26 results about "Binding state" patented technology

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.

A sensor device with the following features is provided: - an optical cavity (3), - fluorescent emitters (7) configured for emitting secondary electromagnetic radiation (8), when excited by primary electromagnetic radiation (9), and - binding sites (10) configured for binding of the substance (11) to be detected, wherein - the secondary electromagnetic radiation (8) comprises a resonance wavelength of an optical bound state in continuum (4) of the optical cavity (3) and / or a resonance wavelength of an optical quasi bound state in continuum of the optical cavity (3), and - the binding sites (10) are arranged such that an optical symmetry of the optical cavity (3) is broken, when the substance (11) to be detected binds to the binding sites (10). Further, a method for detecting a substance is provided.

A sensor refresh system. The sensor refresh system includes a sensor assembly including a sensing surface. The sensor refresh system includes a sensor attached to the sensing surface of the sensing assembly. The sensor includes a receptor binding a chemical species in a binding state. The sensor refresh system further includes an optical source irradiating the sensor when the chemical species is in the binding state to dissociate the chemical species from the receptor of the sensor in a dissociation state.

The invention discloses a binding device and method for thickened archive documents, the binding device comprises an outer cylinder shell (2) used for supporting the inner side face of the thickened archive documents, a pressing seat (4) arranged in the outer cylinder shell (2), and an inner cylinder shell (5) arranged between the pressing seat (4) and the outer cylinder shell (2), one side face of the thickened archive documents is supported through the outer cylinder shell (2), and the inner cylinder shell (5) is arranged between the pressing seat (4) and the outer cylinder shell (2). By means of an inner barrel shell (5), the binding operation space of a penetrating needle and a binding line on the thickened archive document is set, the thickened archive document in the binding state is placed in an arc-shaped gap, and the binding efficiency is improved. The technical problem that due to the fact that a penetrating needle is used, the area of a clamping point of the thickened archive document is limited by a clamp, and the thickened archive document can be misplaced under the action of crossing acting force of the penetrating needle is solved, and therefore the binding effect of the thickened archive document is improved.

The invention relates to a ligand escape path determination method and device, electronic equipment and a storage medium, and the method comprises the steps: obtaining a first structure model of a protein and a ligand in a binding state, the first structure model comprising a protein structure model and a ligand structure model; performing dissociation operation on the ligand structure model to dissociate the ligand structure model and the protein structure model, and monitoring a spatial relationship between the ligand structure model and the protein structure model in the dissociation process to obtain a monitoring result; and under the condition that the monitoring result represents that the ligand structure model enters an external area for the first time, the dissociation operation is terminated, an escape path of the ligand structure model in the dissociation process is obtained, and the external area is an area which is outside the protein structure model and takes the surface of the protein structure model as a boundary. And the efficiency and effectiveness of determining the escape path are improved.

This invention discloses an enhanced sampling molecular dynamics simulation method, belonging to the field of molecular simulation technology. The specific steps include: S1, defining reaction coordinates; S2, transitioning from the binding state to the encounter state; S3, determining constraints on the conformation of the protein and / or ligand; S4, transitioning from the encounter state to the dissociation state; and S5, result analysis. When using umbrella sampling to obtain the protein-ligand binding free energy, this invention proposes dividing the protein-ligand binding process into two parts: from the dissociation state to the encounter state, and then from the encounter state to the binding state. It employs universal reaction coordinates, does not impose constraints on the relative positions of the protein and ligand, and uses multiple sequentially performed umbrella sampling to sample the high-probability binding paths of the protein and ligand. This invention provides a molecular dynamics method that can quickly, accurately, and with high automation calculate the binding free energy of flexible proteins and flexible ligands, as well as the actual binding / dissociation paths.

