11 results about "Joint infections" patented technology

A method, system, and apparatus for drug delivery and treatment may be provided. The drug delivery method may be used to treat health conditions such as periprosthetic joint infections (PJI) and other orthopedic joint infections. The drug delivery method and apparatus may include a fluid delivery mechanism, which may include a fluid reservoir which may be filled with a high-concentration antibiotic formulation. The high-concentration antibiotic formulation may include an antibiotic concentration ranging from about 10 mg / mL to about 200 mg / mL may be dissolved in an aqueous solution, and then may be stored in refrigerated or frozen conditions. The fluid from the reservoir may be delivered, using a medical device or instrument, in discrete doses for bolus administration.

The present application provides a method of preventing or treating joint periprosthetic infection (PJI), or alleviating a PJI-related condition, the method comprising administering to an articular cavity of a patient in need thereof a therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, metabolite, or deuterated substance thereof.

A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

In vitro methods of diagnosing a periprosthetic joint infection and monitoring the treatment thereof, comprising the sequential steps of providing a synovial fluid sample from a joint, determining the expression level(s) of microRNA(s), and classifying the expression level(s) into one of the categories "septic" and "aseptic", by comparing the expression levels to the levels observed in a reference group.

This invention discloses a method for predicting periprosthetic joint infection (PJI) after rheumatoid arthritis surgery, belonging to the field of medical technology. This method can be applied to predict the risk of PJI after rheumatoid arthritis surgery. The method includes: feature selection using the Boruta algorithm; and the development of an ensemble machine learning algorithm based on a combination of genetic algorithms and the SMOTEENN algorithm for risk prediction, thereby improving the accuracy and practicality of PJI risk prediction in rheumatoid arthritis patients after joint replacement surgery. This method can provide doctors with more accurate predictions and personalized treatment plans, optimize preoperative management of joint replacement surgery in rheumatoid arthritis patients, and thus maximize the prevention of PJI, improving patients' joint function and quality of life.

The invention belongs to the technical field of medical instruments in the orthopedics department, and discloses a knee joint revision accessory system and a using method thereof.The knee joint revision accessory system comprises a femoral prosthesis extension rod assembly, a punching guider, a tibia supporting cushion block, a tibia guiding column, a centering drill, a depth limiting sleeve, a supporting platform and a flat head abrasive drill; the thighbone prosthesis extension rod assembly comprises a thighbone prosthesis and a first thighbone extension assembly, through cooperation of a trepanning guider, a centering drill, a depth limiting sleeve and a flat head grinding drill, and through depth limiting design and a guiding function of modular accessories, dependence on experience in an operation is reduced, accuracy of the implant position and depth of the prosthesis is ensured, deviation risks are reduced, and operation efficiency is improved. The tibial plateau supporting condition is improved through leveling treatment of the supporting cushion block and the flat head abrasive drill, in the 1.5-stage operation, periprosthetic joint infection, conversion operation and dislocation are low, prosthesis instability caused by bone defects is avoided, meanwhile, accurate bone treatment and stable prosthesis implantation are achieved, and the possibility of postoperative pain or infection or secondary revision is reduced.

A method and kit for treating a periprosthetic joint infection in skeletally mature patients undergoing an exchange arthroplasty procedure is described. The method may include locally administering a combination of tobramycin sulfate at a dose of 80 mg / day and vancomycin hydrochloride at a dose of 2.6-3 g / day to the patient, where the local administration occurs daily via irrigation for 7 to 10 days.

The present application provides a method for preventing or treating a prosthetic joint infection (PJI), or for alleviating PJI-related symptoms. The method comprises: administering a therapeutic agent to a joint cavity of a patient in need thereof, the therapeutic agent comprising a compound represented by formula (I) and / or a pharmaceutically acceptable salt, a hydrate, a solvate, a prodrug, a metabolite, or a deuterated substance thereof.