55results about How to "Long degradation cycle" patented technology

The invention discloses a mussel mucoprotein gel for repairing and reliving itching. The mussel mucoprotein gel is prepared from the following components in percentage by weight: 0.15%-0.2% of mussel mucoprotein, 0.5%-2% of a macromolecule host material, 3%-10% of a humectant, 1%-5% of a surfactant, 0.1%-0.5% of a preservative, 1%-2% of a protein protectant, 0.5%-3% of a stabilizer, 0.5%-1% of a bacteriostatic agent, 0.8%-5.2% of a pH modifier and the balance of purified water. The mussel mucoprotein gel has good biological adhesion, is rapidly and effectively adhered to a wound surface, is capable of rapidly reliving itching and easing pain, and has the advantages of being low in immunogenicity, good in biocompatibility with a human body, convenient to use, free of thrill to skin, safe, nontoxic and free of bad reaction.

The invention discloses a degradable bio-based seedling raising pot, a production method thereof, a regulation method in a degradation period and an application of the degradable bio-based seedling raising pot. The degradable bio-based seedling raising pot is produced from straw powder, wheat bran and an adhesive through dry-method hot pressing after mixing. The degradable bio-based seedling raising pot can keep certain strength in a seedling raising process and is relatively complete in appearance, after seedlings and the pot are transplanted to a field simultaneously, the pot can crack and disintegrate rapidly, and plant root extension is facilitated.

The invention provides an extraction method of collagen fiber. Through selection of the optimum technological steps and conditions, the collagen fiber is extracted from animal achilles tendon and is sterilized by being soaked in alkaline water and an acid solution, impure protein is removed through trypsin processing, and the collagen fiber which has higher purity, doesn't have viruses and has a larger fiber diameter is obtained. The extracted collagen fiber has excellent biological characteristics of better biological activity and the like and can be applied to the fields of cosmetics and biological materials, for example, researches of a hemostatic material and artificial skin and tissue filler such as cartilage, mucosal tissue, bone tissue and the like.

The invention discloses a face filling agent composition for injection type cosmetic plastic surgery and a preparation method of the face filling agent composition, relates to a ace filling agent composition for cosmetic plastic surgery and a preparation method of the face filling agent composition, and aims to solve the problems that conventional cross-linked hyaluronic acid is poor in cross-linking effect, a user has red and swelling inflammation, potential safety hazards can be caused, not only is a skin repairing effect not achieved, but also vascular thrombosis can be possibly caused. Theface filling agent composition for injection type cosmetic plastic surgery comprises a cross-linked hyaluronic acid composite gel, hydroxyapatite micro particles, collagen powder, cellulose ethers, an epimedium herb extract, a white peony root extract and an injection aqueous solution. The method comprises the following steps: I, weighing materials; and II, performing mixing and sterilization. The face filling agent composition for injection type cosmetic plastic surgery, which is prepared by the invention, has a use mode of being injected into dermis of a part to be filled, of a face. The invention obtains the face filling agent composition for injection type cosmetic plastic surgery.

The invention belongs to the field of biomaterials, and particularly relates to a metal organic framework/electrospinning fiber composite having NO and copper ion slow release synergistic reactions, and a preparation method and application. According to the material, a patterning structure is formed through mutual interweaving of fibers having a core shell structure, hydrophobic biomaterials are used as a core layer of the core shell fibers, hydrophilic biomaterials are used as a shell layer of the core shell fibers, and NO loaded copper bases MOF coat the core layer. The preparation method comprises the steps of using a patterned receiving template, dispersing the NO loaded copper bases MOF, enabling an organic solvent in which the hydrophobic biomaterials dissolve to communicate with aninternal needle of a coaxial electrostatic spray head, enabling an organic solvent in which the hydrophilic biomaterials dissolve to communicate with an external needle of the coaxial electrostatic spray head, and preparing the metal organic framework/electrospinning fiber composite through coaxial electrostatic spinning. In order to solve the problems that the wound healing rate of diabetes is low and angiogenesis is insufficient, the material slowly release NO and copper ions, and the NO and the copper ions are in synergistic reactions to jointly promote angiogenesis, collagen deposition, reduction of inflammatory reactions and the like in wound healing, so that the healing period of the wound of the diabetes is greatly shortened.

The invention discloses a corium tissue bionic sponge preparation method. The mass percent of silk protein in a corium tissue bionic sponge is 10%-95%, the mass percent of collagen is 5%-90%, a silk protein solution and a collagen solution are mixed and steamed through steam to form a film, then the film is soaked in a mixed aqueous solution of 1-(3-dimethylamino propyl)-3-ethyl-carbodiimide hydrochloride and N-hydroxy succinimide, and the corium tissue bionic sponge is prepared through the drying process and other processes. The corium tissue bionic sponge has the corium tissue bionic performance in the aspect of microstructure, mechanical property and molecular structure, can easily improve the performance of inhibiting scar formation and promoting functional corium tissue regeneration, and provides a new method for solving the problem of pathologic scars.

