3results about How to "No crystallization" patented technology

This invention discloses a nano-silicon-based special transformer cooling oil and its preparation method. The cooling oil comprises the following components by mass percentage: 85%–90% modified silicone oil base oil, 2%–3% spherical nano-silicon particles, 1%–5% composite antioxidant, 0.5%–2% polyether-modified silicone oil dispersant and stabilizer, and the balance being functional additives. This invention constructs a three-dimensional thermally conductive network using surface-modified nano-silicon, synergistically combining composite antioxidants, low-temperature flow improvers, and anti-cavitation additives. This allows the cooling oil to maintain high insulation performance while achieving a thermal conductivity increase of ≥50%, good low-temperature fluidity at -80℃, partial discharge ≤5pC, cavitation inhibition rate ≥78%, overload capacity up to 200%, and service life extended to 40 years. This product is particularly suitable for extreme environments with altitudes ≥5000 meters and temperature differences ranging from -80℃ to +120℃, meeting the requirements of ultra-high voltage DC converter transformers and intelligent substations in cold regions for efficient heat dissipation and long-term stable operation.

This invention discloses a highly bioavailable ticagrelor solid dispersion, its formulation, preparation method, and application. The solid dispersion is prepared by hot melt extrusion of ticagrelor and a specific ternary carrier system, wherein the ternary carrier system is from Soluplus. ® The formulation consists of copovidone and hydroxypropyl methylcellulose. This solid dispersion is further combined with disintegrants, fillers, and lubricants to form a pharmaceutical composition. This invention utilizes the synergistic effect of a ternary carrier and hot-melt extrusion technology to ensure ticagrelor exists stably in an amorphous form, significantly improving drug dissolution and oral bioavailability. Experiments show that the formulation exhibits a dissolution rate ≥85% in pH 6.8 phosphate buffer after 30 min, and a relative bioavailability in beagle dogs reaching 150%–250% of commercially available tablets. It also demonstrates excellent stability, with no crystallization observed in a 6-month accelerated assay, indicating significant clinical value and market potential.

A urea ammonium nitrate solution and an integrated clean production method are a liquid nitrogen fertilizer production technology, and the method comprises the following steps: premixing a urea melt solution and a part of an ammonium nitrate solution, and introducing the premixed solution into a neutralization reaction system of ammonium nitrate to realize molecular integration of urea and ammonium nitrate in a synthesis stage; performing evaporation concentration, on-line proportion fine adjustment, compound stabilizer treatment, cooling and filtering and the like to obtain a high-stability finished product. According to the invention, solidification and redissolution processes of urea and ammonium nitrate in the traditional process are omitted, so that the energy consumption is obviously reduced; through process innovation and use of the compound stabilizer, the chemical stability (inhibiting ammonia volatilization and nitrite generation) and the physical stability (preventing crystallization) of the product are fundamentally improved, and the product performance is excellent. The whole technological process is short, airtight, clean and low in investment and production cost.