201results about How to "Improve hypoxia" patented technology

The invention provides an MOFs type nanometer drug and a preparation method thereof in order to improve the deficiencies in an existing nanometer drug preparation technology. ZIF-8 is adopted as a drug delivery carrier, glucose oxidase (GOx) is encapsulated into channels of the ZIF-8, and MnO2 nanometer particles are supported to prepare the GM-ZIF-8 nanometer composite drug. The method for preparing the GM-ZIF-8 nanometer composite drug is simple in operation and mild in reaction condition, and no complicated preparation instruments are needed. The nanometer drug has a good inhibition effecton tumor cell proliferation.

The invention relates to a black fungus scented crisp chip, which is prepared from black fungi, black rice or black beans, black sesame seeds, water, refined salt or white sugar, pepper powder, monosodium glutamate and cooked vegetable oil through processing. The product has fragrant and crisp taste and rich nutrition, has the health-care function on hairs of a human body, can keep the hairs blackand shiny for long-term eating, has tasty, sweet and delicious flavour, simple preparation method and low cost, and is particularly suitable for being eaten by children and tourism to carry.

The invention relates to an albumin-stabilized MnO2 nanomaterial as well as a preparation method and an application. The albumin-stabilized MnO2 nanomaterial is a multi-component BMnNSs-HPPH nanocomposite. The nanomaterial is a multi-component nanocomposite (BMnHNCs) with good water dispersity and is formed by loading a photosensitizer HPPH in a BSA-MnO2 nanosheet. By the aid of high reactivity and high specificity of MnO2 for endogenous H2O2 under the acid condition, BMnHNCs can realize NIRF and MRI bimodal imaging response to the tumor microenvironment and tumor microenvironment enhanced photodynamic therapy. The nanocomposite has good biocompability and biodegradability and safe and efficient diagnosis and treatment capacity, will provide a new idea for comprehensively regulating the tumor microenvironment and improving tumor diagnosis and treatment capacity and has greater potentials in the aspects of clinical conversion.

The invention belongs to the technical field of drugs, also relates to a method for preparing an injection and an application thereof in the drugs, aiming at providing an N-acetyl-cysteine salt xylitol injection which has obvious effects of biological oxidation resistance, inflammation resistance, antianaphylaxis, immune adjustment and detoxication, and features convenient use, good product quality, safe and reliable taking and the like. The method has the advantages of simple technological process and high product yield. The technical scheme of the invention is as follows: the N- acetyl-cysteine salt xylitol injection is characterized by comprising the following bulk pharmaceutical chemicals in weight percent: 1-4% of N- acetyl-cysteine salt, 3-8% of xylitol, 0.01-0.04% of complexing antioxidant, and the balance water for injection.

The invention belongs to the technical field of aquaculture and discloses a compounded oxygen producer for removing nitrite in aquatic water and a preparation method. The oxygen producer is prepared from components in parts by weight as follows: 40-50 parts of oxygen production ingredients, 24-38 parts of a compound microbial agent, 5-29 parts of an adsorbent, 1.0-2.5 parts of a growth accelerant, 7-10 parts of a traditional Chinese medicine admixture, 0.02-0.12 parts of a synergistic agent, 1-3 parts of a stabilizer and 1.4-2.2 parts of a sustained-release agent; the compound microbial agent comprises denitrifying bacteria, trichoderma harzianum, bacillus amyloliquefaciens, bacillus laterosporus, bacillus subtilis, rhodococcus erythropolis, silicate bacteria, streptococcus faecalis and bacillus coagulans. Multiple microbial agents are compounded in the oxygen producer, and the compounded oxygen producer can effectively remove nitrite, has the functions of inhibiting pathogenic bacteria in the aquatic water and improving digestion of intestinal tracts of aquatic animals and has better popularization and application value.

The present invention provides one kind of brain extract extracted from brain tissue of mammal, including pig, dog, ox, sheep, deer, horse and rabbit. The brain extract contains polypeptide, free lysine, free glutamic acid and total sugar in the weight ratio of 1-200 to 0.1-100 to 0.1-80 to 0.1-12, and has molecular weight of 5,000-10,000. The brain extract contains active matters capable of regulating and improving cerebral metabolism and may be used in treating cerebral vascular diseases and corresponding cerebral metabolic disturbance sequela.

