Novel technique of preparing lactic acid ciprofloxacin injection

Abstract

A new type ciprofloxacin lactate injection preparation method is provided, which is characterized in that: dissolve water-soluble ciprofloxacin lactate raw material in water, add hydrophilic polymers such as polyethylene glycol, propanediol and polyvinylpyrrolidone, etc. to form colloidal solution; wrap the drug in the hydrophilic colloidal solution to prolong the absorption duration of liquid medicine after the injection; add 2L water for injection to ciprofloxacin lactate, mix them evenly, add 3.5L polyethylene glycol, mix till full dissolution, then add sodium bisulfite and EDTA-2Na to mix till full dissolution, add water for injection to 10L, check whether the pH value is within the required scope of 3.0 to 5.0, conduct fine filtering with a filter that has the aperture of 0.45um and is qualified in integrity testing, then fill and pack the finished products as per the required specification.

Description

Technical field: [0001] The invention relates to the technical field of veterinary drug preparation, in particular to a preparation process of ciprofloxacin lactate injection. Background technique: [0002] With the continuous changes in the structure of animal husbandry, the proportion of cattle, sheep, and pigs in the structure of animal husbandry is increasing, and the occurrence of various diseases of female livestock is accompanied by the occurrence of various livestock diseases, mainly due to the changes in the status of animals and climate conditions. and feeding management and other reasons. Ciprofloxacin lactate is used in animal husbandry. Because of its good water solubility, it can be quickly absorbed and eliminated in the body, so the curative effect is maintained for a short time. It needs to be injected 2-3 times a day, which is not only inconvenient to use, but also the drug concentration in the blood fluctuates greatly. When the blood concentration is high,...

AI Technical Summary

Problems solved by technology

It needs to be injected 2-3 times a day. Not only is it inconvenient to use, but also the drug concentration in the blood fluctuates greatly. When the blood concentration is high, side effects or even poisoning may occur;

Especially in the animal husbandry industry, large livestock such as pigs, cows, horses, and sheep require two or more laborers for each injection, and special tools are needed to catch and hold them, which consumes a lot of manpower and material resources.