44 results about "Drug permeation" patented technology

The present invention provides an optical device/method for enhancing local administration of pharmaceutical compounds and/or collection of biomaterials. Such device/method is used for various situations which require high concentrations of drugs that are delivered locally.

The present invention provides a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule (10) according to the present invention includes a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion. The ampoule (10) is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability. That is, the parison is extruded from a multilayer blow forming die, and then held between lower split mold pieces to be formed into the container body (11). After a drug solution (15) is filled in the container body (11), the mouth (12) is held between upper split mold pieces to form the fusion-bonded portion (13) and the holder tab (14). Thus, the plastic ampoule is provided.

By providing a non-liquid drug reservoir layer 2 having first and second principal surfaces and containing a drug and a polymer that is to be a base, a drug permeation layer 4 disposed at the first principal surface side of the drug reservoir layer 2 and being lower in permeability of the drug than the drug reservoir layer 2, and a first backing 3 with a bending resistance of 10 to 80 mm that is formed so as to cover a side surface of the drug reservoir layer, skin irritation can be reduced.

The invention provides a non-steroid anti-inflammatory drug microemulsion-based gel patch with good stability and good permeation promotion effect. The patch contains a non-steroid anti-inflammatory drug microemulsion, a polymer gel skeleton, a cross-linking agent, a tackifier, a humectant, a filler and other pharmaceutically acceptable excipients. The non-steroid anti-inflammatory drug microemulsion contains a non-steroid anti-inflammatory drug, an emulsifier, a co-emulsifier, an oil phase and pharmaceutically acceptable excipients. According to the invention, the oil phase, the emulsifier and the co-emulsifier used for preparing the microemulsion can be used as drug permeation promoters at the same time and are cooperated with the microemulsion to promote percutaneous permeability of the drug, so the percutaneous permeability of the drug is effectively improved; thus, the residual quantity of the drug in the patch is reduced and the utilization degree of the drug is improved.

A device and method for administering a consistent and steady dosage of Metformin to patients which includes an implantation component with a composition of Metformin adapted to be inserted either subdermally or subcutaneously to administer a steady incremental dosage of Metformin to the patient throughout a predetermined period of time. A Metformin drug suspension is dispersed in a plurality of microreservoirs and the mixture of microreservoirs and placed in a silicone polymer tube for in situ polymerization and molding, which would allow Metformin molecules to initially diffuse through the microreservoir membrane and then through the silicone polymer containing membrane. In a further embodiment, Metformin implants may be formed by dispersing the drug in a copolymer matrix, which is then coated with a copolymer that serves as a rate-controlling membrane. The drug permeation through the polymer membrane occurs at a rate that is slower than that through the polymer matrix.

A nail and/or skin patch for preventing or treating mycoses is provided that is able to maintain a drug concentration in the nails and/or skin horny layer at a high concentration for a long period of time without adding a dissolving agent that prevents precipitation of drug crystals or permeation enhancer that promotes penetration of drug into the nails and/or skin, retains superior adhesion even when adhered for a long period of time and has causes little skin irritation.

A nail and/or skin patch for preventing or treating mycoses, which contains an antimycotic, having an octanol/water partition coefficient in the form of a logKo/w value of 4 or more, in a dissolved state in an acrylic-based pressure-sensitive adhesive layer or silicone-based pressure-sensitive adhesive layer.

The invention discloses an ultrasonic device for combined imaging and cyclic focusing transmission transdermal drug delivery. The ultrasonic device comprises an ultrasonic host and an ultrasonic transducer array integrated with imaging and treatment functions, wherein the ultrasonic transducer array is used for converting an electric signal into an acoustic signal, converting the acoustic signal into an electric signal, transmitting different ultrasonic fields and generating different receiving effects according to different signal waveforms, amplitudes and phases; and the ultrasonic host is used for driving the ultrasonic transducer array to complete transmission and receiving required by imaging and complete transmission required by transdermal drug delivery, so that ultrasonic cyclic focusing transmission is realized, and an ultrasonic focusing channel from shallow to deep is formed. According to the control method, cyclic focusing transmission is adopted, and a continuous relatively strong sound field in the vertical depth direction can be formed on a transdermal drug delivery channel, so that continuous driving force is provided for drug particles, the drug particles can reacha relatively deep subcutaneous lesion, and drug permeation is better performed.

