Collagen gel and preparation method thereof

A technology of collagen and peptide collagen, which is applied in the field of collagen gel and its preparation, can solve the problems of short duration of effect, hidden safety hazards, short duration, etc., achieve long duration of effect, reduce the frequency of use, The effect of simple preparation method

Active Publication Date: 2017-10-20
GUANGZHOU YICHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, more and more consumers are paying attention to micro-plastic surgery mainly based on injection beauty, among which botulinum toxin and hyaluronic acid occupy most of the market, and botulinum toxin itself is a kind of neurotoxin, and its dosage needs to be strictly controlled. In the domestic market with imperfect development in all aspects of the medical beauty industry, it is easy to cause a series of safety hazards; hyaluronic acid itself absorbs quickly and lasts for a short time, often requiring multiple injections to achieve the desired effect
In addition, there are also collagen-based or biomaterial-based injections, but none of these injections can satisfy the characteristics of being completely absorbable and lasting for a long time
[0003] Some cosmetic injections on the market are not completely absorbable, which will leave a safety hazard after being implanted in the human body
[0004] In addition, some fully absorbable cosmetic injections often degrade within one year or even half a year, and the effect duration is short, which increases the injection frequency of users

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043] The present invention also provides a method for preparing the above-mentioned collagen gel, comprising: uniformly mixing all raw materials.

[0044] Preferably, the raw materials are uniformly mixed by ultrasonic vibration.

[0045]Preferably, the duration of the ultrasound is 5-15 minutes, such as 5 minutes, 8 minutes, 10 minutes, 12 minutes or 15 minutes, etc., and the frequency of the ultrasound is 15-30 Hz, such as 15 Hz, 18 Hz, 20 Hz, 23 Hz, 25 Hz, 28 Hz or 30 Hz.

[0046] Preferably, the PCL microspheres are prepared by an ultrasonic spray method or a microfluidic method, and the viscosity of the PCL raw material used to prepare the PCL microspheres is 40,000 to 100,000 mPa.s, such as 400,000 mPa.s, 500,000 mPa.s, or 600,000 mPa.s. s, 700000mPa.s, 800000mPa.s, 900000mPa.s or 100000mPa.s, etc., different viscosity distributions can be used to adjust the hardness and degradation time of the final microspheres, and to form cosmetic injection products of different sp...

Embodiment 1

[0061] A collagen gel, comprising the following raw materials in mass percentage: 20% collagen solution and 80% PCL microspheres.

[0062] The preparation method of this collagen gel comprises the following steps:

[0063] (1) PCL microspheres were prepared by ultrasonic spraying method to the PCL raw material with a viscosity of 40000mPa.s;

[0064] (2) The collagen solution and the PCL microspheres were mixed uniformly by ultrasonic oscillation to obtain a collagen gel; wherein, the ultrasonic time was 5 min, and the ultrasonic frequency was 15 Hz.

Embodiment 2

[0066] A collagen gel, comprising the following raw materials in mass percentage: 40% collagen solution and 60% PCL microspheres.

[0067] The preparation method of this collagen gel comprises the following steps:

[0068] (1) PCL microspheres were prepared by ultrasonic spraying method to the PCL raw material with a viscosity of 70000mPa.s;

[0069] (2) The collagen solution and the PCL microspheres were mixed uniformly by ultrasonic oscillation to obtain a collagen gel; wherein, the ultrasonic time was 10 min, and the ultrasonic frequency was 18 Hz.

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PUM

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Abstract

The invention discloses collagen gel and a preparation method thereof. The collagen gel is prepared from the following raw materials: 20 to 80 percent of collagen solution, 80 to 20 percent of PCL microspheres, and 0 to 1 percent of lidocaine. The collagen gel of the invention adopts the raw materials which can be completely degraded and can be completely absorbed by the human body after the collagen gel is implanted in the human body; and moreover, the degradation period of the PCL is relatively long and can reach up to 2 years, so that the lasting time of the effect of the collagen gel is long, and the application frequency of the collagen gel is reduced.

Description

technical field [0001] The invention relates to the technical field of tissue engineering materials, in particular to a collagen gel and a preparation method thereof. Background technique [0002] With aging and / or as a consequence of certain diseases, the body's soft tissues, including muscle and fat, decrease, affecting appearance and / or function. Nowadays, more and more consumers are paying attention to micro-plastic surgery mainly based on injection beauty, among which botulinum toxin and hyaluronic acid occupy most of the market, and botulinum toxin itself is a kind of neurotoxin, and its dosage needs to be strictly controlled. In the domestic market with imperfect development in all aspects of the medical beauty industry, it is easy to cause a series of safety hazards; hyaluronic acid itself absorbs quickly and lasts for a short time, often requiring multiple injections to achieve the desired effect. In addition, there are also collagen-based or biomaterial-based inje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/18A61L27/58A61L27/54A61L27/52A61L27/50C08J3/075C08L67/04C08L89/00
CPCA61L27/18A61L27/24A61L27/50A61L27/52A61L27/54A61L27/58A61L2300/402A61L2400/06C08J3/075C08J2367/04C08J2389/00C08J2467/04C08J2489/00C08L67/04
Inventor 金振华杨习锋曾晨光
Owner GUANGZHOU YICHENG BIOTECH CO LTD
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