22results about How to "Avoid exhaustion" patented technology

The invention relates to an environment energy management optimization method and system for a tag chip, and the method comprises the steps: obtaining the temperature data and environment electromagnetic data of a chip environment, and carrying out the spatial distribution analysis, and obtaining the corresponding environment parameter characteristics; acquiring real-time power consumption data of the tag chip, and performing correlation analysis on the real-time power consumption data and the environmental parameter characteristics to obtain corresponding energy consumption information; acquiring chip circuit acquisition data of the tag chip, and performing resonance frequency analysis on the chip circuit acquisition data according to a preset resonance optimization algorithm; performing fault diagnosis on the chip circuit acquisition data to obtain corresponding system state information and a corresponding system operation prediction scheme; and performing strategy optimization on the initial energy scheduling scheme according to the system operation prediction scheme to obtain a corresponding global optimization strategy. According to the invention, the system can flexibly cope with energy demand changes of different application scenes.

The invention discloses a preparation method of a eutectic solvent for separating and recycling metals in waste crystalline silicon photovoltaic panels. According to the method, betaine hydrochloride is used as a hydrogen bond acceptor, ethylene glycol is used as a hydrogen bond donor to prepare a deep eutectic solvent with high solubility, and copper chloride is used as an oxidizing agent to leach metal silver and metal aluminum in the waste photovoltaic panel crystal silicon wafer. The leaching system is easy to operate, strong acid and strong alkali used in traditional wet recovery do not participate in the leaching system, and the problem of discharge of waste gas and waste water is solved. In the recovery process, the used ammonia water and water can be reused after rotary evaporation. Compared with a traditional crystalline silicon photovoltaic panel recycling route, the method has the advantages that the technological process is shortened, the cost is reduced, and an effective method is provided for recycling the waste crystalline silicon photovoltaic panel.

The invention discloses a method and system for providing a public IP address for a private node. The method comprises the following steps: an industrial Internet identifier analysis request end sends an industrial Internet identifier analysis request to an analysis node, and the analysis node analyzes a node public network address and sends the industrial Internet identifier analysis request to a comprehensive service gateway; the integrated service gateway forwards the industrial internet identification analysis request to a node private address of the SD-WAN network according to a forwarding strategy; verifying the public network address of the access node, and obtaining enterprise node data information; and the SD-WAN network returns the enterprise node data information to the industrial internet identifier analysis request end through the comprehensive service gateway. According to the method, the enterprise node can still participate in industrial internet identification analysis and perform security verification when no fixed public network IP address exists, and the enterprise node state information is attached when the enterprise node data information is acquired, so that the public IP address is efficiently utilized, and the enterprise node has high controllability and security.

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.

The invention discloses a casting technology for a nodular cast iron bearing retainer. The casting technology comprises the steps that S1, a precoated sand shell mold is designed through the nodular cast iron bearing retainer; s2, a shell mold is manufactured, an upper shell mold and a lower shell mold are manufactured through the shell mold, and then the upper shell mold and the lower shell mold are connected into a precoated sand shell mold; s3, iron shots are flatly laid at the bottom of a sand box and then compacted through vibration, the precoated sand shell mold is placed on the iron shots in the sand box, the space between the inner wall of the sand box and the precoated sand shell mold is filled with the iron shots layer by layer from bottom to top, the iron shots are compacted through vibration, molten iron is poured into a mold cavity of the precoated sand shell mold, and after cooling, the molten iron is solidified and formed into a bearing retainer casting; and S4, the precoated sand shell mold is separated from the iron shots, the precoated sand shell mold is knocked, broken and removed from the outer side of the bearing retainer casting, and the internally-formed bearing retainer casting is obtained. The process is simple in step, the quality of the bearing retainer casting can be effectively improved, the casting cost is low, the production efficiency is improved, and the probability of defective products is reduced.

The application discloses application of a small-molecule compound targeting TIM-3 in tumor immunotherapy and relates to the technical field of immunology and antitumor drugs. The small-molecule compounds DTS and CT are safe and verified marketed drugs, and it is found that the small-molecule compounds can bind to TIM-3 protein and regulate T cell exhaustion related to TIM-3. + Experiments prove that DTS and CT can effectively inhibit CD8 T cell exhaustion, promote expansion of exhausted precursor T cells, and comprehensively enhance T cell antitumor immune function. In a melanoma model, the compounds significantly inhibit tumor growth and reduce the proportion of tumor-infiltrating T cell exhaustion. The application uses the strategy of "new use of old drugs", provides a TIM-3 small-molecule inhibitor with high safety, oral administration, strong penetration and low cost, effectively solves the clinical transformation predicament of existing antibody drugs and newly synthesized small molecules, and provides a new scheme for rapid transformation of tumor immunotherapy.

