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55results about How to "Long degradation cycle" patented technology
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Mussel mucoprotein gel for repairing and reliving itching and preparation method of mussel mucoprotein gel
InactiveCN104645313ANo stimulationGood bioadhesionPeptide/protein ingredientsAerosol deliveryBiocompatibility TestingWound surface
The invention discloses a mussel mucoprotein gel for repairing and reliving itching. The mussel mucoprotein gel is prepared from the following components in percentage by weight: 0.15%-0.2% of mussel mucoprotein, 0.5%-2% of a macromolecule host material, 3%-10% of a humectant, 1%-5% of a surfactant, 0.1%-0.5% of a preservative, 1%-2% of a protein protectant, 0.5%-3% of a stabilizer, 0.5%-1% of a bacteriostatic agent, 0.8%-5.2% of a pH modifier and the balance of purified water. The mussel mucoprotein gel has good biological adhesion, is rapidly and effectively adhered to a wound surface, is capable of rapidly reliving itching and easing pain, and has the advantages of being low in immunogenicity, good in biocompatibility with a human body, convenient to use, free of thrill to skin, safe, nontoxic and free of bad reaction.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Degradable bio-based seedling raising pot, production method thereof, regulation method in degradation period and application of degradable bio-based seedling raising pot
InactiveCN105613100AImprove liquidityImprove gelatinizationCultivating equipmentsRoot systemAdhesive
The invention discloses a degradable bio-based seedling raising pot, a production method thereof, a regulation method in a degradation period and an application of the degradable bio-based seedling raising pot. The degradable bio-based seedling raising pot is produced from straw powder, wheat bran and an adhesive through dry-method hot pressing after mixing. The degradable bio-based seedling raising pot can keep certain strength in a seedling raising process and is relatively complete in appearance, after seedlings and the pot are transplanted to a field simultaneously, the pot can crack and disintegrate rapidly, and plant root extension is facilitated.
Owner:CHINESE ACAD OF AGRI MECHANIZATION SCI
Nerve conduit and preparation method thereof
ActiveCN106668938AHigh mechanical strengthGood flexibilityFilament/thread formingTissue regenerationPolymer scienceOrganic solvent
The invention provides a nerve conduit and a preparation method thereof, and belongs to the field of neurosurgery. The preparation method comprises the following steps: dissolving a polymer material in an organic solvent, performing sedimentation and bubble removal to obtain a polymer solution, preparing a pipe from the polymer solution, and performing drying, wherein the polymer material has lactic acid monomer content of 45 to 65 molar percent, glycolic acid monomer content of 5 to 20 molar percent and caprolactone monomer content of 30 to 45 molar percent. The method is simple in process, convenient to operate and high in accuracy controllability, and the processing is easy; the nerve conduit prepared by the method is strong in mechanical strength, high in flexibility and long in degradation period, and can be well applied to regeneration and repair of injured nerves.
Owner:SAIKE SAISI BIOTECH CO LTD
Extraction method of collagen fiber
InactiveCN105177094AComplete triple helixBiologically activeMonocomponent protein artificial filamentFermentationMucosal tissueDrug biological activity
The invention provides an extraction method of collagen fiber. Through selection of the optimum technological steps and conditions, the collagen fiber is extracted from animal achilles tendon and is sterilized by being soaked in alkaline water and an acid solution, impure protein is removed through trypsin processing, and the collagen fiber which has higher purity, doesn't have viruses and has a larger fiber diameter is obtained. The extracted collagen fiber has excellent biological characteristics of better biological activity and the like and can be applied to the fields of cosmetics and biological materials, for example, researches of a hemostatic material and artificial skin and tissue filler such as cartilage, mucosal tissue, bone tissue and the like.
