55 results about "Joint infections" patented technology

The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and / or the treatment of bone and joint infections, especially for the prophylaxis and / or treatment of osteomyelitis.

The present invention is directed to a method for treating bone or bone marrow infections, joint infection or infection of the tissues surrounding the joint by administration of the antibiotic tigecycline alone or in combination with a rifamycin antibiotic. In a preferred embodiment the bone or bone marrow infection causes osteomyelitis. In another embodiment the joint infection or infection of the tissues surrounding the joint causes septic arthritis. The invention is also directed to manufacture of a medicament for treatment of bone and / or bone marrow infections, or joint infections and / or infections in tissues surrounding the joint with tigecycline alone or in combination with rifampin.

The invention of novel, effective vaccines against Mycoplasma bovis for use in cattle is described. These vaccines demonstrate no undesirable side effects and protect against M. bovis related disease, such as contagious mastitis, respiratory pneumonia, joint infections, keratoconjunctivitis and middle ear infections. The novel vaccines also lessen the effect M. bovis infections on milk production, weight gain and animal health. Methods of diagnosing characterizing and treating M. bovis infections as specific biotypes are also disclosed. Vaccine compositions made in accordance with the invention may be either of the attenuated or inactivated variety. Vaccines may also include antigens from other pathogens so as to provide a protective immunogenic response to diseases other than those caused by M. bovis.

The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and / or the treatment of bone and joint infections, especially for the prevention and / or treatment of osteomyelitis.

The invention relates to a cefathiamidine hydrate, a preparation method thereof and application thereof. The crystalline hydrate has high storage stability, and is applicable in preparing medicaments for treating or preventing gram positive or negative bacteria sensitive bacteria, infections of human or animal respiratory system, liver and biliary system, five sense organs and urogenital system, bone and joint infection and soft skin tissue infection caused by the gram positive or negative bacteria sensitive bacteria, and diseases such as endocarditis, ichorrhemia, meningitis and the like.

The invention relates to a cefpiramide sodium hydrate and a preparation method and application thereof. The cefpiramide sodium hydrate has high storage stability, and is applicable to the preparation of medicines for treating or preventing diseases of the human being or animals caused by gram-positive or gram-negative sensitive bacteria, such as respiratory system diseases, hepatobiliary system diseases, five-sense organ diseases, urinary tract infection, celiac infection, pelvic infection, ichorrhemia, skin tissue infection, bone and joint infections, endocarditis and cephalomeningitis.

The invention relates to a ceftizoxime sodium crystalline hydrate and a preparation method and application thereof. The ceftizoxime sodium crystalline hydrate has high storage stability, and is suitable for preparing medicaments for treating or preventing diseases such as infection of respiratory systems, liver and biliary systems, five sense organs and urinary tracts of human bodes or animals, infection of abdominal cavity, infection of pelvic cavity, ichorrhemia, infection of skin tissues, and infection of bones and joint caused by gram positive or negative bacteria, meningitis caused by streptococcus pneumonia or haemophilus influenza, and simple gonorrhea.

The invention discloses a cefuroxime sodium compound entity which is relatively poor in hygroscopicity, relatively good in storage stability and applicable to preparation of drugs for treating or preventing respiratory system infection, five-organ infection, urinary system infection, pelvic cavity infection, septicemia, skin soft-tissue infection, bone and joint infection, gonorrhea and meningitis of human or animals, caused by sensitive gram positive or negative bacteria.

