Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof

A white crown disease oral liquid and solution technology, which is applied in the directions of liquid transportation, pharmaceutical formulation, emulsion transportation, etc., can solve the problems of loss of chicken farmers, decline in egg production rate, anemia of laying hens, etc., and improve bioavailability. , the effect of enhanced antibacterial activity and less resistance to drug resistance

Inactive Publication Date: 2010-11-10
天津市万格尔生物工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chicken white crown disease, also known as chicken leukocytosis, is a kind of intracellular parasitic protozoan disease caused by leukocytosis carinii, which can destroy red blood cells in the blood, cause bleeding, and cause anemia in chickens. Laying hens are anemic, and the egg production rate drops sharply, resulting in serious losses for chicken farmers. Especially in the rainy and humid southern regions, the incidence of the disease is high, accounting for more than 70% of the total incidence, and the prevention and treatment of the disease The most effective drugs are sulfonamides. The commonly used ones are Xinuomin and Sulfa-methoxine sodium. Xinuomin is time-consuming and labor-intensive in the use of mixing materials, and its wide use is limited. Sulfa-metamethoxine sodium has a wide range of drug-resistant strains. It is easy to produce drug resistance, so it is of great significance for the southern region to seek a product that is easy to use, has a significant effect, is highly targeted, and is inexpensive

Method used

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  • Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof
  • Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] An oral liquid for preventing and treating white crown disease of chickens, comprising sulfadiazine, trimethoprim, aluminum stearate, ethanol, sodium carboxymethylcellulose and Tween-80, 20 parts by weight of sulfadiazine, formazan 5 parts of Oxypic, 2 parts of aluminum stearate, 20 parts of ethanol, 0.2 parts of sodium carboxymethyl cellulose, and 3 parts of Tween-80.

[0029] The preparation method of the above-mentioned oral liquid for preventing and treating chicken white crown disease, the specific preparation steps are as follows:

[0030] (1) get aluminum stearate by above-mentioned parts by weight and grind finely, and cross 200 mesh sieves, add ethanol, stir while adding; (2) get sulfadiazine, trimethoprim by above-mentioned parts by weight and add step ( 1) in the solution; (3) add distilled water and stir evenly to make it into a uniform paste; (4) add Tween-80 according to the above parts by weight and stir evenly; (5) take another carboxymethyl group accord...

Embodiment 2

[0032] An oral liquid for preventing and treating white crown disease of chickens, comprising sulfadiazine, trimethoprim, aluminum stearate, ethanol, sodium carboxymethylcellulose and Tween-80, 30 parts by weight of sulfadiazine, formazan 6 parts of oxoprim, 4 parts of aluminum stearate, 30 parts of ethanol, 0.5 parts of sodium carboxymethylcellulose, and 4 parts of Tween-80.

[0033] The preparation method of the above-mentioned oral liquid for preventing and treating chicken white crown disease, the specific preparation steps are as follows:

[0034] (1) get aluminum stearate by above-mentioned parts by weight and grind finely, and cross 200 mesh sieves, add ethanol, stir while adding; (2) get sulfadiazine, trimethoprim by above-mentioned parts by weight and add step ( 1) in the solution; (3) add distilled water and stir evenly to make it into a uniform paste; (4) add Tween-80 according to the above parts by weight and stir evenly; (5) take another carboxymethyl group accord...

Embodiment 3

[0036] An oral liquid for preventing and treating chicken white crown disease, comprising sulfadiazine, trimethoprim, aluminum stearate, ethanol, sodium carboxymethylcellulose and Tween-80, 10 parts by weight of sulfadiazine, formazan 2 parts of Oxyprime, 3 parts of aluminum stearate, 25 parts of ethanol, 0.3 parts of sodium carboxymethylcellulose, and 3 parts of Tween-803.

[0037] The preparation method of the above-mentioned oral liquid for preventing and treating chicken white crown disease, the specific preparation steps are as follows:

[0038] (1) Get aluminum stearate by the above-mentioned parts by weight, grind finely, and cross 200 mesh sieves, add ethanol while adding and stir; (2) Get sulfadiazine and trimethoprim by the above-mentioned parts by weight and add the step ( 1) in the solution; (3) add distilled water and stir evenly to make it into a uniform paste; (4) add Tween-80 according to the above parts by weight and stir evenly; (5) take another carboxymethyl...

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Abstract

The invention provides an oral liquid preventing and curing gallinaceous leucocyto zoonosis and a preparation method thereof. The oral liquid comprises sulfadiazine, TMP, aluminum stearate, alcohol, sodium carboxymethyl cellulose, and Tween -80. The concrete preparation method comprises the following steps that: (1) the aluminum stearate is porphyrized, to which the alcohol is added, (2) the sulfadiazine and the TMP are added to the solution of the step (1), (3) distilled water is taken and stirred evenly, (4) the Tween -80 is added and stirred evenly, (5) the sodium carboxymethyl cellulose is taken and is mixed into paste with the distilled water and the paste is added to the solution of the step (4) to be mixed well, and (6) anhydrous sodium sulfate is added and dissolved, the distilled water is added and stirred evenly, the pH value is adjusted to 9.5 to 11.5 with 0.5 percent of sodium hydroxide water solution and the product is obtained. The oral liquid adopts the suspension technology. The slightly soluble sulfadiazine and TMP are made into suspension liquid. The procedure of stirring feed is left out. The use is convenient and the efficacy is obvious.

Description

technical field [0001] The invention relates to an oral liquid and a preparation method thereof, in particular to an oral liquid for preventing and treating chicken white crown disease and a preparation method thereof. Background technique [0002] Chicken white crown disease, also known as chicken leukocytosis, is a kind of intracellular parasitic protozoan disease caused by leukocytosis carinii, which can destroy red blood cells in the blood, cause bleeding, and cause anemia in chickens. Laying hens are anemic, and the egg production rate drops sharply, resulting in serious losses for chicken farmers. Especially in the rainy and humid southern regions, the incidence of the disease is high, accounting for more than 70% of the total incidence, and the prevention and treatment of the disease The most effective drugs are sulfonamides. The commonly used ones are Xinuomin and Sulfa-methoxine sodium. Xinuomin is time-consuming and labor-intensive in the use of mixing materials, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K31/505A61K9/10A61J3/00A61P33/02
Inventor 樊爱丽
Owner 天津市万格尔生物工程有限公司
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