Metal organic framework/electrospinning fiber composite having NO and copper ion slow release synergistic reactions, and preparation method and application

Abstract

The invention belongs to the field of biomaterials, and particularly relates to a metal organic framework / electrospinning fiber composite having NO and copper ion slow release synergistic reactions, and a preparation method and application. According to the material, a patterning structure is formed through mutual interweaving of fibers having a core shell structure, hydrophobic biomaterials are used as a core layer of the core shell fibers, hydrophilic biomaterials are used as a shell layer of the core shell fibers, and NO loaded copper bases MOF coat the core layer. The preparation method comprises the steps of using a patterned receiving template, dispersing the NO loaded copper bases MOF, enabling an organic solvent in which the hydrophobic biomaterials dissolve to communicate with aninternal needle of a coaxial electrostatic spray head, enabling an organic solvent in which the hydrophilic biomaterials dissolve to communicate with an external needle of the coaxial electrostatic spray head, and preparing the metal organic framework / electrospinning fiber composite through coaxial electrostatic spinning. In order to solve the problems that the wound healing rate of diabetes is low and angiogenesis is insufficient, the material slowly release NO and copper ions, and the NO and the copper ions are in synergistic reactions to jointly promote angiogenesis, collagen deposition, reduction of inflammatory reactions and the like in wound healing, so that the healing period of the wound of the diabetes is greatly shortened.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a metal organic framework / electrospun fiber composite material with the synergistic effect of slow release of NO and copper ions, a preparation method and an application. Background technique [0002] As a wide range of chronic skin diseases, diabetic trauma is characterized by the imbalance of blood sugar level. Through complex pathophysiological mechanisms, various cell functions in the patient's wound are disordered, and the expression of inflammatory factors and growth factors is imbalanced, leading to angiogenesis in the wound tissue. Difficulty, overstimulation of inflammation, and difficulty or even no healing. [0003] Nitric oxide (NO), as an important signaling molecule in the human body, plays a key role in the process of wound healing. NO can stimulate the expression of VEGF to promote the proliferation of endothelial cells and the formation of new blood vessels. It...

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Problems solved by technology

[0005] Exogenous NO donors have become a research hotspot due to their advantages of controllable loading, controllable release rate, and directional release. However, traditional NO donors (organic nitrates, metal-NO complexes, nucleophilic-type Nitric oxide donors, etc.) have some common deficiencies, such as limited storage, limited release, poor stability, too fast release rate, short release cycle, difficulty in controlling the concentration, and donor toxicity, which often cannot meet the needs of wound treatment.

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