The invention discloses a propagation method for increasing the grafting survival rate of Madhuca hainanensis Chun et How. The method comprises the following steps of: cutting half-lignified or lignified sun-exposed erect branches serving as scions from a Madhuca hainanensis Chun et How parent tree, removing leaves, keeping 2-4 bud eyes on each section of scion, scattering the scions, and standing for 2-3 days until myron natural juice flows out; stumping parts, which are 10 centimeters away from base parts, of 1-2 year old Madhuca hainanensis Chun et How seedlings serving as root stocks and standing for 2-3 days to make myron juice flows out naturally until incision juice is solidified; and grafting by adopting scion-root stock double side whip grafting. The Madhuca hainanensis Chun et How scions and the root stocks are pretreated, so that the problems of difficulty in operating and easily caused joint infection of a grafted plant due to excessive juice of Madhuca hainanensis Chun et How are solved; the grafting method is improved and the scion-root stock double side whip grafting is used for grafting; and after the method disclosed by the invention is used for grafting, a wound starts to heal 8-12 days later, new buds can grow from the scions 20-25 days later, and the survival rate is increased by 22 percent and is up to 96 percent.

The invention relates to a cefonicid sodium hydrate and a preparation method and application thereof. The cefonicid sodium hydrate has better storage stability and is applicable to preparation of the medicaments for treating or preventing such diseases caused by gram positive or negative sensitive bacteria as respiratory system infection, hepatobiliary system infection, five sense infection, urinary tract infection, abdominal infection, pelvic infection, sepsis, skin soft tissue infection, bone and joint infections, annexitis, intrauterine infection, parametritis, meningitis, gonorrhea and the like of human or animals.

The invention relates to a cefathiamidine hydrate and a preparation method and application thereof. The crystalline hydrate has high storage stability, is suitable for preparing bacteria sensitive to Gram-positive or negative bacteria, and is applied to the preparation of medicaments for treating or preventing infection of respiratory systems, liver and gall bladder systems, five sense organs, urogenital systems, bones, joints and skin soft tissues as well as diseases such as endocarditis, septicemia, brain fever and the like of human beings or animals caused by bacteria which are sensitive to Gram-positive or negative bacteria.

The invention relates to the technical field of medicine, and discloses cefaclor composition particles and a preparation method thereof. The cefaclor composition particles disclosed by the invention are prepared from the following raw materials in parts by weight: 250 parts of cefaclor, 8 parts of bromhexine hydrochloride, 1,490 parts of sucrose, 20 parts of acesulfame, 2.5 parts of essence and 250 parts of sorbitol. The cefaclor composition particles disclosed by the invention comprise sorbitol which can be taken as a medicament dispersing agent for enhancing the medicament solubility and can be used for enhancing the antibacterial action of cefaclor. As proved by a test, the cefaclor composition particles disclosed by the invention have enhanced antibacterial action and high stability and can be widely applied to treatment of bacterial infection diseases such as respiratory tract infection, bone and joint infection, pelvic infection, abdominal infection and the like.

The invention discloses a PRP loaded slow release antibiotic-mesenchymal stem cell gel system and a preparation method thereof. Thrombin and calcium ions are added into PRP, an irregular micro three-dimensional grid structure of 50-200 micrometers is formed, and bacterium-sensitive antibiotics and stem cells are loaded on the grid structure. The PRP loaded slow release antibiotic-mesenchymal stem cell gel system and the preparation method thereof have the advantages that open fractures, bone and joint infection, skin, subcutaneous tissue and muscular tissue infection, four limb and spine implant related infection and artificial joint prosthesis peripheral infection are obviously prevented and treated, and the related infection occurrence rate is reduced. The technology releases the antibiotics within a certain time from inside to outside, bacteria around an implant are directly killed, formation of a bacterial biofilm is restrained or damaged, and the technical purpose that coalescence of bone joints and soft tissue is promoted while the antibiotics are slowly released in the body is achieved.

The invention relates to a cefotetan disodium hydrate and a preparation method and application thereof. The cefotetan disodium hydrate has high storage stability, and is applicable to the preparation of medicines for treating or preventing diseases of the human being or animals caused by gram-positive or gram-negative sensitive bacteria, such as respiratory system diseases, hepatobiliary system diseases, five-sense organ diseases, urinary tract infection, celiac infection, pelvic infection, ichorrhemia, skin tissue infection, bone and joint infections, cephalomeningitis and endocarditis.

