Metal-organic frameworks type nanometer drug and preparation method and application thereof
A metal-organic framework and nano-drug technology, applied in the field of nano-materials, can solve the problems of immunogenic toxicity, short half-life, poor stability, etc., and achieve the effects of increased porosity, simple operation and mild reaction conditions
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Embodiment 1
[0033] Preparation of GM / ZIF-8 Nanomedicine
[0034] experiment procedure:
[0035] 1) Dissolve 250mg BSA in 7mL pure water, add 3mL KMnO dropwise to the BSA solution at 37°C under continuous stirring 4 solution (0.067mmol / mL), dialyzed after 2h of reaction, constant volume to obtain MnO 2 Nanocolloids.
[0036] 2) 1.1g 2-MIM was dissolved in 5mL pure water to obtain solution A, and 0.1g (Zn(NO 3 ) 2 ·6H 2 O) was dissolved in 1 mL of pure water to obtain solution B.
[0037] 3) First add 2.5mg GOx to solution A, then add solution B to react for 30min under room temperature stirring, centrifuge, redissolve in 10mL pure water, add 500μL MnO 2 The nanocolloid was stirred for 2 hours, centrifuged, washed twice with pure water, and dried under vacuum at room temperature to obtain GM / ZIF-8.
[0038] 4) Examine the structure of GM / ZIF-8 with SEM and TEM.
[0039] test results:
[0040] See attached figure 1 , attached figure 2 . From the transmission electron microscope ...
Embodiment 2
[0043] Preparation of GM / ZIF-8 Nanomedicine
[0044] 1) Dissolve 250mg BSA in 7mL pure water, add 3mL KMnO dropwise to the BSA solution at 37°C under continuous stirring 4 solution (0.067mmol / mL), dialyzed after 2h of reaction, constant volume to obtain MnO 2 Nanocolloids.
[0045] 2) 1.1g 2-MIM was dissolved in 5mL pure water to obtain solution A, and 0.1g (Zn(NO 3 ) 2 ·6H 2 O) was dissolved in 1 mL of pure water to obtain solution B.
[0046] 3) First add 1mg GOx to solution A, then add solution B to react for 30min under room temperature stirring, centrifuge, redissolve in 10mL pure water, add 200μL MnO 2 The nanocolloid was stirred for 2 hours, centrifuged, washed twice with pure water, and dried under vacuum at room temperature to obtain GM / ZIF-8.
[0047] Test results: see Figure 4
Embodiment 3
[0049] Preparation of GM / ZIF-8 Nanomedicine
[0050] 1) Dissolve 250mg BSA in 7mL pure water, add 3mL KMnO dropwise to the BSA solution at 37°C under continuous stirring 4 solution (0.067mmol / mL), dialyzed after 2h of reaction, constant volume to obtain MnO 2 Nanocolloids.
[0051] 2) 1.1g 2-MIM was dissolved in 5mL pure water to obtain solution A, and 0.1g (Zn(NO 3 ) 2 ·6H 2 O) was dissolved in 1 mL of pure water to obtain solution B.
[0052] 3) First add 5 mg GOx to solution A, then add solution B to react for 30 min under room temperature stirring, centrifuge, redissolve in 10 mL of pure water, add 50 μL MnO 2 The nanocolloid was stirred for 2 hours, centrifuged, washed twice with pure water, and dried under vacuum at room temperature to obtain GM / ZIF-8.
[0053] Test results: see Figure 5
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