10 results about "Drug permeation" patented technology

A rizatriptan microneedle patch, a preparation method therefor, and use thereof. The rizatriptan microneedle patch comprises a substrate and a needle body arranged on a surface of the substrate. The composition of the needle body comprises rizatriptan benzoate and a skeleton material. The skeleton material comprises a combination of dextran and trehalose, copovidone, a combination of polyvinyl alcohol and dextran, a combination of hypromellose and dextran, or a combination of sodium carboxymethyl cellulose and dextran. The rizatriptan microneedle patch has high mechanical strength and cumulative drug permeation.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The invention discloses application of lipoic acid trisulfide, and belongs to the technical field of medicines. The invention discloses application of lipoic acid trisulfide or salt, isomer and derivative thereof as a drug penetration enhancer or / and an efflux inhibitor. The invention also discloses a medicinal preparation which comprises a medicine penetration enhancer or / and an efflux inhibitor, and the medicine penetration enhancer or / and the efflux inhibitor is lipoic acid trisulfide or salt and isomer thereof. The lipoic acid trisulfide is scientific in design and ingenious in conception, it is found for the first time that the lipoic acid trisulfide or the salt, isomer and derivative thereof not only can improve the drug permeability, but also shows an excellent drug excretion inhibition effect, and has a dual regulation function. As a drug penetration enhancer or / and an excretion inhibitor, the compound can significantly improve the bioavailability of drugs.

The invention belongs to the technical field of medical treatment, and particularly relates to a pulse and ultrasonic energy time sequence synergistic drug delivery method and system. The pulse and ultrasonic energy time sequence synergistic administration method is characterized by comprising the following steps: (1) suspending medicament injection, and only washing with cooling liquid for 2-4 seconds; (2) the conveying of the cooling liquid is suspended, the medicament is sprayed for 0.5-1.5 seconds, and meanwhile, the ultrasound continuously works; (3) suspending injection of the medicament, re-inputting the cooling liquid, and continuing for 2-4 seconds; and (4) repeating the steps (1), (2) and (3) until completion. The system has the advantages that through pulse type drug delivery and time sequence cooperative control, periodic targeted release of high-concentration drugs is achieved, the drug utilization rate and the thrombolysis effect are remarkably improved, drug permeation is enhanced through the ultrasonic cavitation effect, and meanwhile the heat dissipation requirement of the system is met.

The invention discloses a traditional Chinese medicine external application patch with directional drug penetration and thermal magnetic therapy functions, and relates to the technical field of transdermal delivery, the patch comprises a patch body, the patch body is at least provided with a magnetic-thermal synergistic functional layer, the patch body can further comprise a drug storage layer and an isolation liner, the magnetic-thermal synergistic functional layer is a magnetic induced phase change gel layer, and the isolation liner is arranged on the magnetic-thermal synergistic functional layer. The magnetic phase change patch is composed of a gel matrix and a uniformly dispersed magnetic phase change composite unit, the magnetic phase change composite unit comprises a phase change material and magnetic nanoparticles, when the magnetic phase change patch is used, the patch is applied to an area to be treated, an external alternating magnetic field is applied, and the magnetic nanoparticles generate a magnetocaloric effect; the phase-change material maintains the magnetic-thermal synergistic function layer to be close to a specific temperature through the phase-change process, the medicine storage layer carries traditional Chinese medicine active ingredients, directional medicine penetration is achieved under the thermomagnetic synergistic effect, a complex circuit and a wired power source are not needed, the continuous and stable thermomagnetic synergistic effect is achieved, the treatment effect and the medication safety are improved, and the application range is wide. The method is suitable for clinical directional drug penetration treatment scenes.

The utility model relates to the technical field of ultrasonic drug permeation instruments, and discloses a portable ultrasonic drug permeation instrument which comprises an anti-interference case, a mounting table is mounted on the upper side of the anti-interference case, a portable handle is fixedly connected to the upper side of the mounting table, an ultrasonic probe mechanism is arranged on one side of the anti-interference case, and an ultrasonic probe is arranged on the other side of the anti-interference case. The ultrasonic probe mechanism comprises two ultrasonic probe plugs plugged with one side of the anti-interference case, one end of each ultrasonic probe plug is connected with a connecting wire, one end, far away from the ultrasonic probe plug, of each connecting wire is connected with an electrode plate unit, and the lower side of the anti-interference case is fixedly connected with a plurality of supporting legs; according to the utility model, the portable handle is arranged on the upper sides of the mounting table and the anti-interference case, so that a user can conveniently carry and transfer the ultrasonic medicine penetration instrument.

