32 results about "Drug permeation" patented technology

The invention relates to the technical field of drug release control. By providing a multi-modal data fusion nano-drug release kinetics prediction method, device and equipment and a medium, the method comprises the following steps: acquiring permeation path image data of a nano-drug in a target tissue, and acquiring drug release rate chemical data; performing time dimension synchronization processing on the permeation path image data and the drug release rate chemical data to generate a multi-modal space-time correlation data set; performing feature extraction processing on the multi-modal time-space correlation data set to obtain nano-drug permeation behavior features and release dynamics fluctuation features; constructing a space-time diagram neural network prediction model; training the space-time diagram neural network prediction model to obtain a trained prediction model; and generating a personalized drug release scheme through a reverse optimization algorithm on the basis of the drug release kinetics prediction curve and the quantitative index of the degree of variability, so as to achieve the technical effects of improving the prediction precision, enhancing the model adaptability and reducing the curative effect volatility.

A rizatriptan microneedle patch, a preparation method therefor, and use thereof. The rizatriptan microneedle patch comprises a substrate and a needle body arranged on a surface of the substrate. The composition of the needle body comprises rizatriptan benzoate and a skeleton material. The skeleton material comprises a combination of dextran and trehalose, copovidone, a combination of polyvinyl alcohol and dextran, a combination of hypromellose and dextran, or a combination of sodium carboxymethyl cellulose and dextran. The rizatriptan microneedle patch has high mechanical strength and cumulative drug permeation.

The invention discloses a probiotic delivery system based on core-shell structure hydrogel and application of the probiotic delivery system, and belongs to the technical field of biological medicines.The probiotic delivery system based on the core-shell structure hydrogel comprises a hydrogel capsule shell and an inner core containing probiotics, the hydrogel capsule shell isolates the probiotics from the outside, and the inner core contains the probiotics; the hydrogel capsule comprises a shell and a core, the shell is made of sodium alginate, lipopolysaccharide generated by probiotics is adsorbed, the internal aperture of the shell of the hydrogel capsule is 200-300 nm, external nutrient substances are allowed to enter, metabolic substances secreted by the probiotics and having a treatment effect are allowed to go out, and the core is sodium alginate hydrogel which can well keep bacterial activity and contains certain nutrient substances required by bacteria. The probiotic delivery system has double isolation effects of physical isolation and chemical isolation, avoids negative effects of bacterial endotoxin on a human body, can realize bacterial isolation and drug permeation balance, and is good in long-term stability.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

This invention relates to biomimetic mineralized exosomes for programmed drug penetration in tumors that inhibit cell burial, along with their preparation method and applications. Belonging to the field of novel excipients and dosage forms for pharmaceutical formulations, this invention co-loads the small-molecule chemotherapeutic drugs 10-hydroxycamptothecin and banoanthraquinone into exosomes. Then, through a biomimetic mineralization strategy, aTIM-4 is organically combined with mineralized calcium phosphate particles to obtain biomimetic mineralized exosomes. Under the acidic response of the tumor microenvironment, the calcium phosphate shell dissolves, and the exosome nucleus enters the tumor cells, inducing cell death and generating apoptotic bodies. This programmatically delivers the drug, delivering banoanthraquinone deep into the tumor. Simultaneously, the released aTIM-4 inhibits the cell burial of tumor-associated macrophages, amplifying the programmed drug penetration based on apoptotic bodies. This invention provides a new strategy and more options for overcoming the bottleneck of nanomedicine penetration in tumors, meeting the urgent clinical need for highly effective chemotherapeutic agents.