The application discloses a pair of contact lenses with colloid photonic crystal structural color and a preparation method of the contact lenses. The pair of contact lenses contains colloid photonic crystals, the colloid photonic crystals are distributed in the contact lenses as color elements, and the colloid photonic crystals form structural color patterns in the contact lenses. According to the contact lenses based on the colloid photonic crystal structural color, the colloid photonic crystals are arranged in the contact lenses and are distributed in the contact lenses as the color elements to form the structural color patterns, eyes can be beautified, the color elements introduced to the contact lenses can not bring eye discomfort or even eye diseases, conventional pigment and pigment are prevented from being used as a color source of the contact lenses, the contact lenses are elegant in appearance, and the eyes of a wearer are beautiful in colors. Meanwhile, the structural color is realized by unique light interference effect of the colloid photonic crystals, biocompatibility is good, and use is safe.

The invention discloses a snoring treatment mattress, aiming to solve the technical problem of eliminating various hazards caused by obstructive sleep apnea syndromes. The snoring treatment mattress comprises a collector used for collecting physical information of a patient and a healthcare treatment mattress system used for adjusting the sleeping posture of the patient; the collector is connected with the healthcare treatment mattress system in a wireless or wired way; and the healthcare treatment mattress system comprises a mattress, and the mattress is provided with an inflatable airbag. Compared with the prior art, signals of the oxygen content of in the blood of a sleeping person can be collected through the collector and can be promptly transmitted to the healthcare treatment mattress system, the height of the airbag in the mattress can be adjusted according to the signals, the patient subject to the obstructive sleep apnea syndromes can be helped to adjust the sleeping posture on one side, the respiratory tract can be smoothened, the patient can be helped to sleep on one side, the hypoxia caused in sleeping of the patient can be fully eliminated, and the sleeping quality ofthe patient can be improved. Moreover the snoring treatment mattress can be used safely and is suitable for patients suffering from low-degree to moderate obstructive sleep apnea syndromes.

The invention discloses a medicinal composition containing weinaolutong (7, 3', 4'-troxerutin) obtained by hydroxyethylating eldrin and brain extract which is extracted form brain tissue of mammalian except human. The medicinal composition contains 1 to 1000 parts of weinaolutong, by weight, and the weight of the weinaolutong in the medicinal composition is 0.1 to 200 times bigger than total nitrogen content in the brain extract. The invention also discloses preparation method and use of the medicinal composition. The medicinal composition can restrain platelet agglutination thereby preventing thrombosis, and can regulate and improve brain supersession, and is used for treating acute and chronic cerebrovascular disease and sequela such as brain dysfunctional caused by craniocerebral trauma and cerebrovascular disease; and can also be used for treating occlusive syndrome, arteriosclerosis, thrombosis phlebitis, capillary bleeding and dropsy caused by elevation of vascular permeability.

The invention discloses a high-efficiency slow-release fertilizer for high-efficiency cultivation of coix seeds in saline land. The high-efficiency slow-release fertilizer is prepared from, by weight, oyster shells, polylactic acid, activated nano attapulgite, viscid loess, almond residues, tea waste residues, rice chaff ash, modified sea mud, perlite, vermiculite powder, VA mycorrhiza, saccharomycetes, exogenous proline, ardealite, a proper amount of hydrogen peroxide, a proper amount of ammonia water and the like. The almond residues, the tea waste residues, the rice chaff ash, the modified sea mud, the perlite, the vermiculite powder and the like are matched with nutrient substances to prepare the coated slow-release fertilizer after fermentation, and the fertilizer contains rich fermented micromolecular organic matter, the inorganic moisture regulator vermiculite powder and the like itself, is easily absorbed and utilized by plants. In addition, the pH value of saline and alkaline land is automatically regulated by adopting the inorganic moisture regulator, and the resistance of the coix seeds in the saline land is improved. A coating layer capable of supplying oxygen and dynamically regulating pores is adopted, the fertilizer efficiency time is long, organic matter nutrients can be released for a long time, high-efficiency cultivation of the coix seeds in the saline land is promoted, and the high-efficiency slow-release fertilizer can be widely applied and popularized.