The invention is suitable for the technical field of intelligent sound box systems, and provides an intelligent connection method of audio equipment. The intelligent connection method of the audio equipment comprises the following steps: detecting a first binding state of the audio equipment, wherein the first binding state is used for representing whether an intelligent microphone is bound with a target intelligent sound box or not; when the first binding state is a bound state, sending a first broadcast signal in a preset frequency band; in response to a first connection request sent by the target intelligent sound box, analyzing the first connection request to obtain a first connection parameter of the target intelligent sound box, the first connection request being generated by the target intelligent sound box according to the first broadcast signal; and connecting the target intelligent loudspeaker box according to the first connection parameter. According to the embodiment of the invention, the problem of mixed connection in a multi-device coexistence scene can be effectively solved, and disorder and interference of audio signals are avoided, so that the stability and quality of audio transmission are improved.

The invention relates to a method and a system for constructing a free energy surface of a molecular binding / dissociation path. The construction method of the free energy surface of the molecule binding / dissociation path comprises the following steps: quantifying the relevance of an atom pair distance / angle and a binding state by adopting a mutual information analysis method so as to screen out candidate reaction coordinates; performing short-time pre-simulation verification on the candidate reaction coordinates to determine dominant reaction coordinates; taking the dominant reaction coordinates as navigation, and carrying out adaptive path sampling through reinforcement learning to obtain an optimized path; and calculating free energy of the optimized path, and constructing a free energy surface of the molecular binding / dissociation path based on the obtained free energy. According to the method, the dominant reaction coordinates are automatically identified, and the adaptive path sampling technology is adopted, so that the problems of subjectivity and intermediate state omission of a traditional fixed reaction coordinate method can be solved, the calculation precision and efficiency of a free energy surface can be improved, and a more reliable theoretical tool is provided for molecular interaction mechanism research.

The invention provides a covered stent. The covered stent comprises a main stent body and a binding assembly. The body support sequentially comprises a near-end section, a middle section and a far-end section in the axial direction, the side face of the middle section sinks towards an inner cavity of the body support to form a groove, the middle section comprises at least one middle wave ring, and the middle wave ring comprises a plurality of first short waves and at least one first high wave. Wherein at least one first high wave crosses two sides of one edge of the groove in the width direction, the constraint assembly is arranged on the main body support and has a constraint state and a release state, when the constraint assembly is in the constraint state, the constraint assembly constrains at least one area of the middle section in the radial direction, and when the constraint assembly is in the release state, the constraint assembly relieves constraint on the middle section. According to the covered stent provided by the invention, the risk of blocking a branch opening can be reduced, and the shape of the edge of the groove can be better maintained.

The invention discloses a binding method and an unbinding method for fiber aligning equipment and an optical fiber port. The binding method comprises the following steps: executing an application program through a processor to generate an optical fiber port overview interface; the optical fiber port overview interface contains a port control; each port control corresponds to one optical fiber port; when the optical fiber port is in a binding state, the display style of the corresponding port control is a first display style, and when the optical fiber port is in an unbinding state, the display style of the corresponding port control is a second display style. Under the condition that a binding request sent by fiber equipment is received, analyzing the binding request, and obtaining equipment identification information of the fiber equipment; binding the equipment identification information with an optical fiber port to be bound; the to-be-bound optical fiber port is determined after a user selects a port control presenting a second display style on an optical fiber port overview interface. According to the invention, the binding efficiency and success rate can be improved.

Materials, methods, means, steps and systems for determining occupancy of a multi-target agent at two or more targets in the same cell. The method generally includes use of multiple detection reagents to determine a bound condition of the multi-target agent to each of the multiple targets, respectively. Each detection reagent includes a detectable label and is designed to bind a specific region of the multi-target agent unique to the agent's ability to bind to one of the multiple targets on the cell surface, thus providing single bound signals. A total amount of the multi-target agent bound to the multiple targets is determined using a universal detection reagent designed to bind to a common region of the multi-target agent. Subtracting specific single bound signals from bound signals allows calculation of multiply bound signals and specific total signals. This approach allows for the measurement of target occupancy for each bound condition with each target.

