3results about How to "Avoid exhaustion" patented technology

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.

Provided is a device capable of supplying a lubricant to a surface at which two members meet. A device (1) such as a stapler is provided with a first member (2) having a first surface (20) and a second member (3) having a second surface (30) that meets the first surface (20) in part or entirely, the first member (2) and the second member (3) being configured to act in opposition to each other, the first member (2) having a flow path (5) of the lubricant provided with an opening (50) in the first surface (20) on a surface (23a) other than the first surface (20).

This utility model discloses a water bottle with a rotatable cap, including a water bottle body and a flip cap rotatably connected to the water bottle body. The water bottle body has a water dispensing component, and the flip cap has a holding slot for holding the liquid poured out by the water dispensing component. The flip cap can flip and switch between an open and closed state relative to the water bottle body. A handle component is rotatably connected to the water bottle body, and the handle component can rotate and switch between a lifting position and a supporting position relative to the water bottle body. When the handle component is in the supporting position and the flip cap is rotated to the open state relative to the water bottle body, the upper end of the handle component supports and cooperates with the water bottle body, and the lower end of the handle component and the bottom of the water bottle body together form a supporting surface. The flip cap, handle component, and / or water bottle body are positioned and cooperated so that the opening of the holding slot faces upwards for holding liquid. It has the advantages of multifunctionality, ease of use, stable support, and reduced effective contact area between the utility model and the ground.