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Internal lead removal oral preparation and administration method thereof

An oral preparation and lead removal technology, which is applied to the oral preparation of soft agglomerated carbonate powder and its administration field, can solve the problems of high toxicity of lead removal drugs, loss of trace elements, inconvenient administration, etc., and achieve the effect of driving lead Better, lower toxicity, lower dose effect

Active Publication Date: 2017-12-22
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the defects of existing lead-removing drugs such as high toxicity, high cost, inconvenient administration, and loss of trace elements, the present invention intends to provide a safer and more ideal lead-removing drug in vivo and its administration method

Method used

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  • Internal lead removal oral preparation and administration method thereof
  • Internal lead removal oral preparation and administration method thereof
  • Internal lead removal oral preparation and administration method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] An oral formulation for removing lead in vivo is an oral solution based on soft agglomerated carbonate powder. Take 3g of 40nm nano-calcium carbonate PH-sensitive material package and add it to 45ml of ultra-pure water, and use a vortex mixer to rotate and mix to prepare a nano-calcium carbonate suspension.

[0043] The process of preparing above-mentioned nano calcium carbonate is:

[0044] Weigh respectively CaCl with a mass of 3.33Kg2 and 3.18Kg of Na 2 CO 3 Solid, and it is dissolved in the large plastic barrel that 15L distilled water is housed respectively, and the solution that all configuration concentration is 1mol / L, stir constantly to make it dissolve completely. The configured NaCO 3 The solution was slowly added CaCl 2 In the solution, electromechanical stirring was used during the reaction, and the stirring rate was kept at 1500r / min. NaCO 3 The adding time of the solution was controlled at about 1.5h, after that, the stirring was continued for 2h to ...

Embodiment 2

[0047] An oral preparation for removing lead in vivo is a tablet based on soft agglomerated carbonate nanopowder. Take 3g of 40nm nano-calcium carbonate pH-sensitive material wrapping and Tween 80 and add it to 45ml of ultrapure water, and use a vortex mixer to rotate and mix to prepare a nano-calcium carbonate suspension.

[0048] The process of preparing above-mentioned nano calcium carbonate is:

[0049] Weigh the CaCl with a mass of 3.2Kg 2 and 3Kg of Na2CO 3 Solid, and it is dissolved in the large plastic barrel that 15L distilled water is housed respectively, and the solution that all configuration concentration is 1mol / L, stir constantly to make it dissolve completely. The configured NaCO 3 The solution was slowly added CaCl 2 In the solution, electromechanical stirring was used during the reaction, and the stirring rate was kept at 2000r / min. NaCO 3 The adding time of the solution was controlled at about 1.5h, after that, the stirring was continued for 1.5h to ens...

Embodiment 3

[0052] An oral preparation for removing lead in vivo is a granule based on soft agglomerated calcium carbonate nanopowder. Take 3g of 40-80nm nano-calcium carbonate pH-sensitive material package and add it to 45ml of ultra-pure water, and use a vortex mixer to rotate and mix to prepare a nano-calcium carbonate suspension.

[0053] The process of preparing above-mentioned nano calcium carbonate is:

[0054] Weigh respectively CaCl with a mass of 2.22Kg 2 and 2.12Kg of Na2CO 3 Solid, and it is dissolved in the large plastic tank that 10L distilled water is housed respectively, and the solution that all configures concentration is 1mol / L, stir constantly to make it dissolve completely. The configured NaCO 3 The solution was slowly added CaCl 2 In the solution, electromechanical stirring was used during the reaction, and the stirring rate was kept at 2000r / min. NaCO 3 The adding time of the solution was controlled at about 1 h, after that, the stirring was continued for 2 h t...

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Abstract

The invention relates to an internal lead removal oral preparation, in particular to a weakly agglomerated carbonate powdery oral preparation and an administration method thereof. A main component of the oral preparation is carbonate capable of performing precipitation and displacement reaction with lead ions. After the preparation is swallowed, nanometer calcium carbonate is distributed on the endomembrane of the intestine, precipitation and displacement reaction is performed on calcium ions and the lead ions to generate lead carbonate with low water solubility to block the lead ions from being recovered by means of enterohepatic circulation, and the lead carbonate is excreted along with feces in the intestinal tract. According to the oral preparation, a lead removal medicament or a lead removal healthcare product is prepared from the calcium carbonate, is free of obvious toxic or side effects on a human body, and has a good dispersion effect and a good lead removal effect.

Description

technical field [0001] The invention relates to a preparation for removing lead in vivo, in particular to an oral preparation of soft agglomerated carbonate powder and its administration method. Background technique [0002] With the development of urbanization and industrialization, lead poisoning caused by environmental pollution has become an occupational disease and epidemic in our country, and the damage to children is particularly serious. Excessive blood lead levels seriously affect children's normal growth and intellectual development. Therefore, the prevention and treatment of lead poisoning has become a major issue related to the national economy and the people's livelihood. [0003] At present, most clinical lead-dispelling drugs are complexing agents, that is, complexing agents and lead ions are used to form water-soluble lead complexes and then excreted through the kidneys with urine. method. Its curative effect is definite, but there are obvious disadvantage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61P39/02
CPCA61K9/0053A61K33/10A61K47/26
Inventor 肖平邹俭鹏巫放明潘一峰方平飞黄彦凝朱轩仪
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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