A kind of ciprofloxacin lactate injection for veterinary use and preparation method thereof

A technology of ciprofloxacin lactate and injection, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. The problem of large reaction is to prolong the action time, improve the stability, and increase the viscosity of the solution.

Active Publication Date: 2018-08-28
浙江大飞龙动物保健品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional veterinary ciprofloxacin lactate injections on the market have problems such as frequent use, large stress response, and not suitable for large-scale breeding, especially in cold regions such as northern and western regions.

Method used

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  • A kind of ciprofloxacin lactate injection for veterinary use and preparation method thereof
  • A kind of ciprofloxacin lactate injection for veterinary use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A ciprofloxacin lactate injection for animals contains 25.5 g of ciprofloxacin lactate, 50 g of PVP-K30, 50 g of nicotinamide, 5 g of sodium chloride, 0.5 g of sodium bisulfite, and 2 g of lactic acid per 1000 ml of water for injection.

[0023] A preparation process for veterinary ciprofloxacin lactate injection, its preparation method:

[0024] (1) Take 500ml of water for injection, add 0.5g of sodium bisulfite, stir to dissolve;

[0025] (2) Add 5g of sodium chloride and stir to dissolve; add 50g of nicotinamide and stir to dissolve; add 25.5g of ciprofloxacin lactate and stir to dissolve; add 50g of PVP-K30 and stir to dissolve;

[0026] (3) Add 2‰ activated carbon, stir for 15 minutes, stir evenly, and coarsely filter;

[0027] (4) Add water for injection to 1000ml, add lactic acid to adjust the pH, stir evenly, take samples for inspection, fine filter, pour into ampoules, seal with N2, sterilize with circulating steam at 115°C, and keep warm for 30 minutes to get...

Embodiment 2

[0029] A ciprofloxacin lactate injection for animals contains 127.5 g of ciprofloxacin lactate, 150 g of PVP-K30, 100 g of nicotinamide, 15 g of sodium chloride, 5 g of sodium bisulfite, and 10 g of lactic acid per 1000 ml of water for injection.

[0030] A preparation process for veterinary ciprofloxacin lactate injection, its preparation method:

[0031] (1) Take 500ml of water for injection, add 5g of sodium bisulfite, stir to dissolve;

[0032] (2) Add 15g of sodium chloride and stir to dissolve; add 100g of nicotinamide and stir to dissolve; add 127.5g of ciprofloxacin lactate and stir to dissolve; add 150g of PVP-K30 and stir to dissolve;

[0033] (3) Add 2‰ activated carbon, stir for 15 minutes, stir evenly, and coarsely filter;

[0034] (4) Add water for injection to 1000ml, add lactic acid to adjust the pH, stir evenly, take samples for inspection, fine filter, pour into ampoules, seal with N2, sterilize with circulating steam at 115°C, and keep warm for 30 minutes t...

Embodiment 3

[0036] A ciprofloxacin lactate injection for animals contains 63.8 g of ciprofloxacin lactate, 100 g of PVP-K30, 80 g of nicotinamide, 9 g of sodium chloride, 2 g of sodium bisulfite, and 5 g of lactic acid per 1000 ml of water for injection.

[0037] A preparation process for veterinary ciprofloxacin lactate injection, its preparation method:

[0038] (1) Take 500ml of water for injection, add 2g of sodium bisulfite, stir to dissolve;

[0039] (2) Add 9g of sodium chloride and stir to dissolve; add 80g of nicotinamide and stir to dissolve; add 63.8g of ciprofloxacin lactate and stir to dissolve; add 100g of PVP-K30 and stir to dissolve;

[0040] (3) Add 2‰ activated carbon, stir for 15 minutes, stir evenly, and coarsely filter;

[0041] (4) Add water for injection to 1000ml, add lactic acid to adjust the pH, stir evenly, take samples for inspection, fine filter, pour into ampoules, seal with N2, sterilize with circulating steam at 115°C, and keep warm for 30 minutes to get r...

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Abstract

The invention belongs to the technical field of veterinary preparations and discloses a veterinary ciprofloxacin injection and preparation method thereof. The injection (per 1000ml) is composed of 25.5-127.5g of ciprofloxacin, 50-150g of PVP-K, 50-100g of nicotinamide, 5-15g of sodium chloride, 0.5-5g of sodium bisulfate, 2-10g of lactic acid and the rest of water for injection. The veterinary ciprofloxacin injection has the advantages that stability of the veterinary ciprofloxacin injection under the low-temperature condition (0-5 DEG C) can be improved, and action time of the ciprofloxacin can be prolonged.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, in particular to a veterinary ciprofloxacin lactate injection and a preparation method thereof. Background technique [0002] With the large-scale and intensive development of my country's breeding industry, livestock and poultry diseases are becoming more and more complicated, and new diseases are increasing. The development trend of bacterial diseases, viral diseases and mixed infectious diseases of livestock and poultry has caught the breeding colleagues by surprise. . In recent years, the state has vigorously promoted the development of the central and western regions, and made use of the geographical advantages of the central and western regions to vigorously support and encourage the development of the breeding industry. However, livestock and poultry diseases have always plagued the development of the breeding industry. [0003] The rapid development of modern breeding...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/32A61P31/04A61P11/00A61P13/00
Inventor 沈建军舒鑫标柳雪雁彭俊平宋占学施伟领胡永明
Owner 浙江大飞龙动物保健品股份有限公司
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