25 results about "Joint infections" patented technology

The invention discloses a method for predicting periprosthetic infection of an artificial joint after a rheumatoid arthritis operation, and belongs to the technical field of medical treatment, the method can be applied to risk prediction of periprosthetic infection (PJI) of the artificial joint after the rheumatoid arthritis operation, and the method comprises the following steps: carrying out feature selection through a Boruta algorithm; an integrated machine learning algorithm is developed based on a genetic algorithm and an SMOTEENN algorithm in combination with machine learning for risk prediction, so that the accuracy and practicability of PJI risk prediction after joint replacement of a rheumatoid arthritis patient are improved. According to the rheumatoid arthritis artificial joint postoperative periprosthetic infection risk prediction method, a more accurate prediction and personalized treatment scheme can be provided for a doctor, and preoperative management of joint replacement of a rheumatoid arthritis patient is optimized, so that PJI is prevented to the greatest extent, and the joint function and life quality of the patient are improved.

A method, system, and apparatus for drug delivery and treatment may be provided. The drug delivery method may be used to treat health conditions such as periprosthetic joint infections (PJI) and other orthopedic joint infections. The drug delivery method and apparatus may include a fluid delivery mechanism, which may include a fluid reservoir which may be filled with a high-concentration antibiotic formulation. The high-concentration antibiotic formulation may include an antibiotic concentration ranging from about 10 mg / mL to about 200 mg / mL may be dissolved in an aqueous solution, and then may be stored in refrigerated or frozen conditions. The fluid from the reservoir may be delivered, using a medical device or instrument, in discrete doses for bolus administration.

The invention belongs to the technical field of biological medicine, and particularly relates to a bionic nanometer delivery system based on MRSA outer vesicle coating and application of the bionic nanometer delivery system. Chitosan oligosaccharide and monocarboxylated curcumin are coupled through an amide reaction to synthesize an amphiphilic polymer carrier, then drugs such as vancomycin and daptomycin are entrapped through self-assembly to obtain drug micelles, and finally the drug micelles are coated with MRSA outer vesicles to successfully prepare the targeted bionic nano delivery system. The bionic nano delivery system prepared by the invention has an excellent antibacterial effect, can realize targeted delivery and long-acting release of an antibacterial drug at an infected part, is expected to overcome the bottlenecks of drug resistance and insufficient drug permeation in traditional treatment, and provides a potential solution for treatment of diseases such as periprosthetic infection and the like.

The invention provides an early warning method for joint infection after cruciate ligament reconstruction and related equipment, and is applied to the technical field of data processing. The method comprises the steps of obtaining a training data set and target electronic medical record information; preprocessing the training data set to generate a training data set with identification information; processing the training data set with the identification information based on a preset processing rule to generate a training set and a verification set; obtaining an initial postoperative infection early warning model matched with the identification information; training the initial postoperative infection early warning model based on the training set and the verification set to generate a target postoperative infection early warning model; the target electronic medical record information is preprocessed, attribute information of a target user is generated, and the attribute information of the target user comprises knee joint material parameter information of the target user; the attribute information of the target user is processed based on the target postoperative infection early warning model, and the knee joint infection probability of the target user is generated.

The invention discloses a medical puncture catheter for children bone and joint infection treatment, which is characterized in that a circulating mixing tube provided with a puncture catheter main body comprises a first bag body and a second bag body, a flushing tube is connected with the head end of the first bag body, a drainage tube is connected with the head end of the second bag body, a first flushing valve is arranged on the flushing tube, and a first drainage valve is arranged on the drainage tube; the puncture needle is connected with a three-way pipe through a hose, a second separating valve is arranged on the hose, the other two ends of the three-way pipe are connected with the tail ends of a first bag body and a second bag body through hoses respectively, the tail ends of the first bag body and the second bag body are provided with a second flushing valve and a second drainage valve respectively, and the head ends of the first bag body and the second bag body are connected through a connecting pipe. A first separating valve is arranged at the connecting pipe; the pump assembly comprises a peristaltic pump for driving liquid in the first bag body and the second bag body to flow; the flushing pipe is connected with a liquid medicine bag, and the drainage pipe is connected with a drainage bag. The fixing assembly is used for fixing the position of the puncture needle; the early warning device is used for real-time monitoring and early warning.

Provided herein are rapid and effective local infection therapy methods, systems, and devices that significantly reduce the mortality, morbidity, and the cost of care in rare musculoskeletal infections. Continuous delivery of antibiotic therapy locally, at the infection site, reduces edema and provides antibiotic irrigation, significantly improving outcomes while reducing the need for systemic antibiotics.

The present application provides a method of preventing or treating joint periprosthetic infection (PJI), or alleviating a PJI-related condition, the method comprising administering to an articular cavity of a patient in need thereof a therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, metabolite, or deuterated substance thereof.

The present disclosure relates to methods of identifying and detecting metabolites in joint fluid to treat and / or prevent a joint infection. The present disclosure also relates to method of preventing a bacterial biofilm accumulation and treating a joint infection using NMR-based metabolomics.