The invention relates to a nano-enzyme modified polymer carrier and a preparation method and antitumor nanoparticles thereof. The preparation method of the nano-enzyme modified polymer carrier comprises the following steps of enabling 4-phenylboronic acid pinacol ester to dissolve in dimethyl sulfoxide, and adding an activator to obtain activated liquid; enabling polyethyleneimine to dissolve in water, adding the activated liquid, and performing stirring for the first time to obtain a first intermediate product; loading nano-enzymes on polysaccharide to obtain a second intermediate product; and adding the first intermediate product in the second intermediate product, and performing stirring for the second time to obtain the nano-enzyme modified polymer carrier. The polymer carrier preparedby the method can adsorb a functional molecule bearing negative charges, through self-assembly, stable nanoparticles are formed, under the condition that tumor tissues are high in H2O2 content and acid environment exists, specific release of medicine functional molecules in target positions can be realized, and besides, oxygen can be generated under the condition that the H2O2 content is higher and the acid environment exists. The hypoxia can be improved, and the drug tolerance can be reduced.

The invention relates to the technical field of biological medicine, in particular to a perfluorocarbon emulsion and a preparing method and application thereof, and particularly relates to an application to improving the oxygen content of tumors. The perfluorocarbon emulsion is prepared from perfluorocarbon and proteins, high oxygen carrying capacity is achieved, and oxygen can be rapidly released under the ultrasonic effect. An experiment indicates that the perfluorocarbon emulsion is injected into the caudal vein, a mouse is in the oxygen uptake state, the tumor site of the mouse is subjected to ultrasonic treatment, oxygen carried by the perfluorocarbon emulsion can be rapidly released under the mechanical effect of the ultrasonic treatment, and the content of oxygen at the tumor site is continuously increased. By means of the method, the oxygen-shortage condition at the tumor site can be effectively improved, and therefore the treatment effects of photodynamic therapy and radiotherapy are improved.

The invention relates to a Roman hen feed containing a D-ribose feed additive. The feed comprises the following main raw material components: corn, bean pulp, cooked millet, tomato seed dregs, peanut skin, sunflower seed, cooked yolk, sweet potato flour, potato powder, calcium hydrophosphate, stone powder and salt. Microelement premix, the D-ribose feed additive and a traditional Chinese medicine additive are further added in the main raw materials. The D-ribose additive comprises D-ribose, bran, corncob powder, medical stone and high-calcium stone powder. The traditional Chinese medicine additive contains schisandra chinensis, medicated leaven, Scutellaria baicalensis, folium isatidis, houttuynia cordata, salvia root, Chinese angelica, fingered citron, wild buckwheat, white paeony root and malt. By adjusting the main feed recipe and adding the D-ribose feed additive, the premix microelement and the traditional Chinese medicine additive in the main feed, the microbial flora balance in an animal body is improved, and the proliferative activity of intestinal bifidobacterium is promoted selectively, so that the daily gain and the propagation performance of Roman hens are improved.

The invention discloses an efficient controlled release fertilizer favorably improving taste and freshness of ivy mosses. The fertilizer comprises the following components in parts by weight: oyster shells, polylactic acid, expanded graphite, thermally activated nano chernozem, pinecones, pomegranate barks, mosses, sugarcane ash, a soil beneficial microbial inoculant, bacitracin zinc, phytase, amino acid, ground calcium ammonium sulfate, boric acid, sodium selenite, chelated iron, potassium fulvate, lysine, a proper amount of hydrogen peroxide, a proper amount of ammonia water, a proper amount of water and the like. The coated controlled release fertilizer is prepared by using the pinecones, the pomegranate barks, the mosses and the sugarcane ash which are matched with nutritional substances through fermentation. The fertilizer is rich in nutrient elements such as fermented small molecular organic matters, calcium, iron, selenium and zinc, is abundant in nutrient and convenient for plants to absorb and utilize, so that the taste and freshness of the ivy mosses can be enhanced; by adopting the coating layer which can supply oxygen and dynamically adjust the porosity, the fertilizer efficiency time is long, organic matter nutrients can be released for a long time, efficient cultivation of the ivy mosses can be realized, and the fertilizer can be widely applied and popularized.

The invention relates to a method for in situ microbial remediation of urban water body. Specifically, the method comprises the following steps: taking powdered activated carbon, clay mineral, solid carbon source and microorganism growth factor as raw materials for preparing a microorganism enrichment activating filler; keeping full contact between urban polluted water body and microorganism enrichment activating filler under the action of aeration; boosting the fast enrichment, activation and multiplication of microorganisms in fed water by the carbon source and microorganism growth factor released from the filler; guiding the efficient active fungi released from the filler to enter into the urban water body following the effluent, thereby effectively regulating the structure and plumpness of biological colony in water body, enhancing metabolism of microorganisms, accelerating mineralization of organic pollutants and finally achieving the purpose of remediating water body and promoting self-cleaning capacity of ecological system. The method is simple in process, is low in production and running cost, is convenient for engineering application and has an excellent popularization andapplication prospect.

