POSS-PEG hybrid hydrogel capable of adjusting degradation rate and preparation method and application thereof

An adjustable degradation rate technology, applied in medical science, prosthesis, etc., can solve the problems of non-adjustable, unable to adapt to the use situation, fixed degradation rate, etc., and achieve the effect of fast gelation, good mechanical properties, and uniform pore structure

Active Publication Date: 2019-06-14
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The POSS-PEG hybrid hydrogel prepared by it can not only enhance the mechanical properties of the hydrogel, but also delay the degradation rate for a certain period of time, but the above degradation rate is fixed and cannot be adjusted, which cannot meet the needs of various use scenarios

Method used

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  • POSS-PEG hybrid hydrogel capable of adjusting degradation rate and preparation method and application thereof
  • POSS-PEG hybrid hydrogel capable of adjusting degradation rate and preparation method and application thereof
  • POSS-PEG hybrid hydrogel capable of adjusting degradation rate and preparation method and application thereof

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Embodiment Construction

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0031] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0032] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.

[0033] A kind of POSS-PEG hybrid hydrogel with adjustable degradation rate, its preparation method comprises the...

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Abstract

The invention relates to POSS-PEG hybrid hydrogel capable of adjusting the degradation rate and a preparation method and application thereof. The preparation method includes the steps that 4-arm-PEG-MAL and POSS-SH are subjected to a Michael addition reaction in an organic solvent, and a POSS-PEG prepolymer is prepared; the POSS-PEG prepolymer and a crosslinking agent are dissolved in a buffer solution, a pre-gelatized solution is obtained, the pre-gelatized solution is subjected to the Michael addition reaction at reaction temperature, and the POSS-PEG hybrid hydrogel capable of adjusting thedegradation rate is prepared. The crosslinking agent in the pre-gelatized solution is formed by mixing PEG-dithiol and PEG-diester-dithiol. The POSS-PEG hybrid hydrogel has the advantages that the hole structure is uniform, the biocompatibility is good, gelatizing is rapid, the mechanical performance is good, and the POSS-PEG hybrid hydrogel is free of toxins.

Description

technical field [0001] The invention relates to the field of hydrogel polymer materials, in particular to a POSS-PEG hybrid hydrogel with adjustable degradation rate, a preparation method and application thereof. Background technique [0002] 3D scaffolds play a crucial role in tissue engineering and 3D cell culture applications. With the rapid development of tissue engineering, 3D scaffolds have great application potential in various biomedicines, so the requirements for them are getting higher and higher. In order to induce cell adhesion, proliferation and activation to direct the growth and differentiation of specific cells, the materials used to prepare scaffolds must have biocompatibility, suitable degradation rate, porosity, proper mechanical stability and proper chemical induction to Molecular biological recognition of cells. [0003] Scaffold materials used for 3D cell culture require biocompatibility and mechanical strength over a period of time, and should eventu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/52A61L27/58
Inventor 卢翠芬郭仁琦刘斯举李鹤玲杨桂春陈祖兴沈金瑞
Owner HUBEI UNIV
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