The invention discloses an intelligent ultrasonic transdermal drug delivery device which comprises a skin state acquisition module used for acquiring initial skin parameters of a patient when transdermal drug delivery is performed on the patient through the device; the adjustable power ultrasonic transmitting module is used for irradiating the skin of the patient; the ultrasonic response substance loading module is used for loading a mixed solution of an ultrasonic response substance and a medicine; the feedback parameter monitoring module is used for monitoring the cavitation intensity, the skin temperature field and the drug entry amount of ultrasonic transdermal drug delivery in real time and transmitting the cavitation intensity, the skin temperature field and the drug entry amount to the intelligent regulation and control module; the intelligent regulation and control module is used for receiving the initial skin parameters, determining initial parameters of transdermal drug delivery, and dynamically regulating the initial parameters according to the cavitation intensity, the skin temperature field and the drug entry amount and a preset period; according to the application, a monitoring feedback and intelligent regulation and control module is established, and the ultrasonic cavitation effect is enhanced by adjusting ultrasonic parameters and introducing an ultrasonic responder, so that the skin injury is avoided while the permeation efficiency and depth are improved.

The invention relates to an ibuprofen-containing transdermal patch as well as a preparation method and application thereof. The ibuprofen-containing transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises ibuprofen, a compound at least containing one amino group and a pressure-sensitive adhesive, and based on the weight of the polymer matrix layer, the ibuprofen accounts for 10-30% by weight, the compound at least containing one amino group accounts for 0.1-5% by weight, and the pressure-sensitive adhesive accounts for 0.1-5% by weight. The weight content of the pressure-sensitive adhesive is 45%-84%, the pressure-sensitive adhesive is composed of a silicone pressure-sensitive adhesive and an acrylate pressure-sensitive adhesive, and the weight ratio of the silicone pressure-sensitive adhesive to the acrylate pressure-sensitive adhesive is 1: 1-15: 1. According to the transdermal patch, the penetration capacity of ibuprofen is remarkably improved, particularly, the early-stage medicine penetration rate is higher, the medicine utilization rate is greatly improved, meanwhile, the patch is good in application performance, free of skin irritation, free of crystallization in the long-term storage process, good in stability and capable of better meeting the clinical medication requirement.

The invention relates to a needle solution for a double-drug-loading self-emulsifying drug release system and a preparation method thereof.The needle solution is obtained by mixing an SE solution and a water phase, and the SE solution is prepared from an oil phase solution obtained by dissolving a water-insoluble drug 1 in an oil ester organic solvent and a hydrotropy solution, the hydrotropy solution is a mixed solution of an emulsifier and a co-emulsifier; the water phase is an aqueous solution obtained by dissolving a water-soluble medicine 2 into water, and HA, Dex or Chs are added into the aqueous solution. The invention also relates to a drug-loaded soluble microneedle obtained from the needle solution, and also provides an application of the double drug-loaded soluble microneedle in preparation of drugs for treating gouty arthritis. The double-drug-loading microneedle prepared by the invention can obviously improve the corrosion speed in the skin and quickly release the drug, can play a role in promoting the drug permeation after being combined with the ultrasonic action, and can play a role in controlled release by controlling the demulsification release of the drug by utilizing the mechanical action of the ultrasonic.

The utility model discloses a soluble microneedle leading-in device, a soluble microneedle is arranged on the lower surface of a microneedle piece, the leading-in device comprises a pressing assembly, a cleaning assembly and a supporting assembly, the pressing assembly is matched with the microneedle piece, the pressing assembly is provided with a pressing surface in contact with the microneedle piece, and the cleaning assembly is arranged on the supporting assembly. The pressing assembly can press the microneedle piece in the form of applying external force, the cleaning assembly can clean the attached position of the microneedle piece, the supporting assembly can support the pressing assembly and the cleaning assembly, the pressing assembly comprises a first pressing plate, the pressing assembly comprises a plurality of second pressing plates, and the first pressing plate and the second pressing plate are arranged on the supporting assembly. And an elastic rib is fixedly connected between the second pressing plates. Compared with the prior art, the soluble microneedle leading-in device has the advantages that the microneedle piece can be uniformly pressed, the microneedle can be completely punctured into the skin, and the conduction efficiency and the medicine permeability of the microneedle are guaranteed.