The invention relates to the field of preoperative disinfection, in particular to a preoperative disinfection device for treating joint infection through photodynamic therapy, which comprises a mounting rack, a first placement seat fixedly connected to the top end of the mounting rack, a second placement seat arranged on the right side of the first placement seat, a guide mechanism, an adjusting mechanism, a guide rail mechanism and an elastic clamping mechanism. Through the action of a tension spring, a positioning rod is conveniently embedded into positioning holes with different angles, a second placement seat is pulled towards the left side of a first placement seat, so that a rotating block slides to the rightmost side in a guide groove through a connecting rod, and at the moment, the rotating block is located between adjacent extension plates, so that the limitation on a moving plate is relieved; at the moment, the angle of the second placing seat rotates downwards to drive the supporting rod to slide in the sliding groove, and due to blocking of the sliding block, the angle of the second placing seat can be conveniently adjusted according to the bending angle of the limbs of the patient, and the limbs of part of the patient can be conveniently disinfected in the bending state.

A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

The utility model belongs to the technical field of medical instruments, and particularly discloses a joint postoperative infection detection device. The joint postoperative infection detection device comprises a shell, a circuit board, a temperature sensor and a push needle, wherein the shell is provided with a mounting cavity; the circuit board is arranged in the mounting cavity; the temperature sensor is electrically connected with the circuit board, a detection head of the temperature sensor is located outside the shell, and the temperature sensor is used for acquiring temperature information of the contact body / implant; the pushing needle is arranged in the shell and has a protection state arranged outside the detection head and an avoiding state separated from the detection head. According to the joint infection detection device, a patient can conveniently detect the joint infection condition by himself / herself, and infection can be controlled in time.

An ultrasound-responsive nanoscale delivery platform is disclosed for use in treating biofilm-associated diseases. It has been found that the use of a phase-shift nanodroplet / antimicrobial complex platform confers a number of advantages when used in methods for anti-biofllm therapy. Specifically, the inclusion of antimicrobials within the supramolecular structure of the ultrasound-responsive nanoscale delivery platform allows for increased passive cellular and subcellular uptake, stimuli-responsive spatiotemporally controlled drug release, and significantly higher bacterial toxicity in both planktonic cultures and mature biofilms. This platform remains stable in storage at room temperature, in blood components, and does not significantly prematurely release its loaded cargo. The platform may be used as a novel treatment option in biofilm-associated diseases such as, but not limited to, bone and joint infections, cystic fibrosis-associated pleural infections, chronic wounds, and chronic urinary tract infections.

A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

The method describes an invention whose novelty also rests on activating the high existing capacity of individual citizens who are willing or legally obligated to perform a high level of effort in preventing their own infection over a short period of time. This is because asking citizens for help, supported by long-term measures, is not particularly effective because citizens primarily have a self-interest, not necessarily a public interest, and because testing measures in private settings is largely impossible. The inventive achievement is characterized, among other things, by the fact that, taking into account one- and two-stage testing procedures, an automatic mechanism is created to synchronize joint infection prevention during a pandemic. This allows for the longest possible phases in which infection prevention can be carried out with less stress, thus allowing normality to return to everyday life, and subsequently providing the motivation for a short phase of performance. Thus, the method is socially applicable for various infectious diseases, for pandemics, but also for other situations in which infection must be prevented, such as the consequences of the use of biological weapons.

The invention relates to the technical field, in particular to a minimally invasive visual biopsy device for accurately sampling infection around a joint prosthesis, and aims to solve the problem that an existing device is poor in treatment effect on sampling tissue blockage. The device comprises a sampling mechanism, a negative pressure extraction mechanism and a pressure control mechanism, the sampling mechanism comprises a handle, an insertion pipe connected to the handle, and a drill rod rotationally connected into the insertion pipe; the negative pressure extraction mechanism comprises an extraction pipe, one end of the extraction pipe communicates with the insertion pipe, and the other end of the extraction pipe communicates with a collection tank. A medical silica gel layer is attached to the inner wall of the cannula, annular memory metal is installed in the medical silica gel layer, when the cannula is blocked, the negative pressure strength in the collecting tank is increased, and the annular memory metal is heated to deform so as to increase the inner diameter of the cannula; the device can increase the inner diameter of the sampling pipe during sampling blockage and increase sampling negative pressure at the same time, so that sampling blockage is relieved.

A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

In vitro methods of diagnosing a periprosthetic joint infection and monitoring the treatment thereof, comprising the sequential steps of providing a synovial fluid sample from a joint, determining the expression level(s) of microRNA(s), and classifying the expression level(s) into one of the categories "septic" and "aseptic", by comparing the expression levels to the levels observed in a reference group.