The invention relates to a cefodizime sodium hydrate, a preparation method thereof and application thereof. The cefodizime sodium hydrate has high storage stability, and is suitable to be used in the preparation of medicaments for treating and preventing diseases, caused by Gram-positive or negative bacterial sensitive bacteria, such as diseases in respiratory systems, liver and gall systems and five sense organs of human beings and animals, urinary tract infection, enterocoelia infection, pelvic cavity infection, ichorrhemia, skin and soft tissue infection, bone and joint infection, annexitis, intrauterine infection, parametric connective tissue inflammation, cephalomeningitis, gonorrhoea and the like.

The present invention relates to a crystal form of lomefloxacin aspartate and a preparation method thereof. The present invention also relates to a pharmaceutical composition containing the above-mentioned crystal form of lomefloxacin aspartate and the crystal form is used to manufacture a treatment for Gram Human or animal respiratory tract infection, genitourinary system infection, gastrointestinal bacterial infection, abdominal cavity, biliary tract, typhoid and other infections, bone and joint infection, skin and soft tissue infection, sepsis and other systemic infection caused by positive or negative bacterial sensitive bacteria, Other infections, such as sinusitis, otitis media, blepharitis and other drugs.

A hip replacement apparatus that normally includes a supporting rod bent into an acute angle at its center with a rounded head on one end. This supporting rod can be received at the pelvis into a pre-assembled housing with a backplate and front plate where the unit can be cemented and / or screwed into the prepared bone at the hip joint. The backplate can have an anchoring protrusion that mates into the trimmed-out bone at the joint. The front plate can have a center hole that receives, and holds the rounded head of the supporting rod from escaping. The head (and hence the supporting rod) freely rotates captively in the housing with the housing firmly attached to the pelvis. The bottom end of the supporting rod can penetrate into the center of the cut-off femur and can be cemented into the bone. The supporting rod can be held to the femur with a bone clamp apparatus including a side plate that can be banded firmly to the femur with one or a more bands.

The present invention relates to GRCS bacteriophages, as well as to methods and compositions for the treatment of prosthetic joint infection. Particularly, the present invention provides bacteriophages specific against Staphylococcus aureus from prosthetic joint infections.

The invention relates to a cefonicid sodium hydrate and a preparation method and application thereof. The cefonicid sodium hydrate has better storage stability and is applicable to preparation of the medicaments for treating or preventing such diseases caused by gram positive or negative sensitive bacteria as respiratory system infection, hepatobiliary system infection, five sense infection, urinary tract infection, abdominal infection, pelvic infection, sepsis, skin soft tissue infection, bone and joint infections, annexitis, intrauterine infection, parametritis, meningitis, gonorrhea and the like of human or animals.

The invention relates to a lomefloxacin aspartate hydrate and the preparation, as well as the usage. The lomefloxacin aspartate hydrate of the invention (the molecular formula is C17H19F2N3O3.C4H7NO4.nH2O, n is equal to 0.5 to 2.5), the lomefloxacin aspartate hydrate of the invention is the fluoroquinolone antibacterial agent used for human or animal respiratory infection, genitourinary infection, gastrointestinal tract bacterial infection, abdominal infection, bile duct infection, typhoid and other infections, bone and joint infection, skin soft tissue infection, sepsis and other systemic infection, other infections, such as paranasal sinusitis, otitis media, blepharitis and so on which are caused by Gram positive or negative bacteria and sensitive bacteria, the invention has the advantages of stable existence, easy storage and transportation and convenient preparation of the pharmaceutical preparations.

The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compounds are useful as antibiotics for the prevention or treatment of bone and joint infections, especially for the prevention and treatment of osteomyelitis.

The invention relates to cefodizime sodium hydrate as well as a preparation method and application thereof. The cefodizime sodium hydrate has better storage stability, and is suitable for being applied to the preparation of drugs for treating or preventing human or animal respiratory system diseases, hepatobiliary system diseases, diseases related to the five sense organs and urinary tract infection, abdominal cavity infection, pelvic cavity infection, septicemia, skin and soft tissue infections, bone and joint infections, adnexitis, intra-uterine infection, parametric connective tissue inflammation, meningitis, gonorrhea and other diseases caused by Gram-positive or negative bacteria sensitive bacteria.