The invention discloses a cinacalcet-containing transdermal patch as well as a preparation method and application thereof. The transdermal patch comprises a high-molecular matrix layer, wherein the high-molecular matrix layer comprises cinacalcet, a silicone pressure-sensitive adhesive and one or more high-molecular polymers selected from a water-insoluble cellulose derivative, polyvinylpyrrolidone and a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The transdermal patch disclosed by the invention is good in drug permeability and colloid application performance, high in safety, free of skin irritation, high in stability and good in uniformity, and can meet the requirements of clinically treating hyperparathyroidism or hypercalcemia.

The invention belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, and relates to a tumor programmed drug permeation biomimetic mineralization nano-vesicle capable of enhancing macropinocytosis as well as a preparation method and application of the tumor programmed drug permeation biomimetic mineralization nano-vesicle. The drug permeation biomimetic mineralization nano-vesicle is of a shell-core structure, chemotherapy drugs are co-loaded in the cell vesicle, and the exterior of the cell vesicle is encapsulated with a peptide fragment for specifically promoting the macropinocytosis of tumor cells through mineralization. The biomineralized cell membrane nano-vesicles which are good in stability and uniform in particle size are prepared, the calcium phosphate mineralized shell can specifically respond to tumor slightly acidic environment dissolution, and by enhancing the tumor macropinocytosis effect, uptake of apoptotic bodies by tumor cells is promoted, so that tumor apoptosis is promoted, and tumor apoptosis is inhibited. The apoptotic body-mediated drug has the advantages that the apoptotic body-mediated drug can be further improved in infiltration capacity in tumor tissues, programmed infiltration of the drug in the tumor tissues is realized, tumor growth is effectively inhibited, a great potential direction is provided for solving the tumor infiltration bottleneck of nano-drugs, and the apoptotic body-mediated drug has a good clinical application prospect.

The invention discloses application of lipoic acid trisulfide, and belongs to the technical field of medicines. The invention discloses application of lipoic acid trisulfide or salt, isomer and derivative thereof as a drug penetration enhancer or / and an efflux inhibitor. The invention also discloses a medicinal preparation which comprises a medicine penetration enhancer or / and an efflux inhibitor, and the medicine penetration enhancer or / and the efflux inhibitor is lipoic acid trisulfide or salt and isomer thereof. The lipoic acid trisulfide is scientific in design and ingenious in conception, it is found for the first time that the lipoic acid trisulfide or the salt, isomer and derivative thereof not only can improve the drug permeability, but also shows an excellent drug excretion inhibition effect, and has a dual regulation function. As a drug penetration enhancer or / and an excretion inhibitor, the compound can significantly improve the bioavailability of drugs.

The application relates to the technical field of medical devices, in particular to a drug delivery device of a multi-dimensional drug delivery instrument, which comprises a drug delivery instrument shell, the upper end of the drug delivery instrument shell is provided with a sealing end cover, the middle part of the sealing end cover is provided with a drug delivery bin, and the bottom of the drug delivery bin is fixedly connected with a drug delivery cylinder; the inner cavity of a flexible negative pressure head is provided with a positive pressure bin in the middle part, the lower end of the drug delivery cylinder extends to the inner cavity of the positive pressure bin; a matching protruding block is fixedly installed on the inner wall of the positive pressure bin, an air inlet hole is formed in the middle part of the matching protruding block, and the air inlet hole is communicated with the inner cavity of the flexible negative pressure head and the inner cavity of the drug delivery instrument shell; the beneficial effects are as follows: the ultrasonic wave sheet arranged at the bottom of the drug delivery bin is used for atomizing the medicine, the nanometer red light emitter can treat the skin, the generated heat heats the atomized medicine liquid in the inner cavity of the flexible negative pressure head through the annular aluminum sheet, the absorption effect of the medicine is improved, in addition, the inner cavity of the flexible negative pressure head is exhausted to form a negative pressure, so that the medicine can be timely absorbed by the pores on the surface of the skin, and the skin drug permeation effect is better.

