Leflunomide tablet and preparation technology thereof

A leflunomide tablet and its preparation technology are applied in pill delivery, bone diseases, non-central analgesics, etc., and can solve problems such as unsatisfactory curative effect

Inactive Publication Date: 2014-08-20
王俊国
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Existing drugs for the treatment of rheumatoid arthritis and painful osteoarthritis

Method used

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  • Leflunomide tablet and preparation technology thereof
  • Leflunomide tablet and preparation technology thereof
  • Leflunomide tablet and preparation technology thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0017] The present invention is further explained below in conjunction with the examples, but the examples do not limit the present invention in any form.

[0018] (1) Making tablet cores: pass leflunomide, lactose, pregelatinized starch, hydroxypropylmethyl cellulose, and sodium starch glycolate through a 100-mesh sieve, and add them to the wet mixing granulator according to the method of equal increments. Evenly, mixed powder is obtained; dissolve polysorbate-80 and magnesium stearate in 30 to 50 times of ethanol, add to the above mixed powder, mix, and then add 12% pregelatinized starch for pulping to the mixed Powder, made into 18-40 mesh granules, dried at 60-70°C, sieved with 24-mesh sieve, collected when the moisture content was 1.0-3.0%, and prepared tablet cores for later use;

[0019] (2) Coating: the stomach-soluble film coating premix is ​​formulated with 80% ethanol into a 11% suspension, stirred and mixed for 60 minutes for later use; 2~3 rpm, adjust the distanc...

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PUM

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Abstract

The invention discloses a leflunomide tablet and a preparation technology and use thereof. The product is prepared from leflunomide, milk sugar, pregelatinized starch, hydroxypropyl methyl cellulose, carboxymethyl starch sodium, polysorbate-80, 12% slushing pregelatinized starch, magnesium stearate and a gastric soluble film coating premix. The production method comprises the steps of fabricating tablets and coatings, and the like. The leflunomide tablet disclosed by the invention is high in dissolution rate, good in stability, good in anti-inflammatory analgesic effect, and small in effect on erythrocyte sedimentation rate, and the total effective rate is 85%. The drug disclosed by the invention has the characteristics of being fewer in medication administration times, stable in plasma concentration, long in lasting time and the like.

Description

field of invention [0001] The invention relates to a pharmaceutical preparation for treating rheumatoid arthritis and a preparation method thereof, which belongs to medicine for orthopedic diseases, in particular to a leflunomide tablet and a preparation method thereof. Background of the invention [0002] Arthritis is a common and chronic disease, in which osteoarthritis and rheumatoid arthritis are the main forms. According to reports, about 18% of the people in our country suffer from some form of arthritis, and the number of cases exceeds 200 million. Arthritis is a serious threat to human health, affecting the life and work of patients, making some patients unable to take care of themselves and lose their ability to work. Some patients have restricted activities, joint swelling, stiffness and pain, and severe joint permanent deformation, which is an important cause of disability in the elderly, so timely treatment is required. [0003] Leflunomide (Leflunomide) is a k...

Claims

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Application Information

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IPC IPC(8): A61K31/42A61K9/20A61K47/38A61P19/02A61P29/00
Inventor 王俊国朱金强邓念万伟
Owner 王俊国
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