The invention discloses an efficient slow-release fertilizer capable of promoting growth and development of strawberries. The fertilizer is prepared from the following components in parts by weight: oyster shell, graystone nanocellulose, carbon aerogel, activated nano yellow subsoil, silkworm excrement, bean cake dregs, peanut dregs, distiller's yeast, wine-related yeasts, urease inhibitors, ammonium bicarbonate, vegetable amino acids, compound sodium nitrophenolate, dicyandiamide, honey, brassinolide, a proper amount of hydrogen peroxide, a proper amount of ammonium hydroxide and the like. The silkworm excrement, the bean cake dregs, the peanut dregs and the distiller's yeast are adopted to match with a plant growth regulator, thus the coated slow-release fertilizer is prepared by fermenting, the fertilizer contains rich organic matters and is nutrient-rich, a coat film layer capable of supplying oxygen and dynamically regulating pores is adopted, the fertilizer effect time is long, nutrients can be released for a long time, cell viability of the strawberries can be improved, plant growth and development are accelerated, root and seedling growth is improved, the yield is increased, the ability of tolerating adversity is enhanced, efficient cultivation is realized, and the fertilizer can be widely applied and popularized.

The invention discloses carthamus tinctorius tea which specifically is a drink taking carthamus tinctorius as a main material and taking other natural plants as auxiliary materials. The invention aims at providing a carthamus tinctorius tea drink which is rich in nutrition, is capable of preventing and treating cardiovascular and cerebrovascular diseases to a certain extent, good in taste, convenient to drink and carry, and is capable of promoting the secretion of saliva, regulating vital energy and refreshing, without any side effect; and the specific solution scheme disclosed by the invention is as follows: carthamus tinctorius, hawthorn, tea, stevia rebaudiana, chrysanthemum, liquorice, jujube, hippophae rhamnoide, edible pollen and mint are used as raw materials, are processed and synthesised, packaged in small bags, disinfected, boxed, and then subjected to heat sealing to obtain the carthamus tinctorius tea.

The invention discloses an oxygen-increasing water-living machine. The oxygen-increasing water-living machine is characterized by comprising a main shaft, a floating body surrounding the main shaft to rotate, a rotating support, a plurality of gas guiding tubes, a plurality of gas guiding tube frames, a plurality of flow-pushing aerators, a plurality of adjustable-angle water scraping plates surrounding a horizontal center shaft and a conductive slipping ring; the main shaft penetrates through the center of the floating body and is connected with the floating body through a bearing, the rotating support is fixed to the bottom of the floating body, the gas guiding tubes are evenly distributed on the floating body in an equiangular mode, the upper ends of the gas guiding tubes extend out of the floating body, the lower ends of the gas guiding tubes are fixed on the gas guiding tube frames, the gas guiding tube frames are fixedly connected with the rotating support, the middles of the gas guiding tube frames are movably connected with the water scraping plates through water-scraping-plate adjusting screws, the outer sides of the gas guiding tube frames are movably connected with the flow-pushing aerators through a rotating shaft, and the conductive slipping ring is located on the floating body and electrically connected with the flow-pushing aerators. The oxygen-increasing water-living machine has the advantages that the oxygen-increasing water-living machine has the omnibearing oxygen increasing function and the omnibearing water-body-power pushing function, the structure is simple, the application field is wide, energy consumption is low, and oxygen increasing efficiency is high.

The medicine for treating cardiac and cerebral vascular diseases contains astragalus root, red sage, angelica, Chuanxiong rhizome, red peony root, safflower and earthworm. During the preparation process of the medicine, the said Chinese medicinal materials are soaked in water and decocted, the decoction is concentrated and alcohol precipitated before the alcohol is eliminated to produce the oral liquid. The medicine can dilate blood vessel, inhibit platelet aggregation, dissolve thrombus, eliminate atherosclerosis clot, lower blood fat and serum cholesterol and improve cardiac and cerebral vascular circulation. It can cure cardiac and cerebral vascular diseases radically and has high curative effect and less toxic side effect.

