44 results about "Drug permeation" patented technology

A drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption / adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule includes a container body, a fusion-bonded portion which seals a mouth of the container body, and a wrench-off holder tab connected to the fusion-bonded portion. The ampoule is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption / adsorption preventing capability.

The present invention provides a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption / adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule (10) according to the present invention includes a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion. The ampoule (10) is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption / adsorption preventing capability. That is, the parison is extruded from a multilayer blow forming die, and then held between lower split mold pieces to be formed into the container body (11). After a drug solution (15) is filled in the container body (11), the mouth (12) is held between upper split mold pieces to form the fusion-bonded portion (13) and the holder tab (14). Thus, the plastic ampoule is provided.

This invention relates to novel pharmaceutical penetration compositions capable of facilitating penetration of at least one effector across biological barriers. The invention also relates to methods of treating or preventing diseases by administering penetration compositions to affected subjects.

Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

By providing a non-liquid drug reservoir layer 2 having first and second principal surfaces and containing a drug and a polymer that is to be a base, a drug permeation layer 4 disposed at the first principal surface side of the drug reservoir layer 2 and being lower in permeability of the drug than the drug reservoir layer 2, and a first backing 3 with a bending resistance of 10 to 80 mm that is formed so as to cover a side surface of the drug reservoir layer, skin irritation can be reduced.

The invention provides a non-steroid anti-inflammatory drug microemulsion-based gel patch with good stability and good permeation promotion effect. The patch contains a non-steroid anti-inflammatory drug microemulsion, a polymer gel skeleton, a cross-linking agent, a tackifier, a humectant, a filler and other pharmaceutically acceptable excipients. The non-steroid anti-inflammatory drug microemulsion contains a non-steroid anti-inflammatory drug, an emulsifier, a co-emulsifier, an oil phase and pharmaceutically acceptable excipients. According to the invention, the oil phase, the emulsifier and the co-emulsifier used for preparing the microemulsion can be used as drug permeation promoters at the same time and are cooperated with the microemulsion to promote percutaneous permeability of the drug, so the percutaneous permeability of the drug is effectively improved; thus, the residual quantity of the drug in the patch is reduced and the utilization degree of the drug is improved.

The invention discloses a novel headache therapeutic apparatus, which comprises a wearing frame arranged in cooperation with a human head, a massage and percutaneous drug permeation device, a drug liquid delivery pipe, a drug liquid delivery device and a drug liquid storage box. The massage frame is provided with at least one acupoint positioning hole opposite to the human head, and the massage and percutaneous drug permeation device are installed on the massage frame and arranged opposite to the acupoint positioning hole. The drug liquid delivery device transfers the drugs in the drug liquidstorage box to the massage and percutaneous drug permeation device through the drug liquid delivery pipe, and the massage and percutaneous drug permeation device can simultaneously permeate and massage the corresponding acupoints. The novel headache therapeutic apparatus provided by the invention is different from the traditional medicine taking and injection, and adopts the mode of percutaneous treatment to infiltrate the medicine into the human body acupoints through the skin, thereby avoiding the drawbacks of oral administration and injection of the medicine, massaging the medicine while infiltrating the medicine, and can effectively alleviate the migraine problem of the patient.

A device and method for administering a consistent and steady dosage of Metformin to patients which includes an implantation component with a composition of Metformin adapted to be inserted either subdermally or subcutaneously to administer a steady incremental dosage of Metformin to the patient throughout a predetermined period of time. A Metformin drug suspension is dispersed in a plurality of microreservoirs and the mixture of microreservoirs and placed in a silicone polymer tube for in situ polymerization and molding, which would allow Metformin molecules to initially diffuse through the microreservoir membrane and then through the silicone polymer containing membrane. In a further embodiment, Metformin implants may be formed by dispersing the drug in a copolymer matrix, which is then coated with a copolymer that serves as a rate-controlling membrane. The drug permeation through the polymer membrane occurs at a rate that is slower than that through the polymer matrix.