The application provides an automatic access method and device of a Bluetooth terminal device and electronic equipment, which is applied to a Bluetooth host computer, and the method comprises the following steps: obtaining identification information and a first binding state of a target Bluetooth terminal device; obtaining connection permission information and a second binding state of the target Bluetooth terminal device from a server based on the identification information; connecting the target Bluetooth terminal device if the Bluetooth host computer has the permission to connect the target Bluetooth terminal device; and binding the target Bluetooth terminal device and the Bluetooth host computer by using a preset encryption algorithm if the first binding state and the second binding state are both non-binding states, so that the target Bluetooth terminal device and the Bluetooth host computer in the binding state can communicate with each other. In this way, the Bluetooth host computer controls the connection, binding and other processes of the Bluetooth terminal device by obtaining the connection permission and the binding relationship from the server, so that the terminal user can be prevented from participating in the access process of the device, and the complexity of the device use and the technical requirements of the user use are reduced.

The invention provides a method and a system for realizing target capture in a virtual world and an electronic device. The method comprises the following steps: S1, acquiring a capture signal of a master control virtual character; s2, collecting and analyzing virtual target information capable of being captured by a master control virtual character in an open area, wherein the open area is a virtual space displayed on a screen at the current moment; s3, the master control virtual role gets close to the virtual target to be captured, and establishes a mutual induction connective state with the virtual target through operation; s4, the master control virtual character selects and captures virtual targets which can be captured in the open area, if capture succeeds, a capture success signal is displayed, and if capture fails, it is displayed that capture is not successful, and the player continues to capture or ends capture. According to the method, a biological capture mechanism based on a contract conclusion behavior is established, and the strategy, interestingness and immersion of the game are remarkably improved and the game experience is improved by establishing an active cooperation or interaction relationship between players and organisms.

The utility model relates to exoskeleton technology, in particular to a bandage assembly convenient to adjust tightness and an exoskeleton device, which comprise a mounting portion and a bandage portion, the bandage portion is connected with the mounting portion through a first connector and a second connector at two ends, and the two connectors are connected through an upper stay wire and a lower stay wire. A stay wire retractor for adjusting the tightness of each stay wire is arranged; the bandage part further comprises a bandage body attached to the human body, the bandage body has the deformation performance in the length direction, and the tightness of the bandage body can be adjusted by adjusting the pull wire. The two connectors are connected through the pull wire, and the length of the pull wire can be directly adjusted through the arranged pull wire retractor, so that the actual length of the binding belt part can be adjusted through the pull wire retractor, a user does not need to unbind the binding belt assembly in a wearing state, and the binding belt assembly is convenient to use. The binding tightness can be adjusted only by adjusting the stay wire retractor, and a user can sense the adjustment condition in real time, so that the bandage assembly can reach the optimal binding state.

The invention provides a binding tool and a folder, which can replace paper and covers, are difficult to press hands, and are easy to write. This binding tool binds a body to be bound, which includes paper and / or a cover, and is provided with: a support part which is made of a deformable material and which, in a binding state in which the body to be bound is bound, comes into contact with binding holes of the body to be bound and supports the body to be bound; and an in-and-out part which can freely enter and exit from the binding hole when the binding tool is deformed in a replacement state in which the bound body is replaced.

A computer-implemented method for executing a computation task in a molecular dynamic simulation includes identifying a bonding target on a ligand; constructing a protein structure; rendering an image of the ligand; subsampling data pertaining to the constructed protein structure and the image of the ligand at a particular frequency; rendering a two-dimensional image of the constructed protein structure relative to the ligand from a plurality of viewpoints; computing optical flows of the protein structure relative to the ligand based on the two-dimensional image; analyzing the optical flows to determine a displacement of atoms; simulating a binding state outcome of the protein structure relative to the ligand for each of the plurality of viewpoints; and predicting a probability of the protein structure binding with the ligand, based on the predicted binding state outcome for each of the plurality of viewpoints.

