45 results about "Ciprofloxacin lactate" patented technology

The invention discloses a fertilizer and pesticide combination reagent for preventing and killing bacterial canker of kiwifruit and a preparation method of the fertilizer and pesticide combination reagent. The fertilizer and pesticide combination reagent is prepared from the following raw materials in parts by weight: 200 parts of agricultural amino acid water soluble powder, 40-50 parts of anhydrous zinc chloride, 45-65 parts of anhydrous manganese chloride, 40-80 parts of a ciprofloxacin active compound or a ciprofloxacin active compound, 100-200 parts of a 14% methyl chloride isothiazolinone water agent, 100-150 parts of oxine-copper active compound, 0.1 part of forchlorfenuron, 0.1 part of a 5-nitroguaiacol sodium salt active compound, 0.5 part of an alpha-pimacol active compound, 350-450 parts of molasses microbial fermentation concentrate solution, 0.2-0.25 part of sodium polyacrylate powder, 50-60 parts of No.YD-7 liquid fertilizer synergia solution, 0.1-0.2 part of industrial alcohol and the balance of deionized water to supplement the raw materials to 1200-1250 parts. The fertilizer and pesticide combination reagent disclosed by the invention is a high-density liquid product with fertilizer and pesticide effects, has good affinity for both water and plants, mainly contact and kill plant bacteria, and can also kill pathogenic fungus. A layer of compact organic pesticide and fertilizer film is formed outside a tree body when the fertilizer and pesticide combination reagent is applied in large concentration, and a sustained release function is exerted.

The present invention discloses a traditional Chinese medicine and western medicine compound infusion liquid for preventing and treating endometritis of dam and preparing method thereof, wherein the contents of various constituents are as follows: 0.5-5g/L of safflower extract, 1-10g/L of epimedium extract, 1-10g/L of leonurus extract, 5-50g/L of Maquinox, 10-100g/L of salicylic acid, 4-40g/L of Ciprofloxacin Lactate, 3-30g/L of metronidazole, 1-10g/L of borneol, 20-40g/L of polyvinylpyrrolidone, 100-200g/L of ethanol and 5-15g/L of tween-80, the rests are water for injection. In the present invention, the effective combination of traditional Chinese medicine and western medicine overcomes the shortages of big dosage, high dosing strength, becoming effective slowly and long course of treatment in pure traditional Chinese treatment, and the shortages of big side-effects and easily generated resistance in pure western medicine treatment. Symptoms and root causes are all treated, and the organic combination of antibacterial inflammation of antibiotics and repairing uterine function by traditional Chinese medicine ingredients is realized.

A new type ciprofloxacin lactate injection preparation method is provided, which is characterized in that: dissolve water-soluble ciprofloxacin lactate raw material in water, add hydrophilic polymers such as polyethylene glycol, propanediol and polyvinylpyrrolidone, etc. to form colloidal solution; wrap the drug in the hydrophilic colloidal solution to prolong the absorption duration of liquid medicine after the injection; add 2L water for injection to ciprofloxacin lactate, mix them evenly, add 3.5L polyethylene glycol, mix till full dissolution, then add sodium bisulfite and EDTA-2Na to mix till full dissolution, add water for injection to 10L, check whether the pH value is within the required scope of 3.0 to 5.0, conduct fine filtering with a filter that has the aperture of 0.45um and is qualified in integrity testing, then fill and pack the finished products as per the required specification.

The invention relates to the field of veterinary drug formulations, and in particular relates to a compound formulation for treating bacterial infection of the digestive tract of livestock and poultry. The compound formulation comprises the following components in every 100ml: 2-10g of ciprofloxacin on ciprofloxacin basis, 1-9g of colistin sulfate on synthesized pure medicine, and 0.03-0.1g of atropine sulfate. The compound formulation is prepared by adopting ciprofloxacin and colistin sulfate with high bacteria sensitivity and strong synergetic bacteria resistance and combining symptomatic treatment medicines by a method for treating both symptom and root cause, so that a remarkable synergetic sterilization effect can be achieved, the drug dosage can be reduced, the cure rate can be improved, the treatment cost can be reduced, and the compound formulation is stable; occurrence of drug resistance of pathogenic bacteria of the digestive tract of livestock and poultry can be effectively avoided; the compound formulation is low in prescription price and convenient to popularize and apply.

The invention relates to a preparation method of ciprofloxacin lactate and sodium chloride injection, which comprises the steps of concentrated preparation, heating, filtration, dilution, adjustment of pH value, filtration, filling, sealing, sterilization, inspection and the like. The ciprofloxacin lactate sodium chloride injection prepared by the preparation method has good stability and can be packaged in plastic bottles.