The present invention relates to phosphonated fluoroquinolones such as moxifloxacm, gatifloxacm and ciprofloxacin, antibacterial analogs thereof, and methods of using such compounds The disclosed compounds represent prodrugs of fluoroquinolones wherein a phosphonated group is tethered to a fluoroquinolone antibiotic via a cleavable linker These compounds are useful as antibiotics for prevention and / or treatment of bone and joint infections, especially for the prevention and / or treatment of osteomyelitis.

The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and / or the treatment of bone and joint infections, especially for the prophylaxis and / or treatment of osteomyelitis.

The invention discloses an electric sound wave pulse scrubbing device for artificial joint infection revision. The device comprises a high-frequency sound wave vibration scrubbing structure, a positive and negative pressure alternate pulse flushing and sucking structure, a water inlet and sucking structure, a power supply control and power supply structure, a first shell and a second shell; the first shell and the second shell are buckled and connected; the high-frequency sound wave vibration scrubbing structure, the positive and negative pressure alternate pulse flushing and sucking structure, the water inlet and sucking structure, and the power supply control and power supply structure are mounted in an inner cavity formed after the first shell and the second shell are buckled; and the high-frequency sound wave vibration scrubbing structure comprises a magnetic suspension high-frequency vibration motor, connecting rods and brush heads, and the magnetic suspension high-frequency vibration motor is clamped to the position, close to the center of the inner side of a muzzle, of the first shell. The device can effectively remove bacterial biofilms and other infected tissues infectingthe surface of an artificial joint, significantly improve the flushing efficiency, improve the flushing effect, shorten the operation time and improve the operation success rate.

The invention relates to an application of synovial fluid neutrophil gelatinase-associated lipocalin (NGAL) in detection and a diagnostic kit for prosthetic joint infection. Joint replacement is an effective treatment mode for treating joint disease at a terminal stage, and periprosthetic joint infection is a severe complication after joint replacement. The synovial fluid NGAL has high sensitivityand specificity for diagnosing the prosthetic joint infection. According to the invention, fluorescence particles are taken as a maker, and the diagnostic kit (a test paper strip) for the synovial fluid NGAL is prepared through an immunochromatography method. By using an immunofluorescence quantitative analyzer, quantitative detection and instant detection on a synovial fluid specimen can be carried out, and diagnosis of the prosthetic joint infection is realized. A synovial fluid NGAL detection reagent and the diagnostic kit have the advantages of simple usage, sensitive reaction, and high diagnosis accuracy.

The invention relates to a treatment medicament for resisting infectious diseases, and a preparation method and application thereof, in particular to an alkyl acyl acetaldehyde sulfite derivative and a preparation method and application thereof. The derivative has the high storage stability, and is suitable for preparing medicaments for treating or preventing respiratory tract infection of human or animals, urogenital system infection, gastrointestinal tract bacterial infection, the infection of enterocoelia, pelvic cavity, biliary tract and typhia, injection of bones and joints, skin soft tissue infection, septicemia, cervicitis, sinusitis, tympanitis, blepharitis, conjunctivitis and psoriasis which are caused by Gram-positive or negative bacterial sensitive bacteria, virus, chlamydia, mycoplasma and fungi and liver cancers and enhancing immunity.

The present invention is directed to a method for treating bone or bone marrow infections, joint infection or infection of the tissues surrounding the joint by administration of the antibiotic tigecycline alone or in combination with a rifamycin antibiotic. In a preferred embodiment the bone or bone marrow infection causes osteomyelitis. In another embodiment the joint infection or infection of the tissues surrounding the joint causes septic arthritis. The invention is also directed to manufacture of a medicament for treatment of bone and / or bone marrow infections, or joint infections and / or infections in tissues surrounding the joint with tigecycline alone or in combination with rifampin.