Owner:MICONVEY TECH CO LTD
Face filling agent composition for injection type cosmetic plastic surgery and preparation method of face filling agent composition
ActiveCN111249189AFully biodegradable withWide variety of sourcesCosmetic preparationsToilet preparationsCelluloseSkin repair
The invention discloses a face filling agent composition for injection type cosmetic plastic surgery and a preparation method of the face filling agent composition, relates to a ace filling agent composition for cosmetic plastic surgery and a preparation method of the face filling agent composition, and aims to solve the problems that conventional cross-linked hyaluronic acid is poor in cross-linking effect, a user has red and swelling inflammation, potential safety hazards can be caused, not only is a skin repairing effect not achieved, but also vascular thrombosis can be possibly caused. Theface filling agent composition for injection type cosmetic plastic surgery comprises a cross-linked hyaluronic acid composite gel, hydroxyapatite micro particles, collagen powder, cellulose ethers, an epimedium herb extract, a white peony root extract and an injection aqueous solution. The method comprises the following steps: I, weighing materials; and II, performing mixing and sterilization. The face filling agent composition for injection type cosmetic plastic surgery, which is prepared by the invention, has a use mode of being injected into dermis of a part to be filled, of a face. The invention obtains the face filling agent composition for injection type cosmetic plastic surgery.
Owner:陈勇
Metal organic framework/electrospinning fiber composite having NO and copper ion slow release synergistic reactions, and preparation method and application
The invention belongs to the field of biomaterials, and particularly relates to a metal organic framework / electrospinning fiber composite having NO and copper ion slow release synergistic reactions, and a preparation method and application. According to the material, a patterning structure is formed through mutual interweaving of fibers having a core shell structure, hydrophobic biomaterials are used as a core layer of the core shell fibers, hydrophilic biomaterials are used as a shell layer of the core shell fibers, and NO loaded copper bases MOF coat the core layer. The preparation method comprises the steps of using a patterned receiving template, dispersing the NO loaded copper bases MOF, enabling an organic solvent in which the hydrophobic biomaterials dissolve to communicate with aninternal needle of a coaxial electrostatic spray head, enabling an organic solvent in which the hydrophilic biomaterials dissolve to communicate with an external needle of the coaxial electrostatic spray head, and preparing the metal organic framework / electrospinning fiber composite through coaxial electrostatic spinning. In order to solve the problems that the wound healing rate of diabetes is low and angiogenesis is insufficient, the material slowly release NO and copper ions, and the NO and the copper ions are in synergistic reactions to jointly promote angiogenesis, collagen deposition, reduction of inflammatory reactions and the like in wound healing, so that the healing period of the wound of the diabetes is greatly shortened.
Owner:SHANGHAI NORMAL UNIVERSITY
Corium tissue bionic sponge preparation method
ActiveCN105031729AImprove microstructureSlow down the rate of biodegradationProsthesisProtein solutionWater vapor
The invention discloses a corium tissue bionic sponge preparation method. The mass percent of silk protein in a corium tissue bionic sponge is 10%-95%, the mass percent of collagen is 5%-90%, a silk protein solution and a collagen solution are mixed and steamed through steam to form a film, then the film is soaked in a mixed aqueous solution of 1-(3-dimethylamino propyl)-3-ethyl-carbodiimide hydrochloride and N-hydroxy succinimide, and the corium tissue bionic sponge is prepared through the drying process and other processes. The corium tissue bionic sponge has the corium tissue bionic performance in the aspect of microstructure, mechanical property and molecular structure, can easily improve the performance of inhibiting scar formation and promoting functional corium tissue regeneration, and provides a new method for solving the problem of pathologic scars.