The invention discloses an absorbable medical suture line with good mechanical performance. The absorbable medical suture line comprises, by weight, 100-120 parts of modified polylactic acid, 20-40 parts of polyglycollide, 4-6 parts of sorbitol, 3-5 parts of methyl methacrylate and 5-6 parts of cassia oil. The preparation method of the modified polylactic acid includes: in ice-bath, adding chitosan into perchloric acid, well mixing, dripping sorbic acid chloride, stirring, cooling, preserving heat and purifying to obtain modified chitosan; taking polyethylene glycol, feeding inert gas, heating, preserving heat until the polyethylene glycol melt, adding stannous chloride and lactide, well mixing, heating, preserving heat and stirring, and purifying to obtain intermediate material; dissolving the modified chitosan in mixed solvent, adding triethylamine, well mixing, heating, refluxing, adding the intermediate material, well mixing, continuing refluxing, purifying and drying to obtain the modified polylactic acid.

The invention discloses mechanically enhanced gelatin frozen hydrogel as well as a preparation method and application thereof. The method comprises the following steps: compounding methylacryloylated gelatin and a glycidyl acrylate modified silk fibroin solution, adding an ammonium persulfate/tetramethylethylenediamine initiator solution to realize free radical crosslinking at low temperature, and inducing an SF-GMA molecular chain to form a hydrophobic crystal (beta-sheet structure) by post-treatment of a methanol solution to obtain the frozen hydrogel. The frozen hydrogel has a through macroporous structure of about 200 [mu]m under a swelling equilibrium condition, the compression modulus of the frozen hydrogel can be enhanced from 0.057 Mpa to 0.523 Mpa, the degradation period of the frozen hydrogel in an environment containing type II collagenase is prolonged from 7 days to 28 days, the degradation residue is 60%, and the frozen hydrogel has good biocompatibility. The method provided by the invention is simple in preparation process, effectively enhances the performance of the jelly, and has a good application prospect in the fields of drug delivery, tissue repair and the like.

The invention discloses collagen gel and a preparation method thereof. The collagen gel is prepared from the following raw materials: 20 to 80 percent of collagen solution, 80 to 20 percent of PCL microspheres, and 0 to 1 percent of lidocaine. The collagen gel of the invention adopts the raw materials which can be completely degraded and can be completely absorbed by the human body after the collagen gel is implanted in the human body; and moreover, the degradation period of the PCL is relatively long and can reach up to 2 years, so that the lasting time of the effect of the collagen gel is long, and the application frequency of the collagen gel is reduced.

The invention relates to a degradable mulching film for vegetable cultivation in plateau regions and a preparation method and application of the mulching film. The mulching film is prepared from PBAT,polylactic acid, a compatilizer, inorganic filler, an antioxidant, a supported-type ultraviolet light absorber and an ultraviolet light reflection agent. According to the mulching film, the adopted PBAT and polylactic acid are completely biodegradable materials, can be completely degraded into carbon dioxide and water and cannot pollute the environment. Graphene oxide with certain uvioresistant performance is used as a carrier for supporting a traditional ultraviolet light absorber, the defects are overcome that the traditional ultraviolet light absorber is low in thermal stability, easily migrates, is easily decomposed, is poor in compatibility with the PBAT and the like, the anti-aging performance of the composite material is improved, and the degradation period of the composite material is prolonged; meanwhile, addition of the graphene oxide strengthens the mechanical property of the composite material. The mulching film has both properties, namely, a good mechanical property and an anti-aging property and is good in development prospect.

The invention discloses an absorbable plugging device which comprises a mesh grid. The mesh grid includes a degradable macromolecule silk. The polydispersity index of the degradable macromolecule silk material is 3 to 10. A range of weight-average molecular weight is 20,000 D a to 800,000 D a. The absorbable plugging device is capable of avoiding a serious organization inflammatory reaction caused by the centralized release within a certain period of time of the degradation product of the degradable macromolecule silk, forming the mesh grid.

The invention relates to composition gel and applications, belonging to the field of regenerative medicine and biological medicine. The composition gel is mainly composed of biodegradable material geland stem cells. The composition gel provided by the invention has the advantages that the degradation period is permanent, the stability is good, and the source of stem cell raw materials is wide.

The present invention provides a hyaluronic acid injection, which comprises hyaluronic acid or sodium hyaluronate, amino acids, propylene glycol, vitamins and minerals. According to the hyaluronic acid injection, regeneration and reconstruction of collagen in a body are filled and promoted, so that the skin problems of dryness, fine wrinkles and aging are improved.

