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A kind of preparation method of absorbable medical suture thread

A technology of suture and chitosan, applied in the field of medical suture, can solve the problems of inability of cells to adhere and multiply, poor mechanical properties of chitosan, and accelerate wound healing, so as to increase hydrophilicity and cell compatibility. , increase anti-inflammatory, increase antibacterial, anti-inflammatory and water-soluble effects

Active Publication Date: 2018-02-27
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, and smooth wound after healing, but chitosan has poor mechanical properties, poor solubility, and is easy to degrade
[0004] Polylactic acid (PLA) sutures are synthetic polymer sutures. The degradation rate of PLA fibers is slow and the mechanical properties are strong. However, PLA is hydrophobic, and cells cannot adhere and reproduce well on the fibers. The degradation cycle Longer, and the degradation product lactic acid can easily cause inflammation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of absorbable medical sutures, adding chitosan into water, ultrasonically dispersing evenly, adding fumaric acid to mix evenly, adding sulfuric acid dropwise, raising the temperature to 70°C, and stirring for 5 hours to obtain solution A; using sodium hydroxide The solution was adjusted to pH=6 of solution A, added dropwise to acetone, filtered, washed 4 times with ethanol, filtered, added with ethanol, extracted by Soxhlet for 48 hours, and dried in vacuum to obtain modified chitosan, wherein chitosan and water The weight volume ratio (g / ml) of chitosan and fumaric acid is 1:100, the weight ratio of chitosan and fumaric acid is 1.7:3.5, the weight volume (g / ml) ratio of chitosan and sulfuric acid is 1:4; Mix triol, stannous octoate, and lactide evenly, blow in nitrogen, heat up to 120°C, keep stirring at a speed of 400r / min for 1h, add dichloromethane to dissolve, add dropwise to ether, filter, and vacuum dry to obtain intermediate Materials, where...

Embodiment 2

[0027] A method for preparing absorbable medical sutures. Add chitosan to water, disperse evenly by ultrasonic, add fumaric acid to mix evenly, add sulfuric acid dropwise, heat up to 90°C, keep stirring for 3 hours to obtain solution A; The solution adjusts the pH of solution A to 8, adds it dropwise into acetone, filters, washes twice with ethanol, filters, adds ethanol, Soxhlet extraction for 60 hours, and vacuum-dries to obtain modified chitosan, wherein, chitosan and water The weight volume ratio (g / ml) of chitosan and fumaric acid is 1:80, the weight ratio of chitosan and fumaric acid is 1.7:5.5, the weight volume (g / ml) ratio of chitosan and sulfuric acid is 1:2; Mix triol, stannous octoate, and lactide evenly, blow in nitrogen, heat up to 140°C, keep stirring at a speed of 200r / min for 2h, add dichloromethane to dissolve, add dropwise to ether, filter, and vacuum dry to obtain intermediate Materials, wherein the weight ratio of stannous octoate, glycerol, and lactide is...

Embodiment 3

[0029]A method for preparing absorbable medical sutures, adding chitosan to water, ultrasonically dispersing evenly, adding fumaric acid to mix, adding sulfuric acid dropwise, raising the temperature to 75°C, and stirring for 4.5 hours to obtain solution A; Sodium solution adjusts the pH=6.5 of solution A, adds dropwise in acetone, filters, washes 4 times with ethanol, filters, adds ethanol, Soxhlet extraction 50h, vacuum drying obtains modified chitosan, wherein, chitosan and The weight volume ratio (g / ml) of water is 1:95, the weight ratio of chitosan and fumaric acid is 1.7:4, the weight volume (g / ml) ratio of chitosan and sulfuric acid is 1:3.5; Glycerol, stannous octoate, and lactide were mixed evenly, fed with nitrogen, heated to 125°C, kept stirring at a speed of 350r / min for 1.3h, added dichloromethane to dissolve, added dropwise to diethyl ether, filtered, and vacuum-dried The intermediate material is obtained, wherein the weight ratio of stannous octoate, glycerol an...

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PUM

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Abstract

The invention discloses a method for preparing absorbable medical sutures. The method includes the steps that chitosan is added into water to be evenly dispersed, fumaric acid is added to be evenly mixed, sulfuric acid is added, heating is carried out, and stirring is carried out in a heat preservation mode to obtain a solution A; purification is carried out to obtain modified chitosan; glycerin, stannous octoate and lactide are evenly mixed, inert gas is introduced, heating is carried out, stirring is carried out in a heat preservation mode, and purification is carried out to obtain intermediate materials; the modified chitosan is added into water to be dissolved, triethylamine is added to be evenly mixed, heating and refluxing are carried out, the intermediate materials are added to be evenly mixed, refluxing and purification continue to be carried out, and drying is carried out to obtain modified polylactic acid; the modified polylactic acid, epoxidized soybean oil, genipin and castor oil are evenly mixed to be prepared into the absorbable medical sutures with a melt spinning method. The sutures prepared with the method are good in antibacterial performance and inflammation resistance, the mechanical performance is good, the compatibility with biological tissues is good, and cells can be easily attached to and bred on the sutures prepared with the method.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to a preparation method of absorbable medical sutures. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, smooth wound after healing, etc., but chitosan has poor mechanical properties, poor solubility, and is easy to degrade. [0004] Polylactic acid (PLA) sutures are synthetic polymer sutures. The degradation rate of PLA fibers is slow and th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/14D01F8/18D01F1/10D01D5/08A61L17/12
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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