The invention discloses a 3D multi-layer high-flux organ chip as well as a preparation method and an application thereof, and belongs to the field of biological tissue engineering. The chip comprisesa liquid storage layer, a thin film layer and a 3D culture layer which are stacked in sequence. The method is characterized by completing bonding connection of the liquid storage layer, the thin filmlayer and the 3D culture layer by utilizing PDMS glue, and constructing a biological barrier cell layer on the thin film layer on the liquid storage layer side of the chip, and carrying out 3D cell culture in the culture micropores of the 3D culture layer of the chip to construct the biological barrier model. The chip can be used for researching interaction of two cells, angiogenesis, drug permeation, cell polarization, cell migration, drug activity evaluation and the like. Moreover, an in-vitro model and a biological barrier model which are combined with high-throughput drug screening can beconstructed, and the method is used for screening of anti-brain glioma compounds of blood-brain barriers and related research. Moreover, the liquid is convenient to operate and suitable for high flux,and external equipment is not needed. The construction method is simple and effective.

The invention discloses a dairy cow hoof care cream firm in bonding and a preparation method thereof. The dairy cow hoof care cream uses a Chinese herbal medicine preparation effectively killing and inhibiting infectious pathogenic bacteria of dairy cow hoofs, promoting hoof wound heating, effectively preventing and treating multiple hoof diseases and improving the immunity and disease resistance of dairy cows themselves and an aloe extract promoting drug permeation, effectively repairing stratum corneum and strengthening the bonding properties as main raw materials, and a plant extract and plant oil capable of changing the stratum corneum structures of the dairy cow hoofs and promoting Chinese herbal medicines, aloe and other effective ingredients to rapid penetrate into the skin for deep absorption are scientifically compounded. In addition, a natural antioxidant capable of protecting the effective ingredients of the materials against oxidization and improving the stability of the dairy cow hoof care cream is added, meanwhile keratinase and cutinase promoting the bonding and penetration of the dairy cow hoof care cream are added, reduced-pressure concentration is performed to obtain the cream, and finally the dairy cow hoof care cream capable of comprehensively treating various hoof diseases, firm in bonding, good in permeability and free of any antibiotic or chemical toxic substance is prepared.

The invention discloses cow hoof care ointment capable of improving production performance and a preparation method of the cow hoof care ointment. The hoof care ointment takes a Chinese herbal medicine extracting solution and an aloe extract as main raw materials, wherein the Chinese herbal medicine extracting solution can effectively kill and inhibit infectious pathogenic bacteria of a hoof disease of a cow, promote wound healing of hoofs, effectively prevent and treat multiple hoof diseases and improve the immunity and the disease resistibility of the cow, and the aloe extract can promote drug permeation and effectively repair cuticle and has a high cohesive property; plant extracts and plant oil which can change the cuticle structure of the hoofs of the cow and can promote Chinese herbal medicines, aloe and other effective ingredients permeate into skin to be deeply absorbed are scientifically compounded, a natural antioxidant which can protect effective ingredients of components from oxidation and improve the physicochemical stability of the hoof care ointment is added, besides, keratinase and cutinase which promote adhesion and permeation of the hoof care ointment are also added, paste is obtained through concentration under reduced pressure, and finally, the hoof care ointment which can comprehensively treat various hoof diseases, is firm in adhesion and high in permeation and doesn't contain any antibiotics and chemical toxic substances is prepared.

Provided in the present invention is a pharmaceutic osmotic pump preparation comprising a tablet core, wherein the tablet core contains drugs (or pharmaceutically active ingredients) and materials forming a chamber structure; and a coating film coating the tablet core where a drug release hole is set; wherein when the pharmaceutic osmotic pump preparation releases drugs in water or an aqueous medium, the materials forming the chamber structure lead to the formation of a superfine chamber structure in the coating film, and the total volume of the superfine chamber structure Vb gradually increases over the releasing time, but the releasing rate R (or release amount A) of the pharmaceutically active ingredients is proportional to Vb. The osmotic pump preparation of the present invention is suitable for water-soluble drugs and water-insoluble drugs, and especially is suitable for the controlled release of low solubility drugs or pH dependent drugs.