Owner:WUXI NO 3 PEOPLES HOSPITAL
Absorbable medical suture line with good mechanical performance
ActiveCN105079869AImprove mechanical propertiesHigh strengthSuture equipmentsLactidePolyethylene glycol
The invention discloses an absorbable medical suture line with good mechanical performance. The absorbable medical suture line comprises, by weight, 100-120 parts of modified polylactic acid, 20-40 parts of polyglycollide, 4-6 parts of sorbitol, 3-5 parts of methyl methacrylate and 5-6 parts of cassia oil. The preparation method of the modified polylactic acid includes: in ice-bath, adding chitosan into perchloric acid, well mixing, dripping sorbic acid chloride, stirring, cooling, preserving heat and purifying to obtain modified chitosan; taking polyethylene glycol, feeding inert gas, heating, preserving heat until the polyethylene glycol melt, adding stannous chloride and lactide, well mixing, heating, preserving heat and stirring, and purifying to obtain intermediate material; dissolving the modified chitosan in mixed solvent, adding triethylamine, well mixing, heating, refluxing, adding the intermediate material, well mixing, continuing refluxing, purifying and drying to obtain the modified polylactic acid.
Owner:安徽省康宁医疗用品有限公司
Mechanically enhanced gelatin chilled hydrogel as well as preparation method and application thereof
The invention discloses mechanically enhanced gelatin frozen hydrogel as well as a preparation method and application thereof. The method comprises the following steps: compounding methylacryloylated gelatin and a glycidyl acrylate modified silk fibroin solution, adding an ammonium persulfate / tetramethylethylenediamine initiator solution to realize free radical crosslinking at low temperature, and inducing an SF-GMA molecular chain to form a hydrophobic crystal (beta-sheet structure) by post-treatment of a methanol solution to obtain the frozen hydrogel. The frozen hydrogel has a through macroporous structure of about 200 [mu]m under a swelling equilibrium condition, the compression modulus of the frozen hydrogel can be enhanced from 0.057 Mpa to 0.523 Mpa, the degradation period of the frozen hydrogel in an environment containing type II collagenase is prolonged from 7 days to 28 days, the degradation residue is 60%, and the frozen hydrogel has good biocompatibility. The method provided by the invention is simple in preparation process, effectively enhances the performance of the jelly, and has a good application prospect in the fields of drug delivery, tissue repair and the like.
Owner:SOUTH CHINA UNIV OF TECH
Collagen gel and preparation method thereof
ActiveCN107261207ALong duration of actionReduce frequency of usePharmaceutical delivery mechanismProsthesisMicrosphereMedicine
The invention discloses collagen gel and a preparation method thereof. The collagen gel is prepared from the following raw materials: 20 to 80 percent of collagen solution, 80 to 20 percent of PCL microspheres, and 0 to 1 percent of lidocaine. The collagen gel of the invention adopts the raw materials which can be completely degraded and can be completely absorbed by the human body after the collagen gel is implanted in the human body; and moreover, the degradation period of the PCL is relatively long and can reach up to 2 years, so that the lasting time of the effect of the collagen gel is long, and the application frequency of the collagen gel is reduced.
Owner:GUANGZHOU YICHENG BIOTECH CO LTD
Modified superfine rice hull powder reinforced PBAT full-degradable agricultural mulching film material and preparation method thereof
InactiveCN113025003AGood compatibilityReduce processing costsClimate change adaptationPlant protective coveringsBlow moldingAgricultural engineering
The invention discloses a modified superfine rice hull powder reinforced PBAT full-degradable agricultural mulching film material and a preparation method thereof. The prepared superfine modified rice hull powder is simple in manufacturing process, free of pollution, low in processing cost and good in dispersity, the rice hull powder and a PBAT matrix have better compatibility, the prepared rice hull powder / PBAT fully-degradable mulching film material has good appearance, film-forming performance, mechanical performance and other comprehensive performance, and by adjusting the formula, the degradation period of the film material can be regulated and controlled within a certain range so as to meet the requirements of different weather conditions and different crop growth periods, the film is prepared from the material through extrusion blow molding, and the prepared film can meet the national standard requirements of full-biodegradable agricultural ground covering films. The application range of the rice hull powder / PBAT composite material in the field of film products is widened, and more choices are provided for application and development of degradable mulching film materials.
