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Nerve conduit and preparation method thereof

A nerve conduit and tube technology, applied in the field of neurosurgery, can solve the problems of low mechanical strength of the nerve conduit, failure to meet the needs of use, poor mechanical properties of the conduit, etc., and achieve the effects of strong flexibility, easy processing, and long degradation cycle

Active Publication Date: 2017-05-17
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the mechanical strength of the prepared nerve guide is too low and the flexibility is not enough
Similarly, catheters made of collagen also have disadvantages such as poor mechanical properties and difficult processing, which cannot meet the needs of clinical use.

Method used

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  • Nerve conduit and preparation method thereof
  • Nerve conduit and preparation method thereof
  • Nerve conduit and preparation method thereof

Examples

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preparation example Construction

[0017] This embodiment provides a preparation method of a nerve guide, which includes:

[0018] S1: The polymer material is dissolved in an organic solvent, and the polymer solution is obtained after settling to remove air bubbles.

[0019] The content of the lactic acid monomer in the polymer material in this embodiment is 45-65 mol%, the content of the glycolic acid monomer is 5-20 mol%, and the content of the caprolactone monomer is 30-45 mol%. This polymer material is composed of lactic acid, glycolic acid and caprolactone, and is obtained by copolymerizing lactide, glycolide and caprolactone in a specific ratio. This polymer material has a large relative molecular weight, high mechanical strength, strong flexibility, and low expansion, and can be used for regeneration and repair of human tissue. Moreover, this polymer material has a long degradation cycle, and its degradation time in an in vitro environment is about It is 1.5 years, and the degradation time in the in viv...

Embodiment 11

[0054] This embodiment provides a kind of nerve guide, and its preparation method is:

[0055] Take the polymer material provided in Example 6, dissolve it with chloroform, and prepare a polymer solution with a mass fraction of 5% of the polymer material. After standing to remove air bubbles, the polymer solution is evenly coated with a syringe. Horizontally rotate 50rpm on a rod-shaped mold with a diameter of 5mm. After the coating is completed, quickly evaporate the solvent at 150rpm. Continue to repeat this step 30-40 times. The tube was removed from the mold, and vacuum-dried at 50° C. for 3 days to obtain a nerve guide, the specifications of which were: tube inner diameter 5.1 mm, length 3 cm, thickness 0.5 mm.

Embodiment 12

[0057] This embodiment provides a kind of nerve guide, and its preparation method is:

[0058] Take the polymer material provided in Example 6, dissolve it with tetrahydrofuran, and prepare a polymer solution with a mass fraction of the polymer material of 8%. After standing still to remove air bubbles, use a syringe to evenly coat the polymer solution until it rotates horizontally 50rpm, diameter of 5mm rod-shaped mold, after the coating is completed, quickly evaporate the solvent at 200rpm, after the solvent is evaporated, continue to repeat this step 10-20 times, until the pipe has a certain thickness, soak the pipe with absolute ethanol Take it off from the mold, and dry it under vacuum at 40° C. for 5 days to obtain a nerve guide, the specifications of which are: tube inner diameter 5.0 mm, length 3 cm, thickness 0.3 mm.

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Abstract

The invention provides a nerve conduit and a preparation method thereof, and belongs to the field of neurosurgery. The preparation method comprises the following steps: dissolving a polymer material in an organic solvent, performing sedimentation and bubble removal to obtain a polymer solution, preparing a pipe from the polymer solution, and performing drying, wherein the polymer material has lactic acid monomer content of 45 to 65 molar percent, glycolic acid monomer content of 5 to 20 molar percent and caprolactone monomer content of 30 to 45 molar percent. The method is simple in process, convenient to operate and high in accuracy controllability, and the processing is easy; the nerve conduit prepared by the method is strong in mechanical strength, high in flexibility and long in degradation period, and can be well applied to regeneration and repair of injured nerves.

Description

technical field [0001] The invention relates to the field of neurosurgery, in particular to a nerve guide and a preparation method thereof. Background technique [0002] Peripheral nerve injury is relatively common in clinical practice, and regeneration and functional recovery after injury have always been medical problems. The current clinical treatment is autologous nerve transplantation. However, the source of autologous nerves is limited, and at the same time, the function of the donor site is impaired. It has been medically proven that damaged nerves can grow along the direction of the axon. Therefore, using a material to make a tubular connection to the damaged nerve ends creates a closed environment, which is conducive to nerve regeneration and functional restoration. At present, the degradable materials used for nerve connection tubes are mostly collagen, chitosan, polylactic acid and their modifications. [0003] Chinese patent CN200410067183.5 describes a chito...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/58D01D5/00
CPCA61L27/18A61L27/58A61L2300/412A61L2300/602A61L2300/604A61L2430/32D01D5/0069C08L67/04
Inventor 董芳芳赵艳赵成如徐金库孔凡照邓凤娟苑康见王炜
Owner SAIKE SAISI BIOTECH CO LTD
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