The present disclosure provides a device network configuration method and device, apparatus, and a storage medium. The method comprises: receiving at least one Bluetooth broadcast message, and displaying a device corresponding to a Bluetooth broadcast message carrying a first binding state identifier on an interface, wherein the first binding state identifier is used to identify that the corresponding device is in an unbound user state; in response to a selection operation on a target device on the interface, establishing a Bluetooth connection with the target device; and based on the Bluetooth connection, controlling the target device to bind with a target gateway. It can be seen that the present disclosure displays devices in the unbound user state on the interface through the Bluetooth self-discovery function, so that the user can quickly and conveniently complete the network configuration operation of the target device based on the devices displayed on the interface.

The embodiment of the invention provides an equipment binding method, electronic equipment and a storage medium, relates to the field of Internet of Things, and is applied to a gateway. The method comprises the following steps: in response to a scanning instruction sent by a cloud, broadcasting an air interface wake-up signal; in response to first response information sent after the receiving equipment is awakened to the working state, sending a query instruction to the equipment; in response to device information sent by the receiving device, forwarding the device information to the terminal through the cloud, so that the terminal determines a first sequence; the equipment information is sent under the conditions that the equipment determines that the binding state of the equipment is unbound and the query identifier is stored; and in response to the first binding request sent by the cloud, sending the binding instruction to the to-be-bound device, so that when it is determined that the stored query identifier is consistent with the query identifier in the binding instruction and the encrypted information is successfully decrypted through the key, the gateway identifier is stored, and the binding state is updated to be bound, thereby reducing the omission ratio of device scanning, and improving the user experience. And the safety and efficiency of batch binding are improved.

The invention, which relates to the technical field of the binding device, discloses a rapid wire binding device with an extrusion anti-falling function, comprising a host, heat dissipation holes, a guide arm, a limiting bolt and a third motor. An anti-falling mechanism is arranged above the main machine, the anti-falling mechanism comprises a binding head, a first bag, a second bag and a diaphragm, the diaphragm is arranged on one side of the first bag, the first bag is arranged on one side of the second bag, the second bag is arranged on the side edge of the binding head, and special modified expansion type epoxy resin is arranged in the first bag and the second bag. After extrusion, mixed expansion is achieved, gaps are tightly filled to form secondary fixation, the extrusion anti-falling effect is greatly enhanced, and the stable binding state can still be kept in the scenes of vibration, external force pulling and the like.

The application discloses a real-time detection method and system for the binding state of the lower limbs of an exoskeleton robot. The method comprises collecting the gait of a human body currently in a reversing motion state and extracting features therefrom, determining the current gait phase through the feature extraction; and then detecting the binding state of the lower limbs corresponding to the gait phase in real time. The system comprises a state observer module, a gait phase identification module, a binding detection module, a self-anti-interference controller module and a CMSIS-DSP library module. The application significantly improves the real-time performance and reliability of the binding fall-off identification through the phase-by-phase dynamic detection strategy.

In a ring folder having a folder body and a ring binding tool, a binding state of paper or the like is prevented from being released when a front cover is held in a closed posture, the folder body is formed with a hinge between base ends of a pair of covers and can adopt a cover opening and closing state in which the other cover is turned with respect to the hinge orthogonal to one cover, and the ring binding tool has a binding ring in a vicinity of the base end of the one cover of the folder body. In the ring folder having the binding ring provided with first and second ring forming members that engage the tip end portion and configured such that the engagement is released when an external force for releasing the engagement is applied to the two ring forming members in a direction in which the ring forming members are brought closer to each other, the other cover has a locking hole that engages with the binding ring without applying the external force for releasing the engagement to the binding ring halfway through the cover opening and closing state.