The invention belongs to the technical field of medical treatment, and particularly relates to a pulse and ultrasonic energy time sequence synergistic drug delivery method and system. The pulse and ultrasonic energy time sequence synergistic administration method is characterized by comprising the following steps: (1) suspending medicament injection, and only washing with cooling liquid for 2-4 seconds; (2) the conveying of the cooling liquid is suspended, the medicament is sprayed for 0.5-1.5 seconds, and meanwhile, the ultrasound continuously works; (3) suspending injection of the medicament, re-inputting the cooling liquid, and continuing for 2-4 seconds; and (4) repeating the steps (1), (2) and (3) until completion. The system has the advantages that through pulse type drug delivery and time sequence cooperative control, periodic targeted release of high-concentration drugs is achieved, the drug utilization rate and the thrombolysis effect are remarkably improved, drug permeation is enhanced through the ultrasonic cavitation effect, and meanwhile the heat dissipation requirement of the system is met.

1. Name of the design product: shoe pad (self-heating auxiliary medicine permeable). 2. Use of the design product: shoe pad for placing inside shoes, which is self-heating and auxiliary medicine permeable. 3. Design points of the design product: combination of shape and pattern. 4. Picture or photo best indicating the design points: assembly 2 perspective view. 5. Assembly description of other circumstances requiring explanation: the design product is a thin product, and the left and right elevation views of assembly 1 and assembly 2 are omitted.

Improved hypotonic gelling vehicles are described as solubilizing agents for drugs and as a means of providing sustained drug delivery to the eye. The addition of small amounts of low molecular weight PEG to hypotonic gel-forming compositions enhances the viscosity of the solution on the ocular surface, prolongs tear film breakup time, and increases ocular comfort. It has been discovered that while solubilizing drugs at higher concentrations enhances drug penetration into body tissues, hypotonic gelling vehicles further improve the distribution of drugs over a larger surface area for increased absorption and sustained release for reduced side effects and longer duration of action.

The invention discloses a traditional Chinese medicine external application patch with directional drug penetration and thermal magnetic therapy functions, and relates to the technical field of transdermal delivery, the patch comprises a patch body, the patch body is at least provided with a magnetic-thermal synergistic functional layer, the patch body can further comprise a drug storage layer and an isolation liner, the magnetic-thermal synergistic functional layer is a magnetic induced phase change gel layer, and the isolation liner is arranged on the magnetic-thermal synergistic functional layer. The magnetic phase change patch is composed of a gel matrix and a uniformly dispersed magnetic phase change composite unit, the magnetic phase change composite unit comprises a phase change material and magnetic nanoparticles, when the magnetic phase change patch is used, the patch is applied to an area to be treated, an external alternating magnetic field is applied, and the magnetic nanoparticles generate a magnetocaloric effect; the phase-change material maintains the magnetic-thermal synergistic function layer to be close to a specific temperature through the phase-change process, the medicine storage layer carries traditional Chinese medicine active ingredients, directional medicine penetration is achieved under the thermomagnetic synergistic effect, a complex circuit and a wired power source are not needed, the continuous and stable thermomagnetic synergistic effect is achieved, the treatment effect and the medication safety are improved, and the application range is wide. The method is suitable for clinical directional drug penetration treatment scenes.

The invention relates to the technical field of biological medicines, and discloses preparation and application of targeted gram-negative bacterium-resistant bionic dual-modified nanoparticles. Comprising the following steps: S1, synthesis of GBP1c peptide; S2, preparation of PLGA / tigecycline nanoparticles; S3, preparation of GBP1c modified PLGA / tigecycline nanoparticles; S4, preparation of GBP1c-neobaicalein dual modified PLGA / tigecycline nanoparticles; according to the invention, through functional linkage of the GBP1c peptide, the neobaicalein and the macrophage membrane, a synergistic system of targeting anchoring, drug resistance antagonism and inflammation chemotaxis is constructed. The GBP1c peptide is specifically combined with Gram-negative bacterium outer membrane lipopolysaccharide by virtue of a multi-basic amino acid sequence to realize accurate targeting, NEO synchronously blocks LPS transport to destroy the bacterium outer membrane and inhibit a P-glycoprotein efflux pump to prolong drug retention, and MM guides nanoparticles to enrich an infected part by virtue of inflammation chemotactic characteristics, so that the drug retention is prolonged. The three are linked to solve the core problems of poor DDS targeting and insufficient drug permeation in the prior art.