The invention discloses ciprofloxacin thermo-sensitive type in-situ gel composition and belongs to the field of veterinary drug preparations. The thermo-sensitive type in-situ gel composition comprises, by weight volume (g/ml), 5%-10% of ciprofloxacin, 20%-26% of poloxamer 407, 0.5%-10% of poloxamer 188, 0.01%-0.04% of edetic acid, 0.009%-0.03% of bacteriostatic agent, and 0.1%-0.2% of antioxidant. Solvent of the composition is acetic acid - sodium acetate buffer solution. The invention further discloses a preparing method of the composition. The ciprofloxacin thermo-sensitive type in-situ gel composition is liquid at room temperature, jelling temperature is close to body temperature, and therefore dosing is convenient and jelling speed is high, jelling strength and adhering function are good, the dosing can be achieved with accurate positioning, and loss of drug is reduced. Furthermore, the ciprofloxacin thermo-sensitive type in-situ gel composition and the preparing method thereof have controlled-releasing and long-acting functions, dosage is low, the number of times of dosing is small, harm caused by implants normally used is avoided, and pain of patients is relieved.

The invention belongs to the technical field of veterinary preparations and discloses a veterinary ciprofloxacin injection and preparation method thereof. The injection (per 1000ml) is composed of 25.5-127.5g of ciprofloxacin, 50-150g of PVP-K, 50-100g of nicotinamide, 5-15g of sodium chloride, 0.5-5g of sodium bisulfate, 2-10g of lactic acid and the rest of water for injection. The veterinary ciprofloxacin injection has the advantages that stability of the veterinary ciprofloxacin injection under the low-temperature condition (0-5 DEG C) can be improved, and action time of the ciprofloxacin can be prolonged.

The invention discloses a ciprofloxacin effervescent tablet for control of a silkworm bacterial disease and a preparation method. The effervescent tablet is used for controlling the silkworm bacterial disease and comprises the following components: ciprofloxacin (comprising ciprofloxacin hydrochloride or ciprofloxacin lactate), an acid source disintegrating agent, an alkali source disintegrating agent and an adhesion agent. Meanwhile, the invention further discloses the preparation method of the effervescent tablet. The preparation method disclosed by the invention is simple in process and low in cost; the prepared effervescent tablet is accurate in dosage and convenient to use, and capable of being applied to the control of the silkworm diseases.

The invention provides a method for preparing ciprofloxacin lactate sodium chloride injection, and belongs to the field of medicinal preparation. The method includes the steps: firstly, dissolving lactic acid and sodium hydroxide into water for injection to prepare lactic acid solution; secondly, sufficiently mixing ciprofloxacin serving as a raw material, edetate disodium, diluted hydrochloric acid and the water for injection to prepare ciprofloxacin solution; and finally, sufficiently mixing the prepared lactic acid solution and the prepared ciprofloxacin solution, adding sodium chloride for injection into the solution, mixing the sodium chloride with the solution, and adjusting the pH (potential of hydrogen) value, adjusting the volume, pre-filtering, degerming, filling and sealing and performing autoclaved sterilization, inspection and the like to prepare the ciprofloxacin lactate sodium chloride injection. The method has the advantages of simple and convenient process, no environmental pollution, low cost and the like, and the ciprofloxacin lactate sodium chloride injection prepared by the method is high in stability and quality.

The invention belongs to the technical field of pullorum disease treatment and discloses a medicinal composition for treating pullorum disease and a preparation method thereof. The medicinal composition is prepared from the following raw material medicaments: 600 to 800 grams of common andrographis herb, 200 to 400 grams of lightyellow sophora root and 40 to 80 grams of ciprofloxacin lactate. In the invention, the ciprofloxacin lactate is directly added in an recommended amount to produce a remarkable treatment pullorum disease effect together with the common andrographis herb and lightyellow sophora root; and the ciprofloxacin lactate has high antibacterial activity, so the germ medicament resistance problem, which becomes increasingly serious nowadays, is solved. The medicament of the invention has the advantages that: the medicament materials are widely available and cheap; extraction solvent, which is water, is cheap; harm to chickens is avoided; the clinic symptoms of chickens infected with pullorum disease by human can be controlled effectively; and death rate of chickens is reduced obviously.

The invention belongs to the technical field of medicine preparation and particularly relates to a preparation method of ciprofloxacin lactate. The method comprises the steps as follows: mixing ciprofloxacin hydrochloride with a solvent, adjusting pH with alkali, and performing cooling crystallization, filtration, drying and other steps to obtain ciprofloxacin; mixing ciprofloxacin with the solvent, adding a salt forming agent for a salt forming reaction, and then performing cooling crystallization, filtration, drying and other steps to obtain a finished product of ciprofloxacin lactate. The preparation method is simple to operate, the involved reaction condition is mild and easy to control, ciprofloxacin lactate is prepared in two steps, the refining process is omitted, the production cycle is shortened, the cost is greatly reduced, and the mass yield of ciprofloxacin lactate reaches 95% or higher, and the product purity can reach 99.5%.

