A kind of artificial bear bile powder and preparation method thereof
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A bear bile powder, artificial technology, applied in the field of medicine, can solve the problem that the content of tauroursodeoxycholic acid cannot reach the pharmacopoeia, etc., and achieve the effects of easy processing, improved service life and easy control
What is AI technical title?
AI technical title is built by PatSnap AI team. It summarizes the technical point description of the patent document.
A bear bile powder, artificial technology, applied in the field of medicine, can solve the problem that the content of tauroursodeoxycholic acid cannot reach the pharmacopoeia, etc., and achieve the effects of easy processing, improved service life and easy control
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[0043] The present invention will be described in detail below in conjunction with examples.
[0044] 1. Preparation of chicken, duck and goose gall powder
[0045]Chicken gall, duck gall and goose gall are purchased from slaughterhouses. First determine the number and weight of gallbladder. Use 75% alcohol to sterilize parts of chicken gall, duck gall and goose gall respectively, and then dissect the bile separately. The taken out bile was freeze-dried for 48 hours to obtain chicken gall powder, duck gall powder and goose gall powder respectively, which were stored in a desiccator for future use.
[0046] 2. Preparation of artificial bear bile powder
[0047] (1) Treatment of poultry gall powder
[0048] Dissolve poultry gall powder (chicken gall powder, duck gall powder, goose gall powder) in a buffer solution with a pH of 7.0 to 9.0 to prepare a 1L solution, and dissolve fully by ultrasonic waves. The buffer solution is preferably phosphate buffered saline (PBS), Tris-H...
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Abstract
The invention discloses an artificial bear bile powder and a preparation method thereof. The preparation method comprises the following steps: a) dissolving poultry bile powder with a buffer solution of pH=7-9 and then filtering to obtain filter residue and filtrate; b ) adding the filtrate to a reactor equipped with 7α-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase and coenzyme I or coenzyme II for reaction; c) freeze-drying the reaction solution after the reaction and combining with the The filter residue is mixed to obtain artificial bear bile powder. The present invention completely uses natural sources of poultry bile as the raw material for artificial bear bile, without adding other chemical substances, and adopts common animal bile, and its bile source is easy to collect, obtain, and process; through in vitro simulation of the enterohepatic circulation process , to bioconvert poultry bile into artificial bear bile powder that is chemically equivalent to natural bear bile powder, as a substitute for natural bear bile, to protect the endangered Asian black bear, and to promote the healthy development of the bear bile industry.
Description
technical field [0001] The invention belongs to the field of medicines, in particular to an artificial bear bile powder and a preparation method thereof. Background technique [0002] Bear bile, obtained from the dried gallbladder bile of black bears or brown bears, has the effects of clearing away heat, calming the liver, and improving eyesight. Its main component is tauroursodeoxycholic acid (TUDCA). Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use, and a large number of prescriptions contain bear bile. my country's annual output of bear bile powder is about 30 tons, which still cannot meet the needs of human health. At present, the contradiction between supply and demand of high-end bear bile powder is increasingly prominent and the market demand for bear bile powder for low-end raw materials continues to increase, which makes the price of bear bile powder rise steadily, and the market price has exceeded ...
Claims
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