Embodiments of the present application relate to a kind of MHC class molecule and the processing method and device of polypeptide affinity prediction data, the method comprises: receiving molecular sequence;Using protein pre-training model to carry out amino acid sequence feature coding generation first feature tensor;Using Uni-Fold fine-tuning model to carry out three-dimensional structure prediction;The specified module output tensor of Uni-Fold fine-tuning model is formed into second feature tensor;The multiple specified features of MHC class molecule and polypeptide in three-dimensional structure are extracted to generate third feature tensor;First, second, third feature tensor is fused;Using affinity prediction model, the binding state of MHC class molecule and polypeptide is predicted according to fusion tensor;According to prediction vector, three-dimensional structure is optimized.Through the present application, the analysis difficulty of MHC I class, II class molecule and polypeptide affinity can be reduced.

The present application relates to a DNA 5mC or RNA m6A methylation enzyme / demethylase enzyme activity detection method. The method comprises: in the presence of the DNA 5mC methylation enzyme / demethylase or RNA m6A methylation enzyme / demethylase, the change of the binding state of the DNA methylation binding protein or the RNA methylation binding protein with the fluorescently labeled substrate with time is monitored by using the signal of fluorescence polarization, time-resolved fluorescence energy resonance transfer (TR-FRET) or homogeneous photoexcitation chemiluminescence, and then the enzyme activity of the DNA 5mC methylation enzyme / demethylase or the RNA m6A methylation enzyme / demethylase is detected. The method has the characteristics of high efficiency and rapidness, high sensitivity, less required sample and low cost.

The application discloses a stent system and a delivery system. The stent system comprises a stent, a binding member connected with at least two wave coils, the binding member having a binding state and a release state, in the binding state, the binding member makes the wave coils connected with the binding member axially overlap or the axial distance between the wave coils connected with the binding member is shortened and fixed, and in the release state, the wave coils connected with the binding member are released from the fixation; and a pulling member connected with the stent, the axially overlapped wave coils in the release state have an axial overlapping length, the pulling member is pulled to shorten or eliminate the axial overlapping length, or the pulling member is pulled to increase the axial distance between the wave coils connected with the binding member. After the stent system is located at an intervention target position, the stent length can be adjusted in real time, and the stent length can be matched with the actual requirement of a portal systemic shunt.

The invention discloses a low-code data binding method and device, equipment and a storage medium, and relates to the technical field of data processing, a target page is divided according to a top-layer container, and at least one independent top-layer container area is generated; obtaining a to-be-operated target top-layer container selected by a user from the top-layer container area, and displaying corresponding candidate data sources and fields in the interactive interface according to historical data binding conditions of components in the target top-layer container; obtaining a target data source selected by a user from the candidate data sources and displaying a current field contained in the target data source; and obtaining a target field selected by a user from the current fields, establishing a binding relationship between the to-be-bound component in the target top layer container and the target field in the target data source, and adding a binding identifier on the to-be-bound component. Separation of component layout and data binding is realized, invalid data source interference is reduced based on historical binding conditions, the binding state is visually displayed through the binding identifier, and the convenience of data binding is improved.

The invention relates to a terahertz near-field spectrum detection device and method for protein thermophoresis and interaction, the device comprises a nano flow channel structure extending along the length direction, a terahertz near-field probe is arranged on the outer side of the flow channel, and a local heating area is formed at the corresponding position of the nano flow channel so as to establish a stable temperature gradient in a fluid channel. Terahertz near-field signals of a protein solution before and after heating are collected and subjected to ratio treatment, a reduced signal reflecting protein thermophoresis migration characteristics is obtained, and the protein-ligand interaction constant can be calculated in combination with ligand concentration change. Compared with a traditional affinity measurement mode depending on a mark or a fluorescence signal, the method does not need to mark the protein, also does not need to depend on precise flow channel control or large-range near-field scanning imaging, and can characterize migration kinetics and binding state changes of the protein under a temperature gradient in a micro-nano scale; the device has the advantages of simplified structure, high detection sensitivity, low sample consumption, wide application range and the like.