Owner:GUIZHOU MATERIAL IND TECH INSTITUE
Degradable mulching film for vegetable cultivation in plateau regions and preparation method and application of mulching film
ActiveCN110117413AWill not polluteImprove stabilityCultivating equipmentsPlant protective coveringsAntioxidantUltraviolet lights
The invention relates to a degradable mulching film for vegetable cultivation in plateau regions and a preparation method and application of the mulching film. The mulching film is prepared from PBAT,polylactic acid, a compatilizer, inorganic filler, an antioxidant, a supported-type ultraviolet light absorber and an ultraviolet light reflection agent. According to the mulching film, the adopted PBAT and polylactic acid are completely biodegradable materials, can be completely degraded into carbon dioxide and water and cannot pollute the environment. Graphene oxide with certain uvioresistant performance is used as a carrier for supporting a traditional ultraviolet light absorber, the defects are overcome that the traditional ultraviolet light absorber is low in thermal stability, easily migrates, is easily decomposed, is poor in compatibility with the PBAT and the like, the anti-aging performance of the composite material is improved, and the degradation period of the composite material is prolonged; meanwhile, addition of the graphene oxide strengthens the mechanical property of the composite material. The mulching film has both properties, namely, a good mechanical property and an anti-aging property and is good in development prospect.
Owner:LANZHOU XINYINHUAN RUBBER & PLASTIC PROD CO LTD +1
Absorbable plugging device
ActiveCN106491240ALong degradation cycleReduce release concentrationSurgeryProsthesisMacromoleculeMesh grid
The invention discloses an absorbable plugging device which comprises a mesh grid. The mesh grid includes a degradable macromolecule silk. The polydispersity index of the degradable macromolecule silk material is 3 to 10. A range of weight-average molecular weight is 20,000 D a to 800,000 D a. The absorbable plugging device is capable of avoiding a serious organization inflammatory reaction caused by the centralized release within a certain period of time of the degradation product of the degradable macromolecule silk, forming the mesh grid.
Owner:LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
Composition gel and applications
InactiveCN107693844ALong degradation cycleImprove stabilityNervous disorderAerosol deliveryBiologyRegenerative medicine
The invention relates to composition gel and applications, belonging to the field of regenerative medicine and biological medicine. The composition gel is mainly composed of biodegradable material geland stem cells. The composition gel provided by the invention has the advantages that the degradation period is permanent, the stability is good, and the source of stem cell raw materials is wide.
Owner:李媚
Hyaluronic acid injection
PendingCN112294668AImprove water retentionSoft textureCosmetic preparationsToilet preparationsHyaluronate InjectionCollagenan
The present invention provides a hyaluronic acid injection, which comprises hyaluronic acid or sodium hyaluronate, amino acids, propylene glycol, vitamins and minerals. According to the hyaluronic acid injection, regeneration and reconstruction of collagen in a body are filled and promoted, so that the skin problems of dryness, fine wrinkles and aging are improved.
Owner:西安博和医疗科技有限公司
Water and soil conservation type degradable liquid mulching film and preparation and application thereof
ActiveCN105199743AHigh tensile strengthImprove water retentionOther chemical processesClimate change adaptationPolyvinyl alcoholBalance water
The invention belongs to the field of agriculture and forestry application, and particularly relates to a water and soil conservation type degradable liquid mulching film and preparation and application thereof. The water and soil conservation type degradable liquid mulching film is specifically prepared from, by weight, 14%-16% of polyvinyl alcohol, 2%-4% of silica sol, 3%-10% of calcium lignosulphonate, 3%-5% of cross-linking agents, 1%-2% of defoaming agents, 1%-3% of soluble starch, 4%-5% of Twain (80), 1%-3% of glycerin, 1%-2% of blade dye and the balance water. According to the mulching film, the defects that an existing liquid mulching film on the market is poor in film-forming property and tensile strength, high in moisture permeability, prone to being damaged after being formed on the soil surface and unobvious in spraying effect are overcome; a liquid mulching film stock solution is diluted with water, fully stirred and then sprayed on the soil surface of planted land, the nanometer materials of the solution can effectively fill the binding positions of macromolecular hydrophilic groups and active sites on soil particles, and the surface-layer soil particles are bonded on the soil surface to form a black dense special soil film structure.