The invention discloses a preparation method of an absorbable medical suture with good tensile strength. Inert gas is fed into ethylene glycol monomethyl ether, the ethylene glycol monomethyl ether is heated, the temperature is kept until the ethylene glycol monomethyl ether is molten, zinc lactate and lactide are added, the mixture is evenly mixed, heated, kept at the temperature, stirred and purified, and an intermediate material is obtained; carboxymethyl chitosan is added to water for dissolution, the intermediate material and stannous chloride are added and evenly mixed, inert gas is fed, the mixture is heated, kept at the temperature and purified, and modified chitosan is obtained; the modified chitosan, diisopropyl carbodiimide, glucose and cassia oil are evenly mixed, and the absorbable medical suture with the good tensile strength is prepared with a melt spinning method. The prepared suture is good in tensile strength, easy to knot, high in mechanical performance and well compatible with biological tissue, and cells adhere and reproduce on the prepared suture easily.

The invention provides a hydrogel lacrimal passage suppository and a preparation method thereof. The hydrogel lacrimal passage suppository is a hydrogel suppository of which the size can pass througha lacrimal point; the hydrogel lacrimal passage suppository comprising a dehydrated hydrophilic polymer hydrogel (xerogel) of which the cross-sectional width expands to at least 2 times after absorbing physiological water, and thus the suppository is enlarged and can be deployed in a lacrimal duct. The hydrogel lacrimal passage suppository can be used as a drug delivery system. The gel is taken out after being subjected to primary drying to a proper state under the room temperature condition and then placed at the room temperature, the production process condition is mild, the tensile propertyof the prepared gel is greatly improved, the breakage probability in a stretching process is reduced, and the production efficiency is improved. The lacrimal passage suppository product does not contain bubbles, is smooth in appearance, uniform and stable in quality and good in in-vivo compliance, can have a degradation cycle of more than 180 days, and can be used for instruments for treating xerophthalmia, improve the ocular surface environment and relieve xerophthalmia symptoms.

The invention provides an acellular matrix inside-out repair material as well as a preparation method and application thereof. The method comprises the steps as follows: pretreatment, pancreatin soaking, alkali solution degreasing, Triton x-100 decellularization, crosslinking and sterilization. Due to adoption of a milder decellularization process, the collagen microstructure of the acellular matrix inside-out repair material can be saved completely, has good advantages of biocompatibility and low immunity, has good mechanical properties and can meet the condition of long-term existence in in-vivo environment. The acellular matrix inside-out repair material can effectively solve the problems that a polypropylene material has poor biocompatibility, irritates and erodes surrounding soft tissue for a long term and even penetrates urethra or vagina, cannot be degraded in vivo and even requires secondary operation to be taken out, and the acellular matrix inside-out repair material can be well applied as a urethra sling.

The invention relates to POSS-PEG hybrid hydrogel capable of adjusting the degradation rate and a preparation method and application thereof. The preparation method includes the steps that 4-arm-PEG-MAL and POSS-SH are subjected to a Michael addition reaction in an organic solvent, and a POSS-PEG prepolymer is prepared; the POSS-PEG prepolymer and a crosslinking agent are dissolved in a buffer solution, a pre-gelatized solution is obtained, the pre-gelatized solution is subjected to the Michael addition reaction at reaction temperature, and the POSS-PEG hybrid hydrogel capable of adjusting thedegradation rate is prepared. The crosslinking agent in the pre-gelatized solution is formed by mixing PEG-dithiol and PEG-diester-dithiol. The POSS-PEG hybrid hydrogel has the advantages that the hole structure is uniform, the biocompatibility is good, gelatizing is rapid, the mechanical performance is good, and the POSS-PEG hybrid hydrogel is free of toxins.

The invention relates to a preparation process of high-yield collagen fibers. The method comprises comprises the following steps: selecting animal tissues rich in collagen, and cutting into slices or blocks to form tissue slices or tissue blocks; carrying out pretreatment, enzyme reaction, crushing and alkali treatment to obtain collagen with a triple-helical structure; and preparing the collagen sponge through a freeze-drying process. The method disclosed by the invention has the beneficial effects that on the premise of removing terminal peptide and elastin and inactivating viruses, the method has higher extraction efficiency, impure protein is thoroughly removed, and the prepared collagen is relatively high in purity. Compared with acid-soluble collagen sponge, the collagen sponge prepared by the invention has higher tensile strength and bursting strength and longer degradation period. Meanwhile, the use amount of process water is small, the scale of a reaction device is smaller than that of other acid or enzyme extraction methods, and the production site can be greatly saved.