The invention discloses a polyurethane pressure-sensitive adhesive and a preparation method thereof. The polyurethane pressure-sensitive adhesive comprises the following raw materials in percentage by weight: a) 10-40% of polyisocyanate, b) 45-85% of polyether polyol, c) 0-20% of a chain extender, d) 2-20% of glycolipid, e) 0.5-4% of a curing agent, f) 0.02-0.2% of a catalyst and g) 0-20% of a functional component. The polyurethane pressure-sensitive adhesive is modified by utilizing glycolipid, the initial viscosity, the adhesive force and the cohesive force of the polyurethane pressure-sensitive adhesive are regulated and controlled by regulating and controlling the content and the structure of the glycolipid, and meanwhile, the existence of the glycolipid can regulate and control the drug loading property of the pressure-sensitive adhesive, regulate and control the drug absorption of an organism, and promote drug permeation and wound healing.

The invention relates to the field of medical treatment, in particular to a medicine permeator for a patient with metastatic bone cancer. According to the medicine permeator for the metastatic bone cancer patient, the massage force of an electric massage instrument on the patient can be moderate, the comfort of the patient is improved, medicine mist can permeate into the body of the patient more sufficiently, secondary damage to the patient caused by high-temperature medicine mist is avoided as much as possible, and the absorption effect of the skin of the patient on the medicine mist is better. A medicine permeator for a patient with metastatic bone cancer comprises a barrel, a sliding cover, an air bag and the like. The cylinder body is provided with an air dispersing opening, the air dispersing opening of the cylinder body is connected with a sliding cover in a sliding mode, and the two ends of the cylinder body are fixedly connected with air bags. When the medicine mist permeates into the body of a patient, a medical worker can push the push rod and start the medicine evaporator and the electric massage instrument, the medicine mist can permeate into the body of the patient more sufficiently, meanwhile, the patient can pull the sliding cover, harm caused by the too high temperature of the medicine mist in the barrel is reduced, and the safety of the patient during medicine mist permeation is improved conveniently.

The utility model relates to the technical field of medicine permeation instruments, in particular to a medicine permeation instrument with a remote monitoring function, which comprises a host, a fixing block is fixedly connected to the side wall of the host, a lifting groove is formed in the fixing block, a lifting block is slidably connected in the lifting groove, a camera body is rotatably connected to the upper end face of the lifting block, and a remote monitoring device is arranged in the camera body. An adjusting assembly is mounted on the lifting block; and a pop-up assembly. According to the utility model, the host is placed at a specified operation position, then a user pulls the pull ring to move the clamping block out of the clamping groove, and the first spring resets to drive the lifting block to ascend, so that the camera body can be popped out of the lifting groove for real-time monitoring and guidance; and a second spring is matched with a clamping block to fix the lifting block, so that a user can quickly use and store the camera body, and the portability is improved.

The utility model discloses a kind of micro injection needle devices, it is related to medical instrument technical field.The device includes: plastic needle seat, multiple micro injection needles and needle sheath, the inside of one end of plastic needle seat is provided with injection cavity, the other end is equipped with the injection needle slot adjacent to injection cavity, the entrance at close injection cavity is equipped with the connecting structure for connecting injector, the fit surface of injection needle slot and skin is set as inclined plane;Multiple micro injection needles are fixed in injection needle slot, and are communicated with injection cavity;Needle sheath is the cap-shaped structure of one end opening, for covering and protecting micro injection needle outside plastic needle seat is set.The utility model exposes length accurate control in 0.1-2mm with needle tip, can penetrate stratum corneum and reach superficial layer of dermis, effectively avoid nerve ending, ensure stab angle stability simultaneously in combination with fit inclined plane, expand drug permeation area by multiple needle independent channel design, to realize painless injection while significantly promote drug efficient absorption.