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Hyaluronic acid injection and preparation method thereof

A technology of hyaluronic acid and injection, applied in the field of medical cosmetology, can solve problems such as wrinkles, achieve the effects of safe ingredients, simple preparation method and improved synthesis ability

Inactive Publication Date: 2020-01-03
西安博和医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems existing in the prior art, the present invention provides a hyaluronic acid injection and its preparation method, which not only has the function of supplementing the extracellular matrix possessed by traditional filling materials, but also promotes the synthesis of its own collagen, and solves skin wrinkles, Slack and other issues

Method used

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  • Hyaluronic acid injection and preparation method thereof
  • Hyaluronic acid injection and preparation method thereof
  • Hyaluronic acid injection and preparation method thereof

Examples

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Embodiment 1

[0034] This embodiment provides a hyaluronic acid injection, comprising the following components in mass percentage: 0.8% hyaluronic acid, 0.25% amino acid, 1% mannitol, 0.1% edetate calcium disodium; wherein, the Amino acids include the following components in mass percentage: 0.1% proline, 0.05% glycine, 0.05% leucine, and 0.05% valine.

[0035] This embodiment also provides a preparation method of hyaluronic acid injection, comprising the following steps:

[0036] (1) Add hyaluronic acid and mannitol into water and wait until they are completely dissolved to obtain a mixture A;

[0037] (2) Add the amino acid into the water and wait until it is completely dissolved to obtain solution B;

[0038] (3) After solution B is filtered through a 0.22 μm filter membrane, add it to solution A, wait until it is completely dissolved and mix well to obtain mixed solution C;

[0039] (4) Divide the mixed solution C, sterilize with damp heat at 121°C for 8 minutes, and cool to room temp...

Embodiment 2

[0041] This embodiment provides a hyaluronic acid injection, comprising the following components in terms of mass percentage: 0.8% hyaluronic acid, 0.35% amino acid, 1% mannitol, 0.1% calcium disodium edetate; wherein the amino acid It includes the following components in terms of mass percentage: 0.2% proline, 0.05% glycine, 0.05% leucine, and 0.05% valine.

[0042] The preparation method of the hyaluronic acid injection in this example is the same as that in Example 1.

Embodiment 3

[0044] This embodiment provides a hyaluronic acid injection, comprising the following components in terms of mass percentage: 0.8% hyaluronic acid, 0.35% amino acid, 1% mannitol, 0.2% calcium disodium edetate; wherein the amino acid It includes the following components in terms of mass percentage: 0.2% proline, 0.05% glycine, 0.05% leucine, and 0.05% valine.

[0045] The preparation method of the hyaluronic acid injection in this example is the same as that in Example 1.

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Abstract

The invention provides a hyaluronic acid injection and a preparation method thereof. The hyaluronic acid injection is prepared from the following components in percentage by mass: 0.1-1.5% of hyaluronic acid, 0.01-1% of amino acid, 0.1-2% of mannitol and 0.05-0.8% of minerals. The prepared hyaluronic acid injection can supplement the hyaluronic acid in the extracellular matrix of skin and improvethe own collagen synthesis ability of the skin, so that wrinkled skin is restored to be smooth and elastic. The hyaluronic acid injection is safe in ingredients, the preparation method is simple, thecost is low, and the hyaluronic acid injection is suitable for industrialization.

Description

technical field [0001] The invention belongs to the field of medical cosmetology, and in particular relates to a hyaluronic acid injection and a preparation method thereof. Background technique [0002] Over time, changes occur inside human skin, such as reduction of extracellular matrix and degradation of collagen, etc., causing skin wrinkles and sagging. To solve the problems of skin wrinkles and sagging from the root, the most direct and effective way is to supplement extracellular matrix and collagen. Collagen injection fillers commonly used clinically include human collagen and non-human collagen. The former is prepared from the patient’s autologous tissue after being cultured and processed. The advantage is that there is no risk of immunity from autologous sources, but it is time-consuming. Laborious and expensive; non-human collagen is mainly bovine collagen, which still has a certain immune risk after antigen removal treatment. Before injection, a skin test is requi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/44A61K8/49A61K8/73A61Q19/08
CPCA61K8/735A61K8/4913A61K8/44A61K8/345A61Q19/08A61K2800/91
Inventor 张雪彦
Owner 西安博和医疗科技有限公司
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