Veterinary ciprofloxacin lactate injection and preparation method thereof

A technology of ciprofloxacin lactate and ciprofloxacin, applied to ciprofloxacin lactate injection for animals, the preparation of said ciprofloxacin lactate injection for animals, making the ciprofloxacin lactate injection The drug release rate is more stable, povidone (PVP) + sodium bisulfite + E field, to achieve the effect of convenient use, reduce stress response, and save treatment costs

Inactive Publication Date: 2012-10-03
山东省健牧生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above problem that the drug release rate in the ciprofloxacin lactate injection is more stable, the type of auxiliary agent is scarce, the present invention provides a kind of using solubilizing agent and Thickener makes the drug release rate in ciprofloxacin lactate injection more stable, veterinary ciprofloxacin lactate injection

Method used

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  • Veterinary ciprofloxacin lactate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Ciprofloxacin lactate injection for veterinary use consists of the following components:

[0041] Ciprofloxacin lactate calculated as ciprofloxacin 4%,

[0042] Polyoxyl 40 Hydrogenated Castor Oil 10%,

[0043] Carbomer 0.5%,

[0044] Sodium bisulfite 0.1%,

[0045] Disodium edetate 0.01%,

[0046] Add water for injection to 100%,

[0047] Carbomer viscosity is 30000-40000 mPa·s.

[0048] Preparation:

[0049] ① Add a certain amount of ciprofloxacin lactate to water for injection, dissolve, add carbomer, disperse evenly, adjust the pH value to 3.8-4.2, add polyoxyethylene 40 hydrogenated castor oil, mix well, and obtain liquid a;

[0050] ② Dissolve sodium bisulfite and disodium edetate with a certain amount of water for injection respectively to obtain liquid b and liquid c,

[0051] ③ Mix liquid a, liquid b, and liquid c, add water for injection to the full amount, add injection-grade activated carbon, stir and absorb for 10-15 minutes; ④ filter with a 0.45 μm ...

Embodiment 2

[0057] Ciprofloxacin lactate injection for veterinary use consists of the following components:

[0058] Ciprofloxacin lactate 10% calculated as ciprofloxacin,

[0059] Polyoxyethylene 40 Hydrogenated Castor Oil 15%,

[0060] Carbomer 0.1%,

[0061] Sodium bisulfite 0.1%,

[0062] Disodium edetate 0.01%,

[0063] Add water for injection to 100%,

[0064] Carbomer viscosity is 30000-40000 mPa·s.

[0065] Preparation:

[0066] ① Add a certain amount of ciprofloxacin lactate to water for injection, dissolve, add carbomer, disperse evenly, adjust the pH value to 3.8-4.2, add polyoxyethylene 40 hydrogenated castor oil, mix well, and obtain liquid a;

[0067] ② Dissolve sodium bisulfite and disodium edetate with a certain amount of water for injection respectively to obtain liquid b and liquid c,

[0068] ③ Mix liquid a, liquid b, and liquid c, add water for injection to the full amount, add injection-grade activated carbon, stir and absorb for 10-15 minutes; ④ filter with 0....

Embodiment 3

[0070]Ciprofloxacin lactate injection for veterinary use consists of the following components:

[0071] Ciprofloxacin lactate calculated as ciprofloxacin 8%,

[0072] Polyoxyl 40 Hydrogenated Castor Oil 12%,

[0073] Carbomer 0.25%,

[0074] Sodium bisulfite 0.1%,

[0075] Disodium edetate 0.01%,

[0076] Add water for injection to 100%,

[0077] Carbomer viscosity is 30000-40000 mPa·s.

[0078] Preparation:

[0079] ① Add a certain amount of ciprofloxacin lactate to water for injection, dissolve, add carbomer, disperse evenly, adjust the pH value to 3.8-4.2, add polyoxyethylene 40 hydrogenated castor oil, mix well, and obtain liquid a;

[0080] ② Dissolve sodium bisulfite and disodium edetate with a certain amount of water for injection respectively to obtain liquid b and liquid c,

[0081] ③ Mix liquid a, liquid b, and liquid c, add water for injection to the full amount, add injection-grade activated carbon, stir and absorb for 10-15 minutes; ④ filter with a 0.45 μm ...

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Abstract

The invention relates to the technical field of veterinary administration, in particular to a veterinary ciprofloxacin lactate injection. The veterinary ciprofloxacin lactate injection consists of the following components in percentage by weight: 4-10 percent of ciprofloxacin lactate counted by ciprofloxacin, 10-15 percent of polyoxyethylene 40 hydrogenated castor oil, 0.5-1.0 percent of carbomer, 0.1 percent of sodium bisulfite, 0.01 percent of ethylene diamine tetraacetic acid, and the balance of water for injection. The injection is convenient to use; compared with the conventional injection, the veterinary ciprofloxacin lactate injection has the advantages: the injection times are reduced from twice a day to once a day, treatment cost is saved, stress caused by repeated injection for animals is reduced, and medicament tolerance of bacteria is avoided; the veterinary ciprofloxacin lactate injection has low toxicity and a reliable curative effect, acts for a long time, and can be used for effectively treating white scour of piglets and white diarrhea; and the swine muscle injection half-life period is 22.96 hours, which is equivalent to five times that of an ordinary injection (4.6 hours).

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a ciprofloxacin lactate injection for animals, and also relates to a preparation method of the ciprofloxacin lactate injection for animals. Background technique [0002] With the intensive and large-scale development of my country's breeding industry, the incidence of livestock and poultry diseases is also increasing year by year, and new diseases are increasing, especially the rapid spread of livestock and poultry bacterial diseases and viral diseases, which have become a problem that plagues our country. important disease in livestock farming. Bacterial diseases account for about 40% of the total number of livestock and poultry diseases, and mixed infections account for about 60% of the total number of livestock and poultry diseases. Bacterial diseases are currently the main infectious diseases of livestock and poultry diseases. The rapid development of modern anim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/496A61K47/44A61P31/04
Inventor 黄迪海秦卓明张再辉张华刘霞张伟张从敬杨波
Owner 山东省健牧生物药业有限公司
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