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Veterinary-use lactic acid ciprofloxacin suppository and preparation method thereof

A technology of ciprofloxacin lactate and suppository, which is applied in the directions of suppository delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of not being able to play a role in time, not being able to locally administer drugs, etc.

Inactive Publication Date: 2015-01-28
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, ciprofloxacin lactate soluble powder and ciprofloxacin lactate injection have been included in the Veterinary Pharmacopoeia, which cannot be used locally so that the drug cannot play its role in time

Method used

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  • Veterinary-use lactic acid ciprofloxacin suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A ciprofloxacin lactate suppository for veterinary use includes the following components:

[0013] Ciprofloxacin lactate: 100g

[0014] Polyethylene glycol 4000: 900g

[0015] Polyethylene glycol 400: 400g

[0016] Polyoxyethylene monostearate S-40: 200g

[0017] Tween 80: 400g

[0018] The preparation method is as follows: polyethylene glycol 4000 and polyethylene glycol 400 are heated and melted in a water bath at 80° C. and polyoxyethylene monostearate is added, followed by Tween 80 and cyclopropane lactate that has passed through a No. 6 sieve. Sand star, stir well to make it uniform, keep the temperature at 55°C, pour it into a plug mold coated with lubricant, and take it out after cooling. Each capsule contains 100mg of ciprofloxacin lactate, a total of 1000 capsules are prepared, each capsule weighs 2g.

Embodiment 2

[0020] A ciprofloxacin lactate suppository for veterinary use includes the following components:

[0021] Ciprofloxacin lactate: 20g

[0022] Cocoa Butter: 1500g

[0023] Semi-synthetic coco ester: 470g

[0024] Tween 61: 5g

[0025] Sodium Benzoate: 5g

[0026] The preparation method is as follows: heating and melting cocoa butter and semi-synthetic coconut oil in a 60°C water bath, adding Tween 61 and ciprofloxacin lactate and sodium benzoate that have passed through a No. 6 sieve, fully stirring to make it uniform, and keeping the temperature for 50 ℃, and poured into a plug mold coated with lubricant, and taken out after cooling. Each capsule contains 20mg of ciprofloxacin lactate, a total of 1000 capsules are prepared, each capsule weighs 2g.

Embodiment 3

[0028] A ciprofloxacin lactate suppository for veterinary use includes the following components:

[0029] Ciprofloxacin lactate: 300g

[0030] Glycerin Gelatin: 1400g

[0031] Trisodium citrate: 300g

[0032] The preparation method is as follows: heat and melt glycerin gelatin in a water bath at 70°C, add ciprofloxacin lactate and trisodium citrate that have passed through a No. 6 sieve, stir well to make it uniform, keep the temperature at 60°C, and pour into a lubricant In the bolt mold, take it out after cooling. Each capsule contains 300mg of ciprofloxacin lactate, a total of 1000 capsules are prepared, each capsule weighs 2g.

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PUM

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Abstract

The invention discloses a veterinary-use lactic acid ciprofloxacin suppository and the preparation thereof. The suppository comprises, by weight, 1%-15% of lactic acid ciprofloxacin, 70%-98.5% of matrixes, and 0.5%-20% of sorbefacient. The veterinary-use lactic acid ciprofloxacin suppository improves the bioavailability of the lactic acid ciprofloxacin, enhances antibacterial effect of the lactic acid ciprofloxacin, and can be used to cure domestic-animal diseases such as endometritis and intestinal infection.

Description

Technical field: [0001] The invention relates to a ciprofloxacin lactate suppository for veterinary use and a preparation method thereof, belonging to the technical field of veterinary medicine. Background technique [0002] Ciprofloxacin lactate is an antibacterial drug used for genitourinary infections caused by susceptible bacteria, including simple and complicated urinary tract infections, bacterial prostatitis, Neisseria gonorrhoeae urethritis or cervicitis (including those from enzyme-producing strains). to the sender). It can also treat respiratory infections, including acute exacerbations of bronchial infections and pulmonary infections caused by sensitive gram-negative bacilli. Treatment of gastrointestinal infections caused by Shigella, Salmonella, enterotoxigenic Escherichia coli, Aeromonas hydrophila, Vibrio parahaemolyticus, etc. It can also treat systemic infections such as typhoid fever, bone and joint infections, skin and soft tissue infections, and sepsis....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61K31/496A61P31/04A61P15/00A61P1/00
Inventor 吴红云朱丽平吕进召
Owner ZHENGZHOU HOUYI PHARMA
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