The utility model relates to the technical field of ultrasonic drug permeation instruments, and discloses a portable ultrasonic drug permeation instrument which comprises an anti-interference case, a mounting table is mounted on the upper side of the anti-interference case, a portable handle is fixedly connected to the upper side of the mounting table, an ultrasonic probe mechanism is arranged on one side of the anti-interference case, and an ultrasonic probe is arranged on the other side of the anti-interference case. The ultrasonic probe mechanism comprises two ultrasonic probe plugs plugged with one side of the anti-interference case, one end of each ultrasonic probe plug is connected with a connecting wire, one end, far away from the ultrasonic probe plug, of each connecting wire is connected with an electrode plate unit, and the lower side of the anti-interference case is fixedly connected with a plurality of supporting legs; according to the utility model, the portable handle is arranged on the upper sides of the mounting table and the anti-interference case, so that a user can conveniently carry and transfer the ultrasonic medicine penetration instrument.

The utility model discloses a drug delivery experiment device for an ultrasonic drug permeation instrument, which comprises an experiment environment building unit, a drug delivery experiment unit and a drug delivery experiment unit, the ultrasonic unit is arranged in the liquid environment in the experimental environment building unit, the ultrasonic unit comprises a first ultrasonic transducer and a second ultrasonic transducer which are oppositely arranged, and an ultrasonic standing wave field is formed between the first ultrasonic transducer and the second ultrasonic transducer; the medicine conveying unit is used for conveying medicine particles into the ultrasonic standing wave field; the recording unit is used for recording the number of the drug particles captured by the ultrasonic standing wave field. The liquid environment is arranged, and the ultrasonic unit and the medicine conveying unit are arranged in the liquid environment, so that the capturing conditions of different medicine particles by different ultrasonic powers can be effectively experimented, the influence of different ultrasonic powers on the movement of different medicine particles can be verified, and power data support is provided for the ultrasonic medicine penetration instrument; and the leading-in effect of the ultrasonic medicine penetration instrument is greatly enhanced, so that the treatment effect is improved.

The invention discloses a compound bergamot nasal cavity lotion and application thereof, and belongs to the technical field of medicines. According to the invention, the bergamotin, the sodium pyruvate, the honeysuckle flower extract and the lophatherum gracile polysaccharide are combined, the bergamotin can inhibit the combination of virus spike protein and ACE2, the sodium pyruvate can block a virus ROS signal channel, and the honeysuckle flower extract can resist inflammation and inhibit bacteria, through the combination of the substances, the dual mechanisms of physical flushing and drug permeation are realized, and the application prospect is wide. The obtained compound bergamot nasal cavity lotion achieves the synergistic effect, and the antiviral and anti-inflammatory effects are remarkably superior to those of a single-component lotion.

The invention discloses a polyurethane pressure-sensitive adhesive and a preparation method thereof. The polyurethane pressure-sensitive adhesive comprises the following raw materials in percentage by weight: a) 10-40% of polyisocyanate, b) 45-85% of polyether polyol, c) 0-20% of a chain extender, d) 2-20% of glycolipid, e) 0.5-4% of a curing agent, f) 0.02-0.2% of a catalyst and g) 0-20% of a functional component. The polyurethane pressure-sensitive adhesive is modified by utilizing glycolipid, the initial viscosity, the adhesive force and the cohesive force of the polyurethane pressure-sensitive adhesive are regulated and controlled by regulating and controlling the content and the structure of the glycolipid, and meanwhile, the existence of the glycolipid can regulate and control the drug loading property of the pressure-sensitive adhesive, regulate and control the drug absorption of an organism, and promote drug permeation and wound healing.

