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Veterinary ciprofloxacin lactate injection and preparation method thereof

A technology of ciprofloxacin lactate and injection, which is applied in the fields of pharmaceutical formulation, drug delivery, oil/fat/wax non-active ingredients, etc., and can solve the problem of difficult injection of large livestock, unsuitable for large-scale breeding, and drug resistance of livestock and poultry To achieve the effects of saving treatment costs, prolonging drug diffusion speed, and prolonging action time

Inactive Publication Date: 2017-11-03
山东中牧兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional veterinary ciprofloxacin lactate injections on the market have problems such as frequent use, large stress response, easy drug resistance in livestock and poultry, difficulty in injection for large livestock, and unsuitability for large-scale breeding.

Method used

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  • Veterinary ciprofloxacin lactate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A ciprofloxacin lactate injection for animals, containing ciprofloxacin lactate 25.5g, PVP-K3050g, polyoxyethylene 40 hydrogenated castor oil 50g, sodium chloride 5g, sodium bisulfite 0.5g in every 1000ml water for injection g, lactic acid 2g.

[0017] A kind of preparation method of above-mentioned veterinary ciprofloxacin lactate injection, it comprises the following processing steps:

[0018] (1) Get 50% of the total amount of water for injection, add the prescribed amount of sodium bisulfite, and stir to dissolve;

[0019] (2) Add the prescribed amount of sodium chloride, stir to dissolve; add the prescribed amount of polyoxyethylene 40 hydrogenated castor oil, stir to dissolve; add the prescribed amount of ciprofloxacin lactate, stir to dissolve; add the prescribed amount of PVP-K30, stir to dissolve;

[0020] (3) Add step 3) activated carbon with a solution weight of 2‰, stir for 15 minutes, stir evenly, and coarsely filter;

[0021] (4) Add water for injection...

Embodiment 2

[0023] A ciprofloxacin lactate injection for veterinary use, each 1000ml of water for injection contains: ciprofloxacin lactate 127.5g, PVP-K30 150g, polyoxyethylene 40 hydrogenated castor oil 100g, sodium chloride 15g, sodium bisulfite 5g, 10g of lactic acid.

[0024] A kind of preparation method of above-mentioned veterinary ciprofloxacin lactate injection, it comprises the following processing steps:

[0025] (1) Get 50% of the total amount of water for injection, add the prescribed amount of sodium bisulfite, and stir to dissolve;

[0026] (2) Add the prescribed amount of sodium chloride, stir to dissolve; add the prescribed amount of polyoxyethylene 40 hydrogenated castor oil, stir to dissolve; add the prescribed amount of ciprofloxacin lactate, stir to dissolve; add the prescribed amount of PVP-K30, stir to dissolve;

[0027] (3) Add step 3) activated carbon with a solution weight of 2‰, stir for 15 minutes, stir evenly, and coarsely filter;

[0028] (4) Add water for...

Embodiment 3

[0030] A ciprofloxacin lactate injection for animals, containing ciprofloxacin lactate 63.8g, PVP-K30 100g, polyoxyethylene 40 hydrogenated castor oil 80g, sodium chloride 9g, sodium bisulfite per 1000ml of water for injection 2g, 5g of lactic acid.

[0031] A kind of preparation method of above-mentioned veterinary ciprofloxacin lactate injection, it comprises the following processing steps:

[0032] (1) Get 50% of the total amount of water for injection, add the prescribed amount of sodium bisulfite, and stir to dissolve;

[0033] (2) Add the prescribed amount of sodium chloride, stir to dissolve; add the prescribed amount of polyoxyethylene 40 hydrogenated castor oil, stir to dissolve; add the prescribed amount of ciprofloxacin lactate, stir to dissolve; add the prescribed amount of PVP-K30, stir to dissolve;

[0034] (3) Add step 3) activated carbon with a solution weight of 2‰, stir for 15 minutes, stir evenly, and coarsely filter;

[0035] (4) Add water for injection ...

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Abstract

The invention discloses a veterinary ciprofloxacin lactate injection and belongs to the technical field of veterinary medicines. The injection comprises 25.5-127.5g ciprofloxacin lactate, 50-150g PVP (polyvinylpyrrolidone)-K30, 50-100g polyoxyethylene-40-hydrogenated castor oil, 5-15g sodium chloride, 0.5-5g sodium hydrogen sulfite and 2-10g lactic acid per 1000mL water for injection. A diffusion rate of the injection medicine is reduced significantly, so that the action time of ciprofloxacin lactate is prolonged.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a veterinary ciprofloxacin lactate injection and a preparation method thereof. Background technique [0002] With the large-scale and intensive development of my country's breeding industry, livestock and poultry diseases are becoming more and more complicated, and new diseases are increasing. The development trend of bacterial diseases, viral diseases and mixed infectious diseases of livestock and poultry has caught the breeding colleagues by surprise. . In recent years, the state has vigorously promoted the development of the central and western regions, and made use of the geographical advantages of the central and western regions to vigorously support and encourage the development of the breeding industry. However, livestock and poultry diseases have always plagued the development of the breeding industry. Bacterial diseases account for about 40% of the total number...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61K47/44A61P31/04
Inventor 王统高
Owner 山东中牧兽药有限公司
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