Leflunomide dripping pill and its prepn

Abstract

The present invention discloses one kind of medicine composition for treating rheumatoid arthritis, and aims at providing one kind of leflunomide dripping pill for treating rheumatoid arthritis with high bioavailability, fast medicine release, fast acting, high medicine content, easy taking, low cost and production process without pollution. The leflunomide dripping pill is prepared with leflunomide as medicine material and medicine carrier as matrix.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rheumatoid arthritis, in particular to an oral drop pill preparation prepared from eflunomide as a raw material. Background technique [0002] Leflunomide is a kind of pyrimidine synthesis inhibitor, which has been widely used in the treatment of rheumatoid arthritis recently. At the same time, it inhibits tyrosine phosphorylation, inhibits the initiation of transcription of interleukin (IL)-2 gene, thereby inhibiting the production of (IL)-2, blocking the proliferation of activated lymphocytes and cell cycle progression, and reducing antibody production . Leflunomide is also an effective inhibitor of NF-kB activation induced by various inflammatory stimuli, which can inhibit inflammation and immune activity, and is produced by inhibiting the activation of Th1 effector cells and regulating the differentiation of Th1 lymphocytes to Th2 lymphocytes Inhibition of T lymphocyte proliferati...

AI Technical Summary

Problems solved by technology

[0004] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.