3results about How to "Prevent neutralization" patented technology

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.

The application discloses a charging box, a charging device and an electronic device assembly. The charging box comprises a box body, a magnetic element, a driving element and a first coil. The driving element is arranged in the box body and is used for driving the magnetic element to move. The magnetic element is movably arranged at a first position of the box body and is used for driving an electronic device to move relative to the charging box. The first coil is arranged in the box body and is used for charging the charging box or the electronic device. The first coil has a first distance from the magnetic element. When the first coil charges the charging box or the electronic device, the driving element drives the magnetic element to move to a second position of the box body. When the magnetic element is at the second position, the magnetic element has a second distance from the first coil, and the second distance is greater than the first distance.

The invention discloses a high-aggregation charge loss prevention type ion release head and a use method thereof, and relates to the technical field of air purification and electrostatic prevention, the high-aggregation charge loss prevention type ion release head comprises an outer shell, an acoustic focusing tuning assembly and an acoustic driving ion generation assembly, the acoustic focusing tuning assembly and the acoustic driving ion generation assembly are arranged in the outer shell, and the acoustic focusing tuning assembly and the acoustic driving ion generation assembly are arranged in the outer shell. The acoustic focusing tuning assembly comprises a cavity, an acoustic metamaterial lining, an adjusting piston, five inclined push rods, five push blocks, five aperture blades, a grounding ring and an ion current detection probe, and a set of complete charge loss prevention mechanism is constructed through the synergistic effect of the acoustic focusing tuning assembly and the acoustic driving ion generation assembly. Efficient, stable and self-adaptive control of the whole process of ions from generation, focusing to remote transportation is achieved, and the method is specifically embodied in that the ionization process is strictly limited in a specific area through a symmetric electric field constraint unit formed by a spray point and a grounding ring, and disordered diffusion and neutralization of the ions in the initial stage of generation are effectively prevented.