The invention discloses a milk cow hoof bath lotion. A Chinese herbal medicine extract liquid and an aloe extract are used as main raw materials, wherein the Chinese herbal medicine extract liquid is capable of effectively killing and inhibiting infectious pathogenic bacteria of milk cow hoof diseases, promoting healing of hoof wounds, effectively preventing and treating a variety of hoof diseases and improving the milk cow autoimmunity and disease resistibility, and the aloe extract is capable of promoting drug permeation and effectively repairing cuticle and has strong adhesion property; a plant extract capable of changing a milk cow hoof cuticle structure and promoting Chinese herbal medicines, aloe and other effective ingredients to be rapidly permeated to a skin deep layer for absorption is added, and ultrasonic dispersion, dissolution, high pressure homogenization and hot and cold processing technologies are organically combined; a modified dietary fiber with high-efficiency adhesion is scientifically compounded, moreover, trehalose, egg white, a natural antioxidant and the like capable of protecting effective ingredients from oxidation and improving the physical and chemical stability of the hoof care spray are added; finally, the hoof bath lotion which has the advantages of strong stability, safety, high efficiency and no any antibiotics and chemical toxic substances is prepared.

A nail and / or skin patch for preventing or treating mycoses is provided that is able to maintain a drug concentration in the nails and / or skin horny layer at a high concentration for a long period of time without adding a dissolving agent that prevents precipitation of drug crystals or permeation enhancer that promotes penetration of drug into the nails and / or skin, retains superior adhesion even when adhered for a long period of time and has causes little skin irritation.A nail and / or skin patch for preventing or treating mycoses, which contains an antimycotic, having an octanol / water partition coefficient in the form of a logKo / w value of 4 or more, in a dissolved state in an acrylic-based pressure-sensitive adhesive layer or silicone-based pressure-sensitive adhesive layer.

The invention relates to the field of medicinal preparations, in particular to a diclofenac sodium multi-unit sustained-release micro-pill. The diclofenac sodium multi-unit sustained-release micro-pill is formed by tabletting a diclofenac sodium sustained-release micro-pill and a filling auxiliary material, the diclofenac sodium sustained-release micro-pill is prepared by coating a drug-containing pill core with a water insoluble polymer film for drug permeation, and a water soluble polymer is also contained in the film, so that the weight of the coated polymer is increased by 10-30 percent; the filling auxiliary material is one or more of microcrystalline cellulose, corn starch, lactose, cross-linked povidone, cross-linked sodium carboxymethyl cellulose, sodium carboxymethyl starch, hydroxypropyl methylcellulose, povidone, stearic acid, magnesium stearate, colloidal silicon dioxide and talcum powder, and occupies 40-60 percent of the total pill weight. The diclofenac sodium sustained-release micro-pill can be quickly disintegrated into separate small micro-pill units in digestive fluid, and the micro-pill units can reach a 12-hour sustained release effect in a gastrointestinal tract.

The invention discloses an ultrasonic device for combined imaging and cyclic focusing transmission transdermal drug delivery. The ultrasonic device comprises an ultrasonic host and an ultrasonic transducer array integrated with imaging and treatment functions, wherein the ultrasonic transducer array is used for converting an electric signal into an acoustic signal, converting the acoustic signal into an electric signal, transmitting different ultrasonic fields and generating different receiving effects according to different signal waveforms, amplitudes and phases; and the ultrasonic host is used for driving the ultrasonic transducer array to complete transmission and receiving required by imaging and complete transmission required by transdermal drug delivery, so that ultrasonic cyclic focusing transmission is realized, and an ultrasonic focusing channel from shallow to deep is formed. According to the control method, cyclic focusing transmission is adopted, and a continuous relatively strong sound field in the vertical depth direction can be formed on a transdermal drug delivery channel, so that continuous driving force is provided for drug particles, the drug particles can reacha relatively deep subcutaneous lesion, and drug permeation is better performed.

The invention discloses a milk cow hoof-care ointment and a preparation method thereof, and belongs to the technical field of milk cow breeding. The hoof-care ointment takes a Chinese herbal medicine extract liquid and an aloe extract as main raw materials, wherein the Chinese herbal medicine extract liquid is capable of effectively killing and inhibiting infectious pathogenic bacteria of milk cow hoof diseases, promoting healing of hoof wounds, effectively preventing and treating a variety of hoof diseases and improving the milk cow autoimmunity and disease resistibility, and the aloe extract is capable of promoting drug permeation and effectively repairing cuticle and has strong adhesion property; a plant extract and plant oil capable of changing a milk cow hoof cuticle structure and promoting Chinese herbal medicines, aloe and other effective ingredients to be rapidly permeated to a skin deep layer for absorption are scientifically compounded; moreover, a natural antioxidant capable of protecting effective ingredients from oxidation and improving the physical and chemical stability of the hoof-care ointment is added; at the same time, keratinase and cutinase capable of promoting adhesion and permeation of the hoof-care ointment are added; the raw materials are subjected to decompression concentration into a paste, and finally the hoof-care ointment which can comprehensively treat various types of milk cow hoof diseases and has the advantages of firm adhesion, strong permeability and no any antibiotics and chemical toxic substances is prepared.