Owner:浙江敏轩农业科技有限公司
Hyaluronic acid injection and preparation method thereof
InactiveCN110638676AImprove water retentionSoft textureCosmetic preparationsToilet preparationsWrinkle skinHyaluronate Injection
The invention provides a hyaluronic acid injection and a preparation method thereof. The hyaluronic acid injection is prepared from the following components in percentage by mass: 0.1-1.5% of hyaluronic acid, 0.01-1% of amino acid, 0.1-2% of mannitol and 0.05-0.8% of minerals. The prepared hyaluronic acid injection can supplement the hyaluronic acid in the extracellular matrix of skin and improvethe own collagen synthesis ability of the skin, so that wrinkled skin is restored to be smooth and elastic. The hyaluronic acid injection is safe in ingredients, the preparation method is simple, thecost is low, and the hyaluronic acid injection is suitable for industrialization.
Owner:西安博和医疗科技有限公司
Tissue-guided regenerated collagen membrane and preparation method thereof
The invention relates to a tissue-guided regenerated collagen membrane and a preparation method thereof. The preparation method comprises the following steps: swelling type I collagen in an acetic acid solution, adding chondroitin sulfate sodium, and uniformly stirring to obtain collagen-chondroitin sulfate sodium slurry; drying the collagen-chondroitin sulfate sodium slurry to obtain a dried membrane; mixing the dried diaphragm with a crosslinking solution, and carrying out a crosslinking reaction to obtain a crosslinked collagen diaphragm after the crosslinking reaction is completed; and cleaning the cross-linked collagen membrane, carrying out secondary drying, and performing pressing after the secondary drying is completed. The preparation method comprises the following steps: firstly, swelling high-concentration I-type collagen in an acetic acid solution, adding sodium chondroitin sulfate, stirring, and then drying, cross-linking and secondarily drying, so that the obtained tissue-guided regenerated collagen membrane has excellent mechanical properties, and the pore size and porosity are beneficial to cell growth and repair; in addition, the degradation period is long, and sensitization is not prone to occurring; and the comprehensive effect is comprehensive, and the applicability is wide.
Owner:TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
Preparation method of absorbable medical suture with good tensile strength
ActiveCN105063799AImprove hydrophilicityGood compatibilitySuture equipmentsConjugated synthetic polymer artificial filamentsLactideDissolution
The invention discloses a preparation method of an absorbable medical suture with good tensile strength. Inert gas is fed into ethylene glycol monomethyl ether, the ethylene glycol monomethyl ether is heated, the temperature is kept until the ethylene glycol monomethyl ether is molten, zinc lactate and lactide are added, the mixture is evenly mixed, heated, kept at the temperature, stirred and purified, and an intermediate material is obtained; carboxymethyl chitosan is added to water for dissolution, the intermediate material and stannous chloride are added and evenly mixed, inert gas is fed, the mixture is heated, kept at the temperature and purified, and modified chitosan is obtained; the modified chitosan, diisopropyl carbodiimide, glucose and cassia oil are evenly mixed, and the absorbable medical suture with the good tensile strength is prepared with a melt spinning method. The prepared suture is good in tensile strength, easy to knot, high in mechanical performance and well compatible with biological tissue, and cells adhere and reproduce on the prepared suture easily.