Disclosed are novel weak affinity IL-2 variants and uses thereof, including adoptive cell therapies by enhancing the efficacy and duration of CAR-immune cells in the treatment of cancer.

The application relates to the field of fault detection, and provides a bearing fault detection algorithm and system. An original vibration signal is decomposed through a local mean decomposition algorithm, and an effective PF component is screened out by using a Pearson correlation coefficient, and then signal reconstruction is carried out, irrelevant noise signal interference is removed, feature extraction of a bearing degradation process is realized based on a product form of a harmonic noise ratio and a root mean square value, the sensitivity of the harmonic noise ratio to periodic impact is fully utilized, and the problem that the root mean square value has low sensitivity to initial bearing degradation is avoided; a state space model of different bearing degradation processes is constructed based on a Paris model and a Foreman model, compared with a single model prediction model, the prediction precision of RUL is more effectively improved; regularization of a particle filtering resampling process is realized based on an Euclidean distance, the diversity of particles is effectively improved, the particle depletion phenomenon of basic particle filtering is avoided, and the filtering estimation precision of a nonlinear state is improved.

The present invention discloses a true random number generation method and system based on the time difference between Beidou clock and communication clock, which relates to the technical field of time difference measurement, including: performing difference operation according to Beidou clock high-precision time and operating device clock time, obtaining clock timestamp deviation value, and establishing virtual simulation space-time information model mapping to generate random number initial seed; encrypting and converting the random number initial seed by connecting one-way hash function in series to obtain random hash value; determining the safety threshold of random hash value; establishing observable period verification model for random hash value, analyzing observable period change trend of random hash value, evaluating the exhaustive response risk capability of random hash value; judging whether the exhaustive response risk of random hash value meets the safety threshold of random hash value, if so, generating random number, if not, regenerating random hash value. The advantages of the present invention are: being able to prevent random number from being brute-forced and enhancing system security.

The utility model discloses a connecting mechanism, which relates to the technical field of distribution frames, and comprises a connecting unit comprising an L-shaped plate and a magnetic block fixedly connected to the side wall of the L-shaped plate; the clamping unit comprises a first fixing plate, an elastic assembly arranged in the middle of the first fixing plate, cylindrical groove rods symmetrically connected to the interior of the first fixing plate in a sliding mode, and abutting assemblies arranged at the tops of the cylindrical groove rods. And the dismounting unit comprises a baffle plate and cylindrical rods which are symmetrically and fixedly connected to the inner wall of the baffle plate. The utility model provides a device which can be quickly assembled and disassembled with the intelligent optical fiber distribution frame, double fixation is carried out through magnetic attraction between the connecting unit and the optical fiber frame and contact between the clamping unit and the optical fiber frame, and the fixing effect of the optical fiber distribution box and the optical fiber frame is improved. And the optical fiber distribution box is quickly mounted and dismounted by adjusting the dismounting unit, so that the mounting and dismounting time is shortened.

The utility model belongs to the field of municipal administration, and particularly relates to a sewage deodorization extraction device for municipal sewage discharge, which comprises an annular frame, an annular groove arranged in the annular frame, an annular rubber plate connected in the annular groove in an up-down sliding manner, a hydraulic pump in power connection with the annular rubber plate, a sewage extraction frame fixedly connected to the upper end face of the annular frame, and a groove arranged in the sewage extraction frame. The movable plate is rotationally connected with a threaded shaft with the other end located in the annular frame, and the movable plate is fixedly connected with a hard pipe with the other end located in the annular frame. When a motor drives a threaded shaft to rotate, a movable plate can be driven to move downwards, a hard pipe is moved downwards into a sewage well, then an infusion pump is started, sewage is pumped out from the hard pipe through a soft pipe and conveyed to a sewage vehicle from a liquid conveying pipe, and the device can be pushed to the upper side of the sewage well through universal wheels; and a hydraulic pump is started to drive an annular rubber plate to move downwards to be tightly attached to the ground, so that the device is prevented from being exhausted, and meanwhile, a certain limiting effect on the device is achieved.

