11results about How to "Avoid exhaustion" patented technology

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.

The application discloses application of a small-molecule compound targeting TIM-3 in tumor immunotherapy and relates to the technical field of immunology and antitumor drugs. The small-molecule compounds DTS and CT are safe and verified marketed drugs, and it is found that the small-molecule compounds can bind to TIM-3 protein and regulate T cell exhaustion related to TIM-3. + Experiments prove that DTS and CT can effectively inhibit CD8 T cell exhaustion, promote expansion of exhausted precursor T cells, and comprehensively enhance T cell antitumor immune function. In a melanoma model, the compounds significantly inhibit tumor growth and reduce the proportion of tumor-infiltrating T cell exhaustion. The application uses the strategy of "new use of old drugs", provides a TIM-3 small-molecule inhibitor with high safety, oral administration, strong penetration and low cost, effectively solves the clinical transformation predicament of existing antibody drugs and newly synthesized small molecules, and provides a new scheme for rapid transformation of tumor immunotherapy.

Disclosed are novel weak affinity IL-2 variants and uses thereof, including adoptive cell therapies by enhancing the efficacy and duration of CAR-immune cells in the treatment of cancer.

The application relates to the field of fault detection, and provides a bearing fault detection algorithm and system. An original vibration signal is decomposed through a local mean decomposition algorithm, and an effective PF component is screened out by using a Pearson correlation coefficient, and then signal reconstruction is carried out, irrelevant noise signal interference is removed, feature extraction of a bearing degradation process is realized based on a product form of a harmonic noise ratio and a root mean square value, the sensitivity of the harmonic noise ratio to periodic impact is fully utilized, and the problem that the root mean square value has low sensitivity to initial bearing degradation is avoided; a state space model of different bearing degradation processes is constructed based on a Paris model and a Foreman model, compared with a single model prediction model, the prediction precision of RUL is more effectively improved; regularization of a particle filtering resampling process is realized based on an Euclidean distance, the diversity of particles is effectively improved, the particle depletion phenomenon of basic particle filtering is avoided, and the filtering estimation precision of a nonlinear state is improved.

Provided is a device capable of supplying a lubricant to a surface at which two members meet. A device (1) such as a stapler is provided with a first member (2) having a first surface (20) and a second member (3) having a second surface (30) that meets the first surface (20) in part or entirely, the first member (2) and the second member (3) being configured to act in opposition to each other, the first member (2) having a flow path (5) of the lubricant provided with an opening (50) in the first surface (20) on a surface (23a) other than the first surface (20).

This invention belongs to the field of communication technology and discloses a federated learning method based on partial client participation and power constraints. The method includes: employing biased client selection, setting client addressability and continuously reporting to a central server, allowing the central server to understand the state of each client during iteration; and allocating power across communication time slots by adding a total power constraint, enabling devices to transmit their local updates to the server. This invention addresses the problems of existing technologies by reducing communication costs while maintaining model convergence performance. The proposed design can mitigate the negative impacts caused by imperfect channel conditions. Convergence of the learning process is slowed by power control, while biased client selection accelerates convergence, balancing model aggregation. This invention can guarantee fast convergence under harsh wireless conditions with low signal-to-noise ratios, and is cost-effective in terms of time and energy savings in wireless FL systems.

This utility model discloses a water bottle with a rotatable cap, including a water bottle body and a flip cap rotatably connected to the water bottle body. The water bottle body has a water dispensing component, and the flip cap has a holding slot for holding the liquid poured out by the water dispensing component. The flip cap can flip and switch between an open and closed state relative to the water bottle body. A handle component is rotatably connected to the water bottle body, and the handle component can rotate and switch between a lifting position and a supporting position relative to the water bottle body. When the handle component is in the supporting position and the flip cap is rotated to the open state relative to the water bottle body, the upper end of the handle component supports and cooperates with the water bottle body, and the lower end of the handle component and the bottom of the water bottle body together form a supporting surface. The flip cap, handle component, and / or water bottle body are positioned and cooperated so that the opening of the holding slot faces upwards for holding liquid. It has the advantages of multifunctionality, ease of use, stable support, and reduced effective contact area between the utility model and the ground.

