The application discloses a Chinese-
western medicine pharmaceutical composition containing Liuwei Dihuang extract and application thereof in preparation of a
medicine for treating
liver cancer. The pharmaceutical composition comprises
leflunomide and Liuwei Dihuang extract, and the Liuwei Dihuang extract is Liuwei Dihuang
pill water extract or Liuwei Dihuang
pill alcohol extract. In the pharmaceutical composition, the
leflunomide and the Liuwei Dihuang extract can be mixed together to form a
single administration unit, or can be independent administration units and used respectively. The application compares the administration of
leflunomide alone, leflunomide combined with Liuwei Dihuang water extract, leflunomide combined with Liuwei Dihuang
alcohol extract, Liuwei Dihuang water extract alone and Liuwei Dihuang
alcohol extract alone. The results of animal experiments and
cell experiments show that the Liuwei Dihuang alcohol extract has a significant effect of promoting the treatment of
liver cancer by leflunomide. The application can be converted to clinic, and provides a possibility of reducing the dosage of leflunomide for clinical medication, which is helpful for the treatment of
liver cancer.