Owner:安徽省康宁医疗用品有限公司
Chitosan microspheres as well as preparation method and application thereof
PendingCN114392270ALong degradation cycleImprove drug loading capacityOrganic active ingredientsAntipyreticPharmaceutical drugPerylene derivatives
The invention discloses a chitosan microsphere, which is formed by polymerizing an acryloylated chitosan intermediate through a cross-linking agent and a charge modifier, and is prepared by the following steps: (1) dissolving a chitosan derivative in water, adding an acid-binding agent, and reacting with an acryloyl chloride compound to obtain the acryloylated chitosan intermediate; (2) dissolving the acryloylated chitosan intermediate in water, and adding a cross-linking agent, a charge modifier and persulfate to obtain a polymer monomer solution; and adding the polymer monomer solution into the oil phase mixture, and adding an initiator to carry out polymerization reaction to obtain the porous chitosan microspheres. Through water-in-oil reverse phase polymerization reaction, the degradation period of the chitosan microspheres is prolonged and can reach 1-12 months, meanwhile, groups capable of loading different kinds of charge drugs are introduced into the microspheres, the drug loading capacity of the microspheres is improved, and meanwhile the drug loading range of the microspheres is expanded.
Owner:SUZHOU HAOWEI MEDICAL TECH CO LTD
Hydrogel lacrimal passage suppository and preparation method thereof
ActiveCN111773178AReduce breakageReduce wasteSenses disorderEye surgeryXerophthalmiaHydrophilic polymers
The invention provides a hydrogel lacrimal passage suppository and a preparation method thereof. The hydrogel lacrimal passage suppository is a hydrogel suppository of which the size can pass througha lacrimal point; the hydrogel lacrimal passage suppository comprising a dehydrated hydrophilic polymer hydrogel (xerogel) of which the cross-sectional width expands to at least 2 times after absorbing physiological water, and thus the suppository is enlarged and can be deployed in a lacrimal duct. The hydrogel lacrimal passage suppository can be used as a drug delivery system. The gel is taken out after being subjected to primary drying to a proper state under the room temperature condition and then placed at the room temperature, the production process condition is mild, the tensile propertyof the prepared gel is greatly improved, the breakage probability in a stretching process is reduced, and the production efficiency is improved. The lacrimal passage suppository product does not contain bubbles, is smooth in appearance, uniform and stable in quality and good in in-vivo compliance, can have a degradation cycle of more than 180 days, and can be used for instruments for treating xerophthalmia, improve the ocular surface environment and relieve xerophthalmia symptoms.
Owner:NKD PHARMA CO LTD
Application of liposomal clodronate on adjuvant treatment aspect of tumor doxorubicin chemotherapy
InactiveCN107854489AMature and reliable technologyQuality improvementOrganic active ingredientsInorganic phosphorous active ingredientsLipid filmCholesterol
The invention discloses application of liposomal clodronate on the adjuvant treatment aspect of tumor doxorubicin chemotherapy. After an appropriate amount of cholesterol and lecithin are mixed, a chloroform-methyl alcohol mixed solution is added, a rotary thin-film evaporation method is adopted to prepare a uniform dry lipid film, and then a phosphate buffer solution of disodium clodronate is added. The liposomal clodronate has the advantages that it is found that the prepared stable and efficient liposomal clodronate can reduce cardiotoxicity caused by doxorubicin and improve the breast cancer treatment effect of the doxorubicin.
Owner:WUHAN UNIV
Acellular matrix inside-out repair material as well as preparation method and application thereof
ActiveCN110433340AGood biocompatibilityWeakened immunityTissue regenerationProsthesisAcellular matrixBiocompatibility Testing
The invention provides an acellular matrix inside-out repair material as well as a preparation method and application thereof. The method comprises the steps as follows: pretreatment, pancreatin soaking, alkali solution degreasing, Triton x-100 decellularization, crosslinking and sterilization. Due to adoption of a milder decellularization process, the collagen microstructure of the acellular matrix inside-out repair material can be saved completely, has good advantages of biocompatibility and low immunity, has good mechanical properties and can meet the condition of long-term existence in in-vivo environment. The acellular matrix inside-out repair material can effectively solve the problems that a polypropylene material has poor biocompatibility, irritates and erodes surrounding soft tissue for a long term and even penetrates urethra or vagina, cannot be degraded in vivo and even requires secondary operation to be taken out, and the acellular matrix inside-out repair material can be well applied as a urethra sling.
