157results about How to "Less likely to develop drug resistance" patented technology

The invention provides substituted diaryl compounds as shown in general formula (I) or their pharmaceutically acceptable salts, and also provides a preparation method; a class of novel broad-spectrum antiviral compounds and pharmaceutical salts targeting cytokines are screened and obtained through studies on structure-activity relationship and action mechanism of active compounds; the compounds not only have significant broad-spectrum antiviral activity, but also have the advantages of low toxicity and good pharmaceutical properties.

The invention discloses an alkynyl thienone ketone compound, and a preparation method and applications thereof. The alkynyl thienone ketone compound contains a structure shown as a general formula (I): in an inert solvent and under the action of catalyst, substituted 2-aromatic acetylenyl thiophene and substituted aromatic acetyl chloride are reacted to prepare the alkynyl thienone ketone compound. The alkynyl thienone ketone compound has toxicity or lower toxicity in self, can generate free radical for killing the toxicity under the action of light and oxygen, attack more biomacromolecules in an organism and by a free radical chain reaction and shows high efficiency; the compound exerts toxic effect and simultaneously also occurs the degradation and avoids the persistent residues in the environment, thereby further improving the security; the compound has insecticidal activity, weeding activity and the activities to microbes, such as epiphyte, bacteria, virus, and the like and has simple and portable preparation method as well as lower cost.

The present invention provides alkynyl thiofuran compound as shown in the general expression (I), and its preparation process and the application of its pesticide composition in controlling farm pest, germ, weed and pest to human and animal.

The invention discloses a plant powder pesticide and a method for preparing the same. The plant powder pesticide comprises the following plant raw materials in weight portion: 200 to 300 weight portions of macleaya cordata, 300 to 400 weight portions of euphorbia humifusa, 200 to 300 weight portions of polygonum spicy, 50 to 150 weight portions of licorice powder, 300 to 400 weight portions of anisodus mairei, 150 to 250 weight portions of cortex pseudolaricis, 200 to 300 weight portions of cortex moutan, 150 to 250 weight portions of agrimony, and 150 to 250 weight portions of lycoris radiata. The method is relatively simple to operate, is carried out at normal temperature and pressure, and consumes low energy; and various plant raw materials can be combined together to be extracted most properly at the normal temperature, and mutual influences of the components are smaller. The plant powder pesticide has better killing effect on rice leaf insects, cabbage caterpillars, and aphids. The antifeedant rates to pests are more than 96 percent, and the mortality rate is more than 80 percent. The plant powder pesticide adopts a compound preparation of various plant components so that pests are not easy to generate drug resistance generally.

The invention discloses a broad-spectrum net bacteria preparation with a natural plant source as well as a preparation method and an application thereof. The broad-spectrum net bacteria preparation with the natural plant source is prepared from the following raw materials by weight percent: 0.03-5% of plant pyrethrin, 0.01-2% of eucalyptus oil, 0.03-1% of thymol, 0.03-1% of mint, 1-5% of tea tree oil, 0.015-0.5% of dispersant, 0.2-30% of synergist, 0.01-3% of antioxidant, 35-51% of ethyl alcohol and the balance of water, wherein the plant pyrethrin contains 20-80% of active ingredients; and the concentration of the tea tree oil is 10-15%. The broad-spectrum net bacteria preparation with the natural plant source disclosed by the invention is prepared from a natural plant extract as a main raw material, and has a plurality of functions, also has a significant killing effect on insect pests, such as mosquitoes, acarid, ticks and the like caused by damage to human health except for antibiosis, can purify air, is friendly to a human body and the environment, and has a broad application prospect.

