The invention discloses a production device of hindered phenol antioxidant 1010. The production device mainly comprises a catalytic reaction kettle (D101), an isobutylene gasification tank (F101), analkylation kettle (D102), an alkylation water washing kettle (L101), a toluene storage tank (F102), condensers (C101-C107), a rectification kettle (E101), a phenol storage tank (F103), a 2, 4 isomer storage tank (F104), an ortho storage tank (F105), a front and rear fraction storage tank (F106), a finished product crystallization kettle (D105), a filter (L108), a crude ester dissolution kettle (L107), a finished product water washing tank (L106), a petroleum aldehyde storage tank (F109), a dimethyl sulfoxide storage tank (F108), a finished product water washing kettle (D104), centrifuges (L103-L105), a methyl esterification reaction kettle (D103), a separator (L102) and a 2, 6 isomer storage tank (F107), wherein the reaction kettle (D101) has an inner pot diameter of 730-760 mm.