Owner:广州聚明生物科技有限公司 +1
Full-biodegradable mulching film for peanut planting
PendingCN113841551AImprove water retentionImprove mechanical propertiesClimate change adaptationSynthetic resin layered productsPolymer sciencePlastic mulch
A full-biodegradable mulching film for peanut planting comprises a heat-resistant layer, a barrier layer and a hydrolysis-resistant layer, wherein the heat-resistant layer is prepared from the following raw material components: 70-90 parts of PBAT, 0-20 parts of PBS, 0-5 parts of PLA, 0-20 parts of an inorganic filler, 0.1-2 parts of a chain extender, 0.3-4 parts of a light stabilizer, 0.1-0.5 part of an antioxidant and 0.1-0.5 part of a slipping agent; the barrier layer is prepared from the following raw material components: 40-70 parts of PBAT, 0-30 parts of modified PPC, 3-10 parts of PLA, 5-30 parts of the inorganic filler, 0.3-2 parts of the chain extender, 0.2-3 parts of the light stabilizer, 0.1-0.5 part of the antioxidant, 0.1-2 parts of an anti-blocking agent and 0.2-3 parts of the slipping agent; and the hydrolysis-resistant layer is prepared from the following raw material components: 75-94 parts of PBAT, 0-10 parts of PLA, 0-5 parts of the inorganic filler, 0.5-3 parts of the chain extender, 0.1-0.8 part of the light stabilizer, 0.1-0.5 part of the antioxidant and 0.2-3 parts of a hydrolysis-resistant agent. The full-biodegradable mulching film is prepared by a three-layer co-extrusion method, so that the defect that the requirements of all layers cannot be simultaneously met in a single-layer film blowing production process is overcome.
Owner:QINGDAO RICH PLASTIC NEW MATERIAL +1
A kind of preparation method of absorbable medical suture thread with good tensile strength
ActiveCN105063799BImprove hydrophilicityGood compatibilitySuture equipmentsConjugated synthetic polymer artificial filamentsPolymer scienceLactide
The invention discloses a preparation method of absorbable medical suture with good tensile strength. Polyethylene glycol monomethyl ether is taken, inert gas is introduced, the temperature is raised, and the temperature is kept until the polyethylene glycol monomethyl ether melts, and zinc lactate is added. , lactide, mix evenly, heat up, keep warm and stir, and purify to obtain the intermediate material; add carboxymethyl chitosan to dissolve in water, add the intermediate material, stannous chloride, mix evenly, feed inert gas, heat up, keep warm, and purify to obtain modified chitosan; the modified chitosan, diisopropylcarbodiimide, glucose and cinnamon oil are mixed evenly, and the absorbable medical suture thread with good tensile strength is prepared according to the method of melt spinning. The suture prepared by the invention has good tensile strength, is easy to knot, has high mechanical properties, and has good compatibility with biological tissues, and cells are easy to adhere and multiply on the suture prepared by the invention.
Owner:安徽省康宁医疗用品有限公司
A reinforced structure paper diaper with a composite core
The invention relates to the field of disposable hygiene products, and discloses a reinforced structural diaper with a composite core, which includes a diaper body, and the diaper body is composed of an air-permeable surface layer, a diversion layer, a composite core body, and a leak-proof bottom layer. Bonded with degradable hot-melt adhesive, the composite core consists of a dust-free paper, an upper absorbent layer, an elastic layer, a lower absorbent layer, and a spun-bonded non-woven fabric from top to bottom, and the upper absorbent layer includes a middle area and a Anti-side leakage areas on both lateral sides of the middle area, the middle area has several upper absorption sections distributed along the longitudinal direction, each of the upper absorption sections is arranged at intervals, and the distribution density of the superabsorbent resin on the anti-side leakage area is greater than The upper absorbing section, the lower absorbing layer is longitudinally distributed with several lower absorbing sections, each of the lower absorbing sections is arranged at intervals, and the layers of the composite core are bonded by degradable hot-melt adhesives. It solves the problem that the existing paper diapers are easy to agglomerate, break and delaminate, and the hot melt adhesive used for bonding has good bonding effect and is degradable.
