Leflunomide dripping pill and its prepn

A technology of leflunomide dripping pills and leflunomide, which is applied in the direction of pill delivery, bone diseases, antipyretics, etc., can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, low dissolution rate, high production cost, etc., and achieve improvement Effects of bioavailability, accelerated dissolution and absorption, and reduced production cost

Inactive Publication Date: 2006-05-17
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation proce

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] Now with several groups of specific examples, the preparation method of leflunomide dripping pills of the present invention is further described.

[0030] [recipe selection]

[0031] 1. Drug raw material: Leflunomide

[0032] 2. Single matrix: selected from polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac and other carriers;

[0033] 3. Combination matrix: take g or kg as the unit, by weight, choose polyethylene glycol, polyoxyl 40 stearate, sodium carboxymethyl starch, beta cyclodextrin, Tween and other carriers for combination test;

[0034] 3.1 The combination of two different substrates: take g or kg as the unit, by weight, take 1 part of polyoxyl 40 stearate or beta cyclodextrin or sodium carboxymethyl starch or Tween, and 1 part ~10 parts of polyethy...

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PUM

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Abstract

The present invention discloses one kind of medicine composition for treating rheumatoid arthritis, and aims at providing one kind of leflunomide dripping pill for treating rheumatoid arthritis with high bioavailability, fast medicine release, fast acting, high medicine content, easy taking, low cost and production process without pollution. The leflunomide dripping pill is prepared with leflunomide as medicine material and medicine carrier as matrix.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rheumatoid arthritis, in particular to an oral drop pill preparation prepared from eflunomide as a raw material. Background technique [0002] Leflunomide is a kind of pyrimidine synthesis inhibitor, which has been widely used in the treatment of rheumatoid arthritis recently. At the same time, it inhibits tyrosine phosphorylation, inhibits the initiation of transcription of interleukin (IL)-2 gene, thereby inhibiting the production of (IL)-2, blocking the proliferation of activated lymphocytes and cell cycle progression, and reducing antibody production . Leflunomide is also an effective inhibitor of NF-kB activation induced by various inflammatory stimuli, which can inhibit inflammation and immune activity, and is produced by inhibiting the activation of Th1 effector cells and regulating the differentiation of Th1 lymphocytes to Th2 lymphocytes Inhibition of T lymphocyte proliferati...

Claims

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Application Information

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IPC IPC(8): A61K31/42A61K9/20A61P19/02A61P29/00
Inventor 曲韵智韩才峰成爱东
Owner 北京博智绿洲医药科技有限公司
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