The invention discloses a 3D multi-layer high-flux organ chip as well as a preparation method and an application thereof, and belongs to the field of biological tissue engineering. The chip comprisesa liquid storage layer, a thin film layer and a 3D culture layer which are stacked in sequence. The method is characterized by completing bonding connection of the liquid storage layer, the thin filmlayer and the 3D culture layer by utilizing PDMS glue, and constructing a biological barrier cell layer on the thin film layer on the liquid storage layer side of the chip, and carrying out 3D cell culture in the culture micropores of the 3D culture layer of the chip to construct the biological barrier model. The chip can be used for researching interaction of two cells, angiogenesis, drug permeation, cell polarization, cell migration, drug activity evaluation and the like. Moreover, an in-vitro model and a biological barrier model which are combined with high-throughput drug screening can beconstructed, and the method is used for screening of anti-brain glioma compounds of blood-brain barriers and related research. Moreover, the liquid is convenient to operate and suitable for high flux,and external equipment is not needed. The construction method is simple and effective.

The invention discloses a dairy cow hoof care cream firm in bonding and a preparation method thereof. The dairy cow hoof care cream uses a Chinese herbal medicine preparation effectively killing and inhibiting infectious pathogenic bacteria of dairy cow hoofs, promoting hoof wound heating, effectively preventing and treating multiple hoof diseases and improving the immunity and disease resistance of dairy cows themselves and an aloe extract promoting drug permeation, effectively repairing stratum corneum and strengthening the bonding properties as main raw materials, and a plant extract and plant oil capable of changing the stratum corneum structures of the dairy cow hoofs and promoting Chinese herbal medicines, aloe and other effective ingredients to rapid penetrate into the skin for deep absorption are scientifically compounded. In addition, a natural antioxidant capable of protecting the effective ingredients of the materials against oxidization and improving the stability of the dairy cow hoof care cream is added, meanwhile keratinase and cutinase promoting the bonding and penetration of the dairy cow hoof care cream are added, reduced-pressure concentration is performed to obtain the cream, and finally the dairy cow hoof care cream capable of comprehensively treating various hoof diseases, firm in bonding, good in permeability and free of any antibiotic or chemical toxic substance is prepared.

The invention provides a preparation method of a miniature solid silicon needle. The method comprises steps of firstly, growing a layer of silicon dioxide on the surface of monocrystalline silicon; depositing a layer of silicon nitride protective film on the surface of the silicon dioxide, coating photoresist on the surface of the silicon nitride protective film, exposing, developing, etching andthe like, and the etching reaction can be accelerated in the silicon etching process by adopting silicon nitride as the protective film, so that the diameter of the base of the silicon needle is smaller. The preparation method is simple in process, the solid silicon needle is good in durability, and the solid silicon needle is suitable for transdermal drug permeation of biomacromolecule drugs.

The invention discloses cow hoof care ointment capable of improving production performance and a preparation method of the cow hoof care ointment. The hoof care ointment takes a Chinese herbal medicine extracting solution and an aloe extract as main raw materials, wherein the Chinese herbal medicine extracting solution can effectively kill and inhibit infectious pathogenic bacteria of a hoof disease of a cow, promote wound healing of hoofs, effectively prevent and treat multiple hoof diseases and improve the immunity and the disease resistibility of the cow, and the aloe extract can promote drug permeation and effectively repair cuticle and has a high cohesive property; plant extracts and plant oil which can change the cuticle structure of the hoofs of the cow and can promote Chinese herbal medicines, aloe and other effective ingredients permeate into skin to be deeply absorbed are scientifically compounded, a natural antioxidant which can protect effective ingredients of components from oxidation and improve the physicochemical stability of the hoof care ointment is added, besides, keratinase and cutinase which promote adhesion and permeation of the hoof care ointment are also added, paste is obtained through concentration under reduced pressure, and finally, the hoof care ointment which can comprehensively treat various hoof diseases, is firm in adhesion and high in permeation and doesn't contain any antibiotics and chemical toxic substances is prepared.

