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Preparation method of absorbable medical suture with good tensile strength

A technology of tensile strength and sutures, which is applied in the field of medical sutures, can solve the problems of difficult adhesion and reproduction of cells, low mechanical strength of chitosan, and easy inflammation, etc., so as to increase hydrophilicity and cell compatibility Sex, improve cell affinity, reduce the effect of rejection

Active Publication Date: 2015-11-18
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Polylactide has strong mechanical properties and resistance to degradation; however, it has high crystallinity, high melting point, poor water solubility, and strong hydrophobicity. inflammation
[0004] Due to the low mechanical strength of chitosan, when it is implanted into the human body through surgical suture, it will degrade under the action of body fluid soaking and enzymes, which will reduce the mechanical strength of the suture, weaken the function or lose it prematurely, and the tensile strength is not high enough. , poor knot strength, resulting in a mismatch between the degradation rate of the suture and the rate of wound healing
And chitosan has poor solubility and is not easy to process. In order to overcome the above defects, it is necessary to develop a preparation method to prepare absorbable medical sutures with high mechanical properties and good tensile strength.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for preparing absorbable medical sutures with good tensile strength. Take polyethylene glycol monomethyl ether, feed nitrogen gas, heat up to 65°C, keep warm until polyethylene glycol monomethyl ether melts, add zinc lactate, acrylic acid Mix the lactide, heat up to 150°C, keep stirring at a speed of 100r / min for 3h, add dichloromethane to dissolve, add dropwise to ether, filter, and vacuum dry to obtain the intermediate material, wherein the moles of zinc lactate and lactide The ratio is 0.4:100, and the weight ratio of polyethylene glycol monomethyl ether and lactide is 50:144; add carboxymethyl chitosan to water to dissolve, add intermediate materials, stannous chloride, mix well, and pass through nitrogen , heat up to 90°C, keep warm for 35h, filter, add the filtrate dropwise to toluene, filter to obtain a filter cake, and vacuum dry to obtain modified chitosan, wherein the weight volume of carboxymethyl chitosan and water (g / ml ) ratio is 1:100, and the we...

Embodiment 2

[0024] A method for preparing absorbable medical suture with good tensile strength. In the preparation process, polyethylene glycol monomethyl ether is taken, nitrogen gas is passed through, the temperature is raised to 75° C., and the temperature is kept until the polyethylene glycol monomethyl ether melts. Add zinc lactate and lactide and mix well, raise the temperature to 140°C, keep stirring at a speed of 300r / min for 2h, add dichloromethane to dissolve, add dropwise to diethyl ether, filter, and vacuum dry to obtain intermediate materials, in which zinc lactate, The molar ratio of lactide is 0.5:100, and the weight ratio of polyethylene glycol monomethyl ether and lactide is 25:144; add carboxymethyl chitosan to water to dissolve, add intermediate materials, stannous chloride mixed Evenly, nitrogen gas was introduced, the temperature was raised to 120°C, and the temperature was kept for 30h, filtered, and the filtrate was added dropwise to ethyl acetate, filtered to obtain...

Embodiment 3

[0026] A method for preparing absorbable medical suture with good tensile strength. In the preparation process, polyethylene glycol monomethyl ether is taken, nitrogen gas is passed through, the temperature is raised to 67° C., and the temperature is kept until the polyethylene glycol monomethyl ether melts. Add zinc lactate and lactide and mix well, heat up to 147°C, keep stirring at a speed of 150r / min for 2.8h, add dichloromethane to dissolve, add dropwise to ether, filter, and vacuum dry to obtain intermediate materials, in which zinc lactate , The molar ratio of lactide is 0.42:100, the weight ratio of polyethylene glycol monomethyl ether and lactide is 45:144; add carboxymethyl chitosan to dissolve in water, add intermediate material, stannous chloride Mix evenly, feed nitrogen, heat up to 100°C, keep warm for 34 hours, filter, add the filtrate dropwise to toluene, filter to obtain a filter cake, and vacuum dry to obtain modified chitosan, wherein the mixture of carboxyme...

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PUM

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Abstract

The invention discloses a preparation method of an absorbable medical suture with good tensile strength. Inert gas is fed into ethylene glycol monomethyl ether, the ethylene glycol monomethyl ether is heated, the temperature is kept until the ethylene glycol monomethyl ether is molten, zinc lactate and lactide are added, the mixture is evenly mixed, heated, kept at the temperature, stirred and purified, and an intermediate material is obtained; carboxymethyl chitosan is added to water for dissolution, the intermediate material and stannous chloride are added and evenly mixed, inert gas is fed, the mixture is heated, kept at the temperature and purified, and modified chitosan is obtained; the modified chitosan, diisopropyl carbodiimide, glucose and cassia oil are evenly mixed, and the absorbable medical suture with the good tensile strength is prepared with a melt spinning method. The prepared suture is good in tensile strength, easy to knot, high in mechanical performance and well compatible with biological tissue, and cells adhere and reproduce on the prepared suture easily.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to a method for preparing absorbable medical sutures with good tensile strength. Background technique [0002] Among the absorbable sutures made of natural materials, chitosan sutures have good biocompatibility, have the advantages of antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Produce irritation, allergies, and inflammation, and have the advantages of anti-inflammatory, promoting wound healing, and smoothing the wound after healing. [0003] Polylactide has strong mechanical properties and resistance to degradation; however, it has high crystallinity, high melting point, poor water solubility, and strong hydrophobicity. inflammation. [0004] Due to the low mechanical strength of chitosan, when it is implanted into the human body through surgical suture, it will degrade under the action of body fluid soaking and enzymes, which will ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/18D01F8/14D01F8/16A61L17/10
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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