The invention provides a docetaxel-resveratrol co-loaded nano long-circulating liposome as well as a preparation method and application thereof, and belongs to the technical field of medicament preparation. The nano long-circulating liposome comprises a medicinal active component and a lipid membrane material, wherein the medicinal active component comprises docetaxel and resveratrol; and the lipid membrane material comprises soya bean lecithin, cholesterol and DSPE-PEG2000. It verifies for the first time that a combination of the traditional Chinese medicine resveratrol with anti-tumor activity and the docetaxel has a relatively strong synergistic anti-tumor effect when acting on human prostate cancer cells and human lung cancer cells; meanwhile, the docetaxel and the resveratrol are prepared into the nano long-circulating liposome, the solubility of the nano long-circulating liposome is effectively improved, and meanwhile, the drug permeation and retention effects can be improved; the side effects of the docetaxel are reduced on the basis of enhancing the anti-tumor activity of the docetaxel; and a foundation is laid for development and research of a novel docetaxel nano preparation.

The invention discloses an ultrasonic circulating focusing emission transdermal drug delivery device and a control method. The device comprises an ultrasonic host and a transducer array, wherein the ultrasonic host controls the transducer array to emit ultrasonic waves, and the focusing mode of the transducer array is realized through phase modulation. The control method comprises the steps of automatically performing circulating focusing emission and automatically moving drug delivery emission sound beams one by one. By adopting the circulating focusing emission, a continuous stronger sound field in the vertical depth direction can be formed on a transdermal drug delivery passage, so that continuous driving force is provided for drug particles, the drug particles can favorably reach a deeper subcutaneous focus, and the drug permeation can be better performed.

Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

The invention provides a nucleic acid drug carrier with mucus permeation and a preparation method and application thereof. The nucleic acid drug carrier comprises a nucleic acid drug delivery inner core and a functionalization modification shell, the functionalization modification shell is a dopamine modified hyaluronic acid polymer, and the nucleic acid drug carrier has good mucus permeation capacity. The preparation method comprises the following steps: condensing a nucleic acid drug through a cationic polymer to form an inner core, and wrapping the inner core with a dopamine-modified hyaluronic acid polymer under physical interaction force to obtain the multifunctional nucleic acid drug nano-delivery carrier. According to the nano drug delivery carrier disclosed by the invention, the drug-carrying core is functionalized through a shell wrapping strategy, the mucus permeation ability of a nucleic acid drug is remarkably enhanced, target cell targeted delivery is realized, the nano drug delivery carrier can be used for gene therapy of lung diseases, and a new direction is provided for targeted therapy of the drug permeation mucus.

The invention discloses a drug target recognition method for depression and drug addiction diseases. The method comprises the following steps: taking a plurality of to-be-detected drug group samples, taking a plurality of groups of effective cell samples for dyeing respectively, including enzyme, ion channels, gene loci, receptors and nucleic acid inside cells, after fully fusing different to-be-detected drug groups with multiple groups of effective cells for 30 min, adding lithium chloride with different concentrations, detecting a drug permeation concentration curve once every 30 min, carrying out cell activity analysis in the state that lithium salts with different concentrations are fused, and considering an experimental group with the longest drug effect and the stable cell activity to be the optimal concentration of lithium chloride for addiction treatment; According to the present invention, the detected position of the drug target A is re-separated and re-extracted to obtain the drug target in the pollution-free state, and the new anti-depression drug A is searched according to the specific components of the drug target.

The invention relates to a novel fingerstall for beauty. The novel fingerstall comprises a fingerstall body matched in shape with a finger, wherein a finger hole for the finger to be inserted is formed in the fingerstall body; a drug permeation preventing layer is arranged on the outer surface of the fingerstall body and composed of a polyethylene or polyvinylidene chloride material; the wall of the finger hole is composed of an elastic material layer; and a first semispherical bulge protruding out of the wall is arranged on the wall of the finger hole. According to the fingerstall, the decomposition and volatilization of active components can be effectively relieved, the utilization rates of a repair liquid and a rehabilitation liquid can be increased, and the costs of scar repair and beauty can be reduced.

The invention relates to a freckle-removing therapeutic instrument. A coupling agent box and an anesthetic box are installed on an operation pen, and a drug permeation head and a constant-temperature heating piece are installed at the lower end of the anesthetic box. By installing the coupling agent box and the anesthetic box on the operation pen, topical anesthetic is added to the anesthetic box, drug is applied to the skin through the drug permeation head, the constant-temperature heating piece performs heating through massage to make the drug quickly permeate into the skin, coupling agent is applied to the skin through a coupling agent outlet, and then, an electrode therapeutic head is started to perform therapy, thus achieving the purpose of painless therapy.