The invention discloses a hand nerve rehabilitation training device based on targeted regulating and controlling. The problems that an existing hand nerve rehabilitation training device is simplex infunction and poor in treatment effect are mainly solved. The rehabilitation training device comprises a glove, an inflator pump and a control device, wherein the glove matches palms in shape, is of adouble-layer airbag-type structure and has various hand nerve stimulating functions, the inflator pump matches the glove in use to inflate the glove, and the control device is used for controlling theinflator pump and the glove to work. Through the design, part of the shape of the glove in the hand nerve rehabilitation training device is integrated, but internal finger parts, a palm part and a hand back part are mutually independent, through the double-layer airbag-type structure, electric heating wires, drug permeation packages and electric therapeutic apparatus, pressure stimulation, drug stimulation, temperature stimulation and current stimulation of hands are achieved, thus the different parts such as fingers, the palm and the hand back are independently controlled to accept differentstimulation intensity and stimulation modes, the therapeutic effect is improved, and thus the hand nerve rehabilitation training device has high using value and promotion value.

Provided in the present invention is a pharmaceutic osmotic pump preparation comprising a tablet core, wherein the tablet core contains drugs (or pharmaceutically active ingredients) and materials forming a chamber structure; and a coating film coating the tablet core where a drug release hole is set; wherein when the pharmaceutic osmotic pump preparation releases drugs in water or an aqueous medium, the materials forming the chamber structure lead to the formation of a superfine chamber structure in the coating film, and the total volume of the superfine chamber structure Vb gradually increases over the releasing time, but the releasing rate R (or release amount A) of the pharmaceutically active ingredients is proportional to Vb. The osmotic pump preparation of the present invention is suitable for water-soluble drugs and water-insoluble drugs, and especially is suitable for the controlled release of low solubility drugs or pH dependent drugs.

The invention relates to an anti-candida-albicans composition containing streptocin and a preparation method thereof and belongs to the technical field of microbial pharmacy. In order to solve the problems that a biomembrane formed by candida albicans blocks drug permeation and reduces the medicinal effect, the anti-candida-albicans composition containing streptocin comprises medicinal componentsincluding streptocin, short collagen peptides, vitamins, menthol, borneol and xylitol. The composition is a viscous gel dressing and can be pasted to an affected mucous part for a long time to enablemore medicinal components to permeate through the biomembrane of candida albicans to take a medicinal effect, and therefore the problem of short acting time of existing dosage forms is solved. Streptocin is uniformly dispersed in the viscous gel dressing in the form of nano-scale liposome and more easily permeate through the biomembrane to directly act on candida albicans thalli, the medicinal effect is more thoroughly exerted, and the effects of reducing the adhesion of candida albicans and inhibiting and killing candida albicans can be rapidly achieved.

The invention provides a docetaxel-resveratrol co-loaded nano long-circulating liposome as well as a preparation method and application thereof, and belongs to the technical field of medicament preparation. The nano long-circulating liposome comprises a medicinal active component and a lipid membrane material, wherein the medicinal active component comprises docetaxel and resveratrol; and the lipid membrane material comprises soya bean lecithin, cholesterol and DSPE-PEG2000. It verifies for the first time that a combination of the traditional Chinese medicine resveratrol with anti-tumor activity and the docetaxel has a relatively strong synergistic anti-tumor effect when acting on human prostate cancer cells and human lung cancer cells; meanwhile, the docetaxel and the resveratrol are prepared into the nano long-circulating liposome, the solubility of the nano long-circulating liposome is effectively improved, and meanwhile, the drug permeation and retention effects can be improved; the side effects of the docetaxel are reduced on the basis of enhancing the anti-tumor activity of the docetaxel; and a foundation is laid for development and research of a novel docetaxel nano preparation.

The invention discloses an ultrasonic circulating focusing emission transdermal drug delivery device and a control method. The device comprises an ultrasonic host and a transducer array, wherein the ultrasonic host controls the transducer array to emit ultrasonic waves, and the focusing mode of the transducer array is realized through phase modulation. The control method comprises the steps of automatically performing circulating focusing emission and automatically moving drug delivery emission sound beams one by one. By adopting the circulating focusing emission, a continuous stronger sound field in the vertical depth direction can be formed on a transdermal drug delivery passage, so that continuous driving force is provided for drug particles, the drug particles can favorably reach a deeper subcutaneous focus, and the drug permeation can be better performed.

Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

The invention provides a nucleic acid drug carrier with mucus permeation and a preparation method and application thereof. The nucleic acid drug carrier comprises a nucleic acid drug delivery inner core and a functionalization modification shell, the functionalization modification shell is a dopamine modified hyaluronic acid polymer, and the nucleic acid drug carrier has good mucus permeation capacity. The preparation method comprises the following steps: condensing a nucleic acid drug through a cationic polymer to form an inner core, and wrapping the inner core with a dopamine-modified hyaluronic acid polymer under physical interaction force to obtain the multifunctional nucleic acid drug nano-delivery carrier. According to the nano drug delivery carrier disclosed by the invention, the drug-carrying core is functionalized through a shell wrapping strategy, the mucus permeation ability of a nucleic acid drug is remarkably enhanced, target cell targeted delivery is realized, the nano drug delivery carrier can be used for gene therapy of lung diseases, and a new direction is provided for targeted therapy of the drug permeation mucus.

The invention discloses a drug target recognition method for depression and drug addiction diseases. The method comprises the following steps: taking a plurality of to-be-detected drug group samples, taking a plurality of groups of effective cell samples for dyeing respectively, including enzyme, ion channels, gene loci, receptors and nucleic acid inside cells, after fully fusing different to-be-detected drug groups with multiple groups of effective cells for 30 min, adding lithium chloride with different concentrations, detecting a drug permeation concentration curve once every 30 min, carrying out cell activity analysis in the state that lithium salts with different concentrations are fused, and considering an experimental group with the longest drug effect and the stable cell activity to be the optimal concentration of lithium chloride for addiction treatment; According to the present invention, the detected position of the drug target A is re-separated and re-extracted to obtain the drug target in the pollution-free state, and the new anti-depression drug A is searched according to the specific components of the drug target.

The invention relates to a novel fingerstall for beauty. The novel fingerstall comprises a fingerstall body matched in shape with a finger, wherein a finger hole for the finger to be inserted is formed in the fingerstall body; a drug permeation preventing layer is arranged on the outer surface of the fingerstall body and composed of a polyethylene or polyvinylidene chloride material; the wall of the finger hole is composed of an elastic material layer; and a first semispherical bulge protruding out of the wall is arranged on the wall of the finger hole. According to the fingerstall, the decomposition and volatilization of active components can be effectively relieved, the utilization rates of a repair liquid and a rehabilitation liquid can be increased, and the costs of scar repair and beauty can be reduced.

The invention relates to a freckle-removing therapeutic instrument. A coupling agent box and an anesthetic box are installed on an operation pen, and a drug permeation head and a constant-temperature heating piece are installed at the lower end of the anesthetic box. By installing the coupling agent box and the anesthetic box on the operation pen, topical anesthetic is added to the anesthetic box, drug is applied to the skin through the drug permeation head, the constant-temperature heating piece performs heating through massage to make the drug quickly permeate into the skin, coupling agent is applied to the skin through a coupling agent outlet, and then, an electrode therapeutic head is started to perform therapy, thus achieving the purpose of painless therapy.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a gemma agrimoninae suppository and a preparation method thereof. The gemma agrimoninae suppository is prepared by taking gemma agrimoninae fluid extract as a main medicine component and hydroxypropyl methyl cellulose as a penetration enhancer. The gemma agrimoninae suppository is prepared from gemma agrimoninae fluid extract, hydroxypropyl methyl cellulose, glycerol, gelatin and a preservative, and the weight percentage of the gemma agrimoninae fluid extract to the gemma agrimoninae suppository is as follows: 5.0%-5.5% of the gemma agrimoninae fluid extract, 0.5%-2.5% of the hydroxypropyl methyl cellulose, 60%-70% of the glycerol, 20%-30% of the gelatin, 0.075%-0.1% of the preservative and the balance of water. The weight ratio of the gemma agrimoninae fluid extract to the hydroxypropyl methyl cellulose is 10: (0.5-5). The hydroxypropyl methyl cellulose is one or more selected from the group consisting of HPMC-E5, HPMC-E50, HPMC-K4M, HPMC-K15M and HPMC-K100LV, and the hydroxypropyl methyl cellulose is one or more selected from the group consisting of HPMC-E5, HPMC-E50, HPMC-K4M, HPMC-K15M and HPMC-K100LV. The gemma agrimoninae suppository has the advantages of simple formula, simple preparation process, stable drug release speed, no release degree reduction caused by crystal precipitation after drug release, facilitation of drug permeation, and full play of the curative effect of the drug.