The application relates to the technical field, in particular to a minimally invasive visual biopsy device for precise sampling of joint prosthesis periprosthetic infection, which is used for solving the problem of poor treatment effect of existing devices in response to sampling tissue blockage; the device comprises a sampling mechanism, a negative pressure extraction mechanism and a pressure control mechanism; the sampling mechanism comprises a handle, a cannula connected to the handle and a drill rod rotationally connected in the cannula; the negative pressure extraction mechanism comprises an extraction pipe, one end of the extraction pipe is communicated with the cannula and the other end is communicated with a collection tank; a medical silica gel layer is attached to the inner wall of the cannula, an annular memory metal is installed in the medical silica gel layer, when the cannula is blocked, the negative pressure intensity in the collection tank is increased, and the annular memory metal is heated and deformed to increase the inner diameter of the cannula; the device can increase the inner diameter of the sampling pipe and the sampling negative pressure when the sampling is blocked, so as to relieve the sampling blockage.

The invention relates to a joint infection bimodal flexible monitoring sensor based on hydrogel and a preparation method thereof. The sensor comprises a flexible film substrate layer, a packaging layer, a PEDOT: PSS-PVA hydrogel pressure module and an NTC thermistor temperature module, and the PEDOT: PSS-PVA hydrogel pressure module and the NTC thermistor temperature module share a negative electrode. The preparation method comprises the following steps: preparing hydrogel ink, carrying out cross-linking bath, forming a hydrogel structure through low-temperature cross-linking 3D printing, preparing a PDMS film, carrying out plasma surface treatment on the hydrogel and the PDMS film, printing a circuit and a temperature sensing element, and finally assembling the sensor. Compared with the prior art, the sensor has the advantages of high sensitivity, wide measurement range and high stability, can accurately and synchronously acquire temperature and pressure signals of a joint part, realizes real-time monitoring and early warning of bone and soft tissue infection, breaks through the limitation of traditional diagnosis, and improves the early diagnosis efficiency and treatment compliance.

This invention discloses a method for predicting periprosthetic joint infection (PJI) after rheumatoid arthritis surgery, belonging to the field of medical technology. This method can be applied to predict the risk of PJI after rheumatoid arthritis surgery. The method includes: feature selection using the Boruta algorithm; and the development of an ensemble machine learning algorithm based on a combination of genetic algorithms and the SMOTEENN algorithm for risk prediction, thereby improving the accuracy and practicality of PJI risk prediction in rheumatoid arthritis patients after joint replacement surgery. This method can provide doctors with more accurate predictions and personalized treatment plans, optimize preoperative management of joint replacement surgery in rheumatoid arthritis patients, and thus maximize the prevention of PJI, improving patients' joint function and quality of life.

The present invention provides a staphylococcal phage for preventing and treating poultry staphylococcal disease, including staphylococcal phage GSA-P12. The applicant screened out a Staphylococcus aureus phage from a water sample near a chicken farm in Hubei Province. The phage was sent to the China Center for Type Culture Collection for preservation on May 26, 2022. The preservation address is: Wuhan University, Wuhan, China, with a preservation number of CCTCCNO: M2022725 and a classification name of Staphylococcus aureus phage GSA-P12. The staphylococcal phage GSA-P12 is used for the prevention and control of poultry staphylococcal disease and can be used for large-scale industrial fermentation production. It has a good therapeutic effect on poultry arthritis-type staphylococcal disease, can effectively reduce joint infections caused by poultry staphylococci, and improve the survival rate, thereby providing a safe, non-toxic and non-side-effect biological prevention and control measure that can be fermented and produced on a large scale for the treatment of staphylococcal disease.

The invention belongs to the technical field of medical instruments in the orthopedics department, and discloses a knee joint revision accessory system and a using method thereof.The knee joint revision accessory system comprises a femoral prosthesis extension rod assembly, a punching guider, a tibia supporting cushion block, a tibia guiding column, a centering drill, a depth limiting sleeve, a supporting platform and a flat head abrasive drill; the thighbone prosthesis extension rod assembly comprises a thighbone prosthesis and a first thighbone extension assembly, through cooperation of a trepanning guider, a centering drill, a depth limiting sleeve and a flat head grinding drill, and through depth limiting design and a guiding function of modular accessories, dependence on experience in an operation is reduced, accuracy of the implant position and depth of the prosthesis is ensured, deviation risks are reduced, and operation efficiency is improved. The tibial plateau supporting condition is improved through leveling treatment of the supporting cushion block and the flat head abrasive drill, in the 1.5-stage operation, periprosthetic joint infection, conversion operation and dislocation are low, prosthesis instability caused by bone defects is avoided, meanwhile, accurate bone treatment and stable prosthesis implantation are achieved, and the possibility of postoperative pain or infection or secondary revision is reduced.

A method and kit for treating a periprosthetic joint infection in skeletally mature patients undergoing an exchange arthroplasty procedure is described. The method may include locally administering a combination of tobramycin sulfate at a dose of 80 mg / day and vancomycin hydrochloride at a dose of 2.6-3 g / day to the patient, where the local administration occurs daily via irrigation for 7 to 10 days.

The present application provides a method for preventing or treating a prosthetic joint infection (PJI), or for alleviating PJI-related symptoms. The method comprises: administering a therapeutic agent to a joint cavity of a patient in need thereof, the therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, a hydrate, a solvate, a prodrug, a metabolite, or a deuterated substance thereof.