The invention discloses a compound injection for treating porcine diarrhea and a preparation method thereof. Every 100ml of compound injection for treating the porcine diarrhea comprises the following components by weight: 5 to 15g of ciprofloxacin lactate, 3 to 10g of berberine, 2 to 5g of ginger, 1 to 5g of levamisole, 0.5 to 2g of mucosal repairing agent, 2 to 6g of organic cosolvent, 0.05 to 0.3g of antioxidant and the balance of injection water. The compound injection for treating the porcine diarrhea of the invention is prepared by combining the traditional Chinese medicine and foreign medicine, wherein the foreign medicine is formed by matching broad spectrum antibiotic and the levamisole serving as an immunoenhancement for quickly sterilizing, improving the resistance of the ill animals to bacteria and virus infection and preventing secondary infection of other virus diseases; and the traditional Chinese medicine is formed by matching berberine extracted from coptis and ginger juice for reducing the amount of used antibacterial, preventing the medicament resistance, reducing the residue of the medicament, effectively protecting gastrointestinal mucosa and simultaneously reducing the untoward reaction.

The invention discloses a preparation method of an antibacterial spray containing electrostatic spinning fibers. The preparation method comprises the following steps of preparing an electrostatic spinning solution containing ciprofloxacin lactate or norfloxacin; preparing an electrostatic spinning fiber containing the ciprofloxacin lactate or the norfloxacin; preparing electrostatic spinning short fibers containing the ciprofloxacin lactate or the norfloxacin; mixing the electrostatic spinning short fibers containing the ciprofloxacin lactate or the norfloxacin with 75% alcohol to obtain the spray with a long-acting antibacterial effect. According to the technical scheme, the durability of the antibacterial spray is improved, harm to a human body is avoided, and the defects of sprays or antibacterial nanoparticles with single components in a market are overcome.

The invention discloses a dosing tank for production of ciprofloxacin lactate eye drops. The dosing tank comprises a tank body, a grinding hammer and a fixing ring, wherein a feeding pipe is mounted on the left side of the tank body; a drive motor is located on the right side of an aeration pump; a connecting shaft is mounted below the drive motor and connected with the upper end of a rotating shaft through a driving belt located on the outer side; a water inlet pipe is mounted on the left side of the tank body; the grinding hammer is located below a sleeve; a cutting net is mounted in the fixing ring and located on the outer side of the sleeve and above exhaust vents; scattering blades are arranged on the outer side of the fixing ring; a feed delivery pipe is mounted below the tank body.According to the dosing tank for production of the ciprofloxacin lactate eye drops, the raw material in the dosing tank is stirred by stirring blades, gas enters the liquid through the exhaust vents,so that liquid rolling rate is increased, material reaction is accelerated, and by means of the cutting net, bubble breakage is facilitated, and the reaction rate of gas and the material is increased.

The invention discloses a veterinary ciprofloxacin lactate injection and belongs to the technical field of veterinary medicines. The injection comprises 25.5-127.5g ciprofloxacin lactate, 50-150g PVP (polyvinylpyrrolidone)-K30, 50-100g polyoxyethylene-40-hydrogenated castor oil, 5-15g sodium chloride, 0.5-5g sodium hydrogen sulfite and 2-10g lactic acid per 1000mL water for injection. A diffusion rate of the injection medicine is reduced significantly, so that the action time of ciprofloxacin lactate is prolonged.

The invention discloses a medicinal preparation for preventing and treating postpartum diseases of sows and a preparation method thereof. The medicinal preparation is prepared from the following components in parts by weight: 5-10 parts of lincomycin hydrochloride, 2-6 parts of ciprofloxacin lactate, 1-5 parts of sodium trimethoxypyrimidine lactate, 8-12 parts of lonicera japonica, 5-10 parts of houttuynia cordata, 1-5 parts of liquidambar formosana, 20-30 parts of medical stone, 2-5 parts of fructo-oligose and 0.5-2 parts of citric acid. The components are compatible and synergized to stimulate great appetite of sows, so that postpartum feed intake reduction and occurrence of postpartum diseases and mastitis can be effectively prevented, sow diestrus can be reduced, and sow utilization can be improved. Furthermore, the incidence rate of yellow and white scour of piglets can be reduced, healthy growth of piglets can be promoted, the ecological balance of intestinal flora can be regulated, and the side effect that intestinal intestine bacteria are disturbed by antibiotics can be greatly reduced. The medicinal preparation has a wide application prospect.