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Preparation method of antibacterial spray containing electrostatic spinning fibers

An electrospinning and spraying technology, which is applied in the field of preparation of antibacterial sprays, can solve the problem of single ingredients, and achieve the effects of uniform distribution, good biocompatibility, and excellent drug loading effect

Inactive Publication Date: 2021-10-29
THE FIFTH AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The main purpose of the present invention is to propose a method for preparing an antibacterial spray containing electrospun fibers, aiming at improving the durability of the antibacterial spray, avoiding harm to the human body, and solving the problem of single-component spray or antibacterial nanoparticles on the market. Defects

Method used

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  • Preparation method of antibacterial spray containing electrostatic spinning fibers
  • Preparation method of antibacterial spray containing electrostatic spinning fibers
  • Preparation method of antibacterial spray containing electrostatic spinning fibers

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preparation example Construction

[0029] A kind of preparation method that contains the antibacterial spray of electrospun fiber that present embodiment proposes, comprises the steps:

[0030] S1: Configure spinning solution

[0031] Dissolving the spinning solute in an organic solvent and adding antibacterial drugs, wherein the mass-to-volume ratio of the spinning solute to the organic solvent is 10-12%, and the mass-to-volume ratio of the antibacterial drug to the organic solvent is 0.3 ~0.7%, the spinning solute comprises one or a combination of two in PLGA or PLA, the antibacterial drug comprises one or a combination of two in norfloxacin or ciprofloxacin lactate, the The organic solvent comprises one or a combination of at least two of chloroform, acetone, and N,N dimethylformamide;

[0032] S2: Electrospinning the spinning solution

[0033] Put the spinning solution prepared in step S1 into an electrospinning machine for electrospinning, wherein the electrospinning conditions of the electrospinning mac...

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Abstract

The invention discloses a preparation method of an antibacterial spray containing electrostatic spinning fibers. The preparation method comprises the following steps of preparing an electrostatic spinning solution containing ciprofloxacin lactate or norfloxacin; preparing an electrostatic spinning fiber containing the ciprofloxacin lactate or the norfloxacin; preparing electrostatic spinning short fibers containing the ciprofloxacin lactate or the norfloxacin; mixing the electrostatic spinning short fibers containing the ciprofloxacin lactate or the norfloxacin with 75% alcohol to obtain the spray with a long-acting antibacterial effect. According to the technical scheme, the durability of the antibacterial spray is improved, harm to a human body is avoided, and the defects of sprays or antibacterial nanoparticles with single components in a market are overcome.

Description

technical field [0001] The invention relates to the technical field of antibacterial sprays, in particular to a preparation method of an antibacterial spray containing electrospun fibers. Background technique [0002] Electrospun nanofibers have good application value in the fields of tissue regeneration and medicine due to their large pore structure and excellent drug loading. The antibacterial sprays currently used in the market are usually composed of specific antibacterial drugs dissolved in a specific solvent in a certain proportion due to their relatively clear composition. The antibacterial effect is not durable and has certain limitations; modified nano Although particles also have excellent antibacterial effects, nanoparticles tend to easily enter human skin cells and cause cytotoxicity. [0003] Therefore, there are defects in the prior art and need to be improved. Contents of the invention [0004] The main purpose of the present invention is to propose a meth...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/496A61K47/34A61L15/26A61L15/44A61P31/04D01F1/10D01F6/92
CPCA61K9/12A61K31/496A61K9/0014A61K47/34D01F1/103D01F6/92A61P31/04A61L15/26A61L15/44A61L2400/12A61L2300/216A61L2300/404C08L67/04
Inventor 秦大江杨军政王彬
Owner THE FIFTH AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV
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