High bioavailability Leflunomide tablet and preparing method thereof
A leflunomide tablet and leflunomide technology are applied in the field of leflunomide tablet with high bioavailability and its preparation, which can solve problems such as large side effects, achieve small side effects, a simple preparation method, and repair the intestinal tract. organizational effect
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Embodiment 1
[0026] A high bioavailability leflunomide tablet proposed by the present invention comprises the following raw materials in parts by weight: 1 part of leflunomide, 5 parts of starch, 1 part of hydroxypropyl methylcellulose, and 2 parts of povidone K30 , 0.5 parts of magnesium stearate, 0.1 parts of polysorbate-80, 0.1 parts of threonine, 1 part of glutamine, 1 part of β-carotene, and 0.1 parts of glutathione.
[0027] Its preparation method comprises the following steps:
[0028] S1, weigh leflunomide, starch, hydroxypropylmethylcellulose, povidone K30, magnesium stearate, polysorbate-80, threonine, glutamine, β-carotene according to the proportion , Glutathione are all micronized, and the particle size is controlled at D90 1-20µm;
[0029] S2, mixing the raw materials after the micronization treatment in S1 evenly to make a soft material;
[0030] S3, granulating the soft material, drying at 60°C, controlling the water content at 1-2%, to obtain the tablet core;
[0031] S...
Embodiment 2
[0033] A high bioavailability leflunomide tablet proposed by the present invention comprises the following raw materials in parts by weight: 2 parts of leflunomide, 15 parts of starch, 3 parts of hydroxypropyl methylcellulose, and 4 parts of povidone K30 , 1 part of magnesium stearate, 0.3 part of polysorbate-80, 0.8 part of threonine, 1.5 parts of glutamine, 2 parts of β-carotene, and 0.5 part of glutathione.
[0034] Its preparation method comprises the following steps:
[0035] S1, weigh leflunomide, starch, hydroxypropylmethylcellulose, povidone K30, magnesium stearate, polysorbate-80, threonine, glutamine, β-carotene according to the proportion Both glutathione and glutathione are micronized to control particle size D90 1-40µm;
[0036] S2, mixing the raw materials after the micronization treatment in S1 evenly to make a soft material;
[0037] S3, granulating the soft material, drying at 65°C, controlling the water content at 1-3%, and obtaining the tablet core;
[00...
Embodiment 3
[0040] A high bioavailability leflunomide tablet proposed by the present invention comprises the following raw materials in parts by weight: 3 parts of leflunomide, 30 parts of starch, 5 parts of hydroxypropyl methylcellulose, and 6 parts of povidone K30 , 3 parts of magnesium stearate, 0.8 parts of polysorbate-80, 2 parts of threonine, 2 parts of glutamine, 3 parts of β-carotene, and 1 part of glutathione.
[0041] Its preparation method comprises the following steps:
[0042] S1, weigh leflunomide, starch, hydroxypropylmethylcellulose, povidone K30, magnesium stearate, polysorbate-80, threonine, glutamine, β-carotene according to the proportion Both glutathione and glutathione are micronized to control particle size D90 1-60µm;
[0043] S2, mixing the raw materials after the micronization treatment in S1 evenly to make a soft material;
[0044] S3, granulating the soft material, drying at 75°C, controlling the water content at 1-4%, and obtaining the tablet core;
[0045]...
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