Provided is a device capable of supplying a lubricant to a surface at which two members meet. A device (1) such as a stapler is provided with a first member (2) having a first surface (20) and a second member (3) having a second surface (30) that meets the first surface (20) in part or entirely, the first member (2) and the second member (3) being configured to act in opposition to each other, the first member (2) having a flow path (5) of the lubricant provided with an opening (50) in the first surface (20) on a surface (23a) other than the first surface (20).

This invention belongs to the field of communication technology and discloses a federated learning method based on partial client participation and power constraints. The method includes: employing biased client selection, setting client addressability and continuously reporting to a central server, allowing the central server to understand the state of each client during iteration; and allocating power across communication time slots by adding a total power constraint, enabling devices to transmit their local updates to the server. This invention addresses the problems of existing technologies by reducing communication costs while maintaining model convergence performance. The proposed design can mitigate the negative impacts caused by imperfect channel conditions. Convergence of the learning process is slowed by power control, while biased client selection accelerates convergence, balancing model aggregation. This invention can guarantee fast convergence under harsh wireless conditions with low signal-to-noise ratios, and is cost-effective in terms of time and energy savings in wireless FL systems.

The invention belongs to the technical field of nano drug loading, and particularly relates to an acid-responsive drug delivery nanoparticle adaptive to pancreatic cancer and a preparation method of the acid-responsive drug delivery nanoparticle. According to the polyphenol polymer disclosed by the invention, a biodegradable polyethylene glycol (PEG) polyphenol polymer is used as a skeleton, and then a hydrophobic drug improved gemcitabine and leflunomide are entrapped by using a metal ion chelation effect to form nanoparticles. The nanoparticles can respond to a special environment in tumor cells to release improved gemcitabine and leflunomide, can induce cell ferroptosis by regulating and controlling pancreatic tumor cell mitochondrial metabolism, can induce mitochondrial exocytosis to realize deep drug accumulation, and can realize deep drug accumulation through multi-cell immune-metabolic network regulation and control in tumor focus tissues. The immunosuppression microenvironment is relieved, and pancreatic tumors are inhibited.

This utility model discloses a water bottle with a rotatable cap, including a water bottle body and a flip cap rotatably connected to the water bottle body. The water bottle body has a water dispensing component, and the flip cap has a holding slot for holding the liquid poured out by the water dispensing component. The flip cap can flip and switch between an open and closed state relative to the water bottle body. A handle component is rotatably connected to the water bottle body, and the handle component can rotate and switch between a lifting position and a supporting position relative to the water bottle body. When the handle component is in the supporting position and the flip cap is rotated to the open state relative to the water bottle body, the upper end of the handle component supports and cooperates with the water bottle body, and the lower end of the handle component and the bottom of the water bottle body together form a supporting surface. The flip cap, handle component, and / or water bottle body are positioned and cooperated so that the opening of the holding slot faces upwards for holding liquid. It has the advantages of multifunctionality, ease of use, stable support, and reduced effective contact area between the utility model and the ground.

The invention relates to the technical field of biomedicine, in particular to a competitive inhibitor and application thereof, and the competitive inhibitor can be specifically combined with PGK1 and has a competitive inhibition effect on combination of PGK1 and PD-1. According to the present invention, the new mechanism of mediating PD-1 activation of the PGK1 without depending on the PD-1 extracellular ligand is found, and the competitive inhibitor can directly target the PGK1 and block the interaction between the PGK1 and the PD-1 so as to avoid the activation effect of the PGK1 on the PD-1 as much as possible. The competitive inhibitor provided by the invention has a prospect of being used as an effective solution for the problem of PD-1 monoclonal antibody drug resistance.

This invention relates to the technical field of biomass and high-calorific-value solid waste material treatment, and provides an electromagnetic heating carbonization gasification system, including a carbonization gasification device. The carbonization gasification device includes: a carbonization gasification tube, including a first end and a second end along the axial direction, the first end being provided with a feed inlet, and the second end being provided with a solid product outlet and a gaseous product outlet; a mandrel, coaxially disposed inside the carbonization gasification tube, with a conical head at the end facing the feed inlet; a sandwich cavity is formed between the mandrel and the inner wall of the carbonization gasification tube; an electromagnetic heating device, including an excitation power supply and an excitation coil disposed on the outer periphery of the carbonization gasification tube; and a sealed feeding device, the discharge end of which is connected to the feed inlet of the carbonization gasification tube. This configuration reduces the requirements for moisture and particle size of the carbonized material, thereby increasing the carbonization material processing capacity and carbonization gasification capacity. In addition, the electromagnetic heating method enables precise control of the carbon gas temperature, avoiding the problem of waste gas generated by the combustion of combustible or auxiliary fuels during the carbonization process.

