prognosis, and most patients can develop cirrhosis, por...
Claims
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IPC IPC(8): A61K35/74A61P1/16
CPCA61K35/74A61P1/16
Inventor 江萍李磊江宝榕
Owner NANJING MEDICAL UNIV
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