The invention discloses a porphyrin lipid-perfluorocarbon nano preparation and a preparation method and application thereof. The prepared nano preparation is of a core-shell structure, which comprises a porphyrin liposome membrane layer of a shell and perfluorocarbon of an inner core and can be used as a photosensitizer or sonosensitizer medicine and an oxygen delivery system, the photosensitizer/sonosensitizer medicine and oxygen are synchronously delivered to the tumor, under laser or ultrasonic irradiation, the photodynamic therapy/sonodynamic therapy effect is remarkably enhanced, the hypoxic microenvironment of the tumor is improved, and recurrence and metastasis of the tumor are effectively inhibited. According to the invention, photosensitizer/sonosensitizer medicine are covalently linked in lipid molecules, perfluorocarbon is entrapped through strong hydrophobic acting force, which has the characteristics of high stability, high drug loading capacity, high oxygen carrying capacity, difficulty in leakage and the like, and has a good clinical application prospect in tumor diagnosis and treatment.

The invention relates to black fungus instant soup, which is prepared from black fungi, dehydrated vegetables, dehydrated diced meat, essence of chicken, powdered bone soup, pepper, salt, vegetable oil and soy sauce. The product can improve immunity and resist aging; the black fungi is beneficial to the health of a human body if the black fungi are regularly eaten; and the dehydrated vegetables and the dehydrated diced meat are added into the black fungus instant soup so that the black fungus instant soup has rich nutrition, good palatability, convenient edibility, simple preparation and low cost.

The invention provides a pharmaceutical composition for treating viral infection of respiratory system. The pharmaceutical composition contains chloroquine and a sputum-removing drug. The sputum-removing drug is selected from at least one of acetylcysteine, ambroxol or ammonium chloride. The invention provides a preparation method of the pharmaceutical composition for preventing and treating diseases caused by virus infection of a human respiratory system. The medicine composition of the chloroquine and sputum-removing drug is prepared into a spray, an aerosol or an inhalation preparation forpreventing and treating the diseases caused by the virus infection of the human respiratory system.

The invention discloses a new function of cyanobacteria naturally existing in nature, and aims to provide a photosensitizer with a simple preparation process, overcome a tumor hypoxia microenvironmentthrough oxygen self-production by utilizing the characteristic that cyanobacteria generates oxygen through photosynthesis after being illuminated, and target tumors to play an effective photodynamicrole. The in-vitro experiments prove that the cyanobacteria can effectively inhibit the growth of 4T1 cells after being irradiated by laser with a wavelength of 660nm. The photosensitizer is simple inprocess step and low in cost, only a large amount of cyanobacteria needs to be simply multiplied and cultured, and oxygen can be supplied to the photosensitizer by providing specific illumination, sothat tumor hypoxia is overcome, the photodynamic therapy effect is achieved, and the photosensitizer capable of generating oxygen by itself and having industrial practical value is developed.

The invention discloses a silicon plastid-entrapped perfluocarbon preparation as well as a preparation method and application thereof. The prepared preparation can be used as an oxygen and drug delivery system to synchronously deliver oxygen and drugs to tumors in a targeted manner, and under the stimulation of high-intensity focused ultrasound, oxygen and drugs can be quickly released at tumor parts, the hypoxic microenvironment of tumors is improved, and the drug effect of the drugs is improved. A silicate network structure on the surface of the silicon plastid enables the preparation to have good structural stability and drug loading stability, early leakage of drugs in a blood circulation system can be reduced, and toxic and side effects of the drugs are reduced. The preparation can also enhance the effect of ultrasonic imaging and realize drug delivery and drug release under image monitoring.

The invention discloses a water bottom oxygenation method, aiming at solving the defects of the traditional aerating apparatus that dissolved oxygen is centralized on an upper layer and is difficult to reach a water bottom layer which is in lack of oxygen. In the water bottom oxygenation method, a common aerating apparatus and a water bottom horizontal stream establishment oxygen enrichment device which is additionally arranged near the common aerating apparatus are utilized, wherein the common aerating apparatus performs aeration and oxygenation on the upper layer, so that the dissolved oxygen in the upper layer of the water is rapidly increased, thus oxygen-enriched water is formed; and oxygen-enriched water blocks are sucked from the upper water by the water bottom horizontal stream establishment oxygen enrichment device arranged nearby and then are guided into the water bottom at a deep water region to be sprayed out, and a huge horizontal stream is formed at the water bottom, thereby achieving large-area water bottom oxygenation. The method can be used for a deep water aeration tank in a sewage treatment industry, so as to reduce the floor area; and the method can be used for bottom mud oxidation and inner source pollution load reduction, thereby being beneficial to rapid decomposition of deposited matters at the water bottom and the improvement of the water quality.