The invention discloses a regulation and control system of an electric heating moxibustion head and the electric heating moxibustion head, is applied to the technical field of electric heating moxibustion heads, aims to solve the problems of poor synergism and poor effect between moxibustion equipment and electric stimulation equipment, and provides the system applied to the electric heating moxibustion head provided with an electric stimulation layer, a heating layer and a medicine permeation layer. The memory is used for storing computer programs; the processor is used for implementing the following steps when executing the computer program: acquiring electrical parameter information of a current acupuncture point area; determining a new total power of the moxibustion head according to the electrical parameter information; controlling the electric stimulation layer and the heating layer to work according to the new total power of the moxibustion head; according to the electric heating moxibustion head, the electric stimulation layer and the heating layer can be controlled to work cooperatively, the electric heating moxibustion head is provided with the medicine permeation layer, the better medicine property permeation effect can be achieved in the electric stimulation and heating process, operation is easy, and the effect is good.

The invention relates to the field of medical treatment, in particular to a medicine permeator for a patient with metastatic bone cancer. According to the medicine permeator for the metastatic bone cancer patient, the massage force of an electric massage instrument on the patient can be moderate, the comfort of the patient is improved, medicine mist can permeate into the body of the patient more sufficiently, secondary damage to the patient caused by high-temperature medicine mist is avoided as much as possible, and the absorption effect of the skin of the patient on the medicine mist is better. A medicine permeator for a patient with metastatic bone cancer comprises a barrel, a sliding cover, an air bag and the like. The cylinder body is provided with an air dispersing opening, the air dispersing opening of the cylinder body is connected with a sliding cover in a sliding mode, and the two ends of the cylinder body are fixedly connected with air bags. When the medicine mist permeates into the body of a patient, a medical worker can push the push rod and start the medicine evaporator and the electric massage instrument, the medicine mist can permeate into the body of the patient more sufficiently, meanwhile, the patient can pull the sliding cover, harm caused by the too high temperature of the medicine mist in the barrel is reduced, and the safety of the patient during medicine mist permeation is improved conveniently.

The utility model relates to the technical field of directional medicine permeation instrument auxiliary devices, in particular to a directional medicine permeation instrument auxiliary device which comprises two bandages, a plastic plate is fixedly mounted between the two bandages, a sleeve fixedly penetrates through the center of the plastic plate, a rubber plug is arranged in the sleeve, a medicine placing round plate is fixedly mounted at the upper end of the plastic plate, and a medicine placing groove is formed in the middle of the medicine placing round plate. And a rubber ring is fixedly mounted on the outer edge of the upper end of the medicine placing circular plate. Preferably, a circular groove is formed in the upper end of the medicine placing circular plate. Preferably, a filter screen plate is fixedly mounted close to the interior of the circular groove, and the interior of the sleeve is communicated with the filter screen plate. Preferably, a temperature sensor is fixedly installed in the medicine placing circular plate, and the exterior of the temperature sensor is connected with a wire. Preferably, the wire penetrates through the outer portion of the medicine placing circular plate. According to the auxiliary device of the directional medicine permeator, medicine adding is convenient.

The invention is suitable for the technical field of analgesic, and provides a biological medicine type externally-applied analgesic and collateral-dredging agent and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-7 parts of lysimachia triloba, 3-7 parts of fructus liquidambaris, 3-7 parts of mint, 3-7 parts of garden balsam stem, 3-7 parts of radix aconiti, 3-7 parts of radix aconiti agrestis, 3-7 parts of radix angelicae pubescentis, 3-7 parts of notopterygium root, 3-7 parts of cassia twig, 3-7 parts of ramulus mori, 1-5 parts of obscured homalomena rhizome, 1-5 parts of radix clematidis, 1-5 parts of semen strychni, 1-5 parts of caulis sinomenii, 1-5 parts of rhizoma paridis, 1-5 parts of asarum, 1-5 parts of radix saposhnikoviae and 1-5 parts of The pain-relieving and collateral-dredging agent provided by the invention directly acts on a diseased region through skin absorption or local action, so that the side effects of the whole body are reduced, and the principle relates to drug permeation, dosage form assistance and a targeted regulation mechanism; through skin penetration, local treatment and dosage form assistance, the synergistic treatment effect of rapid analgesia, targeted anti-inflammation and tissue repair is achieved, and the treatment effect of relieving pain can be generally achieved within one day after the traditional Chinese medicine composition is used.