Owner:GUANGDONG YINYIN CO LTD
POSS-PEG hybrid hydrogel capable of adjusting degradation rate and preparation method and application thereof
ActiveCN109876194AUniform pore structureGood biocompatibilityProsthesisOrganic solventBiocompatibility Testing
The invention relates to POSS-PEG hybrid hydrogel capable of adjusting the degradation rate and a preparation method and application thereof. The preparation method includes the steps that 4-arm-PEG-MAL and POSS-SH are subjected to a Michael addition reaction in an organic solvent, and a POSS-PEG prepolymer is prepared; the POSS-PEG prepolymer and a crosslinking agent are dissolved in a buffer solution, a pre-gelatized solution is obtained, the pre-gelatized solution is subjected to the Michael addition reaction at reaction temperature, and the POSS-PEG hybrid hydrogel capable of adjusting thedegradation rate is prepared. The crosslinking agent in the pre-gelatized solution is formed by mixing PEG-dithiol and PEG-diester-dithiol. The POSS-PEG hybrid hydrogel has the advantages that the hole structure is uniform, the biocompatibility is good, gelatizing is rapid, the mechanical performance is good, and the POSS-PEG hybrid hydrogel is free of toxins.
Owner:HUBEI UNIV
A kind of preparation method of absorbable medical suture thread
ActiveCN105088408BImprove mechanical propertiesHigh mechanical strengthSuture equipmentsMelt spinning methodsLactideGenipin
Owner:安徽省康宁医疗用品有限公司
Preparation process of high-yield collagen fibers
ActiveCN114032623AHigh purityImprove extraction efficiencyMonocomponent protein artificial filamentConnective tissue peptidesCollagenanCollagen sponge
The invention relates to a preparation process of high-yield collagen fibers. The method comprises comprises the following steps: selecting animal tissues rich in collagen, and cutting into slices or blocks to form tissue slices or tissue blocks; carrying out pretreatment, enzyme reaction, crushing and alkali treatment to obtain collagen with a triple-helical structure; and preparing the collagen sponge through a freeze-drying process. The method disclosed by the invention has the beneficial effects that on the premise of removing terminal peptide and elastin and inactivating viruses, the method has higher extraction efficiency, impure protein is thoroughly removed, and the prepared collagen is relatively high in purity. Compared with acid-soluble collagen sponge, the collagen sponge prepared by the invention has higher tensile strength and bursting strength and longer degradation period. Meanwhile, the use amount of process water is small, the scale of a reaction device is smaller than that of other acid or enzyme extraction methods, and the production site can be greatly saved.
Owner:TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
A tissue-guided regeneration collagen film and its preparation method
The invention relates to a tissue-guided regeneration collagen film and a preparation method thereof. The preparation method is as follows: swell type I collagen in an acetic acid solution, then add sodium chondroitin sulfate and stir evenly to obtain a collagen-chondroitin sulfate sodium slurry; dry the collagen-chondroitin sulfate sodium slurry, Obtain a dry film; mix the dry film with the cross-linking liquid, carry out the cross-linking reaction, and obtain a cross-linked collagen film after completion; clean the cross-linked collagen film and perform secondary drying to complete Then repress it. In the preparation method, high-concentration type I collagen is first swelled in acetic acid solution, and sodium chondroitin sulfate is added to stir, followed by drying, cross-linking, and secondary drying, and the obtained tissue-guided regeneration collagen film has excellent mechanical properties , and the pore size and porosity are conducive to cell growth and repair; in addition, its degradation cycle is long and it is not easy to cause allergies. The comprehensive effect is comprehensive and the applicability is wide.
Owner:TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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