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Method for detecting content of procaine hydrochloride solution

A technology of procaine hydrochloride and a determination method is applied in the field of determination of procaine hydrochloride solution content, and can solve the problems of large error in determination result, complicated operation, difficult to grasp the end point and the like

Inactive Publication Date: 2005-03-23
刘素琴
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Problems solved by technology

[0003] 1 Diazotization method: its operation is cumbersome, time-consuming, the end point is difficult to grasp, and the error of the measurement result is large
[0004] 2. UV spectrophotometry: UV spectrophotometry is used to directly measure its content. Since the antibacterial agent ethylparaben in procaine hydrochloride solution interferes with the measurement results, the measured results have a large deviation
[0005] 3 Perpetual stop titration method: because the perpetual stop instrument used in this method is not popular in general hospitals, and the operation is cumbersome and time-consuming

Method used

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  • Method for detecting content of procaine hydrochloride solution
  • Method for detecting content of procaine hydrochloride solution

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Embodiment Construction

[0023] A new method for determining the content of procaine hydrochloride solution, the determination method is: accurately draw 1.0ml of procaine hydrochloride solution to be determined, put it in a 100ml measuring bottle, add purified water to dilute to the mark and shake to obtain the sample Solution, put the sample solution and purified water into two colorimetric vessels respectively, according to the operating requirements of the ultraviolet spectrophotometer UV-2550, put the two colorimetric vessels containing the sample solution and purified water into the ultraviolet spectrophotometer , taking water as a blank, set the measurement wavelength of the UV spectrophotometer at 308 nanometers, measure the first derivative D value, and then substitute the measured amplitude D value into the equation: D=0.00252C+0.0001, the formula C is the content of procaine hydrochloride in the tested solution, and C can be obtained by calculation.

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Abstract

The invention is a new method for measuring the content of procaine hydrochloride solution. The method is: pipetle the procaine hydrochloride solution 1.0ml precisely, and put into 100ml cylinder, adds in purified water to dilute them to the scale and acquires the sample solution, the sample solution and purified water are put into two color comparators, carries on measurement according to the operation demands of ultraviolet spectrum device UV-2550, the wavelength of the device is set as 308nm, measures the amplitude D between its first order of derivative valley and zero, then the D is substituted in the formula D=0.00252C+0.0001, the C is the content of procaine hydrochloride in solution. The method is accurate and quick.

Description

Technical field: [0001] The invention relates to a method for determining the content of a medicinal mixture, in particular to a method for determining the content of a procaine hydrochloride solution. Background technique: [0002] In clinical medicine, procaine hydrochloride solution is mainly used to treat pain caused by peptic ulcer. The level of its content directly affects the therapeutic effect. If the content is too high, it will cause toxic and side effects to patients, and if the content is low, it will affect the therapeutic effect. , so when preparing the prescription solution, how to measure its content quickly and accurately is extremely critical. The procaine hydrochloride solution consists of procaine hydrochloride, ethylparaben and purified water. At present, there are usually three methods for determining the content of procaine hydrochloride solution: [0003] 1. Diazotization method: its operation is cumbersome, time-consuming, the end point is difficul...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33
Inventor 刘素琴
Owner 刘素琴
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