This invention discloses the application of emodin in the preparation of products that inhibit T cell exhaustion. In vitro screening revealed that emodin significantly inhibits T cell exhaustion. Mechanistic studies showed that emodin does not affect Granzyme B secretion, slightly inhibits the secretion level of the cytokine IFN-γ, and significantly reduces the accumulation of protein aggregates within T cells by inhibiting the AKT phosphorylation signaling pathway, thus maintaining cellular protein homeostasis and inhibiting T cell exhaustion. Animal experiments also confirmed that T cells treated with emodin significantly inhibited melanoma growth after adoptive infusion. Therefore, this invention provides the application of emodin in the preparation of products that inhibit T cell exhaustion, further offering a new small-molecule metabolic intervention strategy for improving the efficacy of immunotherapy for solid tumors.

The invention discloses a culture medium for culturing long-life type iNKT cells and application of the culture medium, and belongs to the technical field of immune cell culture. The culture medium comprises additives of IL-2 (interleukin-2), IL-7 (interleukin-7), IL-15 (interleukin-15), alpha-GalCer (alpha-GalCer), vitamin C, glutamine and TWS119. When the culture medium is used for culturing the iNKT cells, mononuclear cells separated from peripheral blood or umbilical cord blood can be used as a source, and after initial culture and multiplication culture, the longevity type iNKT cells are collected and obtained; the anti-tumor potential of the long-life iNKT cell is further improved due to high purity and longer in-vivo survival life of the long-life iNKT cell, and the long-life iNKT cell is stronger in tumor cell killing ability, so that a foundation is laid for wide application of NKT / iNKT cell immunotherapy, and more tumor patients are benefited.

The present application discloses a heat pump and its valve opening control method, controller, and medium. The method corrects the preset target superheat of the main circuit by the real-time superheat of the auxiliary circuit, and determines whether the corrected target superheat is the same as the real-time superheat of the main circuit; if the corrected target superheat is different from the real-time superheat of the main circuit, the main valve opening is adjusted according to the corrected target superheat; if the corrected target superheat is the same as the real-time superheat of the main circuit, it is determined whether the real-time superheat of the auxiliary circuit has stabilized. The above method can continuously use the real-time superheat of the auxiliary circuit to correct the target superheat of the main circuit, obtain the corrected target superheat, adjust the main valve according to the corrected target superheat, and continuously dynamically adjust the corrected target superheat according to the real-time superheat of the auxiliary circuit, gradually weaken the compensation effect of the main valve, avoid over-adjustment of the main valve, put the heat pump in a better operating state, and avoid safety accidents caused by excessive exhaust temperature of the compressor.

This invention provides a data storage system comprising: a data storage unit that acquires and stores multiple data generated during substrate processing by a substrate processing machine; a standard storage unit that serves as a candidate storage destination for the data; an additional storage unit that is configured to be added to and removed from the system, serving as a candidate storage destination for the data; a priority setting unit that sets a storage priority for each of the multiple data based on the implementation status of the substrate processing when the data is generated; and a storage destination control unit that controls the storage destination of the data based on one or more conditions, including the presence or absence of the additional storage unit, the number of additional storage units, and the storage capacity of the standard storage unit and the additional storage units, and based on the set priorities.

The invention discloses a solar energy coupling medium-deep layer-shallow layer geothermal energy storage and supply system, particularly relates to the technical field of clean energy utilization, and comprises a PVT solar panel, a deep layer geothermal well, a shallow layer geothermal well, a heat pump system, a heat storage water tank, a storage battery, a control unit, and pipelines, valves and a circulating water pump which are used for connecting all the components, the multifunctional adjusting valve is connected with the two-way variable-frequency circulating water pump, the stop valve body and the preheater. According to the solar energy coupling medium-deep layer-shallow layer geothermal energy storage and supply system, the PVT solar panel capable of synchronously completing photoelectric conversion and heat energy collection, the medium-deep layer geothermal well capable of obtaining high-temperature heat energy and the shallow layer geothermal well capable of utilizing shallow layer heat resources are coupled, and diversified utilization of clean energy and self-consistency of internal energy are achieved; carbon emission is reduced from the source; meanwhile, photovoltaic green electricity generated by the PVT solar panel is stored in the storage battery, energy supply interruption when solar power generation is insufficient is avoided, and a self-sufficiency and standby reliable energy supply mode is formed.