The utility model relates to the technical field of medicine permeation instruments, in particular to a medicine permeation instrument with a remote monitoring function, which comprises a host, a fixing block is fixedly connected to the side wall of the host, a lifting groove is formed in the fixing block, a lifting block is slidably connected in the lifting groove, a camera body is rotatably connected to the upper end face of the lifting block, and a remote monitoring device is arranged in the camera body. An adjusting assembly is mounted on the lifting block; and a pop-up assembly. According to the utility model, the host is placed at a specified operation position, then a user pulls the pull ring to move the clamping block out of the clamping groove, and the first spring resets to drive the lifting block to ascend, so that the camera body can be popped out of the lifting groove for real-time monitoring and guidance; and a second spring is matched with a clamping block to fix the lifting block, so that a user can quickly use and store the camera body, and the portability is improved.

The utility model discloses a kind of micro injection needle devices, it is related to medical instrument technical field.The device includes: plastic needle seat, multiple micro injection needles and needle sheath, the inside of one end of plastic needle seat is provided with injection cavity, the other end is equipped with the injection needle slot adjacent to injection cavity, the entrance at close injection cavity is equipped with the connecting structure for connecting injector, the fit surface of injection needle slot and skin is set as inclined plane;Multiple micro injection needles are fixed in injection needle slot, and are communicated with injection cavity;Needle sheath is the cap-shaped structure of one end opening, for covering and protecting micro injection needle outside plastic needle seat is set.The utility model exposes length accurate control in 0.1-2mm with needle tip, can penetrate stratum corneum and reach superficial layer of dermis, effectively avoid nerve ending, ensure stab angle stability simultaneously in combination with fit inclined plane, expand drug permeation area by multiple needle independent channel design, to realize painless injection while significantly promote drug efficient absorption.

According to the flurbiprofen-containing transdermal patch and the preparation method thereof, the problems that an existing transdermal patch is low in medicine permeability, large in skin irritation or poor in adhesion and the like are solved, and the obtained transdermal patch is moderate in adhesion performance, free of colloid residues during stripping, small in skin irritation, good in medicine permeability, convenient to take and rapid in effect; the patient compliance is improved; compared with a conventional preparation method of a solvent type patch, the preparation method provided by the invention does not need to use an organic solvent and drying equipment, and the whole preparation method is simple and suitable for industrial large-scale production.

The invention discloses a pH / active oxygen double-response type hydrogel microneedle and a preparation method thereof.The method comprises the steps that 3-aminophenylboronic acid (PBA-NH2) is modified to a polyglutamic acid (PGA) molecular chain, a polyglutamic acid-phenylboronic acid copolymer (PGA-PBA) is synthesized, then pH of two precursor solutions of sodium alginate (Alg) and PGA-PBA is regulated, and the hydrogel microneedle is prepared. Phenylboronic acid ester bonds formed by a sodium alginate vicinal diol group and a boric acid group of 3-aminophenylboronic acid are used for in-situ preparation of a salicylic acid (SA) drug entrapped polyglutamic acid-phenylboronic acid copolymer / sodium alginate / salicylic acid (PPAS) single-layer network hydrogel, and the single-layer network hydrogel forms the multi-network PPAS hydrogel under the chelation of Ca < 2 + >. And finally, constructing the PPAS hydrogel microneedles (PPAS MNs) by adopting a vacuum injection method. The PPAS MNs disclosed by the invention has pH / ROS dual responsiveness, shows excellent drug permeability, skin compatibility, biocompatibility and antibacterial property, and is expected to be used for treating acne.