1results about How to "Prevent neutralization" patented technology

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.