This invention relates to the technical field of biomass and high-calorific-value solid waste material treatment, and provides an electromagnetic heating carbonization gasification system, including a carbonization gasification device. The carbonization gasification device includes: a carbonization gasification tube, including a first end and a second end along the axial direction, the first end being provided with a feed inlet, and the second end being provided with a solid product outlet and a gaseous product outlet; a mandrel, coaxially disposed inside the carbonization gasification tube, with a conical head at the end facing the feed inlet; a sandwich cavity is formed between the mandrel and the inner wall of the carbonization gasification tube; an electromagnetic heating device, including an excitation power supply and an excitation coil disposed on the outer periphery of the carbonization gasification tube; and a sealed feeding device, the discharge end of which is connected to the feed inlet of the carbonization gasification tube. This configuration reduces the requirements for moisture and particle size of the carbonized material, thereby increasing the carbonization material processing capacity and carbonization gasification capacity. In addition, the electromagnetic heating method enables precise control of the carbon gas temperature, avoiding the problem of waste gas generated by the combustion of combustible or auxiliary fuels during the carbonization process.

This invention discloses the application of emodin in the preparation of products that inhibit T cell exhaustion. In vitro screening revealed that emodin significantly inhibits T cell exhaustion. Mechanistic studies showed that emodin does not affect Granzyme B secretion, slightly inhibits the secretion level of the cytokine IFN-γ, and significantly reduces the accumulation of protein aggregates within T cells by inhibiting the AKT phosphorylation signaling pathway, thus maintaining cellular protein homeostasis and inhibiting T cell exhaustion. Animal experiments also confirmed that T cells treated with emodin significantly inhibited melanoma growth after adoptive infusion. Therefore, this invention provides the application of emodin in the preparation of products that inhibit T cell exhaustion, further offering a new small-molecule metabolic intervention strategy for improving the efficacy of immunotherapy for solid tumors.

This invention provides a data storage system comprising: a data storage unit that acquires and stores multiple data generated during substrate processing by a substrate processing machine; a standard storage unit that serves as a candidate storage destination for the data; an additional storage unit that is configured to be added to and removed from the system, serving as a candidate storage destination for the data; a priority setting unit that sets a storage priority for each of the multiple data based on the implementation status of the substrate processing when the data is generated; and a storage destination control unit that controls the storage destination of the data based on one or more conditions, including the presence or absence of the additional storage unit, the number of additional storage units, and the storage capacity of the standard storage unit and the additional storage units, and based on the set priorities.

The invention discloses a solar energy coupling medium-deep layer-shallow layer geothermal energy storage and supply system, particularly relates to the technical field of clean energy utilization, and comprises a PVT solar panel, a deep layer geothermal well, a shallow layer geothermal well, a heat pump system, a heat storage water tank, a storage battery, a control unit, and pipelines, valves and a circulating water pump which are used for connecting all the components, the multifunctional adjusting valve is connected with the two-way variable-frequency circulating water pump, the stop valve body and the preheater. According to the solar energy coupling medium-deep layer-shallow layer geothermal energy storage and supply system, the PVT solar panel capable of synchronously completing photoelectric conversion and heat energy collection, the medium-deep layer geothermal well capable of obtaining high-temperature heat energy and the shallow layer geothermal well capable of utilizing shallow layer heat resources are coupled, and diversified utilization of clean energy and self-consistency of internal energy are achieved; carbon emission is reduced from the source; meanwhile, photovoltaic green electricity generated by the PVT solar panel is stored in the storage battery, energy supply interruption when solar power generation is insufficient is avoided, and a self-sufficiency and standby reliable energy supply mode is formed.