The invention discloses a composite herbicide, which comprises the following components in percentage by mass: 5 to 60 percent of oxadiazon, 3 to 50 percent of oxyfluorfen, 5 to 70 percent of butachlor, 1 to 20 percent of auxiliaries, and 5 to 80 percent of solvent or carrier. A preparation method of the composite herbicide comprises the following steps: putting the oxadiazon and the oxyfluorfen technical into a preparation kettle; adding the solvent to dissolve the oxadiazon and the oxyfluorfen technical while stirring; sequentially adding the butachlor, the auxiliaries and the solvent; and uniformly stirring to obtain an emulsifiable solution product. The composite herbicide has the advantages that: the oxadiazon, the oxyfluorfen and the butachlor belong to different types of herbicideswith different functions and characteristics, prevent weeds from generating drug resistance after compounded, have complementary advantages to enlarge the range of weed control, in particular to noxious weeds difficult to control insects, and can postpone and control the drug resistance of weeds and succession of weed community in the field; and the herbicide composition has good safety to plantsand afterreap crops.

The invention provides a novel viral vaccine for treating a non-small cell lung cancer and a preparation method thereof. The preparation method of the viral vaccine comprises the first step of constructing a carrier of an MVA virus and the second step of obtaining specificity presenting MAGE-3 antigen DC cells. According to the viral vaccine prepared through the method, the biological stability is high, adverse effects on human bodies are not produced, and pathogenic dangers do not exist; a virus antibody can obtain a large number of viral particles with high purity easily; MAGE-A3 expressed by the viral vaccine has better immunogenicity, more epitopes are achieved, and drug resistance is not prone to being caused; the viral load needed in inoculation of the viral vaccine is smaller than other viruses.

The invention belongs to the technical field of production of agricultural products, and relates to a planting method for producing ginkgo leaf agricultural products. The planting method is used for producing fruit agricultural products and fungus agricultural products. The planting method is characterized by including two steps for planting and cultivating: using biological-organic fertilizers prepared with ginkgo leaf decoction dregs at an adaptive phase; and subcutaneously injecting high-concentration ginkgo leaf extract nutrient solution and increasing the dosage of conveyed and absorbed effective components of ginkgo leaves at an affinity phase. Besides, the formula of the biological-organic fertilizers with the ginkgo leaf decoction dregs and culture media is regulated according to difference of the fruit agricultural products and the fungus agricultural products, and the biological-organic fertilizers with the ginkgo leaf decoction dregs and the culture media are prepared, so that the ginkgo leaf agricultural products are produced. The agricultural products planted and cultured by the method have the flavor of original agricultural products and further have the flavor of the ginkgo leaves and a healthcare function.

The invention provides a fish feed which includes fish meal, bean pulp, cottonseed meal, monocalcium phosphate, soybean oil, wheat, vitamin premix, mineral substance premix and a drug preparation for treating the fish gill rot. The drug preparation of the feed adopts traditional Chinese medicine ingredients which are extracted, has the advantages of high solubility, high absorptivity and high use ratio, and is high in medicinal ingredient and small in impurity. Compared with the traditional drugs for treating the gill rot, the feed is free of residue and pollution, small in toxic and side effects, not prone to tolerance and wide in source. The feed also has multiple functions.

The invention relates to the field of biological control, in particular to a method of controlling pests by the combination of the insect predator Carabussmaragdinus Fischer and Metarrhiziumanisopliae. The method includes the step of releasing the Carabussmaragdinus Fischer which is inoculated with Metarrhiziumanisopliae. The novel biological control technique focuses on the combination of 'pest control via pest' and 'pest control via bacteria' in biological control; the novel control method is explored. Control by long-term praying of the predator and the advantages and mix control of all types of Metarrhiziumanisopliae are given to full play, the control effect is significantly improved, the predator and the Metarrhiziumanisopliae are ready at any moment to be formulated for use, the effect is good, and lasting time is long. Manpower and material resources are saved. Microbial pesticides can be spread by passing and moving of the Carabussmaragdinus Fischer, biological diversity is promoted, and continuous pest control is achieved.

The invention discloses a composite herbicide, which comprises the following components in percentage by mass: 0.5 to 30 percent of trifloxysulfuron, 0.5 to 30 percent of pyrithiobac-sodium, 3 to 20 percent of quizalofop-p-ethyl, 3 to 20 percent of haloxyfop-p-methyl, 5 to 20 percent of auxiliaries, and 5 to 80 percent of solvent and/or carrier. A preparation method of the composite herbicide comprises the following steps: adsorbing the efficient haloxyfop-p-methyl with white black carbon; mixing absorbed haloxyfop-p-methyl with trifloxysulfuron, pyrithiobac-sodium, quizalofop-p-ethyl, the auxiliaries and the carrier; and crushing by virtue of airflow to obtain a wettable powder product. The composite herbicide has the beneficial effects that: a weed killing spectrum is enlarged, the weedkilling effect is improved, and the safety to cotton and afterreap crops is good.

The invention discloses an oxadiargyl and oxyfluorfen-containing compound suspension concentrate and a preparation method and applications thereof. The compound suspension concentrate comprises the following components: 5-30% of oxadiargyl, 5-30% of oxyfluorfen, 2-20% of a surfactant, 0-6% of a co-suspension concentrate, 0-1% of a thickening agent, 0-1% of a defoaming agent, 0-1% of a preservative, 0.5-5% of an antifreezing agent, and the balance of water for supplementing to 100%. According to the oxadiargyl and oxyfluorfen-containing compound suspension concentrate disclosed by the invention, because the components of the compound suspension concentrate have different function characteristics, after the compounded components are simultaneously applicable to paddy fields, and drug resistance of weeds is not easy to produce; the components can have complementary advantages, so that the weed killing range is expanded; the compound suspension concentrate is safe for rice, has no side effect, and has good safety for afterreap crops; and the compound suspension concentrate disclosed by the invention is an environmental-friendly water-based dosage form, and has the advantages of safe production, storage and application, small environment pollution, low production cost, easiness for packing, and the like. The compound suspension concentrate disclosed by the invention has strong affinity with the soil, the pesticide effect is increased, and the field application amount is reduced, and thus the production cost and the application cost are lowered, and the pesticide residues and environmental pollution are reduced.

The invention provides an oral liquid preventing and curing gallinaceous leucocyto zoonosis and a preparation method thereof. The oral liquid comprises sulfadiazine, TMP, aluminum stearate, alcohol, sodium carboxymethyl cellulose, and Tween -80. The concrete preparation method comprises the following steps that: (1) the aluminum stearate is porphyrized, to which the alcohol is added, (2) the sulfadiazine and the TMP are added to the solution of the step (1), (3) distilled water is taken and stirred evenly, (4) the Tween -80 is added and stirred evenly, (5) the sodium carboxymethyl cellulose is taken and is mixed into paste with the distilled water and the paste is added to the solution of the step (4) to be mixed well, and (6) anhydrous sodium sulfate is added and dissolved, the distilled water is added and stirred evenly, the pH value is adjusted to 9.5 to 11.5 with 0.5 percent of sodium hydroxide water solution and the product is obtained. The oral liquid adopts the suspension technology. The slightly soluble sulfadiazine and TMP are made into suspension liquid. The procedure of stirring feed is left out. The use is convenient and the efficacy is obvious.

A medicinal tooth-paste for preventing periodontitis, gingivitis, oral ulcer, foul breath, decayed tooth, etc is prepared from the raw materials used by original tooth-paste, and additional cactus, berberine hydrochloride and metronidazole.

The invention provides a dendropanax dentiger(Harms)Merr. extract, a preparation method and application in medicine for treating rheumatoid arthritis. According to an extraction method of the dendropanax dentiger(Harms)Merr. extract, dendropanax dentiger(Harms)Merr. plant branches are used as raw materials, water is used as an extractant, and the water extraction process is adopted; and the method includes the steps that firstly, the dendropanax dentiger(Harms)Merr. plant branches are cut into the shape of traditional Chinese medicine decoction pieces; secondly, dendropanax dentiger(Harms)Merr. filtrate is prepared; and thirdly, the dendropanax dentiger(Harms)Merr. extract is prepared. According to the application of the dendropanax dentiger(Harms)Merr. extract in preparation of medicine preparations for preventing and treating rheumatic arthritis and rheumatoid arthritis, and the preparation is selected from pharmaceutical preparations including but not limited to water aqua, granular preparations, capsules, powder and the like of the dendropanax dentiger(Harms)Merr. extract, or is a biological preparation. Meanwhile, application of the dendropanax dentiger(Harms)Merr. extract to prevention and treatment of rheumatic arthritis and rheumatoid arthritis diseases is disclosed, the dendropanax dentiger(Harms)Merr. extract has a good treatment effect, and the dendropanax dentiger(Harms)Merr. extract has the beneficial effects of being small in side effect, not likely to cause drug resistance, affordable and the like when used for preventing and treating rheumatic arthritis and rheumatoid arthritis.

The invention discloses a planting method for producing astragalus mongholicus agricultural products, belongs to the technical field of agricultural product production and aims at providing a method for producing fruit class agricultural products and fungus agricultural products. The method comprises the following steps of: injecting an astragalus mongholicus extract nutrient solution with high concentration during a compatibility period according to biological organic fertilizers prepared by using astragalus mongholicus dregs during an adaptive period; additionally carrying out the two steps of conveying and absorbing the rhizoma polygonati effective component dosages for planting and culturing; adjusting the formula of the biological organic fertilizers of the astragalus mongholicus dregs and cultural base materials according to the difference of the fruit class agricultural products and the fungus agricultural products; and preparing the biological organic fertilizers of the astragalus mongholicus dregs and the cultural base materials so as to realize the production of the astragalus mongholicus agricultural products. According to the method, the planted and cultured agricultural products have the flavor of agricultural products, the flavor of the astragalus mongholicus and a health-care function.

The invention relates to a method for disinfecting and sterilizing an aquaculture pond water body with sterilizing electrochemical water, and belongs to the technical field of disinfecting and sterilizing water bodies in aquaculture ponds. A NaCl solution with the concentration of 5-7%o is treated in a sterilizing electrochemical water generator to generate the sterilizing electrochemical water, a specific treatment method is used in cooperation, microorganisms such as germs, algae and worms in the aquaculture water body and live fish body surfaces can be effectively killed, the harmful microorganisms are prevented from breeding in quantity, fish disease prevention and control can be achieved effectively, water quality is improved to a certain degree, and aquaculture benefits are increased. In addition, the adverse effects on fish are avoided due to the specific sterilizing electrochemical water and the specific water body treatment method.

The invention belongs to the technical field of agricultural product production and provides a planting method for producing rhizoma gastrodiae agricultural products. The planting method is a production method for fruit agricultural products and fungus agricultural products and is characterized by comprising the following steps: planting and culturing the rhizoma gastrodiae agricultural products according to two steps of using a biological-organic fertilizer prepared by rhizoma gastrodiae dregs in an adaptive phase and injecting a rhizoma gastrodiae extract nutritional solution with high concentration in an affinity phase so as to increase the conveyed and absorbed dosage of an active ingredient of the rhizoma gastrodiae; meanwhile, adjusting the formulas of the rhizoma gastrodiae dreg biological-organic fertilizer and a culturing basic material according to differences between the fruit agricultural products and the fungus agricultural products; and preparing the rhizoma gastrodiae dreg biological-organic fertilizer and the culturing basic material, so as to realize the production of the rhizoma gastrodiae agricultural products. The agricultural products planted and cultured through the adoption of the method provided by the invention have flavors of the original agricultural products and also